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There are 15635 results for: content related to: Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors

  1. Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality

    Biotechnology Progress

    Volume 30, Issue 3, May/June 2014, Pages: 616–625, William C. Yang, Jiuyi Lu, Chris Kwiatkowski, Hang Yuan, Rashmi Kshirsagar, Thomas Ryll and Yao-Ming Huang

    Article first published online : 3 MAR 2014, DOI: 10.1002/btpr.1884

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    Effects of copper on CHO cells: Cellular requirements and product quality considerations

    Biotechnology Progress

    Volume 31, Issue 1, January/February 2015, Pages: 226–238, Inn H. Yuk, Stephen Russell, Yun Tang, Wei-Ting Hsu, Jacob B. Mauger, Rigzen P. S. Aulakh, Jun Luo, Martin Gawlitzek and John C. Joly

    Article first published online : 24 OCT 2014, DOI: 10.1002/btpr.2004

  3. More similar than different: Host cell protein production using three null CHO cell lines

    Biotechnology and Bioengineering

    Inn H. Yuk, Julie Nishihara, Donald Walker Jr, Eric Huang, Feny Gunawan, Jayashree Subramanian, Abigail F.J. Pynn, X.Christopher Yu, Judith Zhu-Shimoni, Martin Vanderlaan and Denise C. Krawitz

    Article first published online : 12 MAY 2015, DOI: 10.1002/bit.25615

  4. Application of a Quality by Design Approach to the Cell Culture Process of Monoclonal Antibody Production, Resulting in the Establishment of a Design Space

    Journal of Pharmaceutical Sciences

    Volume 102, Issue 12, December 2013, Pages: 4274–4283, Hiroaki Nagashima, Akiko Watari, Yasuharu Shinoda, Hiroshi Okamoto and Shinya Takuma

    Article first published online : 3 OCT 2013, DOI: 10.1002/jps.23744

  5. Efficiency improvement of an antibody production process by increasing the inoculum density

    Biotechnology Progress

    Volume 30, Issue 3, May/June 2014, Pages: 607–615, Volker Hecht, Sevim Duvar, Holger Ziehr, Josef Burg and Alexander Jockwer

    Article first published online : 26 FEB 2014, DOI: 10.1002/btpr.1887

  6. Development of a new bioprocess scheme using frozen seed train intermediates to initiate CHO cell culture manufacturing campaigns

    Biotechnology and Bioengineering

    Volume 110, Issue 5, May 2013, Pages: 1376–1385, Gargi Seth, Robert W. Hamilton, Thomas R. Stapp, Lisa Zheng, Angela Meier, Krista Petty, Stephenie Leung and Srikanth Chary

    Article first published online : 4 JAN 2013, DOI: 10.1002/bit.24808

  7. Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies

    Biotechnology and Bioengineering

    Volume 110, Issue 4, April 2013, Pages: 1087–1097, Lauren Feeney, Veronica Carvalhal, X. Christopher Yu, Betty Chan, David A. Michels, Yajun Jennifer Wang, Amy Shen, Jan Ressl, Brendon Dusel and Michael W. Laird

    Article first published online : 15 FEB 2013, DOI: 10.1002/bit.24759

  8. Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing

    Biotechnology and Bioengineering

    Volume 112, Issue 6, June 2015, Pages: 1232–1242, Kristin N. Valente, Abraham M. Lenhoff and Kelvin H. Lee

    Article first published online : 16 JAN 2015, DOI: 10.1002/bit.25515

  9. Engineering a mammalian super producer

    Journal of Chemical Technology and Biotechnology

    Volume 86, Issue 7, July 2011, Pages: 905–914, Stefanie Dietmair, Lars K. Nielsen and Nicholas E. Timmins

    Article first published online : 15 FEB 2011, DOI: 10.1002/jctb.2576

  10. Factors that determine stability of highly concentrated chemically defined production media

    Biotechnology Progress

    Volume 31, Issue 2, March/April 2015, Pages: 493–502, Rebecca E. McCoy, Nicole A. Costa and Arvia E. Morris

