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There are 12023 results for: content related to: The Pathophysiology of Acute Promyelocytic Leukemia

  1. Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia

    Proteins: Structure, Function, and Bioinformatics

    Volume 80, Issue 4, April 2012, Pages: 1095–1109, Mindy Farris, Astrid Lague, Zara Manuelyan, Jacob Statnekov and Christopher Francklyn

    Article first published online : 7 JAN 2012, DOI: 10.1002/prot.24010

  2. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization


    Volume 61, Issue 5, September 1997, Pages: 321–331, Kathryn Nason-Burchenal, Wolfgang Maerz, Juan Albanell, Janet Allopenna, Patrick Martin, Malcolm A. S. Moore and Ethan Dmitrovsky

    Article first published online : 29 OCT 2002, DOI: 10.1046/j.1432-0436.1997.6150321.x

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    The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease

    British Journal of Haematology

    Volume 106, Issue 3, September 1999, Pages: 591–613, David Grimwade

    Article first published online : 23 FEB 2002, DOI: 10.1046/j.1365-2141.1999.01501.x

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    Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells

    The EMBO Journal

    Volume 24, Issue 6, March 23, 2005, Pages: 1232–1242, Serena Racanicchi, Chiara Maccherani, Concetta Liberatore, Monia Billi, Vania Gelmetti, Maddalena Panigada, Giovanni Rizzo, Clara Nervi and Francesco Grignani

    Article first published online : 24 FEB 2005, DOI: 10.1038/sj.emboj.7600593

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    A surrogate marker profile for PML/RARα expressing acute promyelocytic leukemia and the association of immunophenotypic markers with morphologic and molecular subtypes

    Cytometry Part B: Clinical Cytometry

    Volume 59B, Issue 1, May 2004, Pages: 1–9, E. Paietta, O. Goloubeva, D. Neuberg, J. M. Bennett, R. Gallagher, J. Racevskis, G. Dewald, P. H. Wiernik and M. S. Tallman

    Article first published online : 7 APR 2004, DOI: 10.1002/cyto.b.20001

  6. Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination

    Journal of Cellular Biochemistry

    Volume 113, Issue 5, May 2012, Pages: 1787–1799, Percy Luk Yeung, Natalia G. Denissova, Cara Nasello, Zhanna Hakhverdyan, J. Don Chen and Mark A. Brenneman

    Article first published online : 15 MAR 2012, DOI: 10.1002/jcb.24050

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    HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse

    EMBO Molecular Medicine

    Volume 6, Issue 5, May 2014, Pages: 640–650, Nadia Coltella, Stefano Percio, Roberta Valsecchi, Roberto Cuttano, Jlenia Guarnerio, Maurilio Ponzoni, Pier Paolo Pandolfi, Giovanni Melillo, Linda Pattini and Rosa Bernardi

    Article first published online : 7 APR 2014, DOI: 10.1002/emmm.201303065

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    Identification of the t(15;17) in AML FAB types other than M3: evaluation of the role of molecular screening for the PML/RARα rearrangement in newly diagnosed AML

    British Journal of Haematology

    Volume 105, Issue 1, April 1999, Pages: 198–207, Sarah Allford, David Grimwade, Stephen Langabeer, Estelle Duprez, Andrew Saurin, Stephen Chatters, Helen Walker, Pamela Roberts, Joanne Rogers, Barbara Bain, Keith Patterson, Angela McKernan, Paul Freemont, Ellen Solomon, Alan Burnett, Anthony Goldstone, David Linch and on behalf of the Medical Research Council (MRC) Adult Leukaemia Working Party

    Article first published online : 11 MAR 2005, DOI: 10.1111/j.1365-2141.1999.01312.x

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    MEK inhibition induces caspases activation, differentiation blockade and PML/RARα degradation in acute promyelocytic leukaemia

    British Journal of Haematology

    Volume 142, Issue 1, July 2008, Pages: 27–35, Nuria Barbarroja, Emilio Siendones, Luis Arístides Torres, Mª Jose Luque, Julio Manuel Martinez, Gabriel Dorado, Francisco Velasco, Antonio Torres and Chary López-Pedrera

    Article first published online : 28 APR 2008, DOI: 10.1111/j.1365-2141.2008.07154.x

  10. Expression patterns of specific promyelocytic/retinoic acid receptor-α transcripts in patients with acute promyelocytic leukemia

