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There are 15675 results for: content related to: New pathway links γ-secretase to inflammation and memory while sparing notch

  1. You have free access to this content
    Reconstitution of γ-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of γ-secretase complex

    Genes to Cells

    Volume 11, Issue 1, January 2006, Pages: 83–93, Hirohisa Shiraishi, Toshihiro Marutani, Hua-Qin Wang, Yasuhiro Maeda, Yukihisa Kurono, Akihiko Takashima, Wataru Araki, Masaki Nishimura, Katsuhiko Yanagisawa and Hiroto Komano

    Version of Record online : 22 NOV 2005, DOI: 10.1111/j.1365-2443.2005.00914.x

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    Parte II - Resumos

    Journal of Research in Special Educational Needs

    Volume 16, Issue S1, August 2016, Pages: 1113–1150,

    Version of Record online : 4 AUG 2016, DOI: 10.1111/1471-3802.12260

  3. You have full text access to this Open Access content
    Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease

    Aging Cell

    Volume 11, Issue 4, August 2012, Pages: 559–568, A-Ryeong Gwon, Jong-Sung Park, Thiruma V. Arumugam, Yong-Kook Kwon, Sic L. Chan, Seol-Hee Kim, Sang-Ha Baik, Sunghee Yang, Young-Kwang Yun, Yuri Choi, Saerom Kim, Sung-Chun Tang, Dong-Hoon Hyun, Aiwu Cheng, Charles E. Dann III, Michel Bernier, Jaewon Lee, William R. Markesbery, Mark P. Mattson and Dong-Gyu Jo

    Version of Record online : 9 APR 2012, DOI: 10.1111/j.1474-9726.2012.00817.x

  4. REVIEW: γ-Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

    CNS Neuroscience & Therapeutics

    Volume 16, Issue 5, October 2010, Pages: 272–284, Francesco Panza, Vincenza Frisardi, Bruno P. Imbimbo, Cristiano Capurso, Giancarlo Logroscino, Daniele Sancarlo, Davide Seripa, Gianluigi Vendemiale, Alberto Pilotto and Vincenzo Solfrizzi

    Version of Record online : 16 JUN 2010, DOI: 10.1111/j.1755-5949.2010.00164.x

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    Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

    EMBO Molecular Medicine

    Volume 4, Issue 4, April 2012, Pages: 344–352, Nobuto Kakuda, Mikio Shoji, Hiroyuki Arai, Katsutoshi Furukawa, Takeshi Ikeuchi, Kohei Akazawa, Mako Takami, Hiroyuki Hatsuta, Shigeo Murayama, Yasuhiro Hashimoto, Masakazu Miyajima, Hajime Arai, Yu Nagashima, Haruyasu Yamaguchi, Ryozo Kuwano, Kazuhiro Nagaike, Yasuo Ihara and the Japanese Alzheimer's Disease Neuroimaging Initiative

    Version of Record online : 21 FEB 2012, DOI: 10.1002/emmm.201200214

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    Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for γ-secretase complex formation

    Journal of Neurochemistry

    Volume 98, Issue 1, July 2006, Pages: 300–309, Emily S. Walker, Maribel Martinez, Jun Wang and Alison Goate

    Version of Record online : 12 MAY 2006, DOI: 10.1111/j.1471-4159.2006.03881.x

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    γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratio

    Journal of Cellular and Molecular Medicine

    Volume 15, Issue 10, October 2011, Pages: 2150–2163, Louise Hedskog, Camilla A. Hansson Petersen, Annelie I. Svensson, Hedvig Welander, Lars O. Tjernberg, Helena Karlström and Maria Ankarcrona

    Version of Record online : 26 SEP 2011, DOI: 10.1111/j.1582-4934.2010.01208.x

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    The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity

    The EMBO Journal

    Volume 23, Issue 24, December 8, 2004, Pages: 4738–4748, Christoph Kaether, Anja Capell, Dieter Edbauer, Edith Winkler, Bozidar Novak, Harald Steiner and Christian Haass

    Version of Record online : 18 NOV 2004, DOI: 10.1038/sj.emboj.7600478

  9. β-Amyloid Therapeutic Strategies for Alzheimer's Disease

    Standard Article

    Burger's Medicinal Chemistry and Drug Discovery

    Bruno P. Imbimbo and Francesca Speroni

    Published Online : 14 OCT 2005, DOI: 10.1002/0471266949.bmc112

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    Aph-1 interacts at the cell surface with proteins in the active γ-secretase complex and membrane-tethered Notch

