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There are 65210 results for: content related to: Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened

  1. Contribution of Explicit Solvent Effects to the Binding Affinity of Small-Molecule Inhibitors in Blood Coagulation Factor Serine Proteases


    Volume 6, Issue 6, June 6, 2011, Pages: 1049–1066, Dr. Robert Abel, Dr. Noeris K. Salam, Dr. John Shelley, Dr. Ramy Farid, Prof. Richard A. Friesner and Dr. Woody Sherman

    Article first published online : 19 APR 2011, DOI: 10.1002/cmdc.201000533

  2. Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor


    Volume 7, Issue 6, June 2012, Pages: 1071–1083, Dr. Massimiliano Tognolini, Dr. Matteo Incerti, Iftiin Hassan-Mohamed, Dr. Carmine Giorgio, Simonetta Russo, Dr. Renato Bruni, Dr. Barbara Lelli, Prof. Luisa Bracci, Dr. Roberta Noberini, Prof. Elena B. Pasquale, Prof. Elisabetta Barocelli, Prof. Paola Vicini, Prof. Marco Mor and Dr. Alessio Lodola

    Article first published online : 23 APR 2012, DOI: 10.1002/cmdc.201200102

  3. Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules


    Volume 7, Issue 10, October 2012, Pages: 1712–1740, Dr. Antonio Nardi, Dr. Nils Damann, Dr. Torsten Hertrampf and Dr. Achim Kless

    Article first published online : 4 SEP 2012, DOI: 10.1002/cmdc.201200298

    Corrected by:

    Corrigendum: Corrigendum: Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

    Vol. 7, Issue 11, 1874, Article first published online: 29 OCT 2012

  4. Prospective Validation of a Comprehensive In silico hERG Model and its Applications to Commercial Compound and Drug Databases


    Volume 5, Issue 5, May 3, 2010, Pages: 716–729, Munikumar R. Doddareddy, Elisabeth C. Klaasse, Shagufta, Adriaan P. IJzerman and Andreas Bender

    Article first published online : 26 MAR 2010, DOI: 10.1002/cmdc.201000024

  5. Synthesis and Structure–Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication


    Volume 7, Issue 7, July 2012, Pages: 1217–1229, Dr. Akbar Ali, Dr. Jinhua Wang, Robin S. Nathans, Dr. Hong Cao, Dr. Natalia Sharova, Prof. Dr. Mario Stevenson and Prof. Dr. Tariq M. Rana

    Article first published online : 3 MAY 2012, DOI: 10.1002/cmdc.201200079

  6. Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules


    Volume 6, Issue 8, August 1, 2011, Pages: 1459–1470, Dr. Steven Fletcher, Brent D. G. Page, Xialoei Zhang, Peibin Yue, Zhi Hua Li, Sumaiya Sharmeen, Jagdeep Singh, Wei Zhao, Prof. Aaron D. Schimmer, Prof. Suzanne Trudel, Prof. James Turkson and Prof. Patrick T. Gunning

    Article first published online : 25 MAY 2011, DOI: 10.1002/cmdc.201100194

  7. Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents


    Volume 8, Issue 3, March 2013, Pages: 442–461, Dr. Florian C. Schrader, Dr. Serghei Glinca, Dr. Julia M. Sattler, Dr. Hans-Martin Dahse, Gustavo A. Afanador, Prof. Dr. Sean T. Prigge, Prof. Dr. Michael Lanzer, Dr. Ann-Kristin Mueller, Prof. Dr. Gerhard Klebe and Prof. Dr. Martin Schlitzer

    Article first published online : 22 JAN 2013, DOI: 10.1002/cmdc.201200407

  8. Orexin Receptor Antagonists: A New Concept In CNS Disorders?


    Volume 5, Issue 8, August 2, 2010, Pages: 1197–1214, John Gatfield, Catherine Brisbare-Roch, Francois Jenck and Christoph Boss

    Article first published online : 11 JUN 2010, DOI: 10.1002/cmdc.201000132

  9. 4-Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween-80 in vitro Dependent Families of Antitubercular Agents with Moderate in vivo Activity


    Volume 6, Issue 12, December 9, 2011, Pages: 2252–2263, Dr. Jaime Escribano, Cristina Rivero-Hernández, Hilda Rivera, Dr. David Barros, Dr. Julia Castro-Pichel, Dr. Esther Pérez-Herrán, Dr. Alfonso Mendoza-Losana, Dr. Íñigo Angulo-Barturen, Dr. Santiago Ferrer-Bazaga, Dr. Elena Jiménez-Navarro and Dr. Lluís Ballell

    Article first published online : 16 SEP 2011, DOI: 10.1002/cmdc.201100309

  10. From a Library of MAG Antagonists to Nanomolar CD22 Ligands


    Volume 7, Issue 1, January 2, 2012, Pages: 134–143, Dr. Stefanie Mesch, Katrin Lemme, Dr. Matthias Wittwer, Dr. Hendrik Koliwer-Brandl, Dr. Oliver Schwardt, Prof. Dr. Sørge Kelm and Prof. Dr. Beat Ernst

