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There are 3029 results for: content related to: Simvastatin inhibits secretion of T h17-polarizing cytokines and antigen presentation by DC s in patients with relapsing remitting multiple sclerosis

  1. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells

    Cell Biology International

    Volume 34, Issue 8, August 2010, Pages: 815–826, Sanna S. Virtanen, Jouko Sandholm, Gennady Yegutkin, Kalervo H. Väänänen and Pirkko L. Härkönen

    Article first published online : 2 JAN 2013, DOI: 10.1042/CBI20090288

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    Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone

    Journal of Orthopaedic Research

    Volume 29, Issue 3, March 2011, Pages: 403–413, Carol P.Y. Lau, Lin Huang, Stephen K.W. Tsui, Patrick K.S. Ng, Pui-Yin. Leung and Shekhar M. Kumta

    Article first published online : 30 SEP 2010, DOI: 10.1002/jor.21249

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    Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells

    British Journal of Haematology

    Volume 130, Issue 6, September 2005, Pages: 912–925, Michael A. Morgan, Tarkan Sebil, Erdem Aydilek, Dietrich Peest, Arnold Ganser and Christoph W. M. Reuter

    Article first published online : 11 AUG 2005, DOI: 10.1111/j.1365-2141.2005.05696.x

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    Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

    STEM CELLS

    Volume 30, Issue 7, July 2012, Pages: 1327–1337, Christophe Ginestier, Florence Monville, Julien Wicinski, Olivier Cabaud, Nathalie Cervera, Emmanuelle Josselin, Pascal Finetti, Arnaud Guille, Gaelle Larderet, Patrice Viens, Said Sebti, François Bertucci, Daniel Birnbaum and Emmanuelle Charafe-Jauffret

    Article first published online : 18 JUN 2012, DOI: 10.1002/stem.1122

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    Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI-298

    Journal of Bone and Mineral Research

    Volume 15, Issue 8, August 2000, Pages: 1467–1476, Dr. Fraser P. Coxon, Miep H. Helfrich, Robert Van't Hof, Saïd Sebti, Stuart H. Ralston, Andrew Hamilton and Michael J. Rogers

    Article first published online : 1 AUG 2000, DOI: 10.1359/jbmr.2000.15.8.1467

  6. Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system

    Hippocampus

    Volume 25, Issue 3, March 2015, Pages: 373–384, Maochun Yuan, Shangfeng Gao, Chengdong Sun, Long Chen, Qiong Shi, Jinxia Hu, Rutong Yu and Xiuping Zhou

    Article first published online : 25 NOV 2014, DOI: 10.1002/hipo.22379

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    Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G1-S transition in Ki-Ras-overexpressing transformed adrenocortical cells

    FEBS Letters

    Volume 460, Issue 2, October 29, 1999, Pages: 235–240, Jean-Luc Mazet, Martine Padieu, Hanan Osman, Gabrielle Maume, Patrick Mailliet, Norbert Dereu, Andrew D Hamilton, François Lavelle, Saïd M Sebti and Bernard F Maume

    Article first published online : 25 OCT 1999, DOI: 10.1016/S0014-5793(99)01355-1

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    Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors

    British Journal of Pharmacology

    Volume 162, Issue 5, March 2011, Pages: 1109–1118, G Duque, C Vidal and D Rivas

    Article first published online : 28 JAN 2011, DOI: 10.1111/j.1476-5381.2010.01111.x

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    Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms

    FEBS Journal

    Volume 281, Issue 16, August 2014, Pages: 3719–3738, Anantha Koteswararao Kanugula, Paradesi Naidu Gollavilli, Sathish Babu Vasamsetti, Santosh Karnewar, Raja Gopoju, Ramesh Ummanni and Srigiridhar Kotamraju

    Article first published online : 30 JUL 2014, DOI: 10.1111/febs.12893

  10. Cilostazol enhances integrin-dependent homing of progenitor cells by activation of camp-dependent protein kinase in synergy with Epac1

    Journal of Neuroscience Research

    Volume 89, Issue 5, May 2011, Pages: 650–660, Dong Hyung Lee, Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Ki Whan Hong, Eun Kyoung Kim, Sun Sik Bae, Won Suk Lee, Byung Yong Rhim and Chi Dae Kim

    Article first published online : 17 FEB 2011, DOI: 10.1002/jnr.22558

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    Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles

    EMBO Molecular Medicine

    Volume 6, Issue 2, February 2014, Pages: 239–258, Monica Giannotta, Sara Benedetti, Francesco Saverio Tedesco, Monica Corada, Marianna Trani, Rocco D'Antuono, Queensta Millet, Fabrizio Orsenigo, Beatriz G Gálvez, Giulio Cossu and Elisabetta Dejana

    Article first published online : 30 DEC 2013, DOI: 10.1002/emmm.201302520

  12. R-Ras interacts with filamin a to maintain endothelial barrier function

    Journal of Cellular Physiology

    Volume 226, Issue 9, September 2011, Pages: 2287–2296, G.S. Griffiths, M. Grundl, J.S. Allen III and M.L. Matter

    Article first published online : 9 JUN 2011, DOI: 10.1002/jcp.22565

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    Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: Effects of statins and farnesyl and geranylgeranyl transferase inhibitors

    Arthritis & Rheumatism

    Volume 56, Issue 9, September 2007, Pages: 2840–2853, Aryeh M. Abeles, Nada Marjanovic, Jean Park, Mