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There are 15142 results for: content related to: Structure-Based Design of BACE Inhibitors: Technical and Practical Aspects of Preparation, 3-Dimensional Structure, and Computational Analysis

  1. Peptidic, Peptidomimetic, and HTS-Derived BACE Inhibitors

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    James P. Beck, Dustin J. Mergott, Pages: 59–105, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch4

  2. BACE Biological Assays

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    Alfredo G. Tomasselli, Michael J. Bienkowski, Pages: 35–58, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch3

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    Retromer Regulates Postendocytic Sorting of β-Secretase in Polarized Madin–Darby Canine Kidney Cells

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    Volume 13, Issue 10, October 2012, Pages: 1393–1410, Yasmina Cuartero, Maravillas Mellado, Anja Capell, Manuel Álvarez-Dolado and Marcel Verges

    Version of Record online : 25 JUL 2012, DOI: 10.1111/j.1600-0854.2012.01392.x

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    Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis

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    Volume 14, Issue 9, September 2013, Pages: 997–1013, Pei Zhi Cheryl Chia, Wei Hong Toh, Robyn Sharples, Isabelle Gasnereau, Andrew F. Hill and Paul A. Gleeson

    Version of Record online : 8 JUL 2013, DOI: 10.1111/tra.12088

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    β-Site APP-cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis

    Journal of Neurochemistry

    Volume 120, Issue 6, March 2012, Pages: 869–880, Jiangli Tan and Geneviève Evin

    Version of Record online : 23 JAN 2012, DOI: 10.1111/j.1471-4159.2011.07623.x

  6. Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

    Medicinal Research Reviews

    Volume 29, Issue 2, March 2009, Pages: 295–338, Romano Silvestri

    Version of Record online : 23 JUL 2008, DOI: 10.1002/med.20132

  7. Structure and modeling in the design of β- and γ-secretase inhibitors

    Drug Development Research

    Volume 70, Issue 2, March 2009, Pages: 70–93, M. Katharine Holloway, Peter Hunt and Georgia B. McGaughey

    Version of Record online : 27 FEB 2009, DOI: 10.1002/ddr.20291

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    Insights into the Phosphoregulation of β-Secretase Sorting Signal by the VHS Domain of GGA1

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    Volume 5, Issue 6, June 2004, Pages: 437–448, Tomoo Shiba, Satoshi Kametaka, Masato Kawasaki, Masahiro Shibata, Satoshi Waguri, Yasuo Uchiyama and Soichi Wakatsuki

    Version of Record online : 13 APR 2004, DOI: 10.1111/j.1600-0854.2004.00188.x

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    Surface Trafficking of APP and BACE in Live Cells

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    Volume 16, Issue 6, June 2015, Pages: 655–675, Anna Bauereiss, Oliver Welzel, Jasmin Jung, Simon Grosse-Holz, Natalia Lelental, Piotr Lewczuk, Eva M. Wenzel, Johannes Kornhuber and Teja W. Groemer

    Version of Record online : 14 APR 2015, DOI: 10.1111/tra.12270

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    Efficient inhibition of β-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes

    European Journal of Biochemistry

    Volume 270, Issue 19, October 2003, Pages: 3962–3970, Barbara Nawrot, Slawomir Antoszczyk, Maria Maszewska, Tomoko Kuwabara, Masaki Warashina, Kazunari Taira and Wojciech J. Stec

    Version of Record online : 12 SEP 2003, DOI: 10.1046/j.1432-1033.2003.03784.x

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    Altered β-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain

    FEBS Letters

    Volume 580, Issue 28-29, December 11, 2006, Pages: 6550–6560, John H. Stockley, Rivka Ravid and Cora O’Neill

    Version of Record online : 13 NOV 2006, DOI: 10.1016/j.febslet.2006.10.076

  12. Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease

    Journal of Neuroscience Research

    Volume 90, Issue 12, December 2012, Pages: 2247–2258, Guoxin Wu, Sethu Sankaranarayanan, Jacky Wong, Katherine Tugusheva, Maria S. Michener, Xiaoping Shi, Jacquelynn J. Cook, Adam J. Simon and Mary J. Savage

    Version of Record online : 18 SEP 2012, DOI: 10.1002/jnr.23122

  13. Adsorption, Distribution, Metabolism, Excretion (ADME), Efficacy, and Toxicology for BACE Inhibitors

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    Ishrut Hussain, Emmanuel Demont, Pages: 177–196, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch8

  14. Future Strategies for Development of Novel BACE Inhibitors: Anti-APP β-Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease

    BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease

    Beka Solomon, Michal Arbel-Ornath, Clare Peters-Libeu, Varghese John, Pages: 217–234, 2010

    Published Online : 26 MAR 2010, DOI: 10.1002/9780470594087.ch10

  15. Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

    Brain Pathology

    Volume 20, Issue 4, July 2010, Pages: 794–802, J. Scott Miners, Zoë Van Helmond, Patrick G. Kehoe and Seth Love

    Version of Record online : 12 JAN 2010, DOI: 10.1111/j.1750-3639.2010.00375.x

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    Camelid heavy chain only antibody fragment domain against β-site of amyloid precursor protein cleaving enzyme 1 inhibits β-secretase activity in vitro and in vivo

    The FEBS Journal

    Volume 282, Issue 18, September 2015, Pages: 3618–3631, Bram Dorresteijn, Maarten Rotman, Dorien Faber, Ruud Schravesande, Ernst Suidgeest, Louise van der Weerd, Silvère M. van der Maarel, Cornelis T. Verrips and Mohamed El Khattabi

    Version of Record online : 22 JUL 2015, DOI: 10.1111/febs.13367

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    Membrane Trafficking Pathways in Alzheimer's Disease

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    Volume 13, Issue 6, June 2012, Pages: 759–770, Lawrence Rajendran and Wim Annaert

    Version of Record online : 17 FEB 2012, DOI: 10.1111/j.1600-0854.2012.01332.x

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    The Discovery of Novel β-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies

    Chemical Biology & Drug Design

    Volume 79, Issue 6, June 2012, Pages: 972–980, Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu

    Version of Record online : 17 APR 2012, DOI: 10.1111/j.1747-0285.2012.01367.x

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    Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation

    The EMBO Journal

    Volume 23, Issue 3, February 11, 2004, Pages: 483–488, Christian Haass

    Version of Record online : 29 JAN 2004, DOI: 10.1038/sj.emboj.7600061

  20. Secretases as targets for beta-amyloid lowering drugs

    Drug Development Research

    Volume 56, Issue 2, June 2002, Pages: 201–210, Jochen Walter and Christian Haass

    Version of Record online : 30 AUG 2002, DOI: 10.1002/ddr.10076