    Article first published online : 2 FEB 2015, DOI: 10.1002/btpr.2047

  11. Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells

    Biotechnology and Bioengineering

    Volume 82, Issue 7, 30 June 2003, Pages: 751–765, D. Voisard, F. Meuwly, P.-A. Ruffieux, G. Baer and A. Kadouri

    Article first published online : 11 APR 2003, DOI: 10.1002/bit.10629

  12. Non-invasive UPR monitoring system and its applications in CHO production cultures

    Biotechnology and Bioengineering

    Volume 110, Issue 8, August 2013, Pages: 2184–2194, Zhimei Du, David Treiber, Rebecca E. McCoy, Amanda K. Miller, Mei Han, Feng He, Sarah Domnitz, Carole Heath and Pranhitha Reddy

    Article first published online : 26 MAR 2013, DOI: 10.1002/bit.24877

  13. Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

    Biotechnology and Bioengineering

    Volume 110, Issue 1, January 2013, Pages: 191–205, Franklin Lu, Poh Choo Toh, Iain Burnett, Feng Li, Terry Hudson, Ashraf Amanullah and Jincai Li

    Article first published online : 1 SEP 2012, DOI: 10.1002/bit.24602

  14. Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

    Biotechnology and Bioengineering

    Volume 109, Issue 9, September 2012, Pages: 2306–2315, Jun Luo, Jian Zhang, Diya Ren, Wen-Lin Tsai, Feng Li, Ashraf Amanullah and Terry Hudson

    Article first published online : 11 APR 2012, DOI: 10.1002/bit.24510

  15. Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein

    Biotechnology Progress

    Volume 27, Issue 6, November/December 2011, Pages: 1718–1729, Mairead Looby, Neysi Ibarra, James J. Pierce, Kevin Buckley, Eimear O'Donovan, Mary Heenan, Enda Moran, Suzanne S. Farid and Frank Baganz

    Article first published online : 21 SEP 2011, DOI: 10.1002/btpr.672

  16. Utilization of tyrosine- and histidine-containing dipeptides to enhance productivity and culture viability

    Biotechnology and Bioengineering

    Volume 109, Issue 9, September 2012, Pages: 2286–2294, Sohye Kang, Johanna Mullen, Les P. Miranda and Rohini Deshpande

    Article first published online : 8 APR 2012, DOI: 10.1002/bit.24507

  17. Development of small scale cell culture models for screening poloxamer 188 lot-to-lot variation

    Biotechnology Progress

    Volume 30, Issue 6, November/December 2014, Pages: 1411–1418, Haofan Peng, Kaitlyn M. Hall, Blake Clayton, Kelly Wiltberger, Weiwei Hu, Erik Hughes, John Kane, Rachel Ney and Thomas Ryll

    Article first published online : 19 AUG 2014, DOI: 10.1002/btpr.1967

  18. Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

    Biotechnology and Bioengineering

    Volume 109, Issue 5, May 2012, Pages: 1173–1186, Jincai Li, Chun Loong Wong, Natarajan Vijayasankaran, Terry Hudson and Ashraf Amanullah

    Article first published online : 28 DEC 2011, DOI: 10.1002/bit.24389

  19. Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture

    Biotechnology and Bioengineering

    Volume 98, Issue 4, 1 November 2007, Pages: 825–841, Toey Nivitchanyong, Amanda Martinez, Adiba Ishaque, John E. Murphy, Konstantin Konstantinov, Michael J. Betenbaugh and John Thrift

    Article first published online : 18 MAY 2007, DOI: 10.1002/bit.21479

  20. Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production

    Biotechnology and Bioengineering

    Volume 109, Issue 7, July 2012, Pages: 1685–1692, Jincai Li, Wei Gu, Diane G. Edmondson, Connie Lu, Natarajan Vijayasankaran, Bruno Figueroa, Dave Stevenson, Thomas Ryll and Feng Li

    Article first published online : 6 FEB 2012, DOI: 10.1002/bit.24450