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There are 8894 results for: content related to: CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

  1. Review: Transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

    Neuropathology and Applied Neurobiology

    Volume 36, Issue 2, April 2010, Pages: 97–112, T. F. Gendron, K. A. Josephs and L. Petrucelli

    Version of Record online : 23 MAR 2010, DOI: 10.1111/j.1365-2990.2010.01060.x

  2. Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease

    Annals of Neurology

    Volume 77, Issue 6, June 2015, Pages: 942–952, Sukriti Nag, Lei Yu, Ana W. Capuano, Robert S. Wilson, Sue E. Leurgans, David A. Bennett and Julie A. Schneider

    Version of Record online : 22 APR 2015, DOI: 10.1002/ana.24388

  3. Detection of TDP-43 oligomers in frontotemporal lobar degeneration–TDP

    Annals of Neurology

    Volume 78, Issue 2, August 2015, Pages: 211–221, Patricia F. Kao, Yun-Ru Chen, Xiao-Bo Liu, Charles DeCarli, William W. Seeley and Lee-Way Jin

    Version of Record online : 30 JUN 2015, DOI: 10.1002/ana.24431

  4. TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

    Annals of Neurology

    Volume 78, Issue 5, November 2015, Pages: 697–709, Keith A. Josephs, Jennifer L. Whitwell, Nirubol Tosakulwong, Stephen D. Weigand, Melissa E. Murray, Amanda M. Liesinger, Leonard Petrucelli, Matthew L. Senjem, Robert J. Ivnik, Joseph E. Parisi, Ronald C. Petersen and Dennis W. Dickson

    Version of Record online : 16 SEP 2015, DOI: 10.1002/ana.24493

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    TDP-43 loss of function increases TFEB activity and blocks autophagosome–lysosome fusion

    The EMBO Journal

    Volume 35, Issue 2, 18 January 2016, Pages: 121–142, Qin Xia, Hongfeng Wang, Zongbing Hao, Cheng Fu, Qingsong Hu, Feng Gao, Haigang Ren, Dong Chen, Junhai Han, Zheng Ying and Guanghui Wang

    Version of Record online : 23 DEC 2015, DOI: 10.15252/embj.201591998

  6. TARDBP and FUS Mutations Associated with Amyotrophic Lateral Sclerosis: Summary and Update

    Human Mutation

    Volume 34, Issue 6, June 2013, Pages: 812–826, Serena Lattante, Guy A. Rouleau and Edor Kabashi

    Version of Record online : 29 APR 2013, DOI: 10.1002/humu.22319

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    TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation

    Genes to Cells

    Volume 21, Issue 5, May 2016, Pages: 466–481, Akira Ishiguro, Nobuyuki Kimura, Yuto Watanabe, Sumiko Watanabe and Akira Ishihama

    Version of Record online : 24 FEB 2016, DOI: 10.1111/gtc.12352

  8. Rodent Models of Amyotrophic Lateral Sclerosis


    Current Protocols in Pharmacology


    Thomas Philips and Jeffrey D. Rothstein

    Published Online : 1 JUN 2015, DOI: 10.1002/0471141755.ph0567s69

  9. RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond

    Wiley Interdisciplinary Reviews: RNA

    Volume 3, Issue 2, March/April 2012, Pages: 265–285, Keith A. Hanson, Sang Hwa Kim and Randal S. Tibbetts

    Version of Record online : 25 OCT 2011, DOI: 10.1002/wrna.111

  10. Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis

    European Journal of Neuroscience

    Volume 34, Issue 8, October 2011, Pages: 1179–1188, David B. Wang, Michael A. Gitcho, Brian C. Kraemer and Ronald L. Klein

    Version of Record online : 21 JUL 2011, DOI: 10.1111/j.1460-9568.2011.07803.x

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    Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo


    Volume 34, Issue 1, February 2014, Pages: 83–98, Kazuhiko Watabe, Keiko Akiyama, Emiko Kawakami, Tomohiro Ishii, Kentaro Endo, Hiroko Yanagisawa, Kazunori Sango and Masami Tsukamoto

    Version of Record online : 12 AUG 2013, DOI: 10.1111/neup.12058

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    Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

    The EMBO Journal

    Volume 29, Issue 1, January 6, 2010, Pages: 209–221, Fabienne C Fiesel, Aaron Voigt, Stephanie S Weber, Chris Van den Haute, Andrea Waldenmaier, Karin Görner, Michael Walter, Marlene L Anderson, Jeannine V Kern, Tobias M Rasse, Thorsten Schmidt, Wolfdieter Springer, Roland Kirchner, Michael Bonin, Manuela Neumann, Veerle Baekelandt, Marianna Alunni-Fabbroni, Jörg B Schulz and Philipp J Kahle

    Version of Record online : 12 NOV 2009, DOI: 10.1038/emboj.2009.324

  13. You have full text access to this OnlineOpen article
    Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS)

    Neuropathology and Applied Neurobiology

    Volume 41, Issue 5, August 2015, Pages: 578–597, Phillip Smethurst, Katie Claire Louise Sidle and John Hardy

    Version of Record online : 20 APR 2015, DOI: 10.1111/nan.12206

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    XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats

    Journal of Neurochemistry

    Volume 123, Issue 3, November 2012, Pages: 406–416, Jianbin Tong, Cao Huang, Fangfang Bi, Qinxue Wu, Bo Huang and Hongxia Zhou

    Version of Record online : 8 OCT 2012, DOI: 10.1111/jnc.12014

  15. Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies

    Journal of Neurochemistry

    Volume 140, Issue 4, February 2017, Pages: 645–661, Arumugam Radhakrishnan Jayakumar, Xiao Y. Tong, Nagarajarao Shamaladevi, Stephanie Barcelona, Gabriel Gaidosh, Apeksha Agarwal and Michael D. Norenberg

    Version of Record online : 10 JAN 2017, DOI: 10.1111/jnc.13867

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    Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

    The EMBO Journal

    Volume 32, Issue 13, July 3, 2013, Pages: 1917–1926, Jianbin Tong, Cao Huang, Fangfang Bi, Qinxue Wu, Bo Huang, Xionghao Liu, Fang Li, Hongxia Zhou and Xu-Gang Xia

    Version of Record online : 28 MAY 2013, DOI: 10.1038/emboj.2013.122

  17. You have full text access to this OnlineOpen article
    Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

    EMBO Molecular Medicine

    Volume 5, Issue 2, February 2013, Pages: 221–234, Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama, Gen Sobue and Koji Yamanaka

    Version of Record online : 25 JAN 2013, DOI: 10.1002/emmm.201202303

  18. Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43


    Volume 31, Issue 3, June 2011, Pages: 239–249, Andrew King, Satomi Maekawa, Istvan Bodi, Claire Troakes and Safa Al-Sarraj

    Version of Record online : 1 DEC 2010, DOI: 10.1111/j.1440-1789.2010.01171.x

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    TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

    The FEBS Journal

    Volume 278, Issue 19, October 2011, Pages: 3539–3549, Robert H. Baloh

    Version of Record online : 24 AUG 2011, DOI: 10.1111/j.1742-4658.2011.08256.x

  20. RNA quality control and protein aggregates in amyotrophic lateral sclerosis: A review

    Muscle & Nerve

    Volume 47, Issue 3, March 2013, Pages: 330–338, Ashok Verma and Rup Tandan

    Version of Record online : 4 FEB 2013, DOI: 10.1002/mus.23673