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There are 82733 results for: content related to: A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

  1. You have free access to this content
    PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically-based pharmacokinetic modeling approach

    Journal of Pharmaceutical Sciences

    Volume 100, Issue 10, October 2011, Pages: 4127–4157, Patrick Poulin, Rhys D. O. Jones, Hannah M. Jones, Christopher R. Gibson, Malcolm Rowland, Jenny Y. Chien, Barbara J. Ring, Kimberly K. Adkison, M. Sherry Ku, Handan He, Ragini Vuppugalla, Punit Marathe, Volker Fischer, Sandeep Dutta, Vikash K. Sinha, Thorir Björnsson, Thierry Lavé and James W. T. Yates

    Version of Record online : 3 MAY 2011, DOI: 10.1002/jps.22550

  2. Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

    Clinical Pharmacology & Therapeutics

    Volume 97, Issue 3, March 2015, Pages: 247–262, HM Jones, Y Chen, C Gibson, T Heimbach, N Parrott, SA Peters, J Snoeys, VV Upreti, M Zheng and SD Hall

    Version of Record online : 9 JAN 2015, DOI: 10.1002/cpt.37

  3. Introduction: A Historical Perspective of the Development and Applications of PBPK Models

    Physiologically Based Pharmacokinetic Modeling: Science and Applications

    Melvin E. Andersen, Raymond S. H. Yang, Harvey J. Clewell, Micaela B. Reddy, Pages: 1–18, 2005

    Published Online : 27 JAN 2005, DOI: 10.1002/0471478768.ch1

  4. PBPK Modeling: A Primer

    Quantitative Modeling in Toxicology

    Kannan Krishnan, George D. Loizou, Martin Spendiff, John C. Lipscomb, Melvin E. Andersen, Pages: 19–58, 2010

    Published Online : 30 MAR 2010, DOI: 10.1002/9780470686263.ch2

  5. You have full text access to this OnlineOpen article
    Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development

    CPT: Pharmacometrics & Systems Pharmacology

    Volume 2, Issue 8, August 2013, Pages: 1–12, HM Jones and K Rowland-Yeo

    Version of Record online : 14 AUG 2013, DOI: 10.1038/psp.2013.41

  6. You have free access to this content
    Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

    British Journal of Clinical Pharmacology

    Volume 77, Issue 3, March 2014, Pages: 554–570, Alice Ban Ke, Srikanth C. Nallani, Ping Zhao, Amin Rostami-Hodjegan and Jashvant D. Unadkat

    Version of Record online : 21 FEB 2014, DOI: 10.1111/bcp.12207

  7. You have free access to this content
    Optimizing nanomedicine pharmacokinetics using physiologically based pharmacokinetics modelling

    British Journal of Pharmacology

    Volume 171, Issue 17, September 2014, Pages: 3963–3979, Darren Michael Moss and Marco Siccardi

    Version of Record online : 2 JUL 2014, DOI: 10.1111/bph.12604

  8. Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time-Dependent CYP3A Inhibitor

    Clinical Pharmacology & Therapeutics

    Volume 91, Issue 4, April 2012, Pages: 700–708, Md L T Vieira, P Zhao, E G Berglund, K S Reynolds, L Zhang, L J Lesko and S-M Huang

    Version of Record online : 7 MAR 2012, DOI: 10.1038/clpt.2011.305

  9. Physiologically based predictions of the impact of inhibition of intestinal and hepatic metabolism on human pharmacokinetics of CYP3A substrates

    Journal of Pharmaceutical Sciences

    Volume 99, Issue 1, January 2010, Pages: 486–514, Frederique Fenneteau, Patrick Poulin and Fahima Nekka

    Version of Record online : 28 MAY 2009, DOI: 10.1002/jps.21802

  10. Perinatal Pharmacokinetics

    Physiologically Based Pharmacokinetic Modeling: Science and Applications

    Micaela B. Reddy, Raymond S. H. Yang, Harvey J. Clewell, Melvin E. Andersen, Pages: 319–347, 2005

    Published Online : 27 JAN 2005, DOI: 10.1002/0471478768.ch12

  11. Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

    Clinical Pharmacology & Therapeutics

    Volume 91, Issue 5, May 2012, Pages: 926–931, R Leong, M L T Vieira, P Zhao, Y Mulugeta, C S Lee, S-M Huang and G J Burckart

    Version of Record online : 4 APR 2012, DOI: 10.1038/clpt.2012.19

  12. Physiologically Based Pharmacokinetic (PBPK) Models in Cancer Risk Assessment

    Cancer Risk Assessment

    Mathieu Valcke, Kannan Krishnan, Pages: 557–585, 2010

    Published Online : 5 AUG 2010, DOI: 10.1002/9780470622728.ch21

  13. Development and Application of Physiologically Based Pharmacokinetic-Modeling Tools to Support Drug Discovery

    Chemistry & Biodiversity

    Volume 2, Issue 11, November 2005, Pages: 1462–1486, Christian Lüpfert and Andreas Reichel

    Version of Record online : 23 NOV 2005, DOI: 10.1002/cbdv.200590119

  14. Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessment

    Journal of Pharmaceutical Sciences

    Volume 101, Issue 1, January 2012, Pages: 424–435, Matthew D. Thompson and Daniel A. Beard

    Version of Record online : 3 OCT 2011, DOI: 10.1002/jps.22768

  15. Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

    Clinical Pharmacology & Therapeutics

    Volume 89, Issue 2, February 2011, Pages: 259–267, P Zhao, L Zhang, JA Grillo, Q Liu, JM Bullock, YJ Moon, P Song, SS Brar, R Madabushi, TC Wu, BP Booth, NA Rahman, KS Reynolds, E Gil Berglund, LJ Lesko and S-M Huang

    Version of Record online : 29 DEC 2010, DOI: 10.1038/clpt.2010.298

  16. PBPK: Integrating In Vitro and In Silico Data in Physiologically Based Models

    Predictive ADMET: Integrative Approaches in Drug Discovery and Development

    Hannah M. Jones, Neil Parrott, Pages: 167–188, 2014

    Published Online : 7 MAR 2014, DOI: 10.1002/9781118783344.ch9

  17. American Society for Clinical Pharmacology and Therapeutics

    Clinical Pharmacology & Therapeutics

    Volume 101, Issue S1, February 2017, Pages: S5–S99,

    Version of Record online : 13 JAN 2017, DOI: 10.1002/cpt.570

  18. Alkene and Aromatic Compounds

    Physiologically Based Pharmacokinetic Modeling: Science and Applications

    Micaela B. Reddy, Raymond S. H. Yang, Harvey J. Clewell, Melvin E. Andersen, Pages: 79–117, 2005

    Published Online : 27 JAN 2005, DOI: 10.1002/0471478768.ch4

  19. American Society for Clinical Pharmacology and Therapeutics

    Clinical Pharmacology & Therapeutics

    Volume 99, Issue S1, February 2016, Pages: S5–S107,

    Version of Record online : 24 JAN 2016, DOI: 10.1002/cpt.310

  20. Physiologically Based Pharmacokinetic Modeling

    Preclinical Development Handbook: ADME and Biopharmaceutical Properties

    Harvey J. Clewell, Micaela B. Reddy, Thierry Lave, Melvin E. Andersen, Pages: 1167–1227, 2007

    Published Online : 27 AUG 2007, DOI: 10.1002/9780470249031.ch35