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There are 14767 results for: content related to: Pharmacogenetic testing in the face of unclear clinical efficacy: Lessons from cytochrome P450 2D6 for tamoxifen

  1. Composite Functional Genetic and Comedication CYP2D6 Activity Score in Predicting Tamoxifen Drug Exposure Among Breast Cancer Patients

    The Journal of Clinical Pharmacology

    Volume 50, Issue 4, April 2010, Pages: 450–458, Dr Silvana Borges, Dr Zeruesenay Desta, Dr Yan Jin, Mr Azzouz Faouzi, Mr Jason D. Robarge, Mr Santosh Philip, Ms Anne Nguyen, Mr Vered Stearns, Mr Daniel Hayes, Mr James M. Rae, Dr Todd C. Skaar, Dr David A. Flockhart and Dr Lang Li

    Version of Record online : 7 MAR 2013, DOI: 10.1177/0091270009359182

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    The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone

    British Journal of Pharmacology

    Volume 160, Issue 4, June 2010, Pages: 907–918, CF Samer, Y Daali, M Wagner, G Hopfgartner, CB Eap, MC Rebsamen, MF Rossier, D Hochstrasser, P Dayer and JA Desmeules

    Version of Record online : 24 MAY 2010, DOI: 10.1111/j.1476-5381.2010.00673.x

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    Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population

    British Journal of Clinical Pharmacology

    Volume 48, Issue 3, September 1999, Pages: 395–401, Lise Bathum, Erik Skjelbo, Theonest K. Mutabingwa, Hanne Madsen, Mogens Hørder and Kim Brøsen

    Version of Record online : 24 DEC 2001, DOI: 10.1046/j.1365-2125.1999.00019.x

  4. Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes – a comparative study

    Biotechnology Journal

    Volume 7, Issue 11, November 2012, Pages: 1346–1358, Martina Geier, Andreas Braun, Anita Emmerstorfer, Harald Pichler and Dr. Anton Glieder

    Version of Record online : 2 OCT 2012, DOI: 10.1002/biot.201200187

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    Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism

    The FEBS Journal

    Volume 276, Issue 13, July 2009, Pages: 3440–3453, Michelle Cook Sangar, Hindupur K. Anandatheerthavarada, Weigang Tang, Subbuswamy K. Prabu, Martha V. Martin, Miroslav Dostalek, F. Peter Guengerich and Narayan G. Avadhani

    Version of Record online : 11 MAY 2009, DOI: 10.1111/j.1742-4658.2009.07067.x

  6. Assessment of Activity Levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 Genes by Population Pharmacokinetics of Dextromethorphan

    Clinical Pharmacology & Therapeutics

    Volume 88, Issue 5, November 2010, Pages: 643–651, K Abduljalil, D Frank, A Gaedigk, T Klaassen, D Tomalik-Scharte, A Jetter, U Jaehde, J Kirchheiner and U Fuhr

    Version of Record online : 29 SEP 2010, DOI: 10.1038/clpt.2010.137

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    The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: A preliminary study in a psychiatric population

    Psychiatry and Clinical Neurosciences

    Volume 53, Issue 5, October 1999, Pages: 593–597, Toshiyuki Someya, Yutaro Suzuki, Kazutaka Shimoda, Genta Hirokane, Sachiyo Morita, Aya Yokono, Yoshimasa Inoue and Saburo Takahashi

    Version of Record online : 4 JAN 2002, DOI: 10.1046/j.1440-1819.1999.00611.x

  8. Pharmacogenomics of Central Nervous System (CNS) Drugs

    Drug Development Research

    Volume 73, Issue 8, December 2012, Pages: 461–476, Ramón Cacabelos

    Version of Record online : 18 OCT 2012, DOI: 10.1002/ddr.21039

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    CYP2D6 variation, behaviour and psychopathology: implications for pharmacogenomics-guided clinical trials

    British Journal of Clinical Pharmacology

    Volume 77, Issue 4, April 2014, Pages: 673–683, Eva M. Peñas-LLedó and Adrián LLerena

    Version of Record online : 20 MAR 2014, DOI: 10.1111/bcp.12227

  10. Pharmacokinetics, Safety, and Tolerability of Atomoxetine and Effect of CYP2D6*10/*10 Genotype in Healthy Japanese Men

