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There are 9350 results for: content related to: Ein IAPP-Mimetikum blockiert die zytotoxische Aggregation von Aβ – die Kreuzunterdrückung der Amyloidtoxizität von Aβ und IAPP deutet auf einen molekularen Zusammenhang zwischen Alzheimer-Krankheit und Typ-II-Diabetes hin

  1. Hot-Spot-Regionen der Aβ-IAPP-Wechselwirkungsdomänen als hochaffine Bindungsstellen bei Kreuz- und Selbstassoziation

    Angewandte Chemie

    Volume 122, Issue 17, April 12, 2010, Pages: 3146–3151, Erika Andreetto, Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Ronald Frank and Aphrodite Kapurniotu

    Version of Record online : 22 MAR 2010, DOI: 10.1002/ange.200904902

  2. IAPP Mimic Blocks Aβ Cytotoxic Self-Assembly: Cross-Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes

    Angewandte Chemie International Edition

    Volume 46, Issue 8, February 12, 2007, Pages: 1246–1252, Li-Mei Yan, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto and Aphrodite Kapurniotu

    Version of Record online : 4 JAN 2007, DOI: 10.1002/anie.200604056

  3. Selektiv N-methylierte lösliche IAPP-Mimetika als potente IAPP-Rezeptoragonisten und nanomolare Inhibitoren der Selbstassoziation von IAPP und Aβ40

    Angewandte Chemie

    Volume 125, Issue 39, September 23, 2013, Pages: 10569–10574, Dr. Li-Mei Yan, Dr. Aleksandra Velkova, Dipl.-Chem. Marianna Tatarek-Nossol, Prof. Dr. Gerhard Rammes, Dr. Andrei Sibaev, Dr. Erika Andreetto, Dipl.-Ing. Michael Kracklauer, Dipl.-Biochem. Maria Bakou, Dipl.-Chem. Eleni Malideli, Prof. Dr. Burkhard Göke, Prof. Dr. Jörg Schirra, Prof. Dr. Martin Storr and Prof. Dr. Aphrodite Kapurniotu

    Version of Record online : 19 AUG 2013, DOI: 10.1002/ange.201302840

  4. Dissecting the Role of Single Regions of an IAPP Mimic and IAPP in Inhibition of Aβ40 Amyloid Formation and Cytotoxicity

    ChemBioChem

    Volume 12, Issue 9, June 14, 2011, Pages: 1313–1322, Erika Andreetto, Dr. Li-Mei Yan, Dr. Andrea Caporale and Prof. Aphrodite Kapurniotu

    Version of Record online : 31 MAY 2011, DOI: 10.1002/cbic.201100192

  5. Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

    Angewandte Chemie International Edition

    Volume 49, Issue 17, April 12, 2010, Pages: 3081–3085, Erika Andreetto, Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Ronald Frank and Aphrodite Kapurniotu

    Version of Record online : 22 MAR 2010, DOI: 10.1002/anie.200904902

  6. Eine Hot-Spot-Segmentstrategie zum Entwurf von Mimetika der Kreuzamyloid-Interaktionsflächen als Amyloidinhibitoren

    Angewandte Chemie

    Volume 127, Issue 44, October 26, 2015, Pages: 13287–13292, Dr. Erika Andreetto, Dipl.-Chem. Eleni Malideli, Dr. Li-Mei Yan, Dipl.-Ing. Michael Kracklauer, M. Sc. Karine Farbiarz, Dipl.-Chem. Marianna Tatarek-Nossol, Prof. Dr. Gerhard Rammes, M. Sc. Elke Prade, Tatjana Neumüller, Dr. Andrea Caporale, M. Sc. Anna Spanopoulou, B. Sc. Maria Bakou, Prof. Dr. Bernd Reif and Prof. Dr. Aphrodite Kapurniotu

    Version of Record online : 4 SEP 2015, DOI: 10.1002/ange.201504973

  7. Wechselwirkungen zwischen amyloidogenen Proteinen und Membranen: Modellsysteme liefern mechanistische Einblicke

    Angewandte Chemie

    Volume 122, Issue 33, August 2, 2010, Pages: 5760–5788, Sara M. Butterfield and Hilal A. Lashuel

    Version of Record online : 9 JUL 2010, DOI: 10.1002/ange.200906670

  8. Selectively N-Methylated Soluble IAPP Mimics as Potent IAPP Receptor Agonists and Nanomolar Inhibitors of Cytotoxic Self-Assembly of Both IAPP and Aβ40

    Angewandte Chemie International Edition

    Volume 52, Issue 39, September 23, 2013, Pages: 10378–10383, Dr. Li-Mei Yan, Dr. Aleksandra Velkova, Dipl.-Chem. Marianna Tatarek-Nossol, Prof. Dr. Gerhard Rammes, Dr. Andrei Sibaev, Dr. Erika Andreetto, Dipl.-Ing. Michael Kracklauer, Dipl.-Biochem. Maria Bakou, Dipl.-Chem. Eleni Malideli, Prof. Dr. Burkhard Göke, Prof. Dr. Jörg Schirra, Prof. Dr. Martin Storr and Prof. Dr. Aphrodite Kapurniotu

