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There are 863 results for: content related to: Verbal problem-solving in autism spectrum disorders: A problem of plan construction?

  1. You have free access to this content
    The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

    British Journal of Pharmacology

    Volume 159, Issue 1, January 2010, Pages: 49–57, B Darpo

    Article first published online : 18 NOV 2009, DOI: 10.1111/j.1476-5381.2009.00487.x

  2. The Cost-Effectiveness of Drug Regulation: The Example of Thorough QT/QTc Studies

    Clinical Pharmacology & Therapeutics

    Volume 91, Issue 2, February 2012, Pages: 281–288, J C Bouvy, M A Koopmanschap, R R Shah and H Schellekens

    Article first published online : 28 DEC 2011, DOI: 10.1038/clpt.2011.224

  3. You have free access to this content
    Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development

    British Journal of Pharmacology

    Volume 159, Issue 1, January 2010, Pages: 34–48, Vaibhav Salvi, Dilip R Karnad, Gopi Krishna Panicker and Snehal Kothari

    Article first published online : 23 SEP 2009, DOI: 10.1111/j.1476-5381.2009.00427.x

  4. You have free access to this content
    ICH E14 Q&A(R2) document: commentary on the further updated recommendations on thorough QT studies

    British Journal of Clinical Pharmacology

    Volume 79, Issue 3, March 2015, Pages: 456–464, Rashmi R. Shah, Joel Morganroth and Robert B. Kleiman

    Article first published online : 20 FEB 2015, DOI: 10.1111/bcp.12477

  5. Is a Thorough QTc Study Necessary? The Role of Modeling and Simulation in Evaluating the QTc Prolongation Potential of Drugs

    The Journal of Clinical Pharmacology

    Volume 49, Issue 11, November 2009, Pages: 1284–1296, Dr Shashank Rohatagi, Dr Timothy J. Carrothers, Dr Jon Kuwabara-Wagg and Dr Tatiana Khariton

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270009341184

  6. You have full text access to this OnlineOpen article
    Verbal Problem-Solving Difficulties in Autism Spectrum Disorders and Atypical Language Development

    Autism Research

    Volume 7, Issue 6, December 2014, Pages: 720–730, Ben Alderson-Day

    Article first published online : 23 OCT 2014, DOI: 10.1002/aur.1424

  7. You have full text access to this OnlineOpen article
    Evaluating the Use of Linear Mixed-Effect Models for Inference of the Concentration-QTc Slope Estimate as a Surrogate for a Biological QTc Model

    CPT: Pharmacometrics & Systems Pharmacology

    Volume 4, Issue 1, January 2015, Pages: 1–9, Y Huh and MM Hutmacher

    Article first published online : 28 JAN 2015, DOI: 10.1002/psp4.14

  8. Enhancement of the Power Conversion Efficiency in Organic Photovoltaics by Unveiling the Appropriate Polymer Backbone Enlargement Approach

    Advanced Functional Materials

    Volume 26, Issue 11, March 15, 2016, Pages: 1840–1848, Christos L. Chochos, Ranbir Singh, Min Kim, Nicola Gasparini, Athanasios Katsouras, Chandramouli Kulshreshtha, Vasilis G. Gregoriou, Panagiotis E. Keivanidis, Tayebeh Ameri, Christoph J. Brabec, Kilwon Cho and Apostolos Avgeropoulos

    Article first published online : 10 FEB 2016, DOI: 10.1002/adfm.201504953

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    Drug-induced QT interval prolongation: does ethnicity of the thorough QT study population matter?

    British Journal of Clinical Pharmacology

    Volume 75, Issue 2, February 2013, Pages: 347–358, Rashmi R. Shah

    Article first published online : 10 JAN 2013, DOI: 10.1111/j.1365-2125.2012.04415.x

  10. Moxifloxacin-induced QTc interval prolongations in healthy male Japanese and Caucasian volunteers: a direct comparison in a thorough QT study

    British Journal of Clinical Pharmacology

    Volume 80, Issue 3, September 2015, Pages: 446–459, Joel Morganroth, Yaning Wang, Michael Thorn, Yuji Kumagai, Stuart Harris, Norman Stockbridge, Robert Kleiman and Rashmi Shah