    The Journal of Clinical Pharmacology

    Volume 52, Issue 3, March 2012, Pages: 388–403, Dr A. Matsui, Dr J. Azuma, Dr J. W. Witcher, Ms A. J. Long, Dr J.-M. Sauer, Dr B. P. Smith, Dr K. A. DeSante, Dr H. A. Read, Dr M. Takahashi and Dr M. Nakano

    Version of Record online : 7 MAR 2013, DOI: 10.1177/0091270011398657

  11. Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells

    European Journal of Neuroscience

    Volume 31, Issue 7, April 2010, Pages: 1185–1193, Amandeep Mann and Rachel F. Tyndale

    Version of Record online : 22 MAR 2010, DOI: 10.1111/j.1460-9568.2010.07142.x

  12. Drug disposition of chiral and achiral drug substrates metabolized by cytochrome P450 2D6 isozyme: case studies, analytical perspectives and developmental implications

    Biomedical Chromatography

    Volume 20, Issue 6-7, June - July 2006, Pages: 466–491, Nuggehally R. Srinivas

    Version of Record online : 15 JUN 2006, DOI: 10.1002/bmc.680

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    Elucidation of CYP2D6 Genetic Diversity in a Unique African Population: Implications for the Future Application of Pharmacogenetics in the Xhosa Population

    Annals of Human Genetics

    Volume 74, Issue 4, July 2010, Pages: 340–350, Galen E. B. Wright, Dana J. H. Niehaus, Britt I. Drögemöller, Liezl Koen, Andrea Gaedigk and Louise Warnich

    Version of Record online : 17 JUN 2010, DOI: 10.1111/j.1469-1809.2010.00585.x

  14. Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6


    Volume 11, Issue 1, 1999, Pages: 1–9, Shizuo Narimatsu, Rika Kato, Toshiharu Horie, Satoshi Ono, Michio Tsutsui, Yoshiyasu Yabusaki, Shigeru Ohmori, Mitsukazu Kitada, Takao Ichioka, Noriaki Shimada, Ryuichi Kato and Tsutomu Ishikawa

    Version of Record online : 29 JAN 1999, DOI: 10.1002/(SICI)1520-636X(1999)11:1<1::AID-CHIR1>3.0.CO;2-E

  15. Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6

    Human Mutation

    Volume 37, Issue 3, March 2016, Pages: 315–323, Wanqiong Qiao, Yao Yang, Robert Sebra, Geetu Mendiratta, Andrea Gaedigk, Robert J. Desnick and Stuart A. Scott

    Version of Record online : 18 DEC 2015, DOI: 10.1002/humu.22936

  16. Relationship of CYP2D6 genetic polymorphisms and the pharmacokinetics of tramadol in Chinese volunteers

    Journal of Clinical Pharmacy and Therapeutics

    Volume 35, Issue 2, April 2010, Pages: 239–247, Q. Li, R. Wang, Y. Guo, S. Wen, L. Xu and S. Wang

    Version of Record online : 1 OCT 2009, DOI: 10.1111/j.1365-2710.2009.01102.x

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    Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer

    British Journal of Clinical Pharmacology

    Volume 77, Issue 4, April 2014, Pages: 695–703, Hiltrud Brauch and Matthias Schwab

    Version of Record online : 20 MAR 2014, DOI: 10.1111/bcp.12229

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    Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

    FEBS Letters

    Volume 392, Issue 1, August 19, 1996, Pages: 30–34, Roger Løvlie, Ann K. Daly, Anders Molven, Jeffrey R. Idle and Vidar M. Steen

    Version of Record online : 30 NOV 1999, DOI: 10.1016/0014-5793(96)00779-X

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    Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants

    Clinical Pharmacology & Therapeutics

    Volume 93, Issue 5, May 2013, Pages: 402–408, J K Hicks, J J Swen, C F Thorn, K Sangkuhl, E D Kharasch, V L Ellingrod, T C Skaar, D J Müller, A Gaedigk and J C Stingl

    Version of Record online : 16 JAN 2013, DOI: 10.1038/clpt.2013.2

  20. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment

    Clinical Pharmacology & Therapeutics

    Volume 80, Issue 1, July 2006, Pages: 61–74, Silvana Borges, Zeruesenay Desta, Lang Li, Todd C Skaar, Bryan A Ward, Anne Nguyen, Yan Jin, Anna Maria Storniolo, D Michele Nikoloff, Lin Wu, Grant Hillman, Daniel F Hayes, Vered Stearns and David A Flockhart

    Version of Record online : 3 JUL 2006, DOI: 10.1016/j.clpt.2006.03.013