    International Journal of Laboratory Hematology

    Volume 32, Issue 3, June 2010, Pages: 344–350, J. LIN, L.-X. HAN, J. QIAN, Y.-L. WANG, D.-M. YAO, Z. QIAN, X.-F. YANG and X.-J. SHENG

    Article first published online : 26 OCT 2009, DOI: 10.1111/j.1751-553X.2009.01190.x

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    Internal tandem duplication and Asp835 mutations of the FMS-like tyrosine kinase 3 (FLT3) gene in acute promyelocytic leukemia


    Volume 98, Issue 6, 15 September 2003, Pages: 1206–1216, Lee-Yung Shih, Ming-Chung Kuo, Der-Cherng Liang, Chein-Fuang Huang, Tung-Liang Lin, Jin-Hou Wu, Po-Nan Wang, Po Dunn and Chang-Liang Lai

    Article first published online : 20 AUG 2003, DOI: 10.1002/cncr.11636

  12. PML/RARα fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase

    Journal of Cellular Physiology

    Volume 217, Issue 2, November 2008, Pages: 486–493, Lingna Li, Jie Wang, Richard D. Ye, Guiying Shi, Huifang Jin, Xueming Tang and Jing Yi

    Article first published online : 17 JUL 2008, DOI: 10.1002/jcp.21523

  13. Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor α

    Molecular Carcinogenesis

    Volume 44, Issue 4, December 2005, Pages: 252–261, Y. Alan Wang, Kate Shen, Yasumasa Ishida, Yaolin Wang, Akira Kakizuka and S.C. Brooks

    Article first published online : 4 NOV 2005, DOI: 10.1002/mc.20144

  14. Retinoids

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Marcia I. Dawson

    Published Online : 15 SEP 2010, DOI: 10.1002/0471266949.bmc065.pub2

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    RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

    The EMBO Journal

    Volume 18, Issue 24, December 15, 1999, Pages: 7011–7018, Gérard Benoit, Lucia Altucci, Maria Flexor, Sandrine Ruchaud, Johan Lillehaug, Wolfgang Raffelsberger, Hinrich Gronemeyer and Michel Lanotte

    Article first published online : 15 DEC 1999, DOI: 10.1093/emboj/18.24.7011

  16. Inhibition of all-Trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells

    Molecular Carcinogenesis

    Volume 50, Issue 1, January 2011, Pages: 24–35, Yanfen Fang, Xinglu Zhou, Meihua Lin, Meidan Ying, Peihua Luo, Difeng Zhu, Jianshu Lou, Bo Yang and Qiaojun He

    Article first published online : 13 OCT 2010, DOI: 10.1002/mc.20687

  17. From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era

    Acta Pharmacologica Sinica

    Volume 28, Issue 9, September 2007, Pages: 1434–1449, Guang-biao ZHOU, Guo LI, Sai-juan CHEN and Zhu CHEN

    Article first published online : 2 SEP 2007, DOI: 10.1111/j.1745-7254.2007.00684.x

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    Microgranular and t(11;17)/PLZF-RARα variants of acute promyelocytic leukemia also present the flow cytometric pattern of CD13, CD34, and CD15 expression characteristic of PML-RARα gene rearrangement

    American Journal of Hematology

    Volume 76, Issue 1, May 2004, Pages: 44–51, Edgar G. Rizzatti, Fernando L. Portieres, Sérgio L.R. Martins, Eduardo M. Rego, Marco A. Zago and Roberto P. Falcão

    Article first published online : 22 APR 2004, DOI: 10.1002/ajh.20055

  19. Identification of the STAT5B-RARα fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, c-Kit and C/EBPα mutation

    European Journal of Haematology

    Volume 86, Issue 5, May 2011, Pages: 442–446, Chun Qiao, Su-Jiang Zhang, Li-Juan Chen, Kou-Rong Miao, Jian-Fu Zhang, Yu-Jie Wu, Hai-Rong Qiu and Jian-Yong Li

    Article first published online : 30 MAR 2011, DOI: 10.1111/j.1600-0609.2011.01595.x

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    Anion exchanger 2 mediates the action of arsenic trioxide

    British Journal of Haematology

    Volume 134, Issue 5, September 2006, Pages: 491–499, Xiao-Yan Pan, Guo-Qiang Chen, Li Cai, Stephen Buscemi and Guo-Hui Fu

    Article first published online : 25 JUL 2006, DOI: 10.1111/j.1365-2141.2006.06224.x

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    Vol. 135, Issue 5, 747, Article first published online: 25 OCT 2006