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There are 14999 results for: content related to: Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

  1. Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist


    Volume 9, Issue 11, November 2014, Pages: 2486–2496, Dr. Christoph Boss, Dr. Catherine Roch-Brisbare, Dr. Michel A. Steiner, Dr. Alexander Treiber, Dr. Hendrik Dietrich, Dr. Francois Jenck, Dr. Markus von Raumer, Dr. Thierry Sifferlen, Dr. Christine Brotschi, Dr. Bibia Heidmann, Dr. Jodi T. Williams, Dr. Hamed Aissaoui, Dr. Romain Siegrist and Dr. John Gatfield

    Version of Record online : 21 AUG 2014, DOI: 10.1002/cmdc.201402258

  2. Orexin Receptor Antagonists: A New Concept In CNS Disorders?


    Volume 5, Issue 8, August 2, 2010, Pages: 1197–1214, John Gatfield, Catherine Brisbare-Roch, Francois Jenck and Christoph Boss

    Version of Record online : 11 JUN 2010, DOI: 10.1002/cmdc.201000132

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    Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration

    Journal of Neurochemistry

    Volume 103, Issue 1, October 2007, Pages: 400–407, Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu and John Q. Wang

    Version of Record online : 6 JUN 2007, DOI: 10.1111/j.1471-4159.2007.04748.x

  4. Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach


    Volume 11, Issue 19, October 6, 2016, Pages: 2132–2146, Dr. Bibia Heidmann, Dr. John Gatfield, Dr. Catherine Roch, Dr. Alexander Treiber, Dr. Simone Tortoioli, Dr. Christine Brotschi, Dr. Jodi T. Williams, Dr. Martin H. Bolli, Dr. Stefan Abele, Dr. Thierry Sifferlen, Dr. François Jenck and Dr. Christoph Boss

    Version of Record online : 8 JUL 2016, DOI: 10.1002/cmdc.201600175

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    Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors

    The Journal of Physiology

    Volume 592, Issue 19, 1 October 2014, Pages: 4277–4295, Martina Perin, Fabio Longordo, Christine Massonnet, Egbert Welker and Anita Lüthi

    Version of Record online : 3 SEP 2014, DOI: 10.1113/jphysiol.2014.272757

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    Discovery and development of orexin receptor antagonists as therapeutics for insomnia

    British Journal of Pharmacology

    Volume 171, Issue 2, January 2014, Pages: 283–293, C J Winrow and J J Renger

    Version of Record online : 23 DEC 2013, DOI: 10.1111/bph.12261

  7. ChemInform Abstract: Novel Pyrazolo-tetrahydropyridines as Potent Orexin Receptor Antagonists


    Volume 41, Issue 29, July 20, 2010, Page: no, Thierry Sifferlen, Christoph Boss, Emmanuelle Cottreel, Ralf Koberstein, Markus Gude, Hamed Aissaoui, Thomas Weller, John Gatfield, Catherine Brisbare-Roch and Francois Jenck

    Version of Record online : 24 JUN 2010, DOI: 10.1002/chin.201029174

  8. Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties


    Volume 7, Issue 3, March 5, 2012, Pages: 415–424, Dr. Paul J. Coleman, John D. Schreier, Dr. Christopher D. Cox, Michael J. Breslin, David B. Whitman, Dr. Michael J. Bogusky, Dr. Georgia B. McGaughey, Dr. Rodney A. Bednar, Wei Lemaire, Dr. Scott M. Doran, Steven V. Fox, Susan L. Garson, Dr. Anthony L. Gotter, C. Meacham Harrell, Duane R. Reiss, Dr. Tamara D. Cabalu, Dr. Donghui Cui, Dr. Thomayant Prueksaritanont, Joanne Stevens, Dr. Pamela L. Tannenbaum, Dr. Richard G. Ball, Joyce Stellabott, Dr. Steven D. Young, Dr. George D. Hartman, Dr. Christopher J. Winrow and Dr. John J. Renger

    Version of Record online : 3 FEB 2012, DOI: 10.1002/cmdc.201200025

  9. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus

    Clinical and Experimental Pharmacology and Physiology

    Volume 42, Issue 10, October 2015, Pages: 1059–1067, Mirza I Beig, Jouji Horiuchi, Roger AL Dampney and Pascal Carrive

    Version of Record online : 15 SEP 2015, DOI: 10.1111/1440-1681.12461

  10. Frontiers in Medicinal Chemistry 2009—a Summary of the Meeting at Heidelberg University


    Volume 4, Issue 8, August 3, 2009, Pages: 1371–1376, Christian Gege and Christian D. Klein

