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There are 4605 results for: content related to: Ein IAPP-Mimetikum blockiert die zytotoxische Aggregation von Aβ – die Kreuzunterdrückung der Amyloidtoxizität von Aβ und IAPP deutet auf einen molekularen Zusammenhang zwischen Alzheimer-Krankheit und Typ-II-Diabetes hin

  1. IAPP Mimic Blocks Aβ Cytotoxic Self-Assembly: Cross-Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes

    Angewandte Chemie International Edition

    Volume 46, Issue 8, February 12, 2007, Pages: 1246–1252, Li-Mei Yan, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto and Aphrodite Kapurniotu

    Article first published online : 4 JAN 2007, DOI: 10.1002/anie.200604056

  2. Dissecting the Role of Single Regions of an IAPP Mimic and IAPP in Inhibition of Aβ40 Amyloid Formation and Cytotoxicity

    ChemBioChem

    Volume 12, Issue 9, June 14, 2011, Pages: 1313–1322, Erika Andreetto, Dr. Li-Mei Yan, Dr. Andrea Caporale and Prof. Aphrodite Kapurniotu

    Article first published online : 31 MAY 2011, DOI: 10.1002/cbic.201100192

  3. Hot-Spot-Regionen der Aβ-IAPP-Wechselwirkungsdomänen als hochaffine Bindungsstellen bei Kreuz- und Selbstassoziation

    Angewandte Chemie

    Volume 122, Issue 17, April 12, 2010, Pages: 3146–3151, Erika Andreetto, Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Ronald Frank and Aphrodite Kapurniotu

    Article first published online : 22 MAR 2010, DOI: 10.1002/ange.200904902

  4. Selektiv N-methylierte lösliche IAPP-Mimetika als potente IAPP-Rezeptoragonisten und nanomolare Inhibitoren der Selbstassoziation von IAPP und Aβ40

    Angewandte Chemie

    Volume 125, Issue 39, September 23, 2013, Pages: 10569–10574, Dr. Li-Mei Yan, Dr. Aleksandra Velkova, Dipl.-Chem. Marianna Tatarek-Nossol, Prof. Dr. Gerhard Rammes, Dr. Andrei Sibaev, Dr. Erika Andreetto, Dipl.-Ing. Michael Kracklauer, Dipl.-Biochem. Maria Bakou, Dipl.-Chem. Eleni Malideli, Prof. Dr. Burkhard Göke, Prof. Dr. Jörg Schirra, Prof. Dr. Martin Storr and Prof. Dr. Aphrodite Kapurniotu

    Article first published online : 19 AUG 2013, DOI: 10.1002/ange.201302840

  5. Selectively N-Methylated Soluble IAPP Mimics as Potent IAPP Receptor Agonists and Nanomolar Inhibitors of Cytotoxic Self-Assembly of Both IAPP and Aβ40

    Angewandte Chemie International Edition

    Volume 52, Issue 39, September 23, 2013, Pages: 10378–10383, Dr. Li-Mei Yan, Dr. Aleksandra Velkova, Dipl.-Chem. Marianna Tatarek-Nossol, Prof. Dr. Gerhard Rammes, Dr. Andrei Sibaev, Dr. Erika Andreetto, Dipl.-Ing. Michael Kracklauer, Dipl.-Biochem. Maria Bakou, Dipl.-Chem. Eleni Malideli, Prof. Dr. Burkhard Göke, Prof. Dr. Jörg Schirra, Prof. Dr. Martin Storr and Prof. Dr. Aphrodite Kapurniotu

    Article first published online : 19 AUG 2013, DOI: 10.1002/anie.201302840

  6. Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

    Angewandte Chemie International Edition

    Volume 49, Issue 17, April 12, 2010, Pages: 3081–3085, Erika Andreetto, Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Ronald Frank and Aphrodite Kapurniotu

    Article first published online : 22 MAR 2010, DOI: 10.1002/anie.200904902

  7. Wechselwirkungen zwischen amyloidogenen Proteinen und Membranen: Modellsysteme liefern mechanistische Einblicke

    Angewandte Chemie

    Volume 122, Issue 33, August 2, 2010, Pages: 5760–5788, Sara M. Butterfield and Hilal A. Lashuel

    Article first published online : 9 JUL 2010, DOI: 10.1002/ange.200906670

  8. Amyloid-Kreuzwechselwirkung zur Inhibierung der Proteinaggregation, nicht aber der Proteinfunktion: Inhibierung der Insulinaggregation im nanomolaren Bereich durch ein IAPP-Mimetikum

