Search Results

There are 2105 results for: content related to: The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

  1. The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

    Angewandte Chemie International Edition

    Volume 52, Issue 27, July 1, 2013, Pages: 6921–6925, Tanja Wirth, Dr. Galina F. Pestel, Vanessa Ganal, Thomas Kirmeier, Dr. Ingrid Schuberth, Theo Rein, Professor Lutz F. Tietze and Professor Stephan A. Sieber

    Version of Record online : 16 MAY 2013, DOI: 10.1002/anie.201208941

  2. Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

    Angewandte Chemie

    Volume 124, Issue 12, March 19, 2012, Pages: 2928–2931, M. Sc. Tanja Wirth, Dr. Kianga Schmuck, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 14 FEB 2012, DOI: 10.1002/ange.201106334

  3. Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

    Angewandte Chemie International Edition

    Volume 51, Issue 12, March 19, 2012, Pages: 2874–2877, M. Sc. Tanja Wirth, Dr. Kianga Schmuck, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 14 FEB 2012, DOI: 10.1002/anie.201106334

  4. The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

    Angewandte Chemie

    Volume 125, Issue 21, May 17, 2013, Pages: 5552–5556, Dr. Moana Tercel, Sarah P. McManaway, Dr. Euphemia Leung, H. D. Sarath Liyanage, Dr. Guo-Liang Lu and Dr. Frederik B. Pruijn

    Version of Record online : 24 APR 2013, DOI: 10.1002/ange.201208373

  5. The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

    Angewandte Chemie International Edition

    Volume 52, Issue 21, May 17, 2013, Pages: 5442–5446, Dr. Moana Tercel, Sarah P. McManaway, Dr. Euphemia Leung, H. D. Sarath Liyanage, Dr. Guo-Liang Lu and Dr. Frederik B. Pruijn

    Version of Record online : 24 APR 2013, DOI: 10.1002/anie.201208373

  6. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

    Angewandte Chemie

    Volume 127, Issue 46, November 9, 2015, Pages: 13754–13758, Maximilian F. Koch, Sabrina Harteis, Iris D. Blank, Galina Pestel, Prof. Dr. Lutz F. Tietze, Prof. Dr. Christian Ochsenfeld, Dr. Sabine Schneider and Prof. Dr. Stephan A. Sieber

    Version of Record online : 16 SEP 2015, DOI: 10.1002/ange.201505749

  7. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

    Angewandte Chemie International Edition

    Volume 54, Issue 46, November 9, 2015, Pages: 13550–13554, Maximilian F. Koch, Sabrina Harteis, Iris D. Blank, Galina Pestel, Prof. Dr. Lutz F. Tietze, Prof. Dr. Christian Ochsenfeld, Dr. Sabine Schneider and Prof. Dr. Stephan A. Sieber

    Version of Record online : 16 SEP 2015, DOI: 10.1002/anie.201505749

  8. Duocarmycin Analogues without a DNA-Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply

    Angewandte Chemie

    Volume 125, Issue 21, May 17, 2013, Pages: 5557–5559, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 24 APR 2013, DOI: 10.1002/ange.201301923

  9. Duocarmycin Analogues without a DNA-Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply

    Angewandte Chemie International Edition

    Volume 52, Issue 21, May 17, 2013, Pages: 5447–5449, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 24 APR 2013, DOI: 10.1002/anie.201301923

  10. CC-1065 und die Duocarmycine: mechanistische Studien zum Verständnis ihrer biologischen Funktion

    Angewandte Chemie

    Volume 108, Issue 13-14, 15. Juli 1996, Pages: 1542–1580, Prof. Dale L. Boger and Prof. Douglas S. Johnson

    Version of Record online : 31 JAN 2006, DOI: 10.1002/ange.19961081306

  11. You have free access to this content
    Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation-induced apoptosis

    FEBS Letters

    Volume 442, Issue 1, January 08, 1999, Pages: 65–69, Saeko Tada-Oikawa, Shinji Oikawa, Michiko Kawanishi, Michiyuki Yamada and Shosuke Kawanishi

    Version of Record online : 15 JAN 1999, DOI: 10.1016/S0014-5793(98)01618-4

  12. CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies

    Angewandte Chemie International Edition in English

    Volume 35, Issue 13-14, July 1996, Pages: 1438–1474, Prof. Dale L. Boger and Douglas S. Johnson

