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There are 66051 results for: content related to: Drugs by Numbers: Reaction-Driven De Novo Design of Potent and Selective Anticancer Leads

  1. Wirkstoffe nach Zahlen: reaktionsbasierter De-novo-Entwurf von potenten und selektiven Leitstrukturen für die Krebsforschung

    Angewandte Chemie

    Volume 125, Issue 17, April 22, 2013, Pages: 4774–4779, Priv.-Doz. Dr. Birgit Spänkuch, Dr. Sarah Keppner, Lisa Lange, Dr. Tiago Rodrigues, Dr. Heiko Zettl, Christian P. Koch, Michael Reutlinger, Dr. Markus Hartenfeller, Dr. Petra Schneider and Prof. Dr. Gisbert Schneider

    Version of Record online : 20 NOV 2012, DOI: 10.1002/ange.201206897

  2. Pyrrole-Based Macrocyclic Small-Molecule Inhibitors That Target Oocyte Maturation


    Volume 12, Issue 8, April 20, 2017, Pages: 580–589, Dr. Pethaiah Gunasekaran, So-Rim Lee, Seung-Min Jeong, Jeong-Woo Kwon, Toshiki Takei, Dr. Yuya Asahina, Geul Bang, Seongnyeon Kim, Dr. Mija Ahn, Dr. Eun Kyung Ryu, Hak Nam Kim, Dr. Ki-Yub Nam, Dr. Song Yub Shin, Dr. Hironobu Hojo, Dr. Suk Namgoong, Dr. Nam-Hyung Kim and Dr. Jeong Kyu Bang

    Version of Record online : 28 MAR 2017, DOI: 10.1002/cmdc.201700048

  3. Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1


    Volume 11, Issue 7, April 5, 2016, Pages: 713–717, Taikangxiang Yun, Tan Qin, Prof. Ying Liu and Prof. Luhua Lai

    Version of Record online : 8 MAR 2016, DOI: 10.1002/cmdc.201600051

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    DLK1 is a novel regulator of bone mass that mediates estrogen deficiency–induced bone loss in mice

    Journal of Bone and Mineral Research

    Volume 26, Issue 7, July 2011, Pages: 1457–1471, Basem M Abdallah, Nicholas Ditzel, Amer Mahmood, Adiba Isa, Gunnhildur A Traustadottir, Arndt F Schilling, María-José Ruiz-Hidalgo, Jorge Laborda, Michael Amling and Moustapha Kassem

    Version of Record online : 21 JUN 2011, DOI: 10.1002/jbmr.346

  5. 4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution


    Volume 9, Issue 10, October 2014, Pages: 2327–2343, Dr. Jennifer X. Qiao, Tammy C. Wang, Dr. Sheldon Hiebert, Carol H. Hu, Dr. William A. Schumacher, Dr. Steven A. Spronk, Charles G. Clark, Dr. Ying Han, Ji Hua, Laura A. Price, Hong Shen, Dr. Silvi A. Chacko, Dr. Gerry Everlof, Jeffrey S. Bostwick, Thomas E. Steinbacher, Yi-Xin Li, Dr. Christine S. Huang, Dr. Dietmar A. Seiffert, Dr. Robert Rehfuss, Dr. Ruth R. Wexler and Dr. Patrick Y. S. Lam

    Version of Record online : 2 JUL 2014, DOI: 10.1002/cmdc.201402141

  6. UNC51-like kinase 1, autophagic regulator and cancer therapeutic target

    Cell Proliferation

    Volume 47, Issue 6, December 2014, Pages: 494–505, Y. Chen, J. He, M. Tian, S.-Y. Zhang, M.-R. Guo, R. Kasimu, J.-H. Wang and L. Ouyang

    Version of Record online : 20 OCT 2014, DOI: 10.1111/cpr.12145

  7. De Novo Design: From Models to Molecules

    De novo Molecular Design

    Gisbert Schneider, Karl-Heinz Baringhaus, Pages: 1–55, 2013

    Published Online : 11 OCT 2013, DOI: 10.1002/9783527677016.ch1

  8. Polo-like kinase 1 (Plk1) in cutaneous T-cell lymphoma

    British Journal of Dermatology

    Volume 164, Issue 4, April 2011, Pages: 814–821, N. Stutz, M. Nihal and G.S. Wood

    Version of Record online : 28 JAN 2011, DOI: 10.1111/j.1365-2133.2010.10128.x

  9. Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication


    Volume 66, Issue 6, December 2017, Pages: 1750–1765, Ahmed Diab, Adrien Foca, Floriane Fusil, Thomas Lahlali, Pascal Jalaguier, Fouzia Amirache, Lia N'Guyen, Nathalie Isorce, François-Loïc Cosset, Fabien Zoulim, Ourania Andrisani and David Durantel

    Version of Record online : 6 NOV 2017, DOI: 10.1002/hep.29236

  10. Role of the Non-Canonical Notch Ligand Delta-Like Protein 1 in Hormone-Producing Cells of the Adult Male Mouse Pituitary

