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There are 6031 results for: content related to: Systems Biology to Study Platelet-Related Bleeding Disorders

  1. Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation on collagen via integrin αIIbβ3 activation

    Transfusion

    Volume 54, Issue 7, July 2014, Pages: 1808–1816, Chikahiro Terada, Junpei Mori, Hitoshi Okazaki, Masahiro Satake and Kenji Tadokoro

    Article first published online : 8 FEB 2014, DOI: 10.1111/trf.12566

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    Binding of a fibrinogen mimetic stabilizes integrin αIIbβ3's open conformation

    Protein Science

    Volume 10, Issue 8, August 2001, Pages: 1614–1626, Roy R. Hantgan, Mattia Rocco, Chandrasekaran Nagaswami and John W. Weisel

    Article first published online : 31 DEC 2008, DOI: 10.1110/ps.3001

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    Integrin αIIbβ3:ligand interactions are linked to binding-site remodeling

    Protein Science

    Volume 15, Issue 8, August 2006, Pages: 1893–1906, Roy R. Hantgan, Mary C. Stahle, John H. Connor, David A. Horita, Mattia Rocco, Mary A. McLane, Sergiy Yakovlev and Leonid Medved

    Article first published online : 1 JAN 2009, DOI: 10.1110/ps.052049506

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    Demonstration of novel gain-of-function mutations of αIIbβ3: association with macrothrombocytopenia and glanzmann thrombasthenia-like phenotype

    Molecular Genetics & Genomic Medicine

    Volume 1, Issue 2, July 2013, Pages: 77–86, Hirokazu Kashiwagi, Shinji Kunishima, Kazunobu Kiyomizu, Yoshiro Amano, Hiroyuki Shimada, Masashi Morishita, Yuzuru Kanakura and Yoshiaki Tomiyama

    Article first published online : 22 APR 2013, DOI: 10.1002/mgg3.9

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    Activation of integrin αIIbβ3 expressed in Chinese hamster ovary cells is required for interaction with solid-phase von Willebrand factor

    British Journal of Haematology

    Volume 119, Issue 4, December 2002, Pages: 1024–1032, Médina Mekrache, Paulette Legendre, Nelly Kieffer and Dominique Baruch

    Article first published online : 11 DEC 2002, DOI: 10.1046/j.1365-2141.2002.03960.x

  6. Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort

    Human Mutation

    Volume 36, Issue 5, May 2015, Pages: 548–561, Alan T. Nurden, Xavier Pillois, Mathieu Fiore, Marie-Christine Alessi, Mariana Bonduel, Marie Dreyfus, Jenny Goudemand, Yves Gruel, Schéhérazade Benabdallah-Guerida, Véronique Latger-Cannard, Claude Négrier, Diane Nugent, Roseline d Oiron, Margaret L. Rand, Pierre Sié, Marc Trossaert, Lorenzo Alberio, Nathalie Martins, Peggy Sirvain-Trukniewicz, Arnaud Couloux, Mathias Canault, Juan Pablo Fronthroth, Mathilde Fretigny, Paquita Nurden, Roland Heilig and Christine Vinciguerra

    Article first published online : 22 APR 2015, DOI: 10.1002/humu.22776

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    Thiols in the αIIbβ3 integrin are necessary for platelet aggregation

    British Journal of Haematology

    Volume 142, Issue 3, August 2008, Pages: 457–465, Nagaraj Manickam, Xiuhua Sun, Kevin W. Hakala, Susan T. Weintraub and David W. Essex

    Article first published online : 5 JUN 2008, DOI: 10.1111/j.1365-2141.2008.07200.x

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    Activation of recombinant αIIbβ3 expressed in Chinese hamster ovary cells exposes different binding sites for fibrinogen or von Willebrand factor: evidence using monoclonal antibodies to αIIbβ3

    British Journal of Haematology

    Volume 116, Issue 3, 2002, Pages: 636–644, Médina Mekrache, Nelly Kieffer and Dominique Baruch

    Article first published online : 6 MAR 2002, DOI: 10.1046/j.0007-1048.2001.03332.x

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    Role for β3 integrins in human melanoma growth and survival

    International Journal of Cancer

    Volume 101, Issue 2, 10 September 2002, Pages: 156–167, Mohit Trikha, Jozsef Timar, Alex Zacharek, Jeffrey A. Nemeth, Yinlong Cai, Balazs Dome, Beata Somlai, Elisabeth Raso, Andrea Ladanyi and Kenneth V. Honn

    Article first published online : 26 JUL 2002, DOI: 10.1002/ijc.10521

  10. Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations

    Proteins: Structure, Function, and Bioinformatics

    Volume 82, Issue 12, December 2014, Pages: 3231–3240, Davide Provasi, Ana Negri, Barry S. Coller and Marta Filizola

