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There are 2868 results for: content related to: Photoactivatable Prodrugs of Highly Potent Duocarmycin Analogues for a Selective Cancer Therapy

  1. CC-1065 und die Duocarmycine: mechanistische Studien zum Verständnis ihrer biologischen Funktion

    Angewandte Chemie

    Volume 108, Issue 13-14, 15. Juli 1996, Pages: 1542–1580, Prof. Dale L. Boger and Prof. Douglas S. Johnson

    Version of Record online : 31 JAN 2006, DOI: 10.1002/ange.19961081306

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    Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation-induced apoptosis

    FEBS Letters

    Volume 442, Issue 1, January 08, 1999, Pages: 65–69, Saeko Tada-Oikawa, Shinji Oikawa, Michiko Kawanishi, Michiyuki Yamada and Shosuke Kawanishi

    Version of Record online : 15 JAN 1999, DOI: 10.1016/S0014-5793(98)01618-4

  3. CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies

    Angewandte Chemie International Edition in English

    Volume 35, Issue 13-14, July 1996, Pages: 1438–1474, Prof. Dale L. Boger and Douglas S. Johnson

    Version of Record online : 22 DEC 2003, DOI: 10.1002/anie.199614381

  4. You have free access to this content
    Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies

    Chemical Biology & Drug Design

    Volume 74, Issue 3, September 2009, Pages: 205–211, Lutz F. Tietze and Birgit Krewer

    Version of Record online : 29 JUL 2009, DOI: 10.1111/j.1747-0285.2009.00856.x

  5. Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

    Angewandte Chemie

    Volume 124, Issue 12, March 19, 2012, Pages: 2928–2931, M. Sc. Tanja Wirth, Dr. Kianga Schmuck, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 14 FEB 2012, DOI: 10.1002/ange.201106334

  6. DNA minor groove binders as potential antitumor and antimicrobial agents

    Medicinal Research Reviews

    Volume 24, Issue 4, July 2004, Pages: 475–528, Pier Giovanni Baraldi, Andrea Bovero, Francesca Fruttarolo, Delia Preti, Mojgan Aghazadeh Tabrizi, Maria Giovanna Pavani and Romeo Romagnoli

    Version of Record online : 7 APR 2004, DOI: 10.1002/med.20000

  7. Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

    Angewandte Chemie International Edition

    Volume 51, Issue 12, March 19, 2012, Pages: 2874–2877, M. Sc. Tanja Wirth, Dr. Kianga Schmuck, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 14 FEB 2012, DOI: 10.1002/anie.201106334

  8. The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

    Angewandte Chemie

    Volume 125, Issue 27, July 1, 2013, Pages: 7059–7063, Tanja Wirth, Dr. Galina F. Pestel, Vanessa Ganal, Thomas Kirmeier, Dr. Ingrid Schuberth, Theo Rein, Professor Lutz F. Tietze and Professor Stephan A. Sieber

    Version of Record online : 16 MAY 2013, DOI: 10.1002/ange.201208941

  9. The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity

    Angewandte Chemie International Edition

    Volume 52, Issue 27, July 1, 2013, Pages: 6921–6925, Tanja Wirth, Dr. Galina F. Pestel, Vanessa Ganal, Thomas Kirmeier, Dr. Ingrid Schuberth, Theo Rein, Professor Lutz F. Tietze and Professor Stephan A. Sieber

    Version of Record online : 16 MAY 2013, DOI: 10.1002/anie.201208941

  10. Synthesis, Biological Evaluation, and Live Cell Imaging of Novel Fluorescent Duocarmycin Analogs

    Chemistry & Biodiversity

    Volume 9, Issue 11, November 2012, Pages: 2559–2570, Lutz F. Tietze, Frank Behrendt, Galina F. Pestel, Ingrid Schuberth and Mišo Mitkovski

    Version of Record online : 19 NOV 2012, DOI: 10.1002/cbdv.201200289

  11. Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA

    Chemistry - A European Journal

    Volume 22, Issue 26, June 20, 2016, Pages: 8756–8758, Tingting Zou, Seiichiro Kizaki, Dr. Ganesh N. Pandian and Prof. Hiroshi Sugiyama

