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There are 11531 results for: content related to: BACE Biological Assays

  1. You have free access to this content
    Retromer Regulates Postendocytic Sorting of β-Secretase in Polarized Madin–Darby Canine Kidney Cells


    Volume 13, Issue 10, October 2012, Pages: 1393–1410, Yasmina Cuartero, Maravillas Mellado, Anja Capell, Manuel Álvarez-Dolado and Marcel Verges

    Article first published online : 25 JUL 2012, DOI: 10.1111/j.1600-0854.2012.01392.x

  2. Structure-Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3-Dimensional Structure, and Computational Analysis

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    Felix F. Vajdos, Veerabahu Shanmugasundaram, Alfredo G. Tomasselli, Pages: 123–157, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch6

  3. You have free access to this content
    Structure and modeling in the design of β- and γ-secretase inhibitors

    Drug Development Research

    Volume 70, Issue 2, March 2009, Pages: 70–93, M. Katharine Holloway, Peter Hunt and Georgia B. McGaughey

    Article first published online : 27 FEB 2009, DOI: 10.1002/ddr.20291

  4. Peptidic, Peptidomimetic, and HTS-Derived BACE Inhibitors

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    James P. Beck, Dustin J. Mergott, Pages: 59–105, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch4

  5. You have free access to this content
    Insights into the Phosphoregulation of β-Secretase Sorting Signal by the VHS Domain of GGA1


    Volume 5, Issue 6, June 2004, Pages: 437–448, Tomoo Shiba, Satoshi Kametaka, Masato Kawasaki, Masahiro Shibata, Satoshi Waguri, Yasuo Uchiyama and Soichi Wakatsuki

    Article first published online : 13 APR 2004, DOI: 10.1111/j.1600-0854.2004.00188.x

  6. You have free access to this content
    β-Site APP-cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis

    Journal of Neurochemistry

    Volume 120, Issue 6, March 2012, Pages: 869–880, Jiangli Tan and Geneviève Evin

    Article first published online : 23 JAN 2012, DOI: 10.1111/j.1471-4159.2011.07623.x

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    Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis


    Volume 14, Issue 9, September 2013, Pages: 997–1013, Pei Zhi Cheryl Chia, Wei Hong Toh, Robyn Sharples, Isabelle Gasnereau, Andrew F. Hill and Paul A. Gleeson

    Article first published online : 8 JUL 2013, DOI: 10.1111/tra.12088

  8. You have full text access to this OnlineOpen article
    Surface Trafficking of APP and BACE in Live Cells


    Volume 16, Issue 6, June 2015, Pages: 655–675, Anna Bauereiss, Oliver Welzel, Jasmin Jung, Simon Grosse-Holz, Natalia Lelental, Piotr Lewczuk, Eva M. Wenzel, Johannes Kornhuber and Teja W. Groemer

    Article first published online : 14 APR 2015, DOI: 10.1111/tra.12270

  9. You have free access to this content
    Efficient inhibition of β-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes

    European Journal of Biochemistry

    Volume 270, Issue 19, October 2003, Pages: 3962–3970, Barbara Nawrot, Slawomir Antoszczyk, Maria Maszewska, Tomoko Kuwabara, Masaki Warashina, Kazunari Taira and Wojciech J. Stec

    Article first published online : 12 SEP 2003, DOI: 10.1046/j.1432-1033.2003.03784.x

  10. Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

    Medicinal Research Reviews

    Volume 29, Issue 2, March 2009, Pages: 295–338, Romano Silvestri

    Article first published online : 23 JUL 2008, DOI: 10.1002/med.20132

  11. Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease

    Journal of Neuroscience Research

    Volume 90, Issue 12, December 2012, Pages: 2247–2258, Guoxin Wu, Sethu Sankaranarayanan, Jacky Wong, Katherine Tugusheva, Maria S. Michener, Xiaoping Shi, Jacquelynn J. Cook, Adam J. Simon and Mary J. Savage

    Article first published online : 18 SEP 2012, DOI: 10.1002/jnr.23122

  12. You have free access to this content
    Secretases as targets for beta-amyloid lowering drugs

    Drug Development Research

    Volume 56, Issue 2, June 2002, Pages: 201–210, Jochen Walter and Christian Haass

    Article first published online : 30 AUG 2002, DOI: 10.1002/ddr.10076

  13. Post-translational processing of beta-secretase in Alzheimer's disease


    Volume 5, Issue 6, No. 6 April 2005, Pages: 1533–1543, Christina Sidera, Richard Parsons and Brian Austen

    Article first published online : 24 MAR 2005, DOI: 10.1002/pmic.200401185

  14. Adsorption, Distribution, Metabolism, Excretion (ADME), Efficacy, and Toxicology for BACE Inhibitors

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    Ishrut Hussain, Emmanuel Demont, Pages: 177–196, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch8

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    Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

    The EMBO Journal

    Volume 23, Issue 3, February 11, 2004, Pages: 483–488, Christian Haass

    Article first published online : 29 JAN 2004, DOI: 10.1038/sj.emboj.7600061

  16. You have full text access to this OnlineOpen article
    β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

    EMBO Molecular Medicine

    Volume 4, Issue 9, September 2012, Pages: 980–991, Jun Cai, Xiaoping Qi, Norbert Kociok, Sergej Skosyrski, Alonso Emilio, Qing Ruan, Song Han, Li Liu, Zhijuan Chen, Catherine Bowes Rickman, Todd Golde, Maria B. Grant, Paul Saftig, Lutgarde Serneels, Bart de Strooper, Antonia M. Joussen and Michael E. Boulton

    Article first published online : 20 AUG 2012, DOI: 10.1002/emmm.201101084

  17. You have free access to this content
    The Discovery of Novel β-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies

    Chemical Biology & Drug Design

    Volume 79, Issue 6, June 2012, Pages: 972–980, Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu

    Article first published online : 17 APR 2012, DOI: 10.1111/j.1747-0285.2012.01367.x

  18. Identification of High-Affinity β-Secretase Inhibitors Using Fragment-Based Lead Generation

    Fragment-Based Drug Discovery: A Practical Approach

    Jeffrey S. Albert, Philip D. Edwards, Pages: 261–279, 2008

    Published Online : 27 OCT 2008, DOI: 10.1002/9780470721551.ch11

  19. Future Strategies for Development of Novel BACE Inhibitors: Anti-APP β-Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    Beka Solomon, Michal Arbel-Ornath, Clare Peters-Libeu, Varghese John, Pages: 217–234, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch10

  20. Alzheimer’s Disease: Identification and Development of β-Secretase (BACE-1) Binding Fragments and Inhibitors by Dynamic Ligation Screening (DLS)


    Volume 8, Issue 7, July 2013, Pages: 1041–1056, Dr. María Isabel Fernández-Bachiller, Dr. André Horatscheck, Dr. Michael Lisurek and Prof. Dr. Jörg Rademann

    Article first published online : 11 JUN 2013, DOI: 10.1002/cmdc.201300078