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There are 13771 results for: content related to: Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations

  1. You have free access to this content
    Loss of the JAK2 intramolecular auto-inhibition mechanism is predicted by structural modelling of a novel exon 12 insertion mutation in a case of idiopathic erythrocytosis

    British Journal of Haematology

    Volume 142, Issue 6, September 2008, Pages: 986–990, Elena Albiero, Domenico Madeo, Marco Ruggeri, Martina Bernardi, Alejandro Giorgetti and Francesco Rodeghiero

    Article first published online : 30 JUL 2008, DOI: 10.1111/j.1365-2141.2008.07180.x

  2. You have free access to this content
    The role of Janus kinases in haemopoiesis and haematological malignancy

    British Journal of Haematology

    Volume 134, Issue 4, August 2006, Pages: 366–384, Asim Khwaja

    Article first published online : 5 JUL 2006, DOI: 10.1111/j.1365-2141.2006.06206.x

  3. You have full text access to this Open Access content
    The JAK kinase inhibitor CP-690,550 supresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation

    Cancer Science

    Volume 99, Issue 6, June 2008, Pages: 1265–1273, Taghi Manshouri, Alfonso Quintás-Cardama, Roberto H. Nussenzveig, Amos Gaikwad, Zeev Estrov, Josef Prchal, Jorge E. Cortes, Hagop M. Kantarjian and Srdan Verstovsek

    Article first published online : 28 JUN 2008, DOI: 10.1111/j.1349-7006.2008.00817.x

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    JAK2 and genomic instability in the myeloproliferative neoplasms: A case of the chicken or the egg?

    American Journal of Hematology

    Volume 87, Issue 11, November 2012, Pages: 1028–1036, Linda M. Scott and Vivienne I. Rebel

    Article first published online : 28 MAY 2012, DOI: 10.1002/ajh.23243

  5. Stereoselective C-glycosidation of unprotected D-glycals with trimethylsilyl cyanide

    Chirality

    Volume 15, Issue 1, 2003, Pages: 10–16, Masahiko Hayashi, Hirotoshi Kawabata and Shu-Zo Nakayama

    Article first published online : 20 NOV 2002, DOI: 10.1002/chir.10146

  6. Somatic Mutations in Polycythaemia Vera and Other Philadelphia Chromosome Negative Myeloproliferative Neoplasms

    Standard Article

    eLS

    Lukasz P Gondek and Jerry L Spivak

    Published Online : 17 DEC 2012, DOI: 10.1002/9780470015902.a0024249

  7. Update on the impact of the JAK2 mutation on signalling pathways in myeloproliferative disorders

    European Journal of Haematology

    Volume 79, Issue s68, October 2007, Pages: 5–8, Radek Skoda

    Article first published online : 23 AUG 2007, DOI: 10.1111/j.1600-0609.2007.00935.x

  8. You have full text access to this Open Access content
    Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1

    Journal of Cellular and Molecular Medicine

    Volume 13, Issue 2, February 2009, Pages: 215–237, Ayalew Tefferi

    Article first published online : 23 OCT 2008, DOI: 10.1111/j.1582-4934.2008.00559.x

  9. Janus kinases in immune cell signaling

    Immunological Reviews

    Volume 228, Issue 1, March 2009, Pages: 273–287, Kamran Ghoreschi, Arian Laurence and John J. O’Shea

    Article first published online : 6 MAR 2009, DOI: 10.1111/j.1600-065X.2008.00754.x

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    Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

    The EMBO Journal

    Volume 17, Issue 18, September 15, 1998, Pages: 5321–5333, Juerg Schwaller, Julie Frantsve, Jon Aster, Ifor R. Williams, Michael H. Tomasson, Theodora S. Ross, Pieter Peeters, Luc Van Rompaey, Richard A. Van Etten, Robert Ilaria Jr, Peter Marynen and D.Gary Gilliland

    Article first published online : 15 SEP 1998, DOI: 10.1093/emboj/17.18.5321

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    The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders

    British Journal of Haematology

    Volume 136, Issue 5, March 2007, Pages: 745–751, Thomas Stauffer Larsen, Jacob Haaber Christensen, Hans Carl Hasselbalch and Niels Pallisgaard