    Article first published online : 11 OCT 2011, DOI: 10.1002/cmdc.201100407

  11. FimH Antagonists: Structure–Activity and Structure–Property Relationships for Biphenyl α-D-Mannopyranosides


    Volume 7, Issue 8, August 2012, Pages: 1404–1422, Lijuan Pang, Simon Kleeb, Dr. Katrin Lemme, Dr. Said Rabbani, Dr. Meike Scharenberg, Adam Zalewski, Florentina Schädler, Dr. Oliver Schwardt and Prof. Dr. Beat Ernst

    Article first published online : 29 MAY 2012, DOI: 10.1002/cmdc.201200125

  12. 3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor


    Volume 8, Issue 1, January 2013, Pages: 136–148, Dr. Yi-Yu Ke, Dr. Hui-Yi Shiao, Dr. Yung Chang Hsu, Dr. Chang-Ying Chu, Dr. Wen-Chieh Wang, Yen-Chun Lee, Dr. Wen-Hsing Lin, Chun-Hwa Chen, Dr. John T. A. Hsu, Chun-Wei Chang, Dr. Cheng-Wei Lin, Dr. Teng-Kuang Yeh, Dr. Yu-Sheng Chao, Dr. Mohane Selvaraj Coumar and Dr. Hsing-Pang Hsieh

    Article first published online : 22 NOV 2012, DOI: 10.1002/cmdc.201200464

  13. Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors


    Volume 8, Issue 1, January 2013, Pages: 104–111, Pierre Lacotte, Celine Puente and Dr. Yves Ambroise

    Article first published online : 6 NOV 2012, DOI: 10.1002/cmdc.201200417

  14. From High-Throughput Cell Culture Screening to Mouse Model: Identification of New Inhibitor Classes against Prion Disease


    Volume 6, Issue 10, October 4, 2011, Pages: 1928–1937, Dr. Markus Geissen, Dr. Fabienne Leidel, Dr. Martin Eiden, Dr. Thomas Hirschberger, Dr. Christine Fast, Dr. Uwe Bertsch, Prof. Dr. Paul Tavan, Prof. Dr. Armin Giese, Prof. Dr. Hans Kretzschmar, Prof. Dr. Hermann M. Schatzl and Prof. Dr. Martin H. Groschup

    Article first published online : 13 JUL 2011, DOI: 10.1002/cmdc.201100119

  15. Hydroxamic Acids as Potent Inhibitors of FeII and MnIIE. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate–EcMetAP-Mn Complexes


    Volume 7, Issue 6, June 2012, Pages: 1020–1030, Dr. Florian Huguet, Dr. Armelle Melet, Dr. Rodolphe Alves de Sousa, Dr. Aurélie Lieutaud, Dr. Jacqueline Chevalier, Dr. Laure Maigre, Dr. Patrick Deschamps, Prof. Alain Tomas, Nicolas Leulliot, Dr. Jean-Marie Pages and Dr. Isabelle Artaud

    Article first published online : 4 APR 2012, DOI: 10.1002/cmdc.201200076

  16. Discovery of 3H-Imidazo[4,5-b]pyridines as Potent c-Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation


    Volume 7, Issue 6, June 2012, Pages: 1057–1070, Dr. Danqi Chen, Ying Wang, Yuchi Ma, Dr. Bing Xiong, Dr. Jing Ai, Prof. Yi Chen, Prof. Dr. Meiyu Geng and Prof. Dr. Jingkang Shen

    Article first published online : 13 MAY 2012, DOI: 10.1002/cmdc.201200120

  17. Ionic Liquids as Active Pharmaceutical Ingredients


    Volume 6, Issue 6, June 6, 2011, Pages: 975–985, Ricardo Ferraz, Dr. Luís C. Branco, Prof. Cristina Prudêncio, Prof. João Paulo Noronha and Dr. Željko Petrovski

    Article first published online : 9 MAY 2011, DOI: 10.1002/cmdc.201100082

  18. Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases


    Volume 7, Issue 8, August 2012, Pages: 1385–1403, Dr. Lars Bärfacker, Dr. Alexander Kuhl, Prof. Dr. Alexander Hillisch, Dr. Rolf Grosser, Dr. Santiago Figueroa-Pérez, Dr. Heike Heckroth, Adam Nitsche, Dr. Jens-Kerim Ergüden, Dr. Heike Gielen-Haertwig, Dr. Karl-Heinz Schlemmer, Prof. Dr. Joachim Mittendorf, Dr. Holger Paulsen, Dr. Johannes Platzek and Dr. Peter Kolkhof

    Article first published online : 12 JUL 2012, DOI: 10.1002/cmdc.201200081

  19. Design and Synthesis of 3-Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)


    Volume 7, Issue 10, October 2012, Pages: 1825–1839, Dr. Francesca Aiello, Yumna Shabaik, Adrian Esqueda, Tino W. Sanchez, Dr. Fedora Grande, Prof. Antonio Garofalo and Prof. Nouri Neamati

    Article first published online : 5 SEP 2012, DOI: 10.1002/cmdc.201200334

  20. Probing Small-Molecule Binding to Cytochrome P450 2D6 and 2C9: An In Silico Protocol for Generating Toxicity Alerts


    Volume 5, Issue 12, December 3, 2010, Pages: 2088–2101, Gianluca Rossato, Prof. Beat Ernst, Dr. Martin Smiesko, Dr. Morena Spreafico and Prof. Angelo Vedani

    Article first published online : 29 OCT 2010, DOI: 10.1002/cmdc.201000358