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There are 8249 results for: content related to: Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease

  1. You have free access to this content
    Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity

    International Journal of Cancer

    Volume 133, Issue 5, 1 September 2013, Pages: 1107–1118, Toshimitsu Ohashi, Takashi Akazawa, Mitsuhiro Aoki, Bunya Kuze, Keisuke Mizuta, Yatsuji Ito and Norimitsu Inoue

    Version of Record online : 16 MAR 2013, DOI: 10.1002/ijc.28114

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    Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

    The Journal of Physiology

    Volume 590, Issue 24, December 2012, Pages: 6389–6402, Joanne E. Mallinson, Dumitru Constantin-Teodosiu, Philip D. Glaves, Elizabeth A. Martin, Wendy J. Davies, F. Russell Westwood, James E. Sidaway and Paul L. Greenhaff

    Version of Record online : 16 NOV 2012, DOI: 10.1113/jphysiol.2012.238022

  3. Human Kinetics of Orally and Intravenously Administered Low-Dose 1,2-13C-Dichloroacetate

    The Journal of Clinical Pharmacology

    Volume 46, Issue 12, December 2006, Pages: 1449–1459, Dr Minghong Jia, Ms Bonnie Coats, Dr Monisha Chadha, Dr Barbara Frentzen, Mr Javier Perez-Rodriguez, Dr Paul A. Chadik, Dr Richard A. Yost, Dr George N. Henderson and Dr Peter W. Stacpoole

    Version of Record online : 8 MAR 2013, DOI: 10.1177/0091270006292627

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    Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

    International Journal of Cancer

    Volume 127, Issue 11, 1 December 2010, Pages: 2510–2519, Luke H. Stockwin, Sherry X. Yu, Suzanne Borgel, Chad Hancock, Tracy L. Wolfe, Lawrence R. Phillips, Melinda G. Hollingshead and Dianne L. Newton

    Version of Record online : 7 JUN 2010, DOI: 10.1002/ijc.25499

  5. You have full text access to this OnlineOpen article
    Effects of decreased lactate accumulation after dichloroacetate administration on exercise training–induced mitochondrial adaptations in mouse skeletal muscle

    Physiological Reports

    Volume 3, Issue 9, September 2015, Daisuke Hoshino, Yuki Tamura, Hiroyuki Masuda, Yutaka Matsunaga and Hideo Hatta

    Version of Record online : 28 SEP 2015, DOI: 10.14814/phy2.12555

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    Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect

    Journal of Neurochemistry

    Volume 100, Issue 2, January 2007, Pages: 429–436, Natalia Felitsyn, Peter W. Stacpoole and Lucia Notterpek

    Version of Record online : 2 OCT 2006, DOI: 10.1111/j.1471-4159.2006.04248.x

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    Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells

    International Journal of Cancer

    Volume 130, Issue 7, 1 April 2012, Pages: 1484–1493, Serena Vella, Matteo Conti, Roberta Tasso, Ranieri Cancedda and Aldo Pagano

    Version of Record online : 27 AUG 2011, DOI: 10.1002/ijc.26173

  8. Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate

    The Journal of Clinical Pharmacology

    Volume 52, Issue 6, June 2012, Pages: 837–849, Mr Albert L. Shroads, Dr Taimour Langaee, Ms Bonnie S. Coats, Mr Tracie L. Kurtz, Mr John R. Bullock, Mr David Weithorn, Dr Yan Gong, Dr David A. Wagner, Dr David A. Ostrov, Dr Julie A. Johnson and Dr Peter W. Stacpoole

    Version of Record online : 7 MAR 2013, DOI: 10.1177/0091270011405664

  9. Efficacy of Dichloroacetate as a Lactate-Lowering Drug

    The Journal of Clinical Pharmacology

    Volume 43, Issue 7, July 2003, Pages: 683–691, Dr. Peter W. Stacpoole, Nelamangala V. Nagaraja and Alan D. Hutson

    Version of Record online : 8 MAR 2013, DOI: 10.1177/0091270003254637

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    The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle

    The Journal of Physiology

    Volume 544, Issue 2, October 2002, Pages: 591–602, Paul A. Roberts, Susan J. G. Loxham, Simon M. Poucher, Dumitru Constantin-Teodosiu and Paul L. Greenhaff