    Angewandte Chemie

    Volume 120, Issue 37, September 1, 2008, Pages: 7222–7227, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto and Aphrodite Kapurniotu

    Article first published online : 8 AUG 2008, DOI: 10.1002/ange.200801499

  9. Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic

    Angewandte Chemie International Edition

    Volume 47, Issue 37, September 1, 2008, Pages: 7114–7118, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto and Aphrodite Kapurniotu

    Article first published online : 8 AUG 2008, DOI: 10.1002/anie.200801499

  10. You have free access to this content
    Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

    Protein Science

    Volume 18, Issue 7, July 2009, Pages: 1521–1530, Jed J. W. Wiltzius, Stuart A. Sievers, Michael R. Sawaya and David Eisenberg

    Article first published online : 29 APR 2009, DOI: 10.1002/pro.145

  11. Amyloidogenic Protein–Membrane Interactions: Mechanistic Insight from Model Systems

    Angewandte Chemie International Edition

    Volume 49, Issue 33, August 2, 2010, Pages: 5628–5654, Sara M. Butterfield and Hilal A. Lashuel

    Article first published online : 12 JUL 2010, DOI: 10.1002/anie.200906670

  12. Cross-Amyloid Interaction of Aβ and IAPP at Lipid Membranes

    Angewandte Chemie

    Volume 124, Issue 3, January 16, 2012, Pages: 703–707, Janine Seeliger, Dr. Florian Evers, Christoph Jeworrek, Shobhna Kapoor, Dr. Katrin Weise, Erika Andreetto, Prof. Dr. Metin Tolan, Prof. Dr. Aphrodite Kapurniotu and Prof. Dr. Roland Winter

    Article first published online : 1 DEC 2011, DOI: 10.1002/ange.201105877

  13. New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity

    Peptide Science

    Volume 100, Issue 6, November 2013, Pages: 645–655, Carole Anne De Carufel, Phuong Trang Nguyen, Sabrina Sahnouni and Steve Bourgault

    Article first published online : 26 NOV 2013, DOI: 10.1002/bip.22243

  14. You have free access to this content
    Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid

    Protein Science

    Volume 14, Issue 1, January 2005, Pages: 231–239, Bon W. Koo and Andrew D. Miranker

    Article first published online : 1 JAN 2009, DOI: 10.1110/ps.041051205

  15. You have full text access to this Open Access content
    Protective role of human insulin against the cytotoxicity associated with human mutant S20G islet amyloid polypeptide

    Journal of Diabetes Investigation

    Volume 4, Issue 5, September 2013, Pages: 436–444, Shuhei Morita, Minoru Ueyama, Setsuya Sakagashira, Yoshinori Shimajiri, Akiko Yamana, Machi Furuta and Tokio Sanke

    Article first published online : 18 MAR 2013, DOI: 10.1111/jdi.12069

  16. Islet Amyloid Polypeptide/GLP-1/Exendin

    Standard Article

    International Textbook of Diabetes Mellitus

    Laurie L. Baggio and Daniel J. Drucker

    Published Online : 1 JUL 2003, DOI: 10.1002/0470862092.d0209

  17. Molecular Mapping of the Recognition Interface between the Islet Amyloid Polypeptide and Insulin

    Angewandte Chemie

    Volume 118, Issue 39, October 6, 2006, Pages: 6626–6630, Sharon Gilead, Haguy Wolfenson and Ehud Gazit

    Article first published online : 8 SEP 2006, DOI: 10.1002/ange.200602034

  18. Molecular Mapping of the Recognition Interface between the Islet Amyloid Polypeptide and Insulin

    Angewandte Chemie International Edition

    Volume 45, Issue 39, October 6, 2006, Pages: 6476–6480, Sharon Gilead, Haguy Wolfenson and Ehud Gazit

    Article first published online : 8 SEP 2006, DOI: 10.1002/anie.200602034

  19. Insulin, islet amyloid polypeptide and C-peptide interactions evaluated by mass spectrometric analysis

    Rapid Communications in Mass Spectrometry

    Volume 28, Issue 2, 30 January 2014, Pages: 178–184, Michael Landreh, Gunvor Alvelius, Jan Johansson and Hans Jörnvall

    Article first published online : 5 DEC 2013, DOI: 10.1002/rcm.6772

  20. You have free access to this content
    Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

    Protein Science

    Volume 17, Issue 10, October 2008, Pages: 1850–1856, Jefferson D. Knight, Jessica A. Williamson and Andrew D. Miranker

    Article first published online : 2 JAN 2009, DOI: 10.1110/ps.036350.108