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There are 70160 results for: content related to: Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials

  1. Exploring the benefits of adaptive sequential designs in time-to-event endpoint settings

    Statistics in Medicine

    Volume 30, Issue 11, 20 May 2011, Pages: 1199–1217, Sarah C. Emerson, Kyle D. Rudser and Scott S. Emerson

    Version of Record online : 29 DEC 2010, DOI: 10.1002/sim.4156

  2. Parameter estimation following an adaptive treatment selection trial design

    Biometrical Journal

    Volume 52, Issue 6, December 2010, Pages: 823–835, Xiaolong Luo, Samuel S. Wu and Jie Xiong

    Version of Record online : 19 NOV 2010, DOI: 10.1002/bimj.200900134

  3. Adaptive designs with arbitrary dependence structure

    Biometrical Journal

    Volume 56, Issue 1, January 2014, Pages: 86–106, Rene Schmidt, Andreas Faldum, Olaf Witt and Joachim Gerß

    Version of Record online : 11 NOV 2013, DOI: 10.1002/bimj.201200234

  4. Discussions

    Biometrics

    Volume 62, Issue 3, September 2006, Pages: 670–673, Christopher Jennison and Bruce W. Turnbull

    Version of Record online : 15 AUG 2006, DOI: 10.1111/j.1541-0420.2006.00627.x

  5. Are Flexible Designs Sound?

    Biometrics

    Volume 62, Issue 3, September 2006, Pages: 664–669, Carl-Fredrik Burman and Christian Sonesson

    Version of Record online : 15 AUG 2006, DOI: 10.1111/j.1541-0420.2006.00626.x

  6. Adaptivity in drug discovery and development

    Drug Development Research

    Volume 70, Issue 3, May 2009, Pages: 169–190, Frank Bretz, Michael Branson, Carl-Fredrik Burman, Christy Chuang-Stein and Christopher S. Coffey

    Version of Record online : 27 FEB 2009, DOI: 10.1002/ddr.20285

  7. Discussions

    Biometrics

    Volume 62, Issue 3, September 2006, Pages: 676–678, P. Bauer

    Version of Record online : 15 AUG 2006, DOI: 10.1111/j.1541-0420.2006.00629.x

  8. Rejoinder

    Biometrics

    Volume 62, Issue 3, September 2006, Pages: 680–683, Carl-Fredrik Burman and Christian Sonesson

    Version of Record online : 15 AUG 2006, DOI: 10.1111/j.1541-0420.2006.00631.x

  9. Adaptive sample size modification in clinical trials: start small then ask for more?

    Statistics in Medicine

    Volume 34, Issue 29, 20 December 2015, Pages: 3793–3810, Christopher Jennison and Bruce W. Turnbull

    Version of Record online : 14 JUL 2015, DOI: 10.1002/sim.6575

  10. You have full text access to this OnlineOpen article
    Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls

    Statistics in Medicine

    Volume 35, Issue 3, 10 February 2016, Pages: 325–347, Peter Bauer, Frank Bretz, Vladimir Dragalin, Franz König and Gernot Wassmer

    Version of Record online : 16 MAR 2015, DOI: 10.1002/sim.6472

  11. Stepwise two-stage sample size adaptation

    Statistics in Medicine

    Volume 34, Issue 1, 15 January 2015, Pages: 27–38, Hong Wan, Susan S. Ellenberg and Keaven M. Anderson

    Version of Record online : 23 SEP 2014, DOI: 10.1002/sim.6311

  12. Discussions

    Biometrics

    Volume 62, Issue 3, September 2006, Pages: 674–676, Michael A. Proschan

    Version of Record online : 15 AUG 2006, DOI: 10.1111/j.1541-0420.2006.00628.x

  13. Discussions

    Biometrics

    Volume 62, Issue 3, September 2006, Pages: 678–680, Marianne Frisén

    Version of Record online : 15 AUG 2006, DOI: 10.1111/j.1541-0420.2006.00630.x

  14. Adaptive Dc-optimal designs for dose finding based on a continuous efficacy endpoint

    Biometrical Journal

    Volume 52, Issue 6, December 2010, Pages: 836–852, S. Krishna Padmanabhan and Vladimir Dragalin

    Version of Record online : 4 OCT 2010, DOI: 10.1002/bimj.200900214

  15. Adaptive Trial Design

    Classical and Adaptive Clinical Trial Designs using Expdesign Studio

    Mark Chang, Pages: 75–102, 2008

    Published Online : 11 JUL 2008, DOI: 10.1002/9780470368718.ch5

  16. An Overview of Statistical Approaches for Adaptive Designs and Design Modifications

    Biometrical Journal

    Volume 48, Issue 4, August 2006, Pages: 507–520, Helmut Schäfer, Nina Timmesfeld and Hans-Helge Müller

    Version of Record online : 8 AUG 2006, DOI: 10.1002/bimj.200510234

  17. Adaptive clinical trial designs with pre-specified rules for modifying the sample size: understanding efficient types of adaptation

    Statistics in Medicine

    Volume 32, Issue 8, 15 April 2013, Pages: 1259–1275, Gregory P. Levin, Sarah C. Emerson and Scott S. Emerson

    Version of Record online : 18 OCT 2012, DOI: 10.1002/sim.5662

  18. An objective re-evaluation of adaptive sample size re-estimation: commentary on ‘Twenty-five years of confirmatory adaptive designs’

    Statistics in Medicine

    Volume 35, Issue 3, 10 February 2016, Pages: 350–358, Cyrus Mehta and Lingyun Liu

    Version of Record online : 12 JAN 2016, DOI: 10.1002/sim.6614

  19. Application of Adaptive Designs – a Review

    Biometrical Journal

    Volume 48, Issue 4, August 2006, Pages: 493–506, P. Bauer and J. Einfalt

    Version of Record online : 10 MAY 2006, DOI: 10.1002/bimj.200510204

  20. Adaptive increase in sample size when interim results are promising: A practical guide with examples

    Statistics in Medicine

    Volume 30, Issue 28, 10 December 2011, Pages: 3267–3284, Cyrus R. Mehta and Stuart J. Pocock

    Version of Record online : 30 NOV 2010, DOI: 10.1002/sim.4102