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There are 6472 results for: content related to: Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

  1. Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

    ChemMedChem

    Volume 9, Issue 11, November 2014, Pages: 2486–2496, Dr. Christoph Boss, Dr. Catherine Roch-Brisbare, Dr. Michel A. Steiner, Dr. Alexander Treiber, Dr. Hendrik Dietrich, Dr. Francois Jenck, Dr. Markus von Raumer, Dr. Thierry Sifferlen, Dr. Christine Brotschi, Dr. Bibia Heidmann, Dr. Jodi T. Williams, Dr. Hamed Aissaoui, Dr. Romain Siegrist and Dr. John Gatfield

    Article first published online : 21 AUG 2014, DOI: 10.1002/cmdc.201402258

  2. You have free access to this content
    Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration

    Journal of Neurochemistry

    Volume 103, Issue 1, October 2007, Pages: 400–407, Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu and John Q. Wang

    Article first published online : 6 JUN 2007, DOI: 10.1111/j.1471-4159.2007.04748.x

  3. Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference

    Addiction Biology

    Sui-Jun Guo, Yu Cui, Zhen-Zhen Huang, Huan Liu, Xue-Qin Zhang, Jin-Xiang Jiang and Wen-Jun Xin

    Article first published online : 10 MAR 2015, DOI: 10.1111/adb.12236

  4. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus

    Clinical and Experimental Pharmacology and Physiology

    Accepted manuscript online: 15 JUL 2015, Mirza I. Beig, Jouji Horiuchi, Roger A. L. Dampney and Pascal Carrive

    DOI: 10.1111/1440-1681.12461

  5. Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia

    ChemMedChem

    Volume 9, Issue 2, February 2014, Pages: 311–322, Dr. Anthony J. Roecker, Swati P. Mercer, John D. Schreier, Dr. Christopher D. Cox, Dr. Mark E. Fraley, Justin T. Steen, Wei Lemaire, Joseph G. Bruno, C. Meacham Harrell, Susan L. Garson, Dr. Anthony L. Gotter, Steven V. Fox, Joanne Stevens, Dr. Pamela L. Tannenbaum, Dr. Thomayant Prueksaritanont, Dr. Tamara D. Cabalu, Dr. Donghui Cui, Joyce Stellabott, Dr. George D. Hartman, Dr. Steven D. Young, Dr. Christopher J. Winrow, Dr. John J. Renger and Dr. Paul J. Coleman

    Article first published online : 27 DEC 2013, DOI: 10.1002/cmdc.201300447

  6. Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish

    Proteins: Structure, Function, and Bioinformatics

    Volume 80, Issue 6, June 2012, Pages: 1694–1698, Mickaël Blaise, Husam M. A. B. Alsarraf, Jaslyn E. M. M. Wong, Søren Roi Midtgaard, Fabrice Laroche, Lotte Schack, Herman Spaink, Jens Stougaard and Søren Thirup

    Article first published online : 20 MAR 2012, DOI: 10.1002/prot.24050

  7. Drug Discovery Alliances in India—Indications, Targets, and New Chemical Entities

    ChemMedChem

    Volume 9, Issue 1, January 2014, Pages: 43–60, Dr. Edmond Differding

    Article first published online : 8 OCT 2013, DOI: 10.1002/cmdc.201300341

  8. De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1

    ChemMedChem

    Volume 8, Issue 12, December 2013, Pages: 1986–2014, Dr. Xiao Ding, Dr. Yan Li, Li Lv, Mi Zhou, Dr. Li Han, Zhengxi Zhang, Dr. Qian Ba, Dr. Jingquan Li, Prof. Hui Wang, Prof. Hong Liu and Prof. Renxiao Wang

    Article first published online : 9 OCT 2013, DOI: 10.1002/cmdc.201300316

  9. An overlap between osmotic and anaerobic stress responses: a potential role for DNA supercoiling in the coordinate regulation of gene expression

    Molecular Microbiology

    Volume 3, Issue 7, July 1989, Pages: 933–942, N. Ni Bhriain, C. J. Dorman and C. F. Higgins

    Article first published online : 27 OCT 2006, DOI: 10.1111/j.1365-2958.1989.tb00243.x

  10. Design and Synthesis of (R)-1-Arylsulfonylpiperidine-2-carboxamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

    ChemMedChem

    Volume 8, Issue 4, April 2013, Pages: 577–581, Dr. Guangxin Xia, Lin Liu, Dr. Haiyan Liu, Dr. Jianxin Yu, Zhenmin Xu, Qian Chen, Chen Ma, Dr. Ping Li, Prof. Bing Xiong, Dr. Xuejun Liu and Prof. Jingkang Shen

