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There are 91179 results for: content related to: Challenges for Academic Drug Discovery

  1. Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters

    Chemoinformatics in Drug Discovery

    Karl-Heinz Baringhaus, Hans Matter, Pages: 333–379, 2005

    Published Online : 19 MAY 2005, DOI: 10.1002/3527603743.ch14

  2. Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters

    Bioinformatics - From Genomes to Therapies

    Karl-Heinz Baringhaus, Hans Matter, Pages: 705–754, 2008

    Published Online : 5 FEB 2008, DOI: 10.1002/9783527619368.ch19

  3. The Drug Discovery Process

    Enzyme Inhibition in Drug Discovery and Development: The Good and the Bad

    Chuang Lu, Albert P. Li, Pages: 1–14, 2010

    Published Online : 23 FEB 2010, DOI: 10.1002/9780470538951.ch1

  4. ADME Strategies in Lead Optimization

    Early Drug Development

    Mitchell N. Cayen, Pages: 25–88, 2010

    Published Online : 3 AUG 2010, DOI: 10.1002/9780470613191.ch2

  5. Lead Optimization in Drug Discovery

    Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease

    Craig W. Lindsley, David Weaver, Thomas M. Bridges, J. Phillip Kennedy, Pages: 65–81, 2012

    Published Online : 10 AUG 2012, DOI: 10.1002/9781118435762.ch4

  6. CHEMOINFORMATICS IN LEAD OPTIMIZATION

    Chemoinformatics for Drug Discovery

    Darren V. S. Green, Matthew Segall, Pages: 149–178, 2013

    Published Online : 15 NOV 2013, DOI: 10.1002/9781118742785.ch8

  7. Advances in Medicinal Chemistry and Lead Optimization

    Standard Article

    Wiley Handbook of Current and Emerging Drug Therapies

    Published Online : 15 SEP 2006, DOI: 10.1002/9780470041000.cedt037

  8. Overview: Differentiating Issues in the Development of Macromolecules Compared with Small Molecules

    Handbook of Pharmaceutical Biotechnology

    Günther Blaich, Bernd Janssen, Gregory Roth, Jochen Salfeld, Pages: 89–123, 2006

    Published Online : 24 AUG 2006, DOI: 10.1002/9780470117118.ch1c

  9. Similarity methods in chemoinformatics

    Annual Review of Information Science and Technology

    Volume 43, Issue 1, 2009, Pages: 1–117, Peter Willett

    Version of Record online : 16 FEB 2011, DOI: 10.1002/aris.2009.1440430108

  10. You have free access to this content
    Index

    Chemoinformatics for Drug Discovery

    Jürgen Bajorath, Pages: 401–415, 2013

    Published Online : 15 NOV 2013, DOI: 10.1002/9781118742785.index

  11. Outstanding challenges in protein–ligand docking and structure-based virtual screening

    Wiley Interdisciplinary Reviews: Computational Molecular Science

    Volume 1, Issue 2, March/April 2011, Pages: 229–259, Bohdan Waszkowycz, David E. Clark and Emanuela Gancia

    Version of Record online : 16 MAR 2011, DOI: 10.1002/wcms.18

  12. EXPLORATION OF STRUCTURE–ACTIVITY RELATIONSHIPS (SARs) AND TRANSFER OF KEY ELEMENTS IN LEAD OPTIMIZATION

    Chemoinformatics for Drug Discovery

    Hans Matter, Stefan Güssregen, Friedemann Schmidt, Gerhard Hessler, Thorsten Naumann, Karl-Heinz Baringhaus, Pages: 205–243, 2013

    Published Online : 15 NOV 2013, DOI: 10.1002/9781118742785.ch10

  13. The Changing Face of Innovation in Drug Discovery

    Collaborative Innovation in Drug Discovery

    Litao Zhang, Carl Decicco, Pages: 31–56, 2014

    Published Online : 4 APR 2014, DOI: 10.1002/9781118778166.ch4

  14. You have free access to this content
    Current drug discovery strategies for treatment of hepatitis C virus infection

    Journal of Pharmacy and Pharmacology

    Volume 63, Issue 7, July 2011, Pages: 883–892, K.-C. Cheng, Samir Gupta, Hongwu Wang, Annette S. Uss, George F. Njoroge and Eric Hughes

    Version of Record online : 19 MAY 2011, DOI: 10.1111/j.2042-7158.2011.01267.x

  15. Hit and Lead Identification from Fragments

    De novo Molecular Design

    Michael Mazanetz, Richard Law, Mark Whittaker, Pages: 143–200, 2013

    Published Online : 11 OCT 2013, DOI: 10.1002/9783527677016.ch6

  16. The Role of Chemical Biology in Drug Discovery

    Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease

    Natanya Civjan, Pages: 1–21, 2012

    Published Online : 10 AUG 2012, DOI: 10.1002/9781118435762.ch1

  17. Safety Assessment in Drug Discovery

    Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

    Vito G. Sasseville, William R. Foster, Bruce D. Car, Pages: 219–252, 2010

    Published Online : 7 JAN 2010, DOI: 10.1002/9780470574898.ch9

  18. Molecular interaction fields in drug discovery: recent advances and future perspectives

    Wiley Interdisciplinary Reviews: Computational Molecular Science

    Volume 3, Issue 6, November/December 2013, Pages: 594–613, Anna Artese, Simon Cross, Giosuè Costa, Simona Distinto, Lucia Parrotta, Stefano Alcaro, Francesco Ortuso and Gabriele Cruciani

    Version of Record online : 3 MAY 2013, DOI: 10.1002/wcms.1150

  19. Overview: Differentiating Issues in the Development of Macromolecules Compared with Small Molecules

    Standard Article

    Pharmaceutical Sciences Encyclopedia

    Günter Blaich, Bernd Janssen, Gregory Roth and Jochen Salfeld

    Published Online : 15 MAR 2010, DOI: 10.1002/9780470571224.pse292

  20. Lead Optimization in Drug Discovery

    Standard Article

    Wiley Encyclopedia of Chemical Biology

    Craig W. Lindsley, David Weaver, Thomas M. Bridges and J. Phillip Kennedy

    Published Online : 15 MAY 2008, DOI: 10.1002/9780470048672.wecb634