Search Results

There are 103090 results for: content related to: Kinase in Motion: Insights into the Dynamic Nature of p38α by High-Pressure NMR Spectroscopic Studies

  1. The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38α for High Throughput Screening Binding Assay

    Chemical Biology & Drug Design

    Volume 74, Issue 6, December 2009, Pages: 547–559, Haile Tecle, Frederic Feru, Hu Liu, Cyrille Kuhn, Glen Rennie, Mark Morris, Jiangxing Shao, Alan C. Cheng, Diana Gikunju, Juan Miret, Rocco Coli, Simon (Hualin) Xi, Susan L. Clugston, Simon Low, Steven Kazmirski, Yuan-Hua Ding, Qing Cao, Theresa L. Johnson, Gayatri D. Deshmukh, Jonathan P. DiNitto, Joe C. Wu and Jessie M. English

    Article first published online : 20 OCT 2009, DOI: 10.1111/j.1747-0285.2009.00884.x

  2. You have free access to this content
    Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38α in abrogating myoblast proliferation

    The EMBO Journal

    Volume 26, Issue 5, March 7, 2007, Pages: 1245–1256, Eusebio Perdiguero, Vanessa Ruiz-Bonilla, Lionel Gresh, Lijian Hui, Esteban Ballestar, Pedro Sousa-Victor, Bernat Baeza-Raja, Mercè Jardí, Anna Bosch-Comas, Manel Esteller, Carme Caelles, Antonio L Serrano, Erwin F Wagner and Pura Muñoz-Cánoves

    Article first published online : 15 FEB 2007, DOI: 10.1038/sj.emboj.7601587

  3. A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors


    Volume 10, Issue 6, June 2015, Pages: 957–969, Andrea Astolfi, Dr. Nunzio Iraci, Dr. Giuseppe Manfroni, Dr. Maria Letizia Barreca and Prof. Violetta Cecchetti

    Article first published online : 9 APR 2015, DOI: 10.1002/cmdc.201500030

  4. You have free access to this content
    Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice


    Volume 57, Issue 5, May 2013, Pages: 1950–1961, Ana M. Tormos, Alessandro Arduini, Raquel Talens-Visconti, Ivan del Barco Barrantes, Angel R. Nebreda and Juan Sastre

    Article first published online : 25 JAN 2013, DOI: 10.1002/hep.26174

  5. You have free access to this content
    Identification of Type-II Inhibitors Using Kinase Structures

    Chemical Biology & Drug Design

    Volume 80, Issue 5, November 2012, Pages: 657–664, Frank Lovering, Joseph McDonald, Gavin A. Whitlock, Paul A. Glossop, Chris Phillips, Andrew Bent, Yogesh Sabnis, Mark Ryan, Lori Fitz, Julie Lee, Jeanne S. Chang, Seungil Han, Ravi Kurumbail and Atli Thorarensen

    Article first published online : 3 SEP 2012, DOI: 10.1111/j.1747-0285.2012.01443.x

  6. A Fluorescence-Based Assay for p38α Recruitment Site Binders: Identification of Rooperol as a Novel p38α Kinase Inhibitor


    Volume 14, Issue 1, January 2, 2013, Pages: 66–71, Dr. Jing Li, Dr. Tamer S. Kaoud, Jake LeVieux, Brad Gilbreath, Dr. Swapna Moharana, Prof. Kevin N. Dalby and Prof. Sean M. Kerwin

    Article first published online : 6 DEC 2012, DOI: 10.1002/cbic.201200529

  7. You have free access to this content
    Feedback control of the protein kinase TAK1 by SAPK2a/p38α

    The EMBO Journal

    Volume 22, Issue 21, November 3, 2003, Pages: 5793–5805, Peter C.F. Cheung, David G. Campbell, Angel R. Nebreda and Philip Cohen

    Article first published online : 3 NOV 2003, DOI: 10.1093/emboj/cdg552

  8. NMR Spectroscopic Investigations of the Activated p38α Mitogen-Activated Protein Kinase


    Volume 12, Issue 17, November 25, 2011, Pages: 2599–2607, Gerd Nielsen and Prof. Dr. Harald Schwalbe

    Article first published online : 19 OCT 2011, DOI: 10.1002/cbic.201100527

  9. You have free access to this content
    Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

    The EMBO Journal

    Volume 29, Issue 1, January 6, 2010, Pages: 27–40, Jemma L Webber and Sharon A Tooze

    Article first published online : 5 NOV 2009, DOI: 10.1038/emboj.2009.321

  10. You have full text access to this OnlineOpen article
    Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

    The FEBS Journal

    Volume 282, Issue 10, May 2015, Pages: 1841–1857, Jalaj Gupta and Angel R. Nebreda

