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There are 4495 results for: content related to: The Role of the Apoptosome in Apoptosis and Cancer Therapy

  1. You have free access to this content
    Rsk-mediated phosphorylation and 14-3-3ε binding of Apaf-1 suppresses cytochrome c-induced apoptosis

    The EMBO Journal

    Volume 31, Issue 5, March 7, 2012, Pages: 1279–1292, Jiyeon Kim, Amanda B Parrish, Manabu Kurokawa, Kenkyo Matsuura, Christopher D Freel, Joshua L Andersen, Carrie E Johnson and Sally Kornbluth

    Article first published online : 13 JAN 2012, DOI: 10.1038/emboj.2011.491

  2. You have free access to this content
    Transforming growth factor-β induces apoptosis in rat FaO hepatoma cells via cytochrome c Release and oligomerization of Apaf-1 to form a ∼700-kd apoptosome caspase–processing complex


    Volume 32, Issue 4, October 2000, Pages: 750–760, Caroline Freathy, David G. Brown, Ruth A. Roberts and Kelvin Cain

    Article first published online : 30 DEC 2003, DOI: 10.1053/jhep.2000.18329

  3. You have free access to this content
    α-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation

    European Journal of Biochemistry

    Volume 270, Issue 21, November 2003, Pages: 4388–4399, Lidia Semenkova, 1, Elena Dudich, 1, Igor Dudich, 1 Natalie Tokhtamisheva, 1 Edward Tatulov, 2 Yury Okruzhnov, 3 Jesus Garcia-Foncillas, 3 Juan-Antonio Palop-Cubillo and 4 Timo Korpela 5

    Article first published online : 16 OCT 2003, DOI: 10.1046/j.1432-1033.2003.03836.x

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    Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

    The EMBO Journal

    Volume 20, Issue 5, March 1, 2001, Pages: 998–1009, Shawn B. Bratton, Gail Walker, Srinivasa M. Srinivasula, Xiao-Ming Sun, Michael Butterworth, Emad S. Alnemri and Gerald M. Cohen

    Article first published online : 1 MAR 2001, DOI: 10.1093/emboj/20.5.998

  5. You have free access to this content
    Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

    The EMBO Journal

    Volume 23, Issue 10, May 19, 2004, Pages: 2134–2145, Michelle M Hill, Colin Adrain, Patrick J Duriez, Emma M Creagh and Seamus J Martin

    Article first published online : 22 APR 2004, DOI: 10.1038/sj.emboj.7600210

  6. Molecules that modulate Apaf-1 activity

    Medicinal Research Reviews

    Volume 31, Issue 4, July 2011, Pages: 649–675, Enrique Pérez-Payá, Mar Orzáez, Laura Mondragón, Dennis Wolan, James A. Wells, Angel Messeguer and María J. Vicent

    Article first published online : 22 JAN 2010, DOI: 10.1002/med.20198

  7. Cytochrome c and insect cell apoptosis

    Insect Science

    Volume 19, Issue 1, February 2012, Pages: 30–40, Kai-Yu Liu, Hong Yang, Jian-Xin Peng and Hua-Zhu Hong

    Article first published online : 9 SEP 2011, DOI: 10.1111/j.1744-7917.2011.01431.x

  8. You have free access to this content
    The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

    The EMBO Journal

    Volume 28, Issue 13, July 8, 2009, Pages: 1916–1925, Srinivas Malladi, Madhavi Challa-Malladi, Howard O Fearnhead and Shawn B Bratton

    Article first published online : 4 JUN 2009, DOI: 10.1038/emboj.2009.152

  9. You have full text access to this Open Access content
    The mitochondrial death pathway: a promising therapeutic target in diseases

    Journal of Cellular and Molecular Medicine

    Volume 13, Issue 6, June 2009, Pages: 1004–1033, Sanjeev Gupta, George E.N. Kass, Eva Szegezdi and Bertrand Joseph

    Article first published online : 11 FEB 2009, DOI: 10.1111/j.1582-4934.2009.00697.x

  10. You have full text access to this Open Access content
    Physiological and pathological roles of Apaf1 and the apoptosome

    Journal of Cellular and Molecular Medicine

    Volume 7, Issue 1, January 2003, Pages: 21–34, E. Ferraro, M. Corvaro and F. Cecconi

    Article first published online : 1 MAY 2007, DOI: 10.1111/j.1582-4934.2003.tb00199.x

  11. Apoptosome and Caspase Activation

    Standard Article

    Wiley Encyclopedia of Chemical Biology

    Wim Declercq and Peter Vandenabeele

    Published Online : 15 MAY 2008, DOI: 10.1002/9780470048672.wecb019

  12. You have free access to this content
    Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation

    Clinical & Experimental Immunology

    Volume 167, Issue 3, March 2012, Pages: 369–381, A. K. Mankan, A. Kubarenko and V. Hornung

    Article first published online : 30 JAN 2012, DOI: 10.1111/j.1365-2249.2011.04534.x

  13. Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

    Journal of Pineal Research

    Volume 53, Issue 1, August 2012, Pages: 77–90, Jingshu Wang, Xiangsheng Xiao, Yun Zhang, Dingbo Shi, Wangbing Chen, Lingyi Fu, Liqun Liu, Fangyun Xie, Tiebang Kang, Wenlin Huang and Wuguo Deng

    Article first published online : 16 FEB 2012, DOI: 10.1111/j.1600-079X.2012.00973.x

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    Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

    Genes to Cells

    Volume 3, Issue 11, November 1998, Pages: 697–707, Yoshihide Tsujimoto

    Article first published online : 25 DEC 2001, DOI: 10.1046/j.1365-2443.1998.00223.x

  15. You have free access to this content
    Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis

    Journal of Neurochemistry

    Volume 123, Issue 4, November 2012, Pages: 542–554, Boris Sabirzhanov, Bogdan A. Stoica, Marie Hanscom, Chun-Shu Piao and Alan I. Faden

    Article first published online : 28 SEP 2012, DOI: 10.1111/j.1471-4159.2012.07927.x

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    Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells


    Volume 117, Issue 4, 15 February 2011, Pages: 784–794, Lijun Tan, Roland P. Kwok, Abhishek Shukla, Malti Kshirsagar, Lili Zhao, Anthony W. Opipari Jr and J. Rebecca Liu

    Article first published online : 5 OCT 2010, DOI: 10.1002/cncr.25649

  17. The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis

    Standard Article


    Elisabetta Ferraro and Francesco Cecconi

    Published Online : 15 SEP 2009, DOI: 10.1002/9780470015902.a0021573

  18. Role of Mitochondrial Proteins in Apoptosis

    Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

    Xavier Saelens, Nele Festjens, Lieselotte Vande Walle, Peter Vandenabeele, Pages: 185–221, 2008

    Published Online : 26 MAY 2008, DOI: 10.1002/9783527619665.ch6

  19. Peptides in apoptosis research

    Journal of Peptide Science

    Volume 8, Issue 10, October 2002, Pages: 543–560, Jesús Salgado, Ana J. García-Sáez, Gema Malet, Ismael Mingarro and Dr Enrique Pérez-Payá

    Article first published online : 26 SEP 2002, DOI: 10.1002/psc.414

  20. Pathways to caspase activation

    Cell Biology International

    Volume 29, Issue 7, July 2005, Pages: 489–496, Zi-Bing Wang, Yu-Qing Liu and Yu-Fang Cui

    Article first published online : 2 JAN 2013, DOI: 10.1016/j.cellbi.2005.04.001