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There are 3302 results for: content related to: From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity

  1. You have free access to this content
    A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

    The EMBO Journal

    Volume 19, Issue 12, June 15, 2000, Pages: 2924–2934, Morten Frödin, Claus J. Jensen, Karine Merienne and Steen Gammeltoft

    Version of Record online : 15 JUN 2000, DOI: 10.1093/emboj/19.12.2924

  2. You have free access to this content
    Rsk2 allosterically activates estrogen receptor α by docking to the hormone-binding domain

    The EMBO Journal

    Volume 20, Issue 13, July 2, 2001, Pages: 3484–3494, David E. Clark, Celeste E. Poteet-Smith, Jeffrey A. Smith and Deborah A. Lannigan

    Version of Record online : 2 JUL 2001, DOI: 10.1093/emboj/20.13.3484

  3. You have free access to this content
    Co-application of NMDA and dopamine-induced rapid translation of RSK2 in the mature hippocampus

    Journal of Neurochemistry

    Volume 103, Issue 1, October 2007, Pages: 388–399, Hanoch Kaphzan, Guy Doron and Kobi Rosenblum

    Version of Record online : 18 JUN 2007, DOI: 10.1111/j.1471-4159.2007.04774.x

  4. You have free access to this content
    Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling

    Journal of Neurochemistry

    Volume 102, Issue 4, August 2007, Pages: 1024–1034, C. J. Clark, D. M. McDade, C. T. O’Shaughnessy and B. J. Morris

    Version of Record online : 23 MAR 2007, DOI: 10.1111/j.1471-4159.2007.04601.x

  5. You have free access to this content
    Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes

    The EMBO Journal

    Volume 23, Issue 23, November 24, 2004, Pages: 4649–4659, Maria Paola Paronetto, Ezio Giorda, Rita Carsetti, Pellegrino Rossi, Raffaele Geremia and Claudio Sette

    Version of Record online : 4 NOV 2004, DOI: 10.1038/sj.emboj.7600448

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    Targeting p90 Ribosomal S6 Kinase Eliminates Tumor-Initiating Cells by Inactivating Y-Box Binding Protein-1 in Triple-Negative Breast Cancers


    Volume 30, Issue 7, July 2012, Pages: 1338–1348, Anna L. Stratford, Kristen Reipas, Kaiji Hu, Abbas Fotovati, Rachel Brough, Jessica Frankum, Mandeep Takhar, Peter Watson, Alan Ashworth, Christopher J. Lord, Annette Lasham, Cristin G. Print and Sandra E. Dunn

    Version of Record online : 18 JUN 2012, DOI: 10.1002/stem.1128

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    Small Conductance Ca2+-Activated K+ Channels Formed by the Expression of Rat SK1 and SK2 Genes in HEK 293 Cells

    The Journal of Physiology

    Volume 553, Issue 1, November 2003, Pages: 13–19, David C. H. Benton, Alan S. Monaghan, Ramine Hosseini, Parmvir K. Bahia, Dennis G. Haylett and Guy W. J. Moss

    Version of Record online : 16 JUL 2004, DOI: 10.1113/jphysiol.2003.054551

  8. The Coffin–Lowry Syndrome-associated Protein RSK2 Controls Neuroendocrine Secretion through the Regulation of Phospholipase D1 at the Exocytotic Sites

    Annals of the New York Academy of Sciences

    Volume 1152, Issue 1, January 2009, Pages: 201–208, Maria Zeniou-Meyer, Aurélie Béglé, Marie-France Bader and Nicolas Vitale

    Version of Record online : 21 JAN 2009, DOI: 10.1111/j.1749-6632.2008.04001.x

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    A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

    The EMBO Journal

    Volume 21, Issue 20, October 15, 2002, Pages: 5396–5407, Morten Frödin, Torben L. Antal, Bettina A. Dümmler, Claus J. Jensen, Maria Deak, Steen Gammeltoft and Ricardo M. Biondi

    Version of Record online : 15 OCT 2002, DOI: 10.1093/emboj/cdf551

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    PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

    International Journal of Cancer

    Volume 131, Issue 7, 1 October 2012, Pages: 1556–1568, Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, André S. Bachmann and Joe W. Ramos