    Article first published online : 16 MAR 2015, DOI: 10.1111/febs.13250

  11. You have free access to this content
    p38α MAP kinase-deficient mouse embryonic stem cells can differentiate to endothelial cells, smooth muscle cells, and neurons

    Developmental Dynamics

    Volume 236, Issue 12, December 2007, Pages: 3383–3392, Yan-Lin Guo, Jianming Ye and Faqing Huang

    Article first published online : 9 NOV 2007, DOI: 10.1002/dvdy.21374

  12. You have free access to this content
    PRAK, a novel protein kinase regulated by the p38 MAP kinase

    The EMBO Journal

    Volume 17, Issue 12, June 15, 1998, Pages: 3372–3384, Liguo New, Yong Jiang, Ming Zhao, Kang Liu, Wei Zhu, Laura J. Flood, Yutaka Kato, Graham C.N. Parry and Jiahuai Han

    Article first published online : 15 JUN 1998, DOI: 10.1093/emboj/17.12.3372

  13. You have free access to this content
    A role for p38α mitogen-activated protein kinase in embryonic cardiac differentiation

    FEBS Letters

    Volume 582, Issue 7, April 02, 2008, Pages: 1025–1031, Francisco Hernández-Torres, Sergio Martínez-Fernández, Susana Zuluaga, Ángel Nebreda, Almudena Porras, Amelia E. Aránega and Francisco Navarro

    Article first published online : 29 FEB 2008, DOI: 10.1016/j.febslet.2008.02.050

  14. Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate


    Volume 7, Issue 2, February 6, 2012, Pages: 273–280, Dr. Li Xing, Dr. Balekudru Devadas, Dr. Rajesh V. Devraj, Dr. Shaun R. Selness, Dr. Huey Shieh, Dr. John K. Walker, Dr. Michael Mao, Dean Messing, Brian Samas, Dr. Jerry Z. Yang, Gary D. Anderson, Elizabeth G. Webb and Dr. Joseph B. Monahan

    Article first published online : 15 DEC 2011, DOI: 10.1002/cmdc.201100439

  15. Contributions of water transfer energy to protein-ligand association and dissociation barriers: Watermap analysis of a series of p38α MAP kinase inhibitors

    Proteins: Structure, Function, and Bioinformatics

    Volume 81, Issue 9, September 2013, Pages: 1509–1526, Robert A. Pearlstein, Woody Sherman and Robert Abel

    Article first published online : 2 JUL 2013, DOI: 10.1002/prot.24276

  16. NMR Characterization of Kinase p38 Dynamics in Free and Ligand-Bound Forms

    Angewandte Chemie International Edition

    Volume 45, Issue 6, January 30, 2006, Pages: 993–997, Martin Vogtherr, Krishna Saxena, Swen Hoelder, Susanne Grimme, Marco Betz, Ulrich Schieborr, Barbara Pescatore, Michel Robin, Laure Delarbre, Thomas Langer, K. Ulrich Wendt and Harald Schwalbe

    Article first published online : 22 DEC 2005, DOI: 10.1002/anie.200502770

  17. ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem Cells


    Volume 34, Issue 2, February 2016, Pages: 288–298, Chrishan J.A. Ramachandra, Ashish Mehta, Philip Wong and Winston Shim

    Article first published online : 15 OCT 2015, DOI: 10.1002/stem.2223

  18. You have free access to this content
    p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure

    EMBO reports

    Volume 9, Issue 10, October 2008, Pages: 1048–1054, Jan Heinrichsdorff, Tom Luedde, Eusebio Perdiguero, Angel R Nebreda and Manolis Pasparakis

    Article first published online : 15 AUG 2008, DOI: 10.1038/embor.2008.149

  19. Activin A induction of erythroid differentiation through MKK6-p38α/p38β pathway is inhibited by follistatin

    Journal of Cellular Physiology

    Volume 223, Issue 3, June 2010, Pages: 687–694, Huei-Mei Huang, Yung-Chen Li and Ming-Hui Chung

    Article first published online : 16 FEB 2010, DOI: 10.1002/jcp.22074

  20. ROS-mediated p38α MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas-mediated cell death in Taiwan cobra phospholipase A2-treated U937 cells

    Journal of Cellular Physiology

    Volume 219, Issue 3, June 2009, Pages: 642–651, Wen-Hsin Liu, Yun-Ching Cheng and Long-Sen Chang

    Article first published online : 29 JAN 2009, DOI: 10.1002/jcp.21713