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There are 12548 results for: content related to: The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon

  1. Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

    Medicinal Research Reviews

    Volume 33, Issue 1, January 2013, Pages: 139–189, Rafael León, Antonio G. Garcia and José Marco-Contelles

    Version of Record online : 26 JUL 2011, DOI: 10.1002/med.20248

  2. Strategies for the Inhibition of Protein Aggregation in Human Diseases

    ChemBioChem

    Volume 11, Issue 8, May 17, 2010, Pages: 1018–1035, Manuela Bartolini and Vincenza Andrisano

    Version of Record online : 16 APR 2010, DOI: 10.1002/cbic.200900666

  3. Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

    ChemMedChem

    Volume 11, Issue 12, June 20, 2016, Pages: 1284–1295, Dr. Federica Prati, Dr. Christian Bergamini, Prof. Romana Fato, Dr. Ondrej Soukup, Dr. Jan Korabecny, Prof. Vincenza Andrisano, Prof. Manuela Bartolini and Prof. Maria Laura Bolognesi

    Version of Record online : 16 FEB 2016, DOI: 10.1002/cmdc.201600014

  4. Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease

    ChemMedChem

    Volume 11, Issue 12, June 20, 2016, Pages: 1309–1317, Dr. Elena Simoni, Melania M. Serafini, Prof. Dr. Manuela Bartolini, Roberta Caporaso, Antonella Pinto, Dr. Daniela Necchi, Dr. Jessica Fiori, Prof. Dr. Vincenza Andrisano, Prof. Dr. Anna Minarini, Dr. Cristina Lanni and Prof. Dr. Michela Rosini

    Version of Record online : 26 OCT 2015, DOI: 10.1002/cmdc.201500422

  5. Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates

    ChemMedChem

    Volume 5, Issue 11, November 8, 2010, Pages: 1855–1870, Elisabet Viayna, Tània Gómez, Carles Galdeano, Lorena Ramírez, Dr. Míriam Ratia, Prof. Albert Badia, Prof. M. Victòria Clos, Dr. Ester Verdaguer, Dr. Félix Junyent, Prof. Antoni Camins, Prof. Mercè Pallàs, Dr. Manuela Bartolini, Dr. Francesca Mancini, Prof. Vincenza Andrisano, Dr. Mariana P. Arce, Prof. María Isabel Rodríguez-Franco, Dr. Axel Bidon-Chanal, Prof. F. Javier Luque, Prof. Pelayo Camps and Prof. Diego Muñoz-Torrero

    Version of Record online : 21 SEP 2010, DOI: 10.1002/cmdc.201000322

  6. Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities

    ChemMedChem

    Volume 5, Issue 8, August 2, 2010, Pages: 1215–1220, Maria Laura Bolognesi, Manuela Bartolini, Francesca Mancini, Gianpaolo Chiriano, Luisa Ceccarini, Michela Rosini, Andrea Milelli, Vincenzo Tumiatti, Vincenza Andrisano and Carlo Melchiorre

    Version of Record online : 18 MAY 2010, DOI: 10.1002/cmdc.201000086

  7. Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

    Angewandte Chemie International Edition

    Volume 54, Issue 5, January 26, 2015, Pages: 1578–1582, Federica Prati, Dr. Angela De Simone, Dr. Paola Bisignano, Dr. Andrea Armirotti, Dr. Maria Summa, Dr. Daniela Pizzirani, Dr. Rita Scarpelli, Dr. Daniel I. Perez, Prof. Dr. Vincenza Andrisano, Dr. Ana Perez-Castillo, Prof. Dr. Barbara Monti, Francesca Massenzio, Dr. Letizia Polito, Prof. Dr. Marco Racchi, Dr. Angelo D. Favia, Dr. Giovanni Bottegoni, Prof. Dr. Ana Martinez, Prof. Dr. Maria Laura Bolognesi and Prof. Dr. Andrea Cavalli

    Version of Record online : 11 DEC 2014, DOI: 10.1002/anie.201410456

  8. Multitarget Drugs for Stabilization of Calcium Cycling and Neuroprotection in Neurodegenerative Diseases and Stroke

    Therapeutic Targets: Modulation, Inhibition, and Activation

    Antonio M. G. de Diego, Silvia Lorrio, Jesús M. Hernández-Guijo, Luis Gandía, Antonio G. García, Pages: 123–200, 2012

    Published Online : 29 MAY 2012, DOI: 10.1002/9781118185537.ch4

  9. Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

    Archiv der Pharmazie

    Volume 348, Issue 8, August 2015, Pages: 556–563, Natalia Szałaj, Marek Bajda, Katarzyna Dudek, Boris Brus, Stanislav Gobec and Barbara Malawska

    Version of Record online : 29 MAY 2015, DOI: 10.1002/ardp.201500117

  10. Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography

    ChemMedChem

    Volume 7, Issue 3, March 5, 2012, Pages: 400–405, Dr. Cyril Ronco, Dr. Eugénie Carletti, Dr. Jacques-Philippe Colletier, Dr. Martin Weik, Dr. Florian Nachon, Dr. Ludovic Jean and Prof. Pierre-Yves Renard

    Version of Record online : 4 NOV 2011, DOI: 10.1002/cmdc.201100438

  11. New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds

    ChemMedChem

    Volume 10, Issue 5, May 2015, Pages: 773–786, Martin Nimczick and Prof. Dr. Michael Decker

