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There are 65148 results for: content related to: Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics

  1. Base-Induced Condensation of α-Chloro Oxime Derivatives Furnishes Alkynes

    Angewandte Chemie International Edition

    Volume 42, Issue 45, November 24, 2003, Pages: 5613–5615, Takayuki Tsuritani, Kazunari Yagi, Hiroshi Shinokubo and Koichiro Oshima

    Article first published online : 18 NOV 2003, DOI: 10.1002/anie.200352317

  2. The Fluorenone Imines of Glycine Esters and Their Phosphonic Acid Analogues

    Angewandte Chemie International Edition

    Volume 47, Issue 30, July 14, 2008, Pages: 5613–5615, Shū Kobayashi, Ryo Yazaki, Kazutaka Seki and Yasuhiro Yamashita

    Article first published online : 20 JUN 2008, DOI: 10.1002/anie.200801322

  3. Reversing the Triazole Topology in a Cyclam-Triazole-Dye Ligand Gives a 10-Fold Brighter Signal Response to Zn2+ in Aqueous Solution

    European Journal of Inorganic Chemistry

    Volume 2012, Issue 34, December 2012, Pages: 5611–5615, Sandra Ast, Peter J. Rutledge and Matthew H. Todd

    Article first published online : 25 OCT 2012, DOI: 10.1002/ejic.201201072

  4. De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1


    Volume 8, Issue 12, December 2013, Pages: 1986–2014, Dr. Xiao Ding, Dr. Yan Li, Li Lv, Mi Zhou, Dr. Li Han, Zhengxi Zhang, Dr. Qian Ba, Dr. Jingquan Li, Prof. Hui Wang, Prof. Hong Liu and Prof. Renxiao Wang

    Article first published online : 9 OCT 2013, DOI: 10.1002/cmdc.201300316

  5. Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor


    Volume 7, Issue 6, June 2012, Pages: 1071–1083, Dr. Massimiliano Tognolini, Dr. Matteo Incerti, Iftiin Hassan-Mohamed, Dr. Carmine Giorgio, Simonetta Russo, Dr. Renato Bruni, Dr. Barbara Lelli, Prof. Luisa Bracci, Dr. Roberta Noberini, Prof. Elena B. Pasquale, Prof. Elisabetta Barocelli, Prof. Paola Vicini, Prof. Marco Mor and Dr. Alessio Lodola

    Article first published online : 23 APR 2012, DOI: 10.1002/cmdc.201200102

  6. Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds


    Dr. Sandeep Sundriyal, Dr. Nicholas A. Malmquist, Dr. Joachim Caron, Scott Blundell, Dr. Feng Liu, Xin Chen, Nitipol Srimongkolpithak, Prof. Jian Jin, Prof. Susan A. Charman, Prof. Artur Scherf and Dr. Matthew J. Fuchter

    Article first published online : 9 JUL 2014, DOI: 10.1002/cmdc.201402098

  7. Probing Binding and Cellular Activity of Pyrrolidinone and Piperidinone Small Molecules Targeting the Urokinase Receptor


    Volume 8, Issue 12, December 2013, Pages: 1963–1977, Dr. Timmy Mani, Dr. Degang Liu, Dr. Donghui Zhou, Dr. Liwei Li, Dr. William Eric Knabe, Fang Wang, Prof. Kyungsoo Oh and Prof. Samy O. Meroueh

    Article first published online : 2 OCT 2013, DOI: 10.1002/cmdc.201300340

  8. Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules


    Volume 7, Issue 10, October 2012, Pages: 1712–1740, Dr. Antonio Nardi, Dr. Nils Damann, Dr. Torsten Hertrampf and Dr. Achim Kless

    Article first published online : 4 SEP 2012, DOI: 10.1002/cmdc.201200298

    Corrected by:

    Corrigendum: Corrigendum: Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

    Vol. 7, Issue 11, 1874, Article first published online: 29 OCT 2012

  9. Prospective Validation of a Comprehensive In silico hERG Model and its Applications to Commercial Compound and Drug Databases


    Volume 5, Issue 5, May 3, 2010, Pages: 716–729, Munikumar R. Doddareddy, Elisabeth C. Klaasse, Shagufta, Adriaan P. IJzerman and Andreas Bender

    Article first published online : 26 MAR 2010, DOI: 10.1002/cmdc.201000024

  10. Synthesis and Structural Characterisation of Hafnium(IV) Mono- and Diphthalocyanines Obtained under Oxidation Conditions with Halogens

    European Journal of Inorganic Chemistry

    Volume 2013, Issue 32, November 2013, Pages: 5612–5621, Jan Janczak and Ryszard Kubiak

    Article first published online : 19 SEP 2013, DOI: 10.1002/ejic.201300736

  11. Dynamic Molecular Recognition in Solid State for Separating Mixtures of Isomeric Dicarboxylic Acids

    Angewandte Chemie

    Volume 125, Issue 21, May 17, 2013, Pages: 5614–5618, Dr. Krunoslav Užarević, Dr. Ivan Halasz, Dr. Ivica Đilović, Nikola Bregović, Dr. Mirta Rubčić, Prof. Dubravka Matković-Čalogović and Prof. Vladislav Tomišić

