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There are 32556 results for: content related to: Cytochrome P450 Enzymes: Observations from the Clinic

  1. Cytochrome P450 Enzymes

    Preclinical Development Handbook: ADME and Biopharmaceutical Properties

    Eugene G. Hrycay, Stelvio M. Bandiera, Pages: 627–696, 2007

    Published Online : 27 AUG 2007, DOI: 10.1002/9780470249031.ch18

  2. The Biochemistry of Drug Metabolism – An Introduction

    Chemistry & Biodiversity

    Volume 6, Issue 10, October 2009, Pages: 1477–1660, Stefanie D. Krämer and Bernard Testa

    Version of Record online : 19 OCT 2009, DOI: 10.1002/cbdv.200900233

  3. Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation

    Molecular Nutrition & Food Research

    Volume 56, Issue 5, May 2012, Pages: 797–809, Eun Hee Han, Hyung Gyun Kim, Jae Ho Choi, Yin-Jin Jang, Sang Seop Lee, Kwang-il Kwon, Eunyoung Kim, Kyeumhan Noh, Tae Cheon Jeong, Yong Pil Hwang, Young Chul Chung, Wonku Kang and Hye Gwang Jeong

    Version of Record online : 30 MAY 2012, DOI: 10.1002/mnfr.201100697

  4. You have full text access to this OnlineOpen article
    Applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies

    Pharmacology Research & Perspectives

    Volume 3, Issue 5, October 2015, Sarada D. Ramachandran, Aurélie Vivarès, Sylvie Klieber, Nicola J. Hewitt, Bernhard Muenst, Stefan Heinz, Heike Walles and Joris Braspenning

    Version of Record online : 10 AUG 2015, DOI: 10.1002/prp2.161

  5. Assessing the Potential for Induction of Cytochrome P450 Enzymes and Predicting the In Vivo Response

    Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro/In Vivo Correlations

    J. Andrew Williams, Jeffrey R. Koup, Richard Lalonde, David D. Christ, Pages: 353–382, 2012

    Published Online : 28 FEB 2012, DOI: 10.1002/9781118230275.ch15

  6. You have free access to this content
    In Silico Predictions of Drug – Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition – a Comparative Study of Virtual Screening Performance

    Molecular Informatics

    Volume 34, Issue 6-7, June 2015, Pages: 431–457, Teresa Kaserer, Martina Höferl, Klara Müller, Sebastian Elmer, Markus Ganzera, Walter Jäger and Daniela Schuster

    Version of Record online : 23 JUN 2015, DOI: 10.1002/minf.201400192

  7. Abstracts of papers,** 2001 Annal Meeting Walt Disney Dolphin Orlando, Florida, March 6–10, 2001

    Clinical Pharmacology & Therapeutics

    Volume 69, Issue 2, February 2001, Pages: P1–P95,

    Version of Record online : 2 MAY 2001, DOI: 10.1016/S0009-9236(01)90087-6a

  8. Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models

    The Journal of Clinical Pharmacology

    Volume 41, Issue 11, November 2001, Pages: 1149–1179, Karthik Venkatakrishnan, Lisa L. von Moltke and David J. Greenblatt

    Version of Record online : 8 MAR 2013, DOI: 10.1177/00912700122012724

  9. You have free access to this content
    Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors

    Basic & Clinical Pharmacology & Toxicology

    Volume 117, Issue 4, October 2015, Pages: 261–266, Stina Betts, Linda Björkhem-Bergman, Anders Rane and Lena Ekström

    Version of Record online : 9 MAR 2015, DOI: 10.1111/bcpt.12392

  10. Mice as Clinically Relevant Models for the Study of Cytochrome P450-dependent Metabolism

    Clinical Pharmacology & Therapeutics

    Volume 83, Issue 6, June 2008, Pages: 818–828, S Muruganandan and CJ Sinal

    Version of Record online : 19 MAR 2008, DOI: 10.1038/clpt.2008.50

  11. The Role of Drug Metabolism in Drug Discovery

    Enzyme Inhibition in Drug Discovery and Development: The Good and the Bad

    Tonika Bohnert, Liang-Shang Gan, Pages: 91–176, 2010

    Published Online : 23 FEB 2010, DOI: 10.1002/9780470538951.ch5

  12. Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs

    Phytotherapy Research

    Volume 29, Issue 6, June 2015, Pages: 825–834, Yong Zhao, Bent Håvard Hellum, Aihua Liang and Odd Georg Nilsen

    Version of Record online : 30 JAN 2015, DOI: 10.1002/ptr.5285

  13. You have free access to this content
    Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig

    Basic & Clinical Pharmacology & Toxicology

    Volume 117, Issue 5, November 2015, Pages: 350–357, Els Van Peer, Lies De Bock, Koen Boussery, Jan Van Bocxlaer, Christophe Casteleyn, Chris Van Ginneken and Steven Van Cruchten

    Version of Record online : 18 MAY 2015, DOI: 10.1111/bcpt.12410

  14. In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

    Biopharmaceutics & Drug Disposition

    Volume 22, Issue 2, March 2001, Pages: 53–71, Noriko Hirota, Kiyomi Ito, Takafumi Iwatsubo, Carol E. Green, Charles A. Tyson, Noriaki Shimada, Hiroshi Suzuki and Yuichi Sugiyama

    Version of Record online : 8 NOV 2001, DOI: 10.1002/bdd.261

  15. Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug–Drug Interactions

    Preclinical Development Handbook: ADME and Biopharmaceutical Properties

    Jane R. Kenny, Dermot F. McGinnity, Ken Grime, Robert J. Riley, Pages: 775–827, 2007

    Published Online : 27 AUG 2007, DOI: 10.1002/9780470249031.ch22

  16. You have free access to this content
    Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

    British Journal of Pharmacology

    Volume 165, Issue 8, April 2012, Pages: 2787–2798, AM Filppula, J Laitila, PJ Neuvonen and JT Backman

    Version of Record online : 23 MAR 2012, DOI: 10.1111/j.1476-5381.2011.01732.x

  17. Human Biotransformation

    Biotransformation and Metabolite Elucidation of Xenobiotics

    Andrew Parkinson, Brian W. Ogilvie, Brandy L. Paris, Tiffini N. Hensley, Greg J. Loewen, Pages: 1–77, 2010

    Published Online : 7 SEP 2010, DOI: 10.1002/9780470890387.ch1

  18. Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2 and CYP3A4-selective Inhibitors

    Basic & Clinical Pharmacology & Toxicology

    Accepted manuscript online: 20 NOV 2017, Michael Murray, Wei V. Zhang and Robert J. Edwards

    DOI: 10.1111/bcpt.12933

  19. Biotransformations in Drug Metabolism

    Drug Metabolism Handbook: Concepts and Applications

    Ala F. Nassar, Paul F. Hollenberg, JoAnn Scatina, Pages: 17–40, 2008

    Published Online : 4 AUG 2008, DOI: 10.1002/9780470439265.ch3

  20. Flavonoids and polymer derivatives as CYP3A4 inhibitors for improved oral drug bioavailability

    Journal of Pharmaceutical Sciences

    Volume 102, Issue 2, February 2013, Pages: 541–555, Pius Fasinu, Yahya E. Choonara, Riaz A. Khan, Lisa C. Du Toit, Pradeep Kumar, Valence M. K. Ndesendo and Viness Pillay

    Version of Record online : 27 NOV 2012, DOI: 10.1002/jps.23382