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There are 35804 results for: content related to: Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease

  1. You have free access to this content
    The protein kinase Cdk5

    European Journal of Biochemistry

    Volume 268, Issue 6, March 2001, Pages: 1518–1527, Ricardo B. Maccioni, Carola Otth, Ilona I. Concha and Juan P. Muñoz

    Version of Record online : 15 DEC 2003, DOI: 10.1046/j.1432-1327.2001.02024.x

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    Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level

    FEBS Letters

    Volume 580, Issue 25, October 30, 2006, Pages: 5925–5933, Amitabha Sengupta, Michal Novak, Inge Grundke-Iqbal and Khalid Iqbal

    Version of Record online : 5 OCT 2006, DOI: 10.1016/j.febslet.2006.09.060

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    Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

    British Journal of Pharmacology

    Volume 171, Issue 24, December 2014, Pages: 5757–5773, Wolf Wrasidlo, Leslie A Crews, Igor F Tsigelny, Emily Stocking, Valentina L Kouznetsova, Diana Price, Amy Paulino, Tania Gonzales, Cassia R Overk, Christina Patrick, Edward Rockenstein and Eliezer Masliah

    Version of Record online : 1 DEC 2014, DOI: 10.1111/bph.12875

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    Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease

    Journal of Neurochemistry

    Volume 113, Issue 5, June 2010, Pages: 1221–1229, Kuei-Hua Chang, Yolanda De Pablo, Hyun-pil Lee, Hyoung-gon Lee, Mark A. Smith and Kavita Shah

    Version of Record online : 14 MAR 2010, DOI: 10.1111/j.1471-4159.2010.06687.x

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    Alterations of Cyclin dependent kinase 5 expression and phosphorylation in Amyloid precursor protein (APP)-transfected PC12 cells

    FEBS Letters

    Volume 585, Issue 8, April 20, 2011, Pages: 1243–1248, Grzegorz A. Czapski, Magdalena Gąssowska, Martyna Songin, Urszula D. Radecka and Joanna B. Strosznajder

    Version of Record online : 30 MAR 2011, DOI: 10.1016/j.febslet.2011.03.058

  6. The roles of cyclin-dependent kinase 5 in dendrite and synapse development

    Biotechnology Journal

    Volume 2, Issue 8, August 2007, Pages: 949–957, Zelda H. Cheung and Nancy Y. Ip

    Version of Record online : 25 MAY 2007, DOI: 10.1002/biot.200700056

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    p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing

    Journal of Neurochemistry

    Volume 134, Issue 2, July 2015, Pages: 354–370, Rafael Andres Posada-Duque, Alejandro López-Tobón, Diego Piedrahita, Christian González-Billault and Gloria Patricia Cardona-Gomez

    Version of Record online : 4 MAY 2015, DOI: 10.1111/jnc.13127

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    PKA modulates GSK-3β- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

    FEBS Letters

    Volume 580, Issue 26, November 13, 2006, Pages: 6269–6274, Fei Liu, Zhihou Liang, Jianhua Shi, Dongmei Yin, Ezzat El-Akkad, Inge Grundke-Iqbal, Khalid Iqbal and Cheng-Xin Gong

    Version of Record online : 24 OCT 2006, DOI: 10.1016/j.febslet.2006.10.033

  9. Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays

    PROTEOMICS

    Volume 8, Issue 10, No. 10 May 2008, Pages: 1980–1986, Cathrin Schnack, Bastian Hengerer and Frank Gillardon

    Version of Record online : 19 MAY 2008, DOI: 10.1002/pmic.200701063

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    DNA binding protein dbpA binds Cdk5 and inhibits its activity

    FEBS Letters

    Volume 446, Issue 2-3, March 12, 1999, Pages: 343–350, Mark Moorthamer, Sabine Zumstein-Mecker and Bhabatosh Chaudhuri

