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There are 28268 results for: content related to: Discovery of a Novel Aggregation Domain in the Huntingtin Protein: Implications for the Mechanisms of Htt Aggregation and Toxicity

  1. Discovery of a Novel Aggregation Domain in the Huntingtin Protein: Implications for the Mechanisms of Htt Aggregation and Toxicity

    Angewandte Chemie International Edition

    Volume 52, Issue 2, January 7, 2013, Pages: 562–567, Dr. Zhe-Ming Wang and Prof. Dr. Hilal A. Lashuel

    Version of Record online : 12 NOV 2012, DOI: 10.1002/anie.201206561

  2. Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation

    The EMBO Journal

    Volume 34, Issue 17, 2 September 2015, Pages: 2255–2271, Marie-Thérèse El-Daher, Emilie Hangen, Julie Bruyère, Ghislaine Poizat, Ismael Al-Ramahi, Raul Pardo, Nicolas Bourg, Sylvie Souquere, Céline Mayet, Gérard Pierron, Sandrine Lévêque-Fort, Juan Botas, Sandrine Humbert and Frédéric Saudou

    Version of Record online : 14 JUL 2015, DOI: 10.15252/embj.201490808

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    Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons

    Journal of Neurochemistry

    Volume 85, Issue 1, April 2003, Pages: 160–169, Jin-A Lee, Chae-Seok Lim, Seung-Hee Lee, Hyoung Kim, Nobuyuki Nukina and Bong-Kiun Kaang

    Version of Record online : 6 MAR 2003, DOI: 10.1046/j.1471-4159.2003.01650.x

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    p97 homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat

    Genes to Cells

    Volume 13, Issue 8, August 2008, Pages: 827–838, Shingo Nishikori, Kunitoshi Yamanaka, Toshihiko Sakurai, Masatoshi Esaki and Teru Ogura

    Version of Record online : 31 JUL 2008, DOI: 10.1111/j.1365-2443.2008.01214.x

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    The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies

    Journal of Neurochemistry

    Volume 110, Issue 6, September 2009, Pages: 1737–1765, Peter O. Bauer and Nobuyuki Nukina

    Version of Record online : 23 JUL 2009, DOI: 10.1111/j.1471-4159.2009.06302.x

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    Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors

    FEBS Letters

    Volume 587, Issue 13, June 27, 2013, Pages: 1997–2007, Boris A. Margulis, Vladimir Vigont, Vladimir F. Lazarev, Elena V. Kaznacheyeva and Irina V. Guzhova

    Version of Record online : 15 MAY 2013, DOI: 10.1016/j.febslet.2013.05.022

  7. Glyceraldehyde 3-phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease

    Journal of Neurochemistry

    Volume 136, Issue 5, March 2016, Pages: 1052–1063, Elena R. Mikhaylova, Vladimir F. Lazarev, Alina D. Nikotina, Boris A. Margulis and Irina V. Guzhova

    Version of Record online : 11 JAN 2016, DOI: 10.1111/jnc.13463

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    Expanded polyglutamines impair synaptic transmission and ubiquitin–proteasome system in Caenorhabditis elegans

    Journal of Neurochemistry

    Volume 98, Issue 2, July 2006, Pages: 576–587, Liakot A. Khan, Peter O. Bauer, Haruko Miyazaki, Katrin S. Lindenberg, Bernhard G. Landwehrmeyer and Nobuyuki Nukina

    Version of Record online : 22 MAY 2006, DOI: 10.1111/j.1471-4159.2006.03895.x

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    Peptide sequences converting polyglutamine into a prion in yeast

    The FEBS Journal

    Volume 282, Issue 3, February 2015, Pages: 477–490, Wataru Odani, Kazuhiro Urata, Momoko Okuda, Shunsuke Okuma, Hiroko Koyama, Chan-Gi Pack, Kei Fujiwara, Tatsuya Nojima, Masataka Kinjo, Shigeko Kawai-Noma and Hideki Taguchi

    Version of Record online : 9 DEC 2014, DOI: 10.1111/febs.13152

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    Differential vulnerability of neurons in Huntington’s disease: the role of cell type-specific features

    Journal of Neurochemistry

    Volume 113, Issue 5, June 2010, Pages: 1073–1091, Ina Han, YiMei You, Jeffrey H. Kordower, Scott T. Brady and Gerardo A. Morfini

