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There are 295006 results for: content related to: Characterization of Impurities and Degradants in Protein Therapeutics by Mass Spectrometry

  1. Recent advances in mass spectrometric analysis of protein deamidation

    Mass Spectrometry Reviews

    Piliang Hao, Sunil S. Adav, Xavier Gallart-Palau and Siu Kwan Sze

    Version of Record online : 13 JAN 2016, DOI: 10.1002/mas.21491

  2. Protein deamidation in biopharmaceutical manufacture: understanding, control and impact

    Journal of Chemical Technology and Biotechnology

    Volume 91, Issue 3, March 2016, Pages: 569–575, David Gervais

    Version of Record online : 8 DEC 2015, DOI: 10.1002/jctb.4850

  3. Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

    Journal of Pharmaceutical Sciences

    Volume 95, Issue 11, November 2006, Pages: 2321–2336, Aditya A. Wakankar and Ronald T. Borchardt

    Version of Record online : 7 SEP 2006, DOI: 10.1002/jps.20740

  4. You have free access to this content
    Engineering deamidation-susceptible asparagines leads to improved stability to thermal cycling in a lipase

    Protein Science

    Volume 23, Issue 10, October 2014, Pages: 1479–1490, K. Bhanuramanand, Shoeb Ahmad and N. M. Rao

    Version of Record online : 5 AUG 2014, DOI: 10.1002/pro.2516

  5. Chemical Instability in Peptide and Protein Pharmaceuticals

    Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals

    Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, Mark Cornell Manning, Pages: 41–67, 2010

    Published Online : 5 AUG 2010, DOI: 10.1002/9780470595886.ch2

  6. Multiple asparagine deamidation of Bacillus anthracis protective antigen causes charge isoforms whose complexity correlates with reduced biological activity

    Proteins: Structure, Function, and Bioinformatics

    Volume 68, Issue 2, 1 August 2007, Pages: 458–479, Bradford S. Powell, Jeffrey T. Enama, Wilson J. Ribot, Wendy Webster, Stephen Little, Timothy Hoover, Jeffrey J. Adamovicz and Gerard P. Andrews

    Version of Record online : 27 APR 2007, DOI: 10.1002/prot.21432

  7. The role of the cyclic imide in alternate degradation pathways for asparagine-containing peptides and proteins

    Journal of Pharmaceutical Sciences

    Volume 96, Issue 10, October 2007, Pages: 2667–2685, Michael P. DeHart and Bradley D. Anderson

    Version of Record online : 22 MAY 2007, DOI: 10.1002/jps.20905

  8. The complex inter-relationships between protein flexibility and stability

    Journal of Pharmaceutical Sciences

    Volume 97, Issue 9, September 2008, Pages: 3494–3517, Tim J. Kamerzell and C. Russell Middaugh

    Version of Record online : 10 JAN 2008, DOI: 10.1002/jps.21269

  9. Prediction of primary structure deamidation rates of asparaginyl and glutaminyl peptides through steric and catalytic effects

    The Journal of Peptide Research

    Volume 63, Issue 5, May 2004, Pages: 437–448, N.E. Robinson and A.B. Robinson

    Version of Record online : 10 MAY 2004, DOI: 10.1111/j.1399-3011.2004.00148.x

  10. Deamidation Kinetics of Precipitated by Carbon Dioxide Compared with Commercial Caseinates

    Journal of Food Science

    Volume 64, Issue 3, May 1999, Pages: 400–404, C. V. SANTOS, P. M. TOMASULA and M. J. KURANTZ

    Version of Record online : 20 JUL 2006, DOI: 10.1111/j.1365-2621.1999.tb15051.x

  11. Estimation of the deamidation rate of asparagine side chains

    The Journal of Peptide Research

    Volume 55, Issue 3, March 2000, Pages: 224–229, S. Capasso

    Version of Record online : 15 DEC 2003, DOI: 10.1034/j.1399-3011.2000.00172.x

  12. Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state

    Journal of Pharmaceutical Sciences

    Volume 94, Issue 8, August 2005, Pages: 1723–1735, Bei Li, Matthew H. O'Meara, Joseph W. Lubach, Richard L. Schowen, Elizabeth M. Topp, Eric J. Munson and Ronald T. Borchardt

    Version of Record online : 28 JUN 2005, DOI: 10.1002/jps.20372

  13. Structure-dependent nonenzymatic deamidation of glutaminyl and asparaginyl pentapeptides

    The Journal of Peptide Research

    Volume 63, Issue 5, May 2004, Pages: 426–436, N.E. Robinson, Z.W. Robinson, B.R. Robinson, A.L. Robinson, J.A. Robinson, M.L. Robinson and A.B. Robinson

    Version of Record online : 10 MAY 2004, DOI: 10.1111/j.1399-3011.2004.00151.x

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    Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

    Protein Science

    Volume 17, Issue 9, September 2008, Pages: 1565–1575, Takumi Takata, Julie T. Oxford, Borries Demeler and Kirsten J. Lampi

    Version of Record online : 2 JAN 2009, DOI: 10.1110/ps.035410.108

  15. Detection and Quantitation of Succinimide in Intact Protein via Hydrazine Trapping and Chemical Derivatization

    Journal of Pharmaceutical Sciences

    Volume 103, Issue 10, October 2014, Pages: 3033–3042, Joshua J. Klaene, Wenqin Ni, Joshua F. Alfaro and Zhaohui Sunny Zhou

    Version of Record online : 14 JUL 2014, DOI: 10.1002/jps.24074

  16. Isomerization of Asp residues plays an important role in αA-crystallin dissociation

    The FEBS Journal

    Volume 283, Issue 5, March 2016, Pages: 850–859, Takumi Takata and Noriko Fujii

    Version of Record online : 21 JAN 2016, DOI: 10.1111/febs.13635

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    Age-dependent deamidation of glutamine residues in human γS crystallin: Deamidation and unstructured regions

    Protein Science

    Volume 21, Issue 7, July 2012, Pages: 1074–1079, Michelle Yu Sung Hooi, Mark J. Raftery and Roger John Willis Truscott

    Version of Record online : 11 JUN 2012, DOI: 10.1002/pro.2095

  18. Proteomic Analysis of Protein Deamidation


    Current Protocols in Protein Science


    Piliang Hao and Siu Kwan Sze

    Published Online : 3 NOV 2014, DOI: 10.1002/0471140864.ps2405s78

  19. Role of Post-translational Chemical Modifications in Amyloid Fibril Formation

    Amyloid Proteins: The Beta Sheet Conformation and Disease

    Jean D. Sipe, Pages: 81–109, 2008

    Published Online : 23 JAN 2008, DOI: 10.1002/9783527619344.ch5

  20. Role of Posttranslational Modifications in Amyloid Formation

    Protein Misfolding Diseases: Current and Emerging Principles and Therapies

    Andisheh Abedini, Ruchi Gupta, Peter Marek, Fanling Meng, Daniel P. Raleigh, Humeyra Taskent, Sylvia Tracz, Pages: 131–144, 2010

    Published Online : 2 JUL 2010, DOI: 10.1002/9780470572702.ch7