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There are 5287 results for: content related to: Localization of LRRK2 to membranous and vesicular structures in mammalian brain

  1. Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

    Human Mutation

    Volume 35, Issue 4, April 2014, Pages: 395–412, Ryan D. Mills, Terrence D. Mulhern, Fei Liu, Janetta G. Culvenor and Heung-Chin Cheng

    Article first published online : 24 FEB 2014, DOI: 10.1002/humu.22515

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    Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

    FEBS Journal

    Volume 281, Issue 1, January 2014, Pages: 3–13, Fumitaka Kawakami, Naoki Shimada, Etsuro Ohta, Go Kagiya, Rei Kawashima, Tatsunori Maekawa, Hiroko Maruyama and Takafumi Ichikawa

    Article first published online : 28 NOV 2013, DOI: 10.1111/febs.12579

  3. Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1

    Journal of Neurochemistry

    Volume 128, Issue 4, February 2014, Pages: 561–576, Gregory C. Luerman, Chuong Nguyen, Harry Samaroo, Paula Loos, Hualin Xi, Andres Hurtado-Lorenzo, Elie Needle, G. Stephen Noell, Paul Galatsis, John Dunlop, Kieran F. Geoghegan and Warren D. Hirst

    Article first published online : 11 NOV 2013, DOI: 10.1111/jnc.12483

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    LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles

    FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6445–6454, Zhenyu Yue

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07343.x

  5. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

    Journal of Comparative Neurology

    Andrew B. West, Rita M. Cowell, João P.L. Daher, Mark S. Moehle, Kelly M. Hinkle, Heather L. Melrose, David G. Standaert and Laura A. Volpicelli-Daley

    Article first published online : 12 APR 2014, DOI: 10.1002/cne.23583

  6. You have full text access to this OnlineOpen article
    Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

    Journal of Neurochemistry

    Volume 122, Issue 3, August 2012, Pages: 650–658, Jingwen Niu, Mei Yu, Chunyan Wang and Zhiheng Xu

    Article first published online : 22 JUN 2012, DOI: 10.1111/j.1471-4159.2012.07809.x

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    Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

    Journal of Neurochemistry

    Volume 111, Issue 3, November 2009, Pages: 703–715, Christian L. Klein, Giorgio Rovelli, Wolfdieter Springer, Christoph Schall, Thomas Gasser and Philipp J. Kahle

    Article first published online : 27 AUG 2009, DOI: 10.1111/j.1471-4159.2009.06358.x

  8. You have full text access to this OnlineOpen article
    Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson’s disease R1441C/G mutants

    Journal of Neurochemistry

    Volume 103, Issue 1, October 2007, Pages: 238–247, Xianting Li, Yin-Cai Tan, Shibu Poulose, C. Warren Olanow, Xin-Yun Huang and Zhenyu Yue

    Article first published online : 3 JUN 2007, DOI: 10.1111/j.1471-4159.2007.04743.x

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    LRRK2 in Parkinson’s disease: function in cells and neurodegeneration

    FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6436–6444, Philip J. Webber and Andrew B. West

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07342.x

  10. Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

    Movement Disorders

    Volume 26, Issue 8, July 2011, Pages: 1386–1397, Zhenyu Yue and M. Lenard Lachenmayer

    Article first published online : 29 APR 2011, DOI: 10.1002/mds.23737

  11. You have full text access to this OnlineOpen article
    Investigation of leucine-rich repeat kinase 2

    FEBS Journal

    Volume 276, Issue 2, January 2009, Pages: 466–478, Vasanti S. Anand, Laurie J. Reichling, Kerri Lipinski, Wayne Stochaj, Weili Duan, Kerry Kelleher, Pooja Pungaliya, Eugene L. Brown, Peter H. Reinhart, Richard Somberg, Warren D. Hirst, Steven M. Riddle and Steven P. Braithwaite

    Article first published online : 8 DEC 2008, DOI: 10.1111/j.1742-4658.2008.06789.x

  12. You have full text access to this OnlineOpen article
    MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2

    Journal of Neurochemistry

    Volume 112, Issue 6, March 2010, Pages: 1593–1604, Cindy H. Hsu, Diane Chan, Elisa Greggio, Shamol Saha, Maria D. Guillily, Andrew Ferree, Kesav Raghavan, Grace C. Shen, Lilach Segal, Hoon Ryu, Mark R. Cookson and Benjamin Wolozin

    Article first published online : 7 JAN 2010, DOI: 10.1111/j.1471-4159.2010.06568.x

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    Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

    Journal of Neuroscience Research

    Volume 87, Issue 6, 1 May 2009, Pages: 1283–1295, Payal N. Gandhi, Shu G. Chen and Amy L. Wilson-Delfosse

    Article first published online : 21 NOV 2008, DOI: 10.1002/jnr.21949

  14. You have full text access to this OnlineOpen article
    Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition

    Journal of Neurochemistry

    Volume 120, Issue 1, January 2012, Pages: 37–45, Elizabeth A. Doggett, Jing Zhao, Christina N. Mork, Dongmei Hu and R. Jeremy Nichols

    Article first published online : 11 NOV 2011, DOI: 10.1111/j.1471-4159.2011.07537.x

  15. Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe

    Human Mutation

    Volume 33, Issue 7, July 2012, Pages: 1087–1098, Justin P. Rubio, Simon Topp, Liling Warren, Pamela L. St. Jean, Daniel Wegmann, Darren Kessner, John Novembre, Judong Shen, Dana Fraser, Jennifer Aponte, Keith Nangle, Lon R. Cardon, Margaret G. Ehm, Stephanie L. Chissoe, John C. Whittaker, Matthew R. Nelson and Vincent E. Mooser

    Article first published online : 4 APR 2012, DOI: 10.1002/humu.22075

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    LRRK2 in Parkinson’s disease: biochemical functions

    FEBS Journal

    Volume 276, Issue 22, November 2009, Pages: 6428–6435, Vasanti S. Anand and Steven P. Braithwaite

    Article first published online : 5 OCT 2009, DOI: 10.1111/j.1742-4658.2009.07341.x

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    Poster Presentations

    Movement Disorders

    Volume 27, Issue S1, June 2012, Pages: S1–S523,

    Article first published online : 19 JUN 2012, DOI: 10.1002/mds.25051

  18. You have full text access to this OnlineOpen article
    Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

    Journal of Neurochemistry

    Volume 100, Issue 2, January 2007, Pages: 368–381, Shinji Higashi, Darren J. Moore, Rebecca E. Colebrooke, Saskia Biskup, Valina L. Dawson, Heii Arai, Ted M. Dawson and Piers C. Emson

    Article first published online : 2 OCT 2006, DOI: 10.1111/j.1471-4159.2006.04246.x

  19. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

    Human Mutation

    Volume 32, Issue 12, December 2011, Pages: 1390–1397, Dario C. Angeles, Bong-Hwa Gan, Luisa Onstead, Yi Zhao, Kah-Leong Lim, Justus Dachsel, Heather Melrose, Matt Farrer, Zbigniew K. Wszolek, Dennis W. Dickson and Eng-King Tan

    Article first published online : 12 SEP 2011, DOI: 10.1002/humu.21582

  20. You have full text access to this OnlineOpen article
    The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition

    Journal of Neurochemistry

    Volume 115, Issue 1, October 2010, Pages: 36–46, Jason P. Covy and Benoit I. Giasson

    Article first published online : 8 JUL 2010, DOI: 10.1111/j.1471-4159.2010.06894.x