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There are 27246 results for: content related to: 5′,6′-Nucleoside Phosphonate Analogues Architecture: Synthesis and Comparative Evaluation towards Metabolic Enzymes

  1. Synthesis and Pharmacological Evaluation of 8- and 9-Substituted Benzolactam-V8 Derivatives as Potent Ligands for Protein Kinase C, a Therapeutic Target for Alzheimer's Disease


    Volume 1, Issue 3, March 13, 2006, Pages: 307–314, Ulrich R. Mach, Nancy E. Lewin, Peter M. Blumberg and Alan P. Kozikowski

    Article first published online : 30 JAN 2006, DOI: 10.1002/cmdc.200500068

  2. Prediction of Tyrosinase Inhibition Activity Using Atom-Based Bilinear Indices


    Volume 2, Issue 4, April 16, 2007, Pages: 449–478, Yovani Marrero-Ponce, Mahmud Tareq Hassan Khan, Gerardo M. Casañola Martín, Arjumand Ather, Mukhlis N. Sultankhodzhaev, Francisco Torrens and Richard Rotondo

    Article first published online : 16 MAR 2007, DOI: 10.1002/cmdc.200600186

  3. The Tertiary Amine Nitrogen Atom of Piperazine Sulfonamides as a Novel Determinant of Potent and Selective β3-Adrenoceptor Agonists


    Volume 4, Issue 12, December 7, 2009, Pages: 2080–2097, Maria Grazia Perrone, Laura Bleve, Ernesto Santandrea, Paola Vitale, Mauro Niso and Antonio Scilimati

    Article first published online : 30 OCT 2009, DOI: 10.1002/cmdc.200900292

  4. Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors


    Volume 2, Issue 7, July 9, 2007, Pages: 1015–1029, Richard J. Payne, Fabienne Peyrot, Olivier Kerbarh, Andrew D. Abell and Chris Abell

    Article first published online : 8 MAY 2007, DOI: 10.1002/cmdc.200700032

  5. Preparation of N-Sulfonyl- and N-Carbonyl-11-Azaartemisinins with Greatly Enhanced Thermal Stabilities: in vitro Antimalarial Activities


    Volume 2, Issue 10, October 8, 2007, Pages: 1464–1479, Richard K. Haynes, Ho-Ning Wong, Kin-Wo Lee, Chung-Man Lung, Lai Yung Shek, Ian D. Williams, Simon L. Croft, Livia Vivas, Lauren Rattray, Lindsay Stewart, Vincent K. W. Wong and Ben C. B. Ko

    Article first published online : 4 SEP 2007, DOI: 10.1002/cmdc.200700065

  6. Aziridide-Based Inhibitors of Cathepsin L: Synthesis, Inhibition Activity, and Docking Studies


    Volume 1, Issue 10, October 13, 2006, Pages: 1126–1141, Radim Vicik, Matthias Busemann, Christoph Gelhaus, Nikolaus Stiefl, Josef Scheiber, Werner Schmitz, Franziska Schulz, Milena Mladenovic, Bernd Engels, Matthias Leippe, Knut Baumann and Tanja Schirmeister

    Article first published online : 25 AUG 2006, DOI: 10.1002/cmdc.200600106

  7. Molecular Assembly of Multifunctional 99mTc Radiopharmaceuticals Using “Clickable” Amino Acid Derivatives


    Volume 5, Issue 12, December 3, 2010, Pages: 2026–2038, Prof. Thomas L. Mindt, Dr. Harriet Struthers, Priv.-Doz. Dr. Bernhard Spingler, Dr. Luc Brans, Prof. Dirk Tourwé, Dr. Elisa García-Garayoa and Prof. Roger Schibli

    Article first published online : 4 OCT 2010, DOI: 10.1002/cmdc.201000342

  8. Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase


    Volume 2, Issue 2, February 12, 2007, Pages: 194–207, Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Alan Riboldi-Tunnicliffe, John R. Coggins, Adrian J. Lapthorn and Concepción González-Bello

    Article first published online : 24 JAN 2007, DOI: 10.1002/cmdc.200600208

  9. Bisubstrate Inhibitors of Catechol O-Methyltransferase (COMT): the Crucial Role of the Ribose Structural Unit for Inhibitor Binding Affinity


    Volume 1, Issue 3, March 13, 2006, Pages: 340–357, Ralph Paulini, Christian Trindler, Christian Lerner, Lukas Brändli, W. Bernd Schweizer, Roland Jakob-Roetne, Gerhard Zürcher, Edilio Borroni and François Diederich

    Article first published online : 24 JAN 2006, DOI: 10.1002/cmdc.200500065

  10. Synthesis and Pharmacological Evaluation of a series of the Agomelatine Analogues as Melatonin MT1/MT2 Agonist and 5-HT2C Antagonist


    Volume 8, Issue 11, November 2013, Pages: 1830–1845, Dr. Mohamed Ettaoussi, Dr. Ahmed Sabaouni, Dr. Basile Pérès, Elodie Landagaray, Dr. Olivier Nosjean, Dr. Jean A. Boutin, Dr. Daniel-Henri Caignard, Dr. Philippe Delagrange, Prof. Pascal Berthelot and Dr. Saïd Yous