    Article first published online : 2 JUL 2015, DOI: 10.1111/bcp.12684

  11. Compression of Large-Scale Terrain Data for Real-Time Visualization Using a Tiled Quad Tree

    Computer Graphics Forum

    Volume 23, Issue 4, December 2004, Pages: 741–759, M. Platings and A. M. Day

    Article first published online : 20 DEC 2004, DOI: 10.1111/j.1467-8659.2004.00806.x

  12. You have free access to this content
    Early QT assessment – how can our confidence in the data be improved?

    British Journal of Clinical Pharmacology

    Volume 76, Issue 5, November 2013, Pages: 642–648, Borje Darpo and Christine Garnett

    Article first published online : 21 OCT 2013, DOI: 10.1111/bcp.12068

  13. Detection of QTc Effects in Small Studies—Implications for Replacing the Thorough QT Study

    Annals of Noninvasive Electrocardiology

    Volume 20, Issue 4, July 2015, Pages: 368–377, Georg Ferber, Meijian Zhou and Borje Darpo

    Article first published online : 4 NOV 2014, DOI: 10.1111/anec.12227

  14. Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

    Clinical Pharmacology & Therapeutics

    Volume 97, Issue 4, April 2015, Pages: 326–335, B Darpo, C Benson, C Dota, G Ferber, C Garnett, CL Green, V Jarugula, L Johannesen, J Keirns, K Krudys, J Liu, C Ortemann-Renon, S Riley, N Sarapa, B Smith, RR Stoltz, M Zhou and N Stockbridge

    Article first published online : 16 MAR 2015, DOI: 10.1002/cpt.60

  15. A Perspective on the Use of Concentration-QT Modeling in Drug Development

    The Journal of Clinical Pharmacology

    Volume 48, Issue 1, January 2008, Pages: 9–12, Tanya Russell, Steve P. Riley, Jac A. Cook and Richar L. Lalonde

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270007311115

  16. A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study

    Clinical Pharmacology & Therapeutics

    Volume 98, Issue 6, December 2015, Pages: 630–638, CH Nelson, L Wang, L Fang, W Weng, F Cheng, M Hepner, J Lin, C Garnett and S Ramanathan

    Article first published online : 29 SEP 2015, DOI: 10.1002/cpt.204

  17. You have free access to this content
    The role of concentration−effect relationships in the assessment of QTc interval prolongation

    British Journal of Clinical Pharmacology

    Volume 79, Issue 1, January 2015, Pages: 117–131, Nicholas P. France and Oscar Della Pasqua

    Article first published online : 19 DEC 2014, DOI: 10.1111/bcp.12443

  18. Detecting moxifloxacin-induced QTc prolongation in thorough QT and early clinical phase studies using a highly automated ECG analysis approach

    British Journal of Pharmacology

    Volume 173, Issue 8, April 2016, Pages: 1373–1380, Gopi Krishna Panicker, Dilip R Karnad, Pramod Kadam, Fabio Badilini, Anil Damle and Snehal Kothari

    Article first published online : 4 MAR 2016, DOI: 10.1111/bph.13436

  19. Highly Automated QT Measurement Techniques in 7 Thorough QT Studies Implemented under ICH E14 Guidelines

    Annals of Noninvasive Electrocardiology

    Volume 16, Issue 1, January 2011, Pages: 13–24, Jean-Philippe Couderc, Christine Garnett, Mike Li, Robert Handzel, Scott McNitt, Xiajuan Xia, Slava Polonsky and Wojciech Zareba

    Article first published online : 20 JAN 2011, DOI: 10.1111/j.1542-474X.2010.00402.x

  20. The IQ-CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”

    Annals of Noninvasive Electrocardiology

    Volume 19, Issue 1, January 2014, Pages: 70–81, Borje Darpo, Nenad Sarapa, Christine Garnett, Charles Benson, Corina Dota, Georg Ferber, Venkateswar Jarugula, Lars Johannesen, James Keirns, Kevin Krudys, Catherine Ortemann-Renon, Steve Riley, Danise Rogers-Subramaniam and Norman Stockbridge

    Article first published online : 30 DEC 2013, DOI: 10.1111/anec.12128