    Version of Record online : 17 MAR 2010, DOI: 10.1111/j.1471-4159.2010.06672.x

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    Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant

    The FEBS Journal

    Volume 273, Issue 13, July 2006, Pages: 3076–3093, Wance J. J. Firdaus, Andreas Wyttenbach, Chantal Diaz-Latoud, R. W. Currie and André-Patrick Arrigo

    Version of Record online : 15 JUN 2006, DOI: 10.1111/j.1742-4658.2006.05318.x

  12. One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington’s Disease

    Angewandte Chemie

    Volume 126, Issue 7, February 10, 2014, Pages: 1959–1964, Annalisa Ansaloni, Dr. Zhe-Ming Wang, Dr. Jae Sun Jeong, Francesco Simone Ruggeri, Prof. Dr. Giovanni Dietler and Prof. Dr. Hilal A. Lashuel

    Version of Record online : 20 JAN 2014, DOI: 10.1002/ange.201307510

  13. One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington’s Disease

    Angewandte Chemie International Edition

    Volume 53, Issue 7, February 10, 2014, Pages: 1928–1933, Annalisa Ansaloni, Dr. Zhe-Ming Wang, Dr. Jae Sun Jeong, Francesco Simone Ruggeri, Prof. Dr. Giovanni Dietler and Prof. Dr. Hilal A. Lashuel

    Version of Record online : 20 JAN 2014, DOI: 10.1002/anie.201307510

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    Huntingtin inclusion bodies are iron-dependent centers of oxidative events

    The FEBS Journal

    Volume 273, Issue 23, December 2006, Pages: 5428–5441, Wance J. J. Firdaus, Andreas Wyttenbach, Paola Giuliano, Carole Kretz-Remy, R. William Currie and André-Patrick Arrigo

    Version of Record online : 15 NOV 2006, DOI: 10.1111/j.1742-4658.2006.05537.x

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    Erratum

    Vol. 274, Issue 4, 1123, Version of Record online: 29 JAN 2007

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    Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies

    FEBS Letters

    Volume 588, Issue 1, January 03, 2014, Pages: 151–159, Sabine Schipper-Krom, Katrin Juenemann, Anne H. Jansen, Anne Wiemhoefer, Rianne van den Nieuwendijk, Donna L. Smith, Mark A. Hink, Gillian P. Bates, Hermen Overkleeft, Huib Ovaa and Eric Reits

    Version of Record online : 26 NOV 2013, DOI: 10.1016/j.febslet.2013.11.023

  16. Pathogenesis of Polyglutamine Diseases

    Standard Article

    eLS

    Maria Pennuto and Fabio Sambataro

    Published Online : 15 DEC 2010, DOI: 10.1002/9780470015902.a0021486

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    Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

    The EMBO Journal

    Volume 29, Issue 20, October 20, 2010, Pages: 3459–3469, Naoki Hayashida, Mitsuaki Fujimoto, Ke Tan, Ramachandran Prakasam, Toyohide Shinkawa, Liangping Li, Hitoshi Ichikawa, Ryosuke Takii and Akira Nakai

    Version of Record online : 10 SEP 2010, DOI: 10.1038/emboj.2010.225

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    Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

    Journal of Neurochemistry

    Volume 119, Issue 2, October 2011, Pages: 398–407, Ana Roscic, Barbara Baldo, Christophe Crochemore, David Marcellin and Paolo Paganetti

    Version of Record online : 20 SEP 2011, DOI: 10.1111/j.1471-4159.2011.07435.x

  19. BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin

    European Journal of Neuroscience

    Volume 31, Issue 11, June 2010, Pages: 1915–1925, Rebecca Leon, Nithya Bhagavatula, Onome Ulukpo, Mark McCollum and Jianning Wei

    Version of Record online : 24 MAY 2010, DOI: 10.1111/j.1460-9568.2010.07215.x

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    The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling

    EMBO Molecular Medicine

    Volume 5, Issue 2, February 2013, Pages: 309–325, Cristovão Moreira Sousa, John Russel McGuire, Morgane Sonia Thion, David Gentien, Pierre de la Grange, Sophie Tezenas du Montcel, Anne Vincent-Salomon, Alexandra Durr and Sandrine Humbert

    Version of Record online : 9 JAN 2013, DOI: 10.1002/emmm.201201546