    Version of Record online : 22 JUL 2004, DOI: 10.1113/jphysiol.2002.021097

  11. Population Kinetics, Efficacy, and Safety of Dichloroacetate for Lactic Acidosis Due to Severe Malaria in Children

    The Journal of Clinical Pharmacology

    Volume 43, Issue 4, April 2003, Pages: 386–396, Tsiri Agbenyega, Tim Planche, George Bedu-Addo, Daniel Ansong, Alex Owusu-Ofori, Venkatesh A. Bhattaram, Nelamangala V. Nagaraja, Albert L. Shroads, George N. Henderson, Alan D. Hutson, Hartmut Derendorf, Sanjeev Krishna and Peter W. Stacpoole

    Version of Record online : 8 MAR 2013, DOI: 10.1177/0091270003251392

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    Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation

    Liver Transplantation

    Volume 14, Issue 7, July 2008, Pages: 989–998, Robert E. Shangraw, Deirdre Lohan-Mannion, Agnes Hayes, Rose M. Moriarty, Rongwei Fu and Stephen T. Robinson

    Version of Record online : 25 JUN 2008, DOI: 10.1002/lt.21485

  13. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children

    The Journal of Clinical Pharmacology

    Volume 55, Issue 1, January 2015, Pages: 50–55, A. L. Shroads, B. S. Coats, C. W. McDonough, T. Langaee and P. W. Stacpoole

    Version of Record online : 6 AUG 2014, DOI: 10.1002/jcph.371

  14. In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate

    NMR in Biomedicine

    Volume 26, Issue 12, December 2013, Pages: 1680–1687, Sonal Josan, Jae Mo Park, Ralph Hurd, Yi-Fen Yen, Adolf Pfefferbaum, Daniel Spielman and Dirk Mayer

    Version of Record online : 31 JUL 2013, DOI: 10.1002/nbm.3003

  15. Volumetric spiral chemical shift imaging of hyperpolarized [2-13c]pyruvate in a rat c6 glioma model

    Magnetic Resonance in Medicine

    Volume 75, Issue 3, March 2016, Pages: 973–984, Jae Mo Park, Sonal Josan, Taichang Jang, Milton Merchant, Ron Watkins, Ralph E. Hurd, Lawrence D. Recht, Dirk Mayer and Daniel M. Spielman

    Version of Record online : 6 MAY 2015, DOI: 10.1002/mrm.25766

  16. Treatment for Leigh syndrome by monitoring dichloroacetate concentration

    Pediatrics International

    Volume 51, Issue 2, April 2009, Pages: 293–295, Yoshiki Katsumi, Masafumi Morimoto, Akira Nishimura, Etsuo Naito and Tohru Sugimoto

    Version of Record online : 30 MAR 2009, DOI: 10.1111/j.1442-200X.2009.02815.x

  17. Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic

    Biotechnology and Bioengineering

    Volume 108, Issue 6, June 2011, Pages: 1413–1420, Ning Zhang and Andre F. Palmer

    Version of Record online : 18 FEB 2011, DOI: 10.1002/bit.23071

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    Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2

    FEBS Letters

    Volume 581, Issue 16, June 26, 2007, Pages: 2988–2992, Alla Klyuyeva, Alina Tuganova and Kirill M. Popov

    Version of Record online : 29 MAY 2007, DOI: 10.1016/j.febslet.2007.05.052

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    Dual effects of dichloroacetate on cardiac ischaemic preconditioning in the rat isolated perfused heart

    British Journal of Pharmacology

    Volume 124, Issue 1, May 1998, Pages: 245–251, Michael D Randall, Claudia A Keon, Paul L Greenhaff and Dumitru Constantin-Teodosiu

    Version of Record online : 3 FEB 2009, DOI: 10.1038/sj.bjp.0701828

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    Ursodeoxycholic acid inhibits interleukin beta 1 and deoxycholic acid-induced activation of NF-κB and AP-1 in human colon cancer cells

    International Journal of Cancer

    Volume 118, Issue 3, 1 February 2006, Pages: 532–539, Syed A. Shah, Yuri Volkov, Qamrul Arfin, Mohamed M. Abdel-Latif and Dermot Kelleher

    Version of Record online : 16 AUG 2005, DOI: 10.1002/ijc.21365