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There are 63487 results for: content related to: Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened

  1. You have free access to this content
    Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics


    Volume 5, Issue 4, April 6, 2010, Pages: 500–512, Stefan Peukert and Karen Miller-Moslin

    Article first published online : 12 MAR 2010, DOI: 10.1002/cmdc.201000011

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    Hedgehog Pathway Agonism: Therapeutic Potential and Small-Molecule Development


    Volume 9, Issue 1, January 2014, Pages: 27–37, Prof. M. Kyle Hadden

    Article first published online : 7 NOV 2013, DOI: 10.1002/cmdc.201300358

  3. Contribution of Explicit Solvent Effects to the Binding Affinity of Small-Molecule Inhibitors in Blood Coagulation Factor Serine Proteases


    Volume 6, Issue 6, June 6, 2011, Pages: 1049–1066, Dr. Robert Abel, Dr. Noeris K. Salam, Dr. John Shelley, Dr. Ramy Farid, Prof. Richard A. Friesner and Dr. Woody Sherman

    Article first published online : 19 APR 2011, DOI: 10.1002/cmdc.201000533

  4. Hydroxamic Acids as Potent Inhibitors of FeII and MnIIE. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate–EcMetAP-Mn Complexes


    Volume 7, Issue 6, June 2012, Pages: 1020–1030, Dr. Florian Huguet, Dr. Armelle Melet, Dr. Rodolphe Alves de Sousa, Dr. Aurélie Lieutaud, Dr. Jacqueline Chevalier, Dr. Laure Maigre, Dr. Patrick Deschamps, Prof. Alain Tomas, Nicolas Leulliot, Dr. Jean-Marie Pages and Dr. Isabelle Artaud

    Article first published online : 4 APR 2012, DOI: 10.1002/cmdc.201200076

  5. From a Library of MAG Antagonists to Nanomolar CD22 Ligands


    Volume 7, Issue 1, January 2, 2012, Pages: 134–143, Dr. Stefanie Mesch, Katrin Lemme, Dr. Matthias Wittwer, Dr. Hendrik Koliwer-Brandl, Dr. Oliver Schwardt, Prof. Dr. Sørge Kelm and Prof. Dr. Beat Ernst

    Article first published online : 11 OCT 2011, DOI: 10.1002/cmdc.201100407

  6. Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates


    Volume 5, Issue 11, November 8, 2010, Pages: 1855–1870, Elisabet Viayna, Tània Gómez, Carles Galdeano, Lorena Ramírez, Dr. Míriam Ratia, Prof. Albert Badia, Prof. M. Victòria Clos, Dr. Ester Verdaguer, Dr. Félix Junyent, Prof. Antoni Camins, Prof. Mercè Pallàs, Dr. Manuela Bartolini, Dr. Francesca Mancini, Prof. Vincenza Andrisano, Dr. Mariana P. Arce, Prof. María Isabel Rodríguez-Franco, Dr. Axel Bidon-Chanal, Prof. F. Javier Luque, Prof. Pelayo Camps and Prof. Diego Muñoz-Torrero

    Article first published online : 21 SEP 2010, DOI: 10.1002/cmdc.201000322

  7. A Facile Synthesis of Novel Bis-(indolyl)-1,3,4-oxadiazoles as Potent Cytotoxic Agents


    Volume 7, Issue 11, November 2012, Pages: 1915–1920, Prof. Dalip Kumar, V. Arun, N. Maruthi Kumar, Glen Acosta, Brett Noel and Prof. Kavita Shah

    Article first published online : 20 SEP 2012, DOI: 10.1002/cmdc.201200363

  8. Synthesis, 3D-QSAR, and Structural Modeling of Benzolactam Derivatives with Binding Affinity for the D2 and D3 Receptors


    Volume 5, Issue 8, August 2, 2010, Pages: 1300–1317, Laura López, Jana Selent, Raquel Ortega, Christian F. Masaguer, Eduardo Domínguez, Filipe Areias, José Brea, María Isabel Loza, Ferran Sanz and Manuel Pastor

    Article first published online : 11 JUN 2010, DOI: 10.1002/cmdc.201000101

  9. Synthesis and Biological Evaluation of Acridine Derivatives as Antimalarial Agents


    Volume 7, Issue 4, April 2012, Pages: 587–605, Dr. Xiao-Min Yu, Dr. Florence Ramiandrasoa, Dr. Lucie Guetzoyan, Dr. Bruno Pradines, Edgar Quintino, Dr. Daniele Gadelle, Dr. Patrick Forterre, Dr. Thierry Cresteil, Prof. Jean-Pierre Mahy and Dr. Stéphanie Pethe

    Article first published online : 13 FEB 2012, DOI: 10.1002/cmdc.201100554

  10. FimH Antagonists: Structure–Activity and Structure–Property Relationships for Biphenyl α-D-Mannopyranosides


    Volume 7, Issue 8, August 2012, Pages: 1404–1422, Lijuan Pang, Simon Kleeb, Dr. Katrin Lemme, Dr. Said Rabbani, Dr. Meike Scharenberg, Adam Zalewski, Florentina Schädler, Dr. Oliver Schwardt and Prof. Dr. Beat Ernst