    Version of Record online : 21 MAY 2009, DOI: 10.1002/cmdc.200900151

  11. Orexin a phosphorylates the γ-Aminobutyric acid type A receptor β2 subunit on a serine residue and changes the surface expression of the receptor in SH-SY5Y cells exposed to propofol

    Journal of Neuroscience Research

    Volume 93, Issue 11, November 2015, Pages: 1748–1755, Henrik Andersson, Karin Björnström, Christina Eintrei and Tommy Sundqvist

    Version of Record online : 18 AUG 2015, DOI: 10.1002/jnr.23631

  12. Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish

    Proteins: Structure, Function, and Bioinformatics

    Volume 80, Issue 6, June 2012, Pages: 1694–1698, Mickaël Blaise, Husam M. A. B. Alsarraf, Jaslyn E. M. M. Wong, Søren Roi Midtgaard, Fabrice Laroche, Lotte Schack, Herman Spaink, Jens Stougaard and Søren Thirup

    Version of Record online : 20 MAR 2012, DOI: 10.1002/prot.24050

  13. miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression

    Cell Proliferation

    Volume 50, Issue 3, June 2017, Hui Zhou, Changwei Lin, Yi Zhang, Xiuzhong Zhang, Chong Zhang, Pengbo Zhang, Xingwang Xie and Zeqiang Ren

    Version of Record online : 19 FEB 2017, DOI: 10.1111/cpr.12341

  14. Tetrahydroisoquinolines as Orexin Receptor Antagonists: Strategies for Lead Optimization by Solution-Phase Chemistry


    Volume 35, Issue 7, February 17, 2004, Page: no, Ralf Koberstein, Hamed Aissaoui, Daniel Bur, Martine Clozel, Walter Fischli, Francois Jenck, Celia Mueller, Oliver Nayler, Thierry Sifferlen, Alexander Treiber and et al. et al.

    Version of Record online : 21 JAN 2004, DOI: 10.1002/chin.200407310

  15. The Role of Orexin Signaling in the Ventral Tegmental Area and Central Amygdala in Modulating Binge-Like Ethanol Drinking Behavior

    Alcoholism: Clinical and Experimental Research

    Volume 41, Issue 3, March 2017, Pages: 551–561, Jeffrey J. Olney, Montserrat Navarro and Todd E. Thiele

    Version of Record online : 9 FEB 2017, DOI: 10.1111/acer.13336

  16. Controlling factors of volumetrically important marine carbonate cementation in deep slope settings



    Version of Record online : 21 MAY 2010, DOI: 10.1111/j.1365-3091.2010.01153.x

  17. Production of the Streptomyces scabies coronafacoyl phytotoxins involves a novel biosynthetic pathway with an F420-dependent oxidoreductase and a short-chain dehydrogenase/reductase

    Molecular Microbiology

    Volume 101, Issue 1, July 2016, Pages: 122–135, Luke Bown, Mead S. Altowairish, Joanna K. Fyans and Dawn R. D. Bignell

    Version of Record online : 20 APR 2016, DOI: 10.1111/mmi.13378

  18. Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference

    Addiction Biology

    Volume 21, Issue 3, May 2016, Pages: 547–559, Sui-Jun Guo, Yu Cui, Zhen-Zhen Huang, Huan Liu, Xue-Qin Zhang, Jin-Xiang Jiang and Wen-Jun Xin

    Version of Record online : 10 MAR 2015, DOI: 10.1111/adb.12236

  19. Magnesian calcite cements and their diagenesis: dissolution and dolomitization, Mururoa Atoll


    Volume 35, Issue 5, October 1988, Pages: 821–841, DJAFAR M. AISSAOUI

    Version of Record online : 14 JUN 2006, DOI: 10.1111/j.1365-3091.1988.tb01253.x

  20. Discovery of 5′′-Chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia


    Volume 9, Issue 2, February 2014, Pages: 311–322, Dr. Anthony J. Roecker, Swati P. Mercer, John D. Schreier, Dr. Christopher D. Cox, Dr. Mark E. Fraley, Justin T. Steen, Wei Lemaire, Joseph G. Bruno, C. Meacham Harrell, Susan L. Garson, Dr. Anthony L. Gotter, Steven V. Fox, Joanne Stevens, Dr. Pamela L. Tannenbaum, Dr. Thomayant Prueksaritanont, Dr. Tamara D. Cabalu, Dr. Donghui Cui, Joyce Stellabott, Dr. George D. Hartman, Dr. Steven D. Young, Dr. Christopher J. Winrow, Dr. John J. Renger and Dr. Paul J. Coleman

    Version of Record online : 27 DEC 2013, DOI: 10.1002/cmdc.201300447