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There are 13946 results for: content related to: Therapeutic potential of activators and inhibitors of sirtuins

  1. Cytoplasm-localized SIRT1 enhances apoptosis

    Journal of Cellular Physiology

    Volume 213, Issue 1, October 2007, Pages: 88–97, Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi and Qiwei Zhai

    Article first published online : 21 MAY 2007, DOI: 10.1002/jcp.21091

  2. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus

    Journal of Neuroscience Research

    Volume 91, Issue 5, May 2013, Pages: 642–659, Sumiti Saharan, Dhanisha J. Jhaveri and Perry F. Bartlett

    Article first published online : 13 FEB 2013, DOI: 10.1002/jnr.23199

  3. SIRT1 silencing confers neuroprotection through IGF-1 pathway activation

    Journal of Cellular Physiology

    Volume 228, Issue 8, August 2013, Pages: 1754–1761, Luigi Sansone, Valentina Reali, Laura Pellegrini, Lidia Villanova, Michele Aventaggiato, Gabriella Marfe, Roberta Rosa, Marcella Nebbioso, Marco Tafani, Massimo Fini, Matteo A. Russo and Bruna Pucci

    Article first published online : 18 APR 2013, DOI: 10.1002/jcp.24334

  4. You have full text access to this OnlineOpen article
    Janus-faced role of SIRT1 in tumorigenesis

    Annals of the New York Academy of Sciences

    Volume 1271, Issue 1, October 2012, Pages: 10–19, Na-Young Song and Young-Joon Surh

    Article first published online : 10 OCT 2012, DOI: 10.1111/j.1749-6632.2012.06762.x

  5. You have free access to this content
    Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells

    Genes to Cells

    Volume 10, Issue 4, April 2005, Pages: 321–332, Nobuko Matsushita, Yasunari Takami, Masayo Kimura, Seiji Tachiiri, Masamichi Ishiai, Takeo Nakayama and Minoru Takata

    Article first published online : 1 MAR 2005, DOI: 10.1111/j.1365-2443.2005.00836.x

  6. You have full text access to this Open Access content
    mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

    Aging Cell

    Volume 11, Issue 1, February 2012, Pages: 139–149, Manlio Vinciguerra, Maria Paola Santini, Conception Martinez, Valerio Pazienza, William C. Claycomb, Alessandro Giuliani and Nadia Rosenthal

    Article first published online : 11 DEC 2011, DOI: 10.1111/j.1474-9726.2011.00766.x

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    The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis

    The Journal of Physiology

    Volume 587, Issue 8, April 2009, Pages: 1817–1828, Brendon J. Gurd, Yuko Yoshida, James Lally, Graham P. Holloway and Arend Bonen

    Article first published online : 14 APR 2009, DOI: 10.1113/jphysiol.2008.168096

  8. Sox2 deacetylation by Sirt1 is involved in mouse somatic reprogramming

    STEM CELLS

    Wen-Li Mu, Ya-Jun Wang, Peng Xu, De-Long Hao, Xiu-Zhen Liu, Ting-Ting Wang, Feng Chen, Hou-Zao Chen, Xiang Lv and De-Pei Liu

    Article first published online : 4 MAY 2015, DOI: 10.1002/stem.2012

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    SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

    Arthritis & Rheumatism

    Volume 62, Issue 5, May 2010, Pages: 1383–1392, Viktoria Gagarina, Odile Gabay, Mona Dvir-Ginzberg, Eun Jin Lee, Jillian K. Brady, Michael J. Quon and David J. Hall

    Article first published online : 29 JAN 2010, DOI: 10.1002/art.27369

  10. SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells

    The Prostate

    Volume 73, Issue 5, April 2013, Pages: 522–530, Jenna D. Lovaas, Lijia Zhu, Christine Y. Chiao, Vanessa Byles, Douglas V. Faller and Yan Dai

    Article first published online : 4 OCT 2012, DOI: 10.1002/pros.22592

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    SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence

    Aging Cell

    Volume 13, Issue 5, October 2014, Pages: 890–899, Yan-Zhen Wan, Peng Gao, Shuang Zhou, Zhu-Qin Zhang, De-Long Hao, Li-Shan Lian, Yong-Jun Li, Hou-Zao Chen and De-Pei Liu

    Article first published online : 18 JUL 2014, DOI: 10.1111/acel.12247

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    Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

    The EMBO Journal

    Volume 21, Issue 10, May 15, 2002, Pages: 2383–2396, Emma Langley, Mark Pearson, Mario Faretta, Uta-Maria Bauer, Roy A. Frye, Saverio Minucci, Pier Giuseppe Pelicci and Tony Kouzarides

    Article first published online : 15 MAY 2002, DOI: 10.1093/emboj/21.10.2383

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    SirT1 fails to affect p53-mediated biological functions

    Aging Cell

    Volume 5, Issue 1, February 2006, Pages: 81–88, Christopher Kamel, Meena Abrol, Karen Jardine, Xiaohong He and Michael W. McBurney

    Article first published online : 30 JAN 2006, DOI: 10.1111/j.1474-9726.2006.00191.x

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    SIRT1 transgenic mice show phenotypes resembling calorie restriction

    Aging Cell

    Volume 6, Issue 6, December 2007, Pages: 759–767, Laura Bordone, Dena Cohen, Ashley Robinson, Maria Carla Motta, Ed Van Veen, Agnieszka Czopik, Andrew D. Steele, Hayley Crowe, Stephen Marmor, Jianyuan Luo, Wei Gu and Leonard Guarente

    Article first published online : 13 AUG 2007, DOI: 10.1111/j.1474-9726.2007.00335.x

  15. Sirtuin activators and inhibitors

    BioFactors

    Volume 38, Issue 5, September/October 2012, Pages: 349–359, José M. Villalba and Francisco J. Alcaín

    Article first published online : 25 JUN 2012, DOI: 10.1002/biof.1032

  16. MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial–mesenchymal transition

    EMBO reports

    Lidong Sun, Kenji Kokura, Victoria Izumi, John M Koomen, Edward Seto, Jiandong Chen and Jia Fang

    Article first published online : 13 APR 2015, DOI: 10.15252/embr.201439792

  17. SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response

    Journal of Cellular Physiology

    Volume 229, Issue 9, September 2014, Pages: 1224–1235, Diana J. Liu, David Hammer, Daniel Komlos, Kuang Yu Chen, Bonnie L. Firestein and Alice Y.-C. Liu

    Article first published online : 23 MAY 2014, DOI: 10.1002/jcp.24556

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    SIRT1 regulation of apoptosis of human chondrocytes

    Arthritis & Rheumatism

    Volume 60, Issue 9, September 2009, Pages: 2731–2740, Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka and Ryosuke Kuroda

    Article first published online : 27 AUG 2009, DOI: 10.1002/art.24864

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    Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol

    Experimental Physiology

    Volume 97, Issue 3, March 2012, Pages: 400–418, Amarjit Saini, Nasser Al-Shanti, Adam P. Sharples and Claire E. Stewart

    Article first published online : 3 FEB 2012, DOI: 10.1113/expphysiol.2011.061028

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    Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity

    FEBS Journal

    Volume 282, Issue 9, May 2015, Pages: 1745–1767, Laia Bosch-Presegué and Alejandro Vaquero

    Article first published online : 13 OCT 2014, DOI: 10.1111/febs.13053