    Article first published online : 25 SEP 2014, DOI: 10.1002/prot.24540

  11. A new Ser472Asn (Cab2a+) polymorphism localized within the αIIb “thigh” domain is involved in neonatal thrombocytopenia

    Transfusion

    Volume 51, Issue 2, February 2011, Pages: 393–400, Vincent Jallu, Mathilde Dusseaux and Cecile Kaplan

    Article first published online : 17 AUG 2010, DOI: 10.1111/j.1537-2995.2010.02815.x

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    A Ser752[RIGHTWARDS ARROW]Pro substitution in the cytoplasmic domain of β3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the αIIbβ3 integrin and the platelet granule pool of fibrinogen

    British Journal of Haematology

    Volume 118, Issue 4, September 2002, Pages: 1143–1151, Paquita Nurden, Christel Poujol, Joelle Winckler, Robert Combrié, Jacques P. Caen and Alan T. Nurden

    Article first published online : 29 AUG 2002, DOI: 10.1046/j.1365-2141.2002.03758.x

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    The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

    The EMBO Journal

    Volume 28, Issue 9, May 6, 2009, Pages: 1351–1361, Tong-Lay Lau, Chungho Kim, Mark H Ginsberg and Tobias S Ulmer

    Article first published online : 12 MAR 2009, DOI: 10.1038/emboj.2009.63

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    Parallel expression of αIIbβ3 and αvβ3 integrins in human melanoma cells upregulates bFGF expression and promotes their angiogenic phenotype

    International Journal of Cancer

    Volume 116, Issue 1, 10 August 2005, Pages: 27–35, Balázs Döme, Erzsébet Rásó, Judit Dobos, Livia Mészáros, Norbert Varga, László G. Puskás, László Z. Fehér, Tamár Lörincz, Andrea Ladányi, Mohit Trikha, Kenneth V. Honn and József Tímár

    Article first published online : 10 MAR 2005, DOI: 10.1002/ijc.20991

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    Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice

    Journal of Thrombosis and Haemostasis

    Volume 10, Issue 9, September 2012, Pages: 1867–1874, J.-R. KIM-KANEYAMA, A. MIYAUCHI, X.-F. LEI, S. ARITA, T. MINO, N. TAKEDA, K. KOU, K. ETO, T. YOSHIDA, T. MIYAZAKI, S. SHIODA and A. MIYAZAKI

    Article first published online : 4 SEP 2012, DOI: 10.1111/j.1538-7836.2012.04856.x

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    Proteomic analysis of integrin αIIbβ3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions

    Journal of Thrombosis and Haemostasis

    Volume 7, Issue 10, October 2009, Pages: 1718–1726, Y. A. SENIS, R. ANTROBUS, S. SEVERIN, A. F. PARGUIÑA, I. ROSA, N. ZITZMANN, S. P. WATSON and A. GARCÍA

    Article first published online : 11 AUG 2009, DOI: 10.1111/j.1538-7836.2009.03565.x

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    Wiskott–Aldrich syndrome protein is involved in αIIbβ3-mediated cell adhesion

    EMBO reports

    Volume 7, Issue 5, May 2006, Pages: 506–511, Shigeru Tsuboi, Shigeaki Nonoyama and Hans D Ochs

    Article first published online : 31 MAR 2006, DOI: 10.1038/sj.embor.7400665

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    Vicinal thiols are required for activation of the αIIbβ3 platelet integrin

    Journal of Thrombosis and Haemostasis

    Volume 9, Issue 6, June 2011, Pages: 1207–1215, N. MANICKAM, S. S. AHMAD and D. W. ESSEX

    Article first published online : 6 JUN 2011, DOI: 10.1111/j.1538-7836.2011.04266.x

  19. The αIIb p.Leu841Met (Cab3a+) polymorphism results in a new human platelet alloantigen involved in neonatal alloimmune thrombocytopenia

    Transfusion

    Volume 53, Issue 3, March 2013, Pages: 554–563, Vincent Jallu, Gerald Bertrand, Frederic Bianchi, Christophe Chenet, Pierre Poulain and Cecile Kaplan

    Article first published online : 27 JUN 2012, DOI: 10.1111/j.1537-2995.2012.03762.x

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    An αIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the β-propeller (Asn2Asp) disrupts a calcium binding site in blade 6

    Journal of Thrombosis and Haemostasis

    Volume 9, Issue 1, January 2011, Pages: 192–200, W. MANSOUR, Y. EINAV, H. HAUSCHNER, A. KOREN, U. SELIGSOHN and N. ROSENBERG

    Article first published online : 7 JAN 2011, DOI: 10.1111/j.1538-7836.2010.04087.x