    Article first published online : 8 FEB 2007, DOI: 10.1111/j.1365-2141.2007.06497.x

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    Experimental therapeutics for patients with myeloproliferative neoplasias

    Cancer

    Volume 117, Issue 4, 15 February 2011, Pages: 662–676, Meetu Agrawal, Ravin J. Garg, Jorge Cortes, Hagop Kantarjian, Srdan Verstovsek and Alfonso Quintas-Cardama

    Article first published online : 4 OCT 2010, DOI: 10.1002/cncr.25672

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    Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

    Journal of Cellular and Molecular Medicine

    Volume 14, Issue 3, March 2010, Pages: 504–527, Claude Haan, Iris Behrmann and Serge Haan

    Article first published online : 28 JAN 2010, DOI: 10.1111/j.1582-4934.2010.01018.x

  14. Unusual structures derived from N-acridin-9-yl methyl N′-acridin-9-yl thiourea based on the propensity of N-10 to retain H

    Journal of Heterocyclic Chemistry

    Volume 43, Issue 3, May/June 2006, Pages: 739–743, Karel D. Klika, Kalevi Pihlaja, Ján Imrich, Mária Vilková and Juraj Bernát

    Article first published online : 13 MAR 2009, DOI: 10.1002/jhet.5570430331

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    Janus kinase Inhibition and its effect upon the therapeutic landscape for myelofibrosis: from palliation to cure?

    British Journal of Haematology

    Volume 157, Issue 4, May 2012, Pages: 426–437, Claire Harrison, Srdan Verstovsek, Mary F. McMullin and Ruben Mesa

    Article first published online : 29 MAR 2012, DOI: 10.1111/j.1365-2141.2012.09108.x

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    The prevalence of the activating JAK2 tyrosine kinase mutation in chronic porto-splenomesenteric venous thrombosis

    Alimentary Pharmacology & Therapeutics

    Volume 31, Issue 12, June 2010, Pages: 1330–1336, D. W. ORR, R. K. PATEL, N. C. LEA, R. H. WESTBROOK, J. G. O’GRADY, N. D. HEATON, A. PAGLIUCA, G. J. MUFTI and M. A. HENEGHAN

    Article first published online : 13 MAR 2010, DOI: 10.1111/j.1365-2036.2010.04299.x

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    Molecular diagnosis of the myeloproliferative neoplasms: UK guidelines for the detection of JAK2 V617F and other relevant mutations

    British Journal of Haematology

    Volume 160, Issue 1, January 2013, Pages: 25–34, Anthony J. Bench, Helen E. White, Letizia Foroni, Anna L. Godfrey, Gareth Gerrard, Susanna Akiki, Abida Awan, Ian Carter, Andrea Goday-Fernandez, Stephen E. Langabeer, Tim Clench, Jordan Clark, Paul A. Evans, David Grimwade, Anna Schuh, Mary F. McMullin, Anthony R. Green, Claire N. Harrison and Nicholas C. P. Cross

    Article first published online : 11 OCT 2012, DOI: 10.1111/bjh.12075

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    Advances in Understanding and Management of Myeloproliferative Neoplasms

    CA: A Cancer Journal for Clinicians

    Volume 59, Issue 3, May/June 2009, Pages: 171–191, Alessandro M. Vannucchi, Paola Guglielmelli and Ayalew Tefferi

    Article first published online : 16 APR 2009, DOI: 10.3322/caac.20009

  19. You have free access to this content
    Nuclear JAK2: Form and Function in Cancer

    The Anatomical Record

    Volume 294, Issue 9, September 2011, Pages: 1446–1459, Cui-Juan Qian, Jun Yao and Jian-Min Si

    Article first published online : 1 AUG 2011, DOI: 10.1002/ar.21443

  20. You have free access to this content
    Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease

    American Journal of Hematology

    Volume 90, Issue 1, January 2015, Pages: E17–E21, Axel Muendlein, Elena Kinz, Klaus Gasser, Andreas Leiherer, Philipp Rein, Christoph H. Saely, Harald Grallert, Annette Peters, Peter Fraunberger, Heinz Drexel and Alois H. Lang

    Article first published online : 20 NOV 2014, DOI: 10.1002/ajh.23874