    Journal of Neuroendocrinology

    Volume 23, Issue 9, September 2011, Pages: 849–859, R. A. Puertas-Avendaño, M. J. González-Gómez, M. D. Ruvira, M. J. Ruiz-Hidalgo, N. Morales-Delgado, J. Laborda, C. Díaz and A. R. Bello

    Version of Record online : 11 AUG 2011, DOI: 10.1111/j.1365-2826.2011.02189.x

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    Characterization of DLK1+ Cells Emerging During Skeletal Muscle Remodeling in Response to Myositis, Myopathies, and Acute Injury


    Volume 27, Issue 4, April 2009, Pages: 898–908, Ditte C. Andersen, Stine J. Petersson, Louise H. Jørgensen, Peter Bollen, Pernille B. Jensen, Børge Teisner, Henrik D. Schroeder and Charlotte H. Jensen

    Version of Record online : 6 APR 2009, DOI: 10.1634/stemcells.2008-0826

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    Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

    Journal of Neurochemistry

    Volume 104, Issue 4, February 2008, Pages: 1101–1115, Matthias Bauer, Jolanta Szulc, Morten Meyer, Charlotte Harken Jensen, Toufik Abbas Terki, Andrea Meixner, Norbert Kinkl, Thomas Gasser, Patrick Aebischer and Marius Ueffing

    Version of Record online : 18 AUG 2008, DOI: 10.1111/j.1471-4159.2007.05037.x

  13. Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts

    Molecular Reproduction and Development

    Volume 65, Issue 3, July 2003, Pages: 245–253, Martin Anger, Wilfried A. Kues, Jiri Klima, Manfred Mielenz, Michal Kubelka, Jan Motlik, Milan Esner, Petr Dvorak, Joseph W. Carnwath and Heiner Niemann

    Version of Record online : 29 MAY 2003, DOI: 10.1002/mrd.10289

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    Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta

    Developmental Dynamics

    Volume 235, Issue 4, April 2006, Pages: 1115–1123, Aleksey Yevtodiyenko and Jennifer V. Schmidt

    Version of Record online : 2 FEB 2006, DOI: 10.1002/dvdy.20705

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    Antitumor activity of ALK1 in pancreatic carcinoma cells

    International Journal of Cancer

    Volume 120, Issue 8, 15 April 2007, Pages: 1641–1651, Hendrik Ungefroren, Bodo Schniewind, Stephanie Groth, Wen-Bin Chen, Susanne Sebens Müerköster, Holger Kalthoff and Fred Fändrich

    Version of Record online : 17 JAN 2007, DOI: 10.1002/ijc.22393

  16. Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

    Journal of Cellular Physiology

    Volume 226, Issue 12, December 2011, Pages: 3340–3348, Erin Morris, Izabela Chrobak, Andreea Bujor, Faye Hant, Christine Mummery, Peter ten Dijke and Maria Trojanowska

    Version of Record online : 23 SEP 2011, DOI: 10.1002/jcp.22690

  17. Innovative Disulfide Esters of Dithiocarbamic Acid as Women-Controlled Contraceptive Microbicides: A Bioisosterism Approach


    Volume 10, Issue 10, October 2015, Pages: 1739–1753, Dhanaraju Mandalapu, Dr. Nand Lal, Lokesh Kumar, Bhavana Kushwaha, Sonal Gupta, Dr. Lalit Kumar, Dr. Veenu Bala, Dr. Santosh K. Yadav, Pratiksha Singh, Nidhi Singh, Dr. Jagdamba P. Maikhuri, Dr. Satya N. Sankhwar, Dr. Praveen K. Shukla, Dr. Imran Siddiqi, Dr. Gopal Gupta and Dr. Vishnu L. Sharma

    Version of Record online : 4 SEP 2015, DOI: 10.1002/cmdc.201500291

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    Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

    The EMBO Journal

    Volume 22, Issue 7, April 1, 2003, Pages: 1676–1687, Anja Groth, Jiri Lukas, Erich A. Nigg, Herman H. W. Silljé, Christer Wernstedt, Jiri Bartek and Klaus Hansen

    Version of Record online : 1 APR 2003, DOI: 10.1093/emboj/cdg151

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    Polo-like kinase 1 inhibition results in misaligned chromosomes and aberrant spindles in porcine oocytes during the first meiotic division

    Reproduction in Domestic Animals

    Volume 53, Issue 1, February 2018, Pages: 256–265, Y Liao, D Lin, P Cui, B Abbasi, C Chen, Z Zhang, Y Zhang, Y Dong, R Rui and S Ju

    Version of Record online : 16 NOV 2017, DOI: 10.1111/rda.13102

  20. DLK1 regulates branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling

    Biology of the Cell

    Volume 106, Issue 8, August 2014, Pages: 237–253, Patricia García-Gallastegui, Gaskon Ibarretxe, José-Javier Garcia-Ramírez, Victoriano Baladrón, Maitane Aurrekoetxea, María-Luisa Nueda, Ana-Isabel Naranjo, Francisco Santaolalla, Ana Sánchez-del Rey, Jorge Laborda and Fernando Unda

    Version of Record online : 9 JUL 2014, DOI: 10.1111/boc.201300086