    Article first published online : 29 MAY 2012, DOI: 10.1002/cmdc.201200125

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    Synthesis and Structure–Activity Relationship Studies of Derivatives of the Dual Aromatase–Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate


    Volume 8, Issue 5, May 2013, Pages: 779–799, L. W. Lawrence Woo, Paul M. Wood, Christian Bubert, Mark P. Thomas, Atul Purohit and Barry V. L. Potter

    Article first published online : 11 MAR 2013, DOI: 10.1002/cmdc.201300015

  12. Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds


    Volume 6, Issue 5, May 2, 2011, Pages: 759–764, Kai-Hsuan Chang, Dr. Oliver N. F. King, Dr. Anthony Tumber, Dr. Esther C. Y. Woon, Dr. Tom D. Heightman, Dr. Michael A. McDonough, Prof. Dr. Christopher J. Schofield and Dr. Nathan R. Rose

    Article first published online : 15 MAR 2011, DOI: 10.1002/cmdc.201100026

  13. Structure–Activity Relationships and Mechanism of Action of Eph–ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor


    Volume 7, Issue 6, June 2012, Pages: 1071–1083, Dr. Massimiliano Tognolini, Dr. Matteo Incerti, Iftiin Hassan-Mohamed, Dr. Carmine Giorgio, Simonetta Russo, Dr. Renato Bruni, Dr. Barbara Lelli, Prof. Luisa Bracci, Dr. Roberta Noberini, Prof. Elena B. Pasquale, Prof. Elisabetta Barocelli, Prof. Paola Vicini, Prof. Marco Mor and Dr. Alessio Lodola

    Article first published online : 23 APR 2012, DOI: 10.1002/cmdc.201200102

  14. Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules


    Volume 7, Issue 10, October 2012, Pages: 1712–1740, Dr. Antonio Nardi, Dr. Nils Damann, Dr. Torsten Hertrampf and Dr. Achim Kless

    Article first published online : 4 SEP 2012, DOI: 10.1002/cmdc.201200298

    Corrected by:

    Corrigendum: Corrigendum: Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules

    Vol. 7, Issue 11, 1874, Article first published online: 29 OCT 2012

  15. Prospective Validation of a Comprehensive In silico hERG Model and its Applications to Commercial Compound and Drug Databases


    Volume 5, Issue 5, May 3, 2010, Pages: 716–729, Munikumar R. Doddareddy, Elisabeth C. Klaasse, Shagufta, Adriaan P. IJzerman and Andreas Bender

    Article first published online : 26 MAR 2010, DOI: 10.1002/cmdc.201000024

  16. A Versatile and Practical Synthesis toward the Development of Novel HIV-1 Integrase Inhibitors


    Volume 6, Issue 2, February 7, 2011, Pages: 343–352, Dr. Marta Rinaldi, Dr. Cristina Tintori, Dr. Luigi Franchi, Dr. Giulia Vignaroli, Dr. Anna Innitzer, Prof. Silvio Massa, Prof. José A. Esté, Dr. Encarna Gonzalo, Dr. Frauke Christ, Prof. Zeger Debyser and Prof. Maurizio Botta

    Article first published online : 18 JAN 2011, DOI: 10.1002/cmdc.201000510

  17. Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents


    Volume 8, Issue 3, March 2013, Pages: 442–461, Dr. Florian C. Schrader, Dr. Serghei Glinca, Dr. Julia M. Sattler, Dr. Hans-Martin Dahse, Gustavo A. Afanador, Prof. Dr. Sean T. Prigge, Prof. Dr. Michael Lanzer, Dr. Ann-Kristin Mueller, Prof. Dr. Gerhard Klebe and Prof. Dr. Martin Schlitzer

    Article first published online : 22 JAN 2013, DOI: 10.1002/cmdc.201200407

  18. Orexin Receptor Antagonists: A New Concept In CNS Disorders?


    Volume 5, Issue 8, August 2, 2010, Pages: 1197–1214, John Gatfield, Catherine Brisbare-Roch, Francois Jenck and Christoph Boss

    Article first published online : 11 JUN 2010, DOI: 10.1002/cmdc.201000132

  19. Synthesis and Structure–Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication


    Volume 7, Issue 7, July 2012, Pages: 1217–1229, Dr. Akbar Ali, Dr. Jinhua Wang, Robin S. Nathans, Dr. Hong Cao, Dr. Natalia Sharova, Prof. Dr. Mario Stevenson and Prof. Dr. Tariq M. Rana

    Article first published online : 3 MAY 2012, DOI: 10.1002/cmdc.201200079

  20. 4-Substituted Thioquinolines and Thiazoloquinolines: Potent, Selective, and Tween-80 in vitro Dependent Families of Antitubercular Agents with Moderate in vivo Activity


    Volume 6, Issue 12, December 9, 2011, Pages: 2252–2263, Dr. Jaime Escribano, Cristina Rivero-Hernández, Hilda Rivera, Dr. David Barros, Dr. Julia Castro-Pichel, Dr. Esther Pérez-Herrán, Dr. Alfonso Mendoza-Losana, Dr. Íñigo Angulo-Barturen, Dr. Santiago Ferrer-Bazaga, Dr. Elena Jiménez-Navarro and Dr. Lluís Ballell

    Article first published online : 16 SEP 2011, DOI: 10.1002/cmdc.201100309