    Article first published online : 15 APR 2013, DOI: 10.1002/ange.201301032

  12. Enantioselective Synthesis of Planar-Chiral Carba-Paracyclophanes: Rhodium-Catalyzed [2+2+2] Cycloaddition of Cyclic Diynes with Terminal Monoynes

    Angewandte Chemie International Edition

    Volume 52, Issue 21, May 17, 2013, Pages: 5617–5621, Tatsuya Araki, Prof. Dr. Keiichi Noguchi and Prof. Dr. Ken Tanaka

    Article first published online : 25 MAR 2013, DOI: 10.1002/anie.201300696

  13. Regioselective Conjugate Addition of Nitriles to α,β-Unsaturated Imines: Synthesis of Fluorinated Primary Enamines and 2-Aminopyridine Derivatives

    European Journal of Organic Chemistry

    Volume 2013, Issue 25, September 2013, Pages: 5614–5620, Guillermo Fernández de Trocóniz, Ana M. Ochoa de Retana, Sergio Pascual, José M. Ezpeleta and Francisco Palacios

    Article first published online : 19 JUL 2013, DOI: 10.1002/ejoc.201300580

  14. Spin-State Ordering on One Sub-lattice of a Mononuclear Iron(III) Spin Crossover Complex Exhibiting LIESST and TIESST

    Chemistry - A European Journal

    Volume 20, Issue 19, May 5, 2014, Pages: 5613–5618, Dr. Kevin D. Murnaghan, Dr. Chiara Carbonera, Dr. Loic Toupet, Dr. Michael Griffin, Dr. Marinela M. Dîrtu, Dr. Cédric Desplanches, Prof. Dr. Yann Garcia, Prof. Eric Collet, Prof. Jean-François Létard and Dr. Grace G. Morgan

    Article first published online : 27 MAR 2014, DOI: 10.1002/chem.201400286

  15. Contribution of Explicit Solvent Effects to the Binding Affinity of Small-Molecule Inhibitors in Blood Coagulation Factor Serine Proteases


    Volume 6, Issue 6, June 6, 2011, Pages: 1049–1066, Dr. Robert Abel, Dr. Noeris K. Salam, Dr. John Shelley, Dr. Ramy Farid, Prof. Richard A. Friesner and Dr. Woody Sherman

    Article first published online : 19 APR 2011, DOI: 10.1002/cmdc.201000533

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    Drug Discovery Alliances in India—Indications, Targets, and New Chemical Entities


    Volume 9, Issue 1, January 2014, Pages: 43–60, Dr. Edmond Differding

    Article first published online : 8 OCT 2013, DOI: 10.1002/cmdc.201300341

  17. Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents


    Volume 8, Issue 3, March 2013, Pages: 442–461, Dr. Florian C. Schrader, Dr. Serghei Glinca, Dr. Julia M. Sattler, Dr. Hans-Martin Dahse, Gustavo A. Afanador, Prof. Dr. Sean T. Prigge, Prof. Dr. Michael Lanzer, Dr. Ann-Kristin Mueller, Prof. Dr. Gerhard Klebe and Prof. Dr. Martin Schlitzer

    Article first published online : 22 JAN 2013, DOI: 10.1002/cmdc.201200407

  18. Orexin Receptor Antagonists: A New Concept In CNS Disorders?


    Volume 5, Issue 8, August 2, 2010, Pages: 1197–1214, John Gatfield, Catherine Brisbare-Roch, Francois Jenck and Christoph Boss

    Article first published online : 11 JUN 2010, DOI: 10.1002/cmdc.201000132

  19. Synthesis and Structure–Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication


    Volume 7, Issue 7, July 2012, Pages: 1217–1229, Dr. Akbar Ali, Dr. Jinhua Wang, Robin S. Nathans, Dr. Hong Cao, Dr. Natalia Sharova, Prof. Dr. Mario Stevenson and Prof. Dr. Tariq M. Rana

    Article first published online : 3 MAY 2012, DOI: 10.1002/cmdc.201200079

  20. 8-Benzyltetrahydropyrazino[2,1-f]purinediones: Water-Soluble Tricyclic Xanthine Derivatives as Multitarget Drugs for Neurodegenerative Diseases


    Dr. Andreas Brunschweiger, Dr. Pierre Koch, Dr. Miriam Schlenk, Dr. Felipe Pineda, Dr. Petra Küppers, Dr. Sonja Hinz, Dr. Meryem Köse, Dr. Stefan Ullrich, Dr. Jörg Hockemeyer, Prof. Dr. Michael Wiese, Dr. Jag Heer and Prof. Dr. Christa E. Müller

    Article first published online : 9 MAY 2014, DOI: 10.1002/cmdc.201402082