    Version of Record online : 19 AUG 2013, DOI: 10.1002/anie.201302840

  9. A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly

    Angewandte Chemie International Edition

    Volume 54, Issue 44, October 26, 2015, Pages: 13095–13100, Dr. Erika Andreetto, Dipl.-Chem. Eleni Malideli, Dr. Li-Mei Yan, Dipl.-Ing. Michael Kracklauer, MSc. Karine Farbiarz, Dipl.-Chem. Marianna Tatarek-Nossol, Prof. Dr. Gerhard Rammes, M. Sc. Elke Prade, Tatjana Neumüller, Dr. Andrea Caporale, M. Sc. Anna Spanopoulou, B. Sc. Maria Bakou, Prof. Dr. Bernd Reif and Prof. Dr. Aphrodite Kapurniotu

    Version of Record online : 4 SEP 2015, DOI: 10.1002/anie.201504973

  10. Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms

    ChemMedChem

    Volume 7, Issue 3, March 5, 2012, Pages: 359–374, Tingyu Liu and Dr. Gal Bitan

    Version of Record online : 9 FEB 2012, DOI: 10.1002/cmdc.201100585

  11. You have free access to this content
    Aβ40 modulates GABAA receptor α6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway

    Journal of Neurochemistry

    Volume 128, Issue 3, February 2014, Pages: 350–362, Xiao-Qin Zhan, Jin-Jing Yao, Dong-Dong Liu, Qianqian Ma and Yan-Ai Mei

    Version of Record online : 24 OCT 2013, DOI: 10.1111/jnc.12471

  12. Amyloid-Kreuzwechselwirkung zur Inhibierung der Proteinaggregation, nicht aber der Proteinfunktion: Inhibierung der Insulinaggregation im nanomolaren Bereich durch ein IAPP-Mimetikum

    Angewandte Chemie

    Volume 120, Issue 37, September 1, 2008, Pages: 7222–7227, Aleksandra Velkova, Marianna Tatarek-Nossol, Erika Andreetto and Aphrodite Kapurniotu

    Version of Record online : 8 AUG 2008, DOI: 10.1002/ange.200801499

  13. Bildung von Peptidfibrillen

    Angewandte Chemie

    Volume 119, Issue 43, November 5, 2007, Pages: 8274–8295, Ian W. Hamley

    Version of Record online : 12 OCT 2007, DOI: 10.1002/ange.200700861

  14. An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations

    ChemBioChem

    Volume 17, Issue 8, April 15, 2016, Pages: 657–676, Dr. Luitgard Nagel-Steger, Dr. Michael C. Owen and Prof. Dr. Birgit Strodel

    Version of Record online : 21 MAR 2016, DOI: 10.1002/cbic.201500623

  15. You have free access to this content
    Membrane and surface interactions of Alzheimer’s Aβ peptide – insights into the mechanism of cytotoxicity

    The FEBS Journal

    Volume 278, Issue 20, October 2011, Pages: 3905–3917, Thomas L. Williams and Louise C. Serpell

    Version of Record online : 26 JUL 2011, DOI: 10.1111/j.1742-4658.2011.08228.x

  16. Amyloidogenic Protein–Membrane Interactions: Mechanistic Insight from Model Systems

    Angewandte Chemie International Edition

    Volume 49, Issue 33, August 2, 2010, Pages: 5628–5654, Sara M. Butterfield and Hilal A. Lashuel

    Version of Record online : 12 JUL 2010, DOI: 10.1002/anie.200906670

  17. You have free access to this content
    The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

    The FEBS Journal

    Volume 281, Issue 11, June 2014, Pages: 2674–2687, Yu-Jen Chang and Yun-Ru Chen

    Version of Record online : 6 MAY 2014, DOI: 10.1111/febs.12813

  18. Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry

    Mass Spectrometry Reviews

    Volume 32, Issue 3, May/June 2013, Pages: 169–187, Danielle M. Williams and Tara L. Pukala

    Version of Record online : 23 JAN 2013, DOI: 10.1002/mas.21358

  19. You have free access to this content
    Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

    Journal of Neurochemistry

    Volume 126, Issue 3, August 2013, Pages: 305–311, Lei Gu and Zhefeng Guo

    Version of Record online : 12 MAR 2013, DOI: 10.1111/jnc.12202

  20. Amyloids and Protein Aggregation—Analytical Methods

    Standard Article

    Encyclopedia of Analytical Chemistry

    Huiyuan Li, Farid Rahimi, Sharmistha Sinha, Panchanan Maiti, Gal Bitan and Kazuma Murakami

    Published Online : 15 SEP 2009, DOI: 10.1002/9780470027318.a9038