    Article first published online : 7 MAR 2013, DOI: 10.1002/cmdc.201300022

  11. Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

    ChemMedChem

    Volume 7, Issue 3, March 5, 2012, Pages: 415–424, Dr. Paul J. Coleman, John D. Schreier, Dr. Christopher D. Cox, Michael J. Breslin, David B. Whitman, Dr. Michael J. Bogusky, Dr. Georgia B. McGaughey, Dr. Rodney A. Bednar, Wei Lemaire, Dr. Scott M. Doran, Steven V. Fox, Susan L. Garson, Dr. Anthony L. Gotter, C. Meacham Harrell, Duane R. Reiss, Dr. Tamara D. Cabalu, Dr. Donghui Cui, Dr. Thomayant Prueksaritanont, Joanne Stevens, Dr. Pamela L. Tannenbaum, Dr. Richard G. Ball, Joyce Stellabott, Dr. Steven D. Young, Dr. George D. Hartman, Dr. Christopher J. Winrow and Dr. John J. Renger

    Article first published online : 3 FEB 2012, DOI: 10.1002/cmdc.201200025

  12. Crystal elasticity and inner strain: a computational model

    Acta Crystallographica Section A

    Volume 45, Issue 1, January 1989, Pages: 20–25, M. Catti

    DOI: 10.1107/S0108767388008748

  13. Distribution of IgG and IgM receptors on human peripheral natural killer cells measured on the level of the single effector cell

    European Journal of Immunology

    Volume 11, Issue 7, 1981, Pages: 531–535, Mikael Jondal and Jean E. Merrill

    Article first published online : 16 NOV 2005, DOI: 10.1002/eji.1830110702

  14. EVOLUTIONARY-DEVELOPMENTAL CHANGE IN THE GROWTH ARCHITECTURE OF FOSSIL RHIZOMORPHIC LYCOPSIDS: SCENARIOS CONSTRUCTED ON CLADISTIC FOUNDATIONS

    Biological Reviews

    Volume 69, Issue 4, November 1994, Pages: 527–597, RICHARD M. BATEMAN

    Article first published online : 21 JAN 2008, DOI: 10.1111/j.1469-185X.1994.tb01249.x

  15. Frontiers in Medicinal Chemistry 2009—a Summary of the Meeting at Heidelberg University

    ChemMedChem

    Volume 4, Issue 8, August 3, 2009, Pages: 1371–1376, Christian Gege and Christian D. Klein

    Article first published online : 21 MAY 2009, DOI: 10.1002/cmdc.200900151

  16. You have free access to this content
    Graphical Abstract: ChemMedChem 6/2013

    ChemMedChem

    Volume 8, Issue 6, June 2013, Pages: 867–873,

    Article first published online : 24 MAY 2013, DOI: 10.1002/cmdc.201390022

  17. You have free access to this content
    Graphical Abstract: ChemMedChem 6/2013

    ChemMedChem

    Volume 8, Issue 6, June 2013, Pages: 867–873,

    Article first published online : 3 DEC 2013, DOI: 10.1002/cmdc.201390055

  18. Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl-Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

    ChemMedChem

    Volume 8, Issue 7, July 2013, Pages: 1138–1160, Dr. Jozef Stec, Alina Fomovska, Gustavo A. Afanador, Prof. Dr. Stephen P. Muench, Dr. Ying Zhou, Bo-Shiun Lai, Prof. Dr. Kamal El Bissati, Dr. Mark R. Hickman, Patty J. Lee, Susan E. Leed, Jennifer M. Auschwitz, Dr. Caroline Sommervile, Dr. Stuart Woods, Prof. Dr. Craig W. Roberts, Prof. Dr. David Rice, Dr. Sean T. Prigge, Dr. Rima McLeod and Prof. Dr. Alan P. Kozikowski

    Article first published online : 14 JUN 2013, DOI: 10.1002/cmdc.201300050

  19. Orexin Receptor Antagonists: A New Concept In CNS Disorders?

    ChemMedChem

    Volume 5, Issue 8, August 2, 2010, Pages: 1197–1214, John Gatfield, Catherine Brisbare-Roch, Francois Jenck and Christoph Boss

    Article first published online : 11 JUN 2010, DOI: 10.1002/cmdc.201000132

  20. You have full text access to this OnlineOpen article
    Structure–Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands

    ChemMedChem

    Volume 8, Issue 6, June 2013, Pages: 946–955, Dr. Andrew J. Thompson, Dr. Mark H. P. Verheij, Dr. Jacqueline E. van Muijlwijk-Koezen, Prof. Sarah C. R. Lummis, Prof. Rob Leurs and Dr. Iwan J. P. de Esch

    Article first published online : 2 MAY 2013, DOI: 10.1002/cmdc.201300032