    Journal of Neurochemistry

    Volume 92, Issue 5, March 2005, Pages: 1010–1020, Emil M. Hansson, Kia Strömberg, Susanne Bergstedt, Gang Yu, Jan Näslund, Johan Lundkvist and Urban Lendahl

    Version of Record online : 2 FEB 2005, DOI: 10.1111/j.1471-4159.2004.02926.x

  11. Identity and function of γ-secretase

    Journal of Neuroscience Research

    Volume 74, Issue 3, 1 November 2003, Pages: 353–360, W. Taylor Kimberly and Michael S. Wolfe

    Version of Record online : 28 OCT 2003, DOI: 10.1002/jnr.10736

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    Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

    Journal of Neurochemistry

    Volume 133, Issue 3, May 2015, Pages: 409–421, Alexandre Matz, Blanka Halamoda-Kenzaoui, Romain Hamelin, Sebastien Mosser, Jean-René Alattia, Mitko Dimitrov, Marc Moniatte and Patrick C. Fraering

    Version of Record online : 24 FEB 2015, DOI: 10.1111/jnc.12996

  13. Functional reconstitution of γ-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2

    Journal of Neuroscience Research

    Volume 77, Issue 3, 1 August 2004, Pages: 309–322, Goran Periz and Mark E. Fortini

    Version of Record online : 14 JUN 2004, DOI: 10.1002/jnr.20203

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    γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

    Traffic

    Volume 11, Issue 9, September 2010, Pages: 1234–1245, Erika B. Sorensen and Sean D. Conner

    Version of Record online : 21 JUN 2010, DOI: 10.1111/j.1600-0854.2010.01090.x

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    Membrane Trafficking Pathways in Alzheimer's Disease

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    Volume 13, Issue 6, June 2012, Pages: 759–770, Lawrence Rajendran and Wim Annaert

    Version of Record online : 17 FEB 2012, DOI: 10.1111/j.1600-0854.2012.01332.x

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    Active γ-secretase is localized to detergent-resistant membranes in human brain

    The FEBS Journal

    Volume 275, Issue 6, March 2008, Pages: 1174–1187, Ji-Yeun Hur, Hedvig Welander, Homira Behbahani, Mikio Aoki, Jenny Frånberg, Bengt Winblad, Susanne Frykman and Lars O. Tjernberg

    Version of Record online : 6 FEB 2008, DOI: 10.1111/j.1742-4658.2008.06278.x

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    Alterations in phosphatidylethanolamine levels affect the generation of Aβ

    Aging Cell

    Volume 11, Issue 1, February 2012, Pages: 63–72, Iva Nesic, Francesc X. Guix, Krist’l Vennekens, Vasiliki Michaki, Paul P. Van Veldhoven, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti and Tina Wahle

    Version of Record online : 28 NOV 2011, DOI: 10.1111/j.1474-9726.2011.00760.x

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    A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

    EMBO reports

    Volume 3, Issue 7, July 2002, Pages: 688–694, Andrea Geling, Harald Steiner, Michael Willem, Laure Bally-Cuif and Christian Haass

    Version of Record online : 1 JUL 2002, DOI: 10.1093/embo-reports/kvf124

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    Masking of Transmembrane-Based Retention Signals Controls ER Export of γ-Secretase

    Traffic

    Volume 11, Issue 2, February 2010, Pages: 250–258, Matthias Fassler, Michael Zocher, Sebastian Klare, Alerie Guzman De La Fuente, Johanna Scheuermann, Anja Capell, Christian Haass, Christina Valkova, Anbazhagan Veerappan, Dirk Schneider and Christoph Kaether

    Version of Record online : 5 NOV 2009, DOI: 10.1111/j.1600-0854.2009.01014.x

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    The same γ-secretase accounts for the multiple intramembrane cleavages of APP

    Journal of Neurochemistry

    Volume 100, Issue 5, March 2007, Pages: 1234–1246, Guojun Zhao, Jianxin Tan, Guozhang Mao, Mei-Zhen Cui and Xuemin Xu

    Version of Record online : 6 NOV 2006, DOI: 10.1111/j.1471-4159.2006.04302.x