    Version of Record online : 11 MAY 2016, DOI: 10.1002/chem.201600950

  12. Duocarmycin Analogues without a DNA-Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply

    Angewandte Chemie

    Volume 125, Issue 21, May 17, 2013, Pages: 5557–5559, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 24 APR 2013, DOI: 10.1002/ange.201301923

  13. Duocarmycin Analogues without a DNA-Binding Indole Unit Associate with Aldehyde Dehydrogenase 1A1 and not DNA: A Reply

    Angewandte Chemie International Edition

    Volume 52, Issue 21, May 17, 2013, Pages: 5447–5449, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

    Version of Record online : 24 APR 2013, DOI: 10.1002/anie.201301923

  14. The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

    Angewandte Chemie

    Volume 125, Issue 21, May 17, 2013, Pages: 5552–5556, Dr. Moana Tercel, Sarah P. McManaway, Dr. Euphemia Leung, H. D. Sarath Liyanage, Dr. Guo-Liang Lu and Dr. Frederik B. Pruijn

    Version of Record online : 24 APR 2013, DOI: 10.1002/ange.201208373

  15. The Cytotoxicity of Duocarmycin Analogues is Mediated through Alkylation of DNA, not Aldehyde Dehydrogenase 1: A Comment

    Angewandte Chemie International Edition

    Volume 52, Issue 21, May 17, 2013, Pages: 5442–5446, Dr. Moana Tercel, Sarah P. McManaway, Dr. Euphemia Leung, H. D. Sarath Liyanage, Dr. Guo-Liang Lu and Dr. Frederik B. Pruijn

    Version of Record online : 24 APR 2013, DOI: 10.1002/anie.201208373

  16. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

    Angewandte Chemie

    Volume 127, Issue 46, November 9, 2015, Pages: 13754–13758, Maximilian F. Koch, Sabrina Harteis, Iris D. Blank, Galina Pestel, Prof. Dr. Lutz F. Tietze, Prof. Dr. Christian Ochsenfeld, Dr. Sabine Schneider and Prof. Dr. Stephan A. Sieber

    Version of Record online : 16 SEP 2015, DOI: 10.1002/ange.201505749

  17. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

    Angewandte Chemie International Edition

    Volume 54, Issue 46, November 9, 2015, Pages: 13550–13554, Maximilian F. Koch, Sabrina Harteis, Iris D. Blank, Galina Pestel, Prof. Dr. Lutz F. Tietze, Prof. Dr. Christian Ochsenfeld, Dr. Sabine Schneider and Prof. Dr. Stephan A. Sieber

    Version of Record online : 16 SEP 2015, DOI: 10.1002/anie.201505749

  18. Antikörper-Wirkstoff-Konjugate: ein neues Konzept in der Krebstherapie

    Angewandte Chemie

    Volume 126, Issue 15, April 7, 2014, Pages: 3872–3904, Dr. Ravi V. J. Chari, Dr. Michael L. Miller and Dr. Wayne C. Widdison

    Version of Record online : 20 FEB 2014, DOI: 10.1002/ange.201307628

  19. Antibody–Drug Conjugates: An Emerging Concept in Cancer Therapy

    Angewandte Chemie International Edition

    Volume 53, Issue 15, April 7, 2014, Pages: 3796–3827, Dr. Ravi V. J. Chari, Dr. Michael L. Miller and Dr. Wayne C. Widdison

    Version of Record online : 20 FEB 2014, DOI: 10.1002/anie.201307628

  20. Mechanism of Action of AminoCBIs: Highly Reactive but Highly Cytotoxic Analogues of the Duocarmycins

    ChemBioChem

    Volume 15, Issue 13, September 5, 2014, Pages: 1998–2006, Dr. Moana Tercel, Dr. Frederik B. Pruijn, Dr. Patrick D. O'Connor, H. D. Sarath Liyanage, Graham J. Atwell and Sonia M. Alix

    Version of Record online : 1 AUG 2014, DOI: 10.1002/cbic.201402256