    Article first published online : 12 SEP 2013, DOI: 10.1002/cmdc.201300294

  11. Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents


    Volume 8, Issue 3, March 2013, Pages: 442–461, Dr. Florian C. Schrader, Dr. Serghei Glinca, Dr. Julia M. Sattler, Dr. Hans-Martin Dahse, Gustavo A. Afanador, Prof. Dr. Sean T. Prigge, Prof. Dr. Michael Lanzer, Dr. Ann-Kristin Mueller, Prof. Dr. Gerhard Klebe and Prof. Dr. Martin Schlitzer

    Article first published online : 22 JAN 2013, DOI: 10.1002/cmdc.201200407

  12. A Multidisciplinary Approach for the Identification of Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: S-DABOCs and DAVPs


    Volume 3, Issue 4, April 14, 2008, Pages: 573–593, Marco Radi, Chiara Falciani, Lorenzo Contemori, Elena Petricci, Giovanni Maga, Alberta Samuele, Samantha Zanoli, Montserrat Terrazas, Marinunzia Castria, Andrea Togninelli, José A. Esté, Imma Clotet-Codina, Mercedes Armand-Ugón and Maurizio Botta

    Article first published online : 14 DEC 2007, DOI: 10.1002/cmdc.200700198

  13. Enzyme Isoselective Inhibitors: A Tool for Binding-Trend Analysis


    Volume 1, Issue 6, June 12, 2006, Pages: 631–638, Rachel Ozeri, Netaly Khazanov, Nurit Perlman, Michael Shokhen and Amnon Albeck

    Article first published online : 4 APR 2006, DOI: 10.1002/cmdc.200600029

  14. You have full text access to this OnlineOpen article
    Aromatase and Dual Aromatase-Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates


    Volume 6, Issue 8, August 1, 2011, Pages: 1423–1438, Dr. Paul M. Wood, Dr. L. W. Lawrence Woo, Dr. Mark P. Thomas, Dr. Mary F. Mahon, Dr. Atul Purohit and Prof. Barry V. L. Potter

    Article first published online : 23 MAY 2011, DOI: 10.1002/cmdc.201100145

  15. Inhibitors of Inducible NO Synthase Expression: Total Synthesis of (S)-Curvularin and Its Ring Homologues


    Volume 3, Issue 6, June 16, 2008, Pages: 924–939, Stephan Elzner, Denise Schmidt, Dieter Schollmeyer, Gerhard Erkel, Timm Anke, Hartmut Kleinert, Ulrich Förstermann and Horst Kunz

    Article first published online : 25 MAR 2008, DOI: 10.1002/cmdc.200800022

  16. Discovery of 7-Aryl-Substituted (1,5-Naphthyridin-4-yl)ureas as Aurora Kinase Inhibitors


    Volume 9, Issue 1, January 2014, Pages: 217–232, Dr. Julien Defaux, Dr. Maud Antoine, Prof. Marc Le Borgne, Dr. Tilmann Schuster, Dr. Irene Seipelt, Dr. Babette Aicher, Dr. Michael Teifel, Dr. Eckhard Günther, Dr. Matthias Gerlach and Prof. Pascal Marchand

    Article first published online : 24 NOV 2013, DOI: 10.1002/cmdc.201300384

  17. A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands


    Volume 1, Issue 1, January 16, 2006, Pages: 140–154, Jordi Corbera, David Vaño, Daniel Martínez, José M. Vela, Daniel Zamanillo, Alberto Dordal, Francesc Andreu, Enric Hernandez, Raquel Perez, Marisol Escriche, Leonardo Salgado, Sandra Yeste, Maria Teresa Serafini, Rosalia Pascual, Júlia Alegre, Maria Carme Calvet, Núria Cano, Mónica Carro, Helmut Buschmann and Jörg Holenz

    Article first published online : 5 JAN 2006, DOI: 10.1002/cmdc.200500034

  18. Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency


    Volume 5, Issue 9, September 3, 2010, Pages: 1476–1488, Mark J. Thompson, Jennifer C. Louth, Gemma K. Greenwood, Fiona J. Sorrell, Sandra G. Knight, Nathan B. P. Adams and Beining Chen

    Article first published online : 15 JUL 2010, DOI: 10.1002/cmdc.201000217

  19. Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 1)


    Volume 1, Issue 12, December 11, 2006, Pages: 1367–1378, Roberto Di Santo, Roberta Costi, Marino Artico, Gaetano Miele, Antonio Lavecchia, Ettore Novellino, Alberto Bergamini, Reynel Cancio and Giovanni Maga

    Article first published online : 7 NOV 2006, DOI: 10.1002/cmdc.200600119

  20. Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6]pyrido[3,4-b]indoles: A Group of Urokinase Inhibitors, their Synthesis, and Stereochemistry-Dependent Activity


    Volume 6, Issue 12, December 9, 2011, Pages: 2312–2322, Dr. Jiawang Liu, Dr. Yuji Wang, Yifan Yang, Dr. Xueyun Jiang, Prof. Dr. Ming Zhao, Wenjing Wang, Dr. Guofeng Wu, Dr. Jianhui Wu, Meiqing Zheng and Prof. Dr. Shiqi Peng

    Article first published online : 23 SEP 2011, DOI: 10.1002/cmdc.201100345