    Version of Record online : 27 MAR 2015, DOI: 10.1002/cmdc.201500041

  12. (S)-Allyl Cysteine Derivatives as a New-type Cholinesterase Inhibitor

    Bulletin of the Korean Chemical Society

    Volume 36, Issue 1, January 2015, Pages: 52–58, Beom-Cheol Kim, Seung-Hwan Lee, Mi Jang, Moo-Ho Won and Jeong Ho Park

    Version of Record online : 5 JAN 2015, DOI: 10.1002/bkcs.10010

  13. Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives

    ChemMedChem

    Volume 11, Issue 12, June 20, 2016, Pages: 1296–1308, Dr. Serena Montanari, Prof. Manuela Bartolini, Dr. Paolo Neviani, Dr. Federica Belluti, Prof. Silvia Gobbi, Dr. Letizia Pruccoli, Prof. Andrea Tarozzi, Dr. Federico Falchi, Prof. Vincenza Andrisano, Dr. Przemysław Miszta, Prof. Andrea Cavalli, Prof. Sławomir Filipek, Prof. Alessandra Bisi and Dr. Angela Rampa

    Version of Record online : 28 OCT 2015, DOI: 10.1002/cmdc.201500392

  14. Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine–Ferulic Acid Hybrids

    ChemMedChem

    Volume 10, Issue 3, March 2015, Pages: 523–539, Mohamed Benchekroun, Dr. Manuela Bartolini, Dr. Javier Egea, Dr. Alejandro Romero, Dr. Elena Soriano, Dr. Marc Pudlo, Vincent Luzet, Prof. Vincenza Andrisano, Dr. María-Luisa Jimeno, Dr. Manuela G. López, Sarah Wehle, Prof. Tijani Gharbi, Prof. Bernard Refouvelet, Lucía de Andrés, Clara Herrera-Arozamena, Prof. Barbara Monti, Prof. Maria Laura Bolognesi, Prof. María Isabel Rodríguez-Franco, Prof. Dr. Michael Decker, Prof. José Marco-Contelles and Dr. Lhassane Ismaili

    Version of Record online : 23 DEC 2014, DOI: 10.1002/cmdc.201402409

  15. 8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease

    ChemistrySelect

    Volume 1, Issue 11, July 16, 2016, Pages: 2742–2749, Dr. José L. Domínguez, Dr. Fernando Fernández-Nieto, Dr. José M. Brea, Dr. Marco Catto, Prof. M. Rita Paleo, Dr. Silvia Porto, Prof. F. Javier Sardina, Prof. Marian Castro, Dr. Leonardo Pisani, Prof. Angelo Carotti, Prof. Ramón Soto-Otero, Prof. Estefanía Méndez-Alvarez, Prof. M. Carmen Villaverde and Dr. Fredy Sussman

    Version of Record online : 22 JUL 2016, DOI: 10.1002/slct.201600735

  16. Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

    Angewandte Chemie

    Volume 127, Issue 5, January 26, 2015, Pages: 1598–1602, Federica Prati, Dr. Angela De Simone, Dr. Paola Bisignano, Dr. Andrea Armirotti, Dr. Maria Summa, Dr. Daniela Pizzirani, Dr. Rita Scarpelli, Dr. Daniel I. Perez, Prof. Dr. Vincenza Andrisano, Dr. Ana Perez-Castillo, Prof. Dr. Barbara Monti, Francesca Massenzio, Dr. Letizia Polito, Prof. Dr. Marco Racchi, Dr. Angelo D. Favia, Dr. Giovanni Bottegoni, Prof. Dr. Ana Martinez, Prof. Dr. Maria Laura Bolognesi and Prof. Dr. Andrea Cavalli

    Version of Record online : 11 DEC 2014, DOI: 10.1002/ange.201410456

  17. Reversible human serum albumin binding of lipocrine: A circular dichroism study

    Chirality

    Volume 23, Issue 9, October 2011, Pages: 827–832, Carlo Bertucci, Angela De Simone, Marco Pistolozzi and Michela Rosini

    Version of Record online : 25 AUG 2011, DOI: 10.1002/chir.21006

  18. Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

    ChemMedChem

    Volume 5, Issue 9, September 3, 2010, Pages: 1616–1630, Leonardo Pisani, Marco Catto, Ilenia Giangreco, Francesco Leonetti, Orazio Nicolotti, Angela Stefanachi, Saverio Cellamare and Angelo Carotti

    Version of Record online : 2 AUG 2010, DOI: 10.1002/cmdc.201000210

  19. Polymethylene tetraamine backbone as template for the development of biologically active polyamines

    Medicinal Research Reviews

    Volume 23, Issue 2, March 2003, Pages: 200–233, Carlo Melchiorre, Alessandra Antonello, Rita Banzi, Maria Laura Bolognesi, Anna Minarini, Michela Rosini and Vincenzo Tumiatti

    Version of Record online : 19 DEC 2002, DOI: 10.1002/med.10029

  20. Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors

    Molecular Informatics

    Volume 31, Issue 6-7, July 2012, Pages: 473–490, Subhash Ajmani and Sudhir A. Kulkarni

    Version of Record online : 4 JUL 2012, DOI: 10.1002/minf.201100160