    Version of Record online : 31 JAN 2012, DOI: 10.1002/ijc.27415

  11. A novel RSK2 (RPS6KA3) gene mutation associated with abnormal brain MRI findings in a family with Coffin–Lowry syndrome

    American Journal of Medical Genetics Part A

    Volume 140A, Issue 12, 15 June 2006, Pages: 1274–1279, Yueying Wang, Jose E. Martinez, Glen L. Wilson, Xi-Yu He, Cathy M. Tuck-Muller, Paul Maertens, Wladimir Wertelecki and Tian-Jian Chen

    Version of Record online : 11 MAY 2006, DOI: 10.1002/ajmg.a.31266

  12. Coffin–Lowry Syndrome

    Standard Article


    André Hanauer

    Published Online : 15 MAR 2009, DOI: 10.1002/9780470015902.a0021431

  13. Expression of small-conductance calcium-activated potassium channels (SK) in outer hair cells of the rat cochlea

    European Journal of Neuroscience

    Volume 10, Issue 3, March 1998, Pages: 907–915, Didier Dulon, Lin Luo, Chunyan Zhang and Allen F. Ryan

    Version of Record online : 25 DEC 2001, DOI: 10.1046/j.1460-9568.1998.00098.x

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    Brain-derived neurotrophic factor stimulates the transcriptional and neuroprotective activity of myocyte-enhancer factor 2C through an ERK1/2-RSK2 signaling cascade

    Journal of Neurochemistry

    Volume 102, Issue 3, August 2007, Pages: 957–966, Yupeng Wang, Lidong Liu and Zhengui Xia

    Version of Record online : 23 MAR 2007, DOI: 10.1111/j.1471-4159.2007.04606.x

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    Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin-Lowry syndrome

    Journal of Neurochemistry

    Volume 119, Issue 3, November 2011, Pages: 447–459, Anne Schneider, Tahir Mehmood, Solange Pannetier and André Hanauer

    Version of Record online : 28 SEP 2011, DOI: 10.1111/j.1471-4159.2011.07423.x

  16. Identification of novel mutations in the RSK2 gene (RPS6KA3) in patients with Coffin–Lowry syndrome

    Clinical Genetics

    Volume 70, Issue 2, August 2006, Pages: 161–166, JP Delaunoy, A Dubos, P Marques Pereira and A Hanauer

    Version of Record online : 7 JUL 2006, DOI: 10.1111/j.1399-0004.2006.00660.x

  17. You have free access to this content
    Pharmacological characterization of small-conductance Ca2+-activated K+ channels stably expressed in HEK 293 cells

    British Journal of Pharmacology

    Volume 129, Issue 5, March 2000, Pages: 991–999, Dorte Strøbæk, Tino D Jørgensen, Palle Christophersen, Philip K Ahring and Søren-Peter Olesen

    Version of Record online : 2 FEB 2009, DOI: 10.1038/sj.bjp.0703120

  18. You have free access to this content
    Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes

    British Journal of Pharmacology

    Volume 145, Issue 4, June 2005, Pages: 477–489, Neil A Roberts, Robert S Haworth and Metin Avkiran

    Version of Record online : 29 JAN 2009, DOI: 10.1038/sj.bjp.0706210

  19. The historical Coffin–Lowry syndrome family revisited: Identification of two novel mutations of RPS6KA3 in three male patients

    American Journal of Medical Genetics Part A

    Volume 164, Issue 9, September 2014, Pages: 2172–2179, Hiromi Koso Nishimoto, Kyungsoo Ha, Julie R. Jones, Alka Dwivedi, Hyun-Min Cho, Lawrence C. Layman and Hyung-Goo Kim

    Version of Record online : 7 JUL 2014, DOI: 10.1002/ajmg.a.36488

  20. You have free access to this content
    Rsk-mediated phosphorylation and 14-3-3ε binding of Apaf-1 suppresses cytochrome c-induced apoptosis

    The EMBO Journal

    Volume 31, Issue 5, March 7, 2012, Pages: 1279–1292, Jiyeon Kim, Amanda B Parrish, Manabu Kurokawa, Kenkyo Matsuura, Christopher D Freel, Joshua L Andersen, Carrie E Johnson and Sally Kornbluth

    Version of Record online : 13 JAN 2012, DOI: 10.1038/emboj.2011.491