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There are 18477 results for: content related to: Identification and Quantification of Degradants and Impurities in Antibodies

  1. Recent advances in mass spectrometric analysis of protein deamidation

    Mass Spectrometry Reviews

    Volume 36, Issue 6, November/December, Pages: 677–692, Piliang Hao, Sunil S. Adav, Xavier Gallart-Palau and Siu Kwan Sze

    Version of Record online : 13 JAN 2016, DOI: 10.1002/mas.21491

  2. Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

    Journal of Pharmaceutical Sciences

    Volume 95, Issue 11, November 2006, Pages: 2321–2336, Aditya A. Wakankar and Ronald T. Borchardt

    Version of Record online : 7 SEP 2006, DOI: 10.1002/jps.20740

  3. Protein deamidation in biopharmaceutical manufacture: understanding, control and impact

    Journal of Chemical Technology and Biotechnology

    Volume 91, Issue 3, March 2016, Pages: 569–575, David Gervais

    Version of Record online : 8 DEC 2015, DOI: 10.1002/jctb.4850

  4. You have free access to this content
    Engineering deamidation-susceptible asparagines leads to improved stability to thermal cycling in a lipase

    Protein Science

    Volume 23, Issue 10, October 2014, Pages: 1479–1490, K. Bhanuramanand, Shoeb Ahmad and N. M. Rao

    Version of Record online : 5 AUG 2014, DOI: 10.1002/pro.2516

  5. Chemical Instability in Peptide and Protein Pharmaceuticals

    Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals

    Elizabeth M. Topp, Lei Zhang, Hong Zhao, Robert W. Payne, Gabriel J. Evans, Mark Cornell Manning, Pages: 41–67, 2010

    Published Online : 5 AUG 2010, DOI: 10.1002/9780470595886.ch2

  6. Characterization of Impurities and Degradants in Protein Therapeutics by Mass Spectrometry

    Characterization of Impurities and Degradants Using Mass Spectrometry

    Li Tao, Michael Ackerman, Wei Wu, Peiran Liu, Reb Russell, Pages: 391–426, 2011

    Published Online : 12 JUL 2011, DOI: 10.1002/9780470921371.ch12

  7. Multiple asparagine deamidation of Bacillus anthracis protective antigen causes charge isoforms whose complexity correlates with reduced biological activity

    Proteins: Structure, Function, and Bioinformatics

    Volume 68, Issue 2, 1 August 2007, Pages: 458–479, Bradford S. Powell, Jeffrey T. Enama, Wilson J. Ribot, Wendy Webster, Stephen Little, Timothy Hoover, Jeffrey J. Adamovicz and Gerard P. Andrews

    Version of Record online : 27 APR 2007, DOI: 10.1002/prot.21432

  8. The role of the cyclic imide in alternate degradation pathways for asparagine-containing peptides and proteins

    Journal of Pharmaceutical Sciences

    Volume 96, Issue 10, October 2007, Pages: 2667–2685, Michael P. DeHart and Bradley D. Anderson

    Version of Record online : 22 MAY 2007, DOI: 10.1002/jps.20905

  9. Prediction of primary structure deamidation rates of asparaginyl and glutaminyl peptides through steric and catalytic effects

    The Journal of Peptide Research

    Volume 63, Issue 5, May 2004, Pages: 437–448, N.E. Robinson and A.B. Robinson

    Version of Record online : 10 MAY 2004, DOI: 10.1111/j.1399-3011.2004.00148.x

  10. Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

    Journal of Pharmaceutical Sciences

    Volume 98, Issue 10, October 2009, Pages: 3509–3521, Boxu Yan, Sean Steen, David Hambly, John Valliere-Douglass, Tim Vanden Bos, Scott Smallwood, Zac Yates, Thomas Arroll, Yihong Han, Himanshu Gadgil, Ramil F. Latypov, Alison Wallace, Aiching Lim, Gerd R. Kleemann, Weichun Wang and Alain Balland

    Version of Record online : 27 MAY 2009, DOI: 10.1002/jps.21655

  11. Estimation of the deamidation rate of asparagine side chains

    The Journal of Peptide Research

    Volume 55, Issue 3, March 2000, Pages: 224–229, S. Capasso

    Version of Record online : 15 DEC 2003, DOI: 10.1034/j.1399-3011.2000.00172.x

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    Characterization of deamidation of barstar using electrospray ionization quadrupole time-of-flight mass spectrometry, which stabilizes an equilibrium unfolding intermediate

    Protein Science

    Volume 21, Issue 5, May 2012, Pages: 633–646, Santosh Kumar Jha, Putchen Dakshinamoorthy Deepalakshmi and Jayant B. Udgaonkar

    Version of Record online : 16 MAR 2012, DOI: 10.1002/pro.2047

  13. Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state

    Journal of Pharmaceutical Sciences

    Volume 94, Issue 8, August 2005, Pages: 1723–1735, Bei Li, Matthew H. O'Meara, Joseph W. Lubach, Richard L. Schowen, Elizabeth M. Topp, Eric J. Munson and Ronald T. Borchardt

    Version of Record online : 28 JUN 2005, DOI: 10.1002/jps.20372

  14. The complex inter-relationships between protein flexibility and stability

    Journal of Pharmaceutical Sciences

    Volume 97, Issue 9, September 2008, Pages: 3494–3517, Tim J. Kamerzell and C. Russell Middaugh

    Version of Record online : 10 JAN 2008, DOI: 10.1002/jps.21269

  15. Structure-dependent nonenzymatic deamidation of glutaminyl and asparaginyl pentapeptides

    The Journal of Peptide Research

    Volume 63, Issue 5, May 2004, Pages: 426–436, N.E. Robinson, Z.W. Robinson, B.R. Robinson, A.L. Robinson, J.A. Robinson, M.L. Robinson and A.B. Robinson

    Version of Record online : 10 MAY 2004, DOI: 10.1111/j.1399-3011.2004.00151.x

  16. Detection and Quantitation of Succinimide in Intact Protein via Hydrazine Trapping and Chemical Derivatization

    Journal of Pharmaceutical Sciences

    Volume 103, Issue 10, October 2014, Pages: 3033–3042, Joshua J. Klaene, Wenqin Ni, Joshua F. Alfaro and Zhaohui Sunny Zhou

    Version of Record online : 14 JUL 2014, DOI: 10.1002/jps.24074

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    Isomerization of Asp residues plays an important role in αA-crystallin dissociation

    The FEBS Journal

    Volume 283, Issue 5, March 2016, Pages: 850–859, Takumi Takata and Noriko Fujii

    Version of Record online : 21 JAN 2016, DOI: 10.1111/febs.13635

  18. You have free access to this content
    Age-dependent deamidation of glutamine residues in human γS crystallin: Deamidation and unstructured regions

    Protein Science

    Volume 21, Issue 7, July 2012, Pages: 1074–1079, Michelle Yu Sung Hooi, Mark J. Raftery and Roger John Willis Truscott

    Version of Record online : 11 JUN 2012, DOI: 10.1002/pro.2095

  19. Proteomic Analysis of Protein Deamidation

    Unit

    Current Protocols in Protein Science

    24:24.5.1–24.5.14

    Piliang Hao and Siu Kwan Sze

    Published Online : 3 NOV 2014, DOI: 10.1002/0471140864.ps2405s78

  20. Role of Post-translational Chemical Modifications in Amyloid Fibril Formation

    Amyloid Proteins: The Beta Sheet Conformation and Disease

    Jean D. Sipe, Pages: 81–109, 2008

    Published Online : 23 JAN 2008, DOI: 10.1002/9783527619344.ch5