    Version of Record online : 22 DEC 2003, DOI: 10.1002/anie.199614381

  13. ALDH1A1 is a Marker of Astrocytic Differentiation during Brain Development and Correlates with Better Survival in Glioblastoma Patients

    Brain Pathology

    Volume 22, Issue 6, November 2012, Pages: 788–797, S. Alexandra Adam, Oliver Schnell, Julia Pöschl, Sabina Eigenbrod, Hans A. Kretzschmar, Jörg-Christian Tonn and Ulrich Schüller

    Version of Record online : 19 APR 2012, DOI: 10.1111/j.1750-3639.2012.00592.x

  14. You have full text access to this Open Access content
    Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling

    Molecular Oncology

    Volume 9, Issue 1, January 2015, Pages: 17–31, Paola Marcato, Cheryl A. Dean, Rong-Zong Liu, Krysta M. Coyle, Moamen Bydoun, Melissa Wallace, Derek Clements, Colin Turner, Edward G. Mathenge, Shashi A. Gujar, Carman A. Giacomantonio, John R. Mackey, Roseline Godbout, Patrick W.K. Lee

    Version of Record online : 24 JUL 2014, DOI: 10.1016/j.molonc.2014.07.010

  15. Is retinoic acid genetic machinery a chordate innovation?

    Evolution & Development

    Volume 8, Issue 5, September/October 2006, Pages: 394–406, Cristian Cañestro, John H. Postlethwait, Roser Gonzàlez-Duarte and Ricard Albalat

    Version of Record online : 22 AUG 2006, DOI: 10.1111/j.1525-142X.2006.00113.x

  16. You have free access to this content
    Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development

    Developmental Dynamics

    Volume 238, Issue 8, August 2009, Pages: 2073–2080, Josephine Bowles, Chun-Wei Feng, Deon Knight, Craig A. Smith, Kelly N. Roeszler, Stefan Bagheri-Fam, Vincent R. Harley, Andrew H. Sinclair and Peter Koopman

    Version of Record online : 17 JUL 2009, DOI: 10.1002/dvdy.22024

  17. NOR1 Suppresses Cancer Stem-Like Cells Properties of Tumor Cells via the Inhibition of the AKT-GSK-3β-Wnt/β-catenin-ALDH1A1 Signal Circuit

    Journal of Cellular Physiology

    Volume 232, Issue 10, October 2017, Pages: 2829–2840, Wei Wang, Mei Yi, Shengnan Chen, Junjun Li, Haijing Zhang, Wei Xiong, Guiyuan Li, Xiaoling Li and Bo Xiang

    Version of Record online : 27 MAR 2017, DOI: 10.1002/jcp.25706

  18. Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity

    ChemBioChem

    Volume 15, Issue 5, March 21, 2014, Pages: 701–712, Dr. Bibek Parajuli, Prof. Dr. Taxiarchis M. Georgiadis, Prof. Dr. Melissa L. Fishel and Prof. Dr. Thomas D. Hurley

    Version of Record online : 13 FEB 2014, DOI: 10.1002/cbic.201300625

  19. You have free access to this content
    ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets

    STEM CELLS

    Volume 30, Issue 10, October 2012, Pages: 2100–2113, Yuchun Luo, Katiuscia Dallaglio, Ying Chen, William A. Robinson, Steven E. Robinson, Martin D. McCarter, Jianbin Wang, Rene Gonzalez, David C. Thompson, David A. Norris, Dennis R. Roop, Vasilis Vasiliou and Mayumi Fujita

    Version of Record online : 20 SEP 2012, DOI: 10.1002/stem.1193

  20. DNA minor groove binders as potential antitumor and antimicrobial agents

    Medicinal Research Reviews

    Volume 24, Issue 4, July 2004, Pages: 475–528, Pier Giovanni Baraldi, Andrea Bovero, Francesca Fruttarolo, Delia Preti, Mojgan Aghazadeh Tabrizi, Maria Giovanna Pavani and Romeo Romagnoli

    Version of Record online : 7 APR 2004, DOI: 10.1002/med.20000