    Version of Record online : 24 MAR 1999, DOI: 10.1016/S0014-5793(99)00248-3

  11. The complex p25/Cdk5 kinase in neurofibrillary degeneration and neuronal death: The missing link to cell cycle

    Biotechnology Journal

    Volume 2, Issue 8, August 2007, Pages: 967–977, Malika Hamdane and Luc Buée

    Version of Record online : 15 JUN 2007, DOI: 10.1002/biot.200700059

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    Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease

    Genes to Cells

    Volume 10, Issue 2, February 2005, Pages: 165–179, Yutaka Uchida, Toshio Ohshima, Yukio Sasaki, Hiromi Suzuki, Shigeki Yanai, Naoya Yamashita, Fumio Nakamura, Kohtaro Takei, Yasuo Ihara, Katsuhiko Mikoshiba, Papachan Kolattukudy, Jerome Honnorat and Yoshio Goshima

    Version of Record online : 25 JAN 2005, DOI: 10.1111/j.1365-2443.2005.00827.x

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    Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission

    Developmental Neurobiology

    Volume 69, Issue 6, May 2009, Pages: 365–377, Alexander E. Kissler, Nina Pettersson, Andreas Frölich, Stephan J. Sigrist and Beat Suter

    Version of Record online : 4 MAR 2009, DOI: 10.1002/dneu.20711

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    Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism

    European Journal of Biochemistry

    Volume 268, Issue 6, March 2001, Pages: 1534–1546, Philip Grant, Pushkar Sharma and Harish C. Pant

    Version of Record online : 15 DEC 2003, DOI: 10.1046/j.1432-1327.2001.02025.x

  15. Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5

    Biotechnology Journal

    Volume 2, Issue 8, August 2007, Pages: 978–987, Sashi Kesavapany, Ya-Li Zheng, Niranjana Amin and Harish C. Pant

    Version of Record online : 25 MAY 2007, DOI: 10.1002/biot.200700057

  16. Expression of Cdk5, p35, and Cdk5-associated kinase activity in the developing rat lens

    Developmental Genetics

    Volume 20, Issue 3, 1997, Pages: 267–275, Chun Y. Gao, Zahra Zakeri, Yong Zhu, Haiying He and Peggy S. Zelenka

    Version of Record online : 6 DEC 1998, DOI: 10.1002/(SICI)1520-6408(1997)20:3<267::AID-DVG9>3.0.CO;2-5

  17. CDK5 phosphorylates eNOS at Ser-113 and regulates NO production

    Journal of Cellular Biochemistry

    Volume 110, Issue 1, 1 May 2010, Pages: 112–117, Chien-Hsing Lee, Yin-Win Wei, Yi-Ting Huang, Yuh-Te Lin, Yu-Cheng Lee, Kuen-Haur Lee and Pei-Jung Lu

    Version of Record online : 8 MAR 2010, DOI: 10.1002/jcb.22515

  18. Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus

    European Journal of Neuroscience

    Volume 34, Issue 8, October 2011, Pages: 1212–1221, Noora Putkonen, Jyrki P. Kukkonen, Guiseppa Mudo, Jaana Putula, Natale Belluardo, Dan Lindholm and Laura Korhonen

    Version of Record online : 7 OCT 2011, DOI: 10.1111/j.1460-9568.2011.07858.x

  19. CDK5 is present in sea urchin and starfish eggs and embryos and can interact with p35, cyclin E and cyclin B3

    Molecular Reproduction and Development

    Volume 77, Issue 5, May 2010, Pages: 449–461, Jean-Claude Lozano, Philippe Schatt, Valérie Vergé, Jérôme Gobinet, Vincent Villey and Gérard Peaucellier

    Version of Record online : 2 MAR 2010, DOI: 10.1002/mrd.21165

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    The role of the Cdk5–p35 kinase in neuronal development

    European Journal of Biochemistry

    Volume 268, Issue 6, March 2001, Pages: 1528–1533, Gabriela Paglini and Alfredo Cáceres

    Version of Record online : 15 DEC 2003, DOI: 10.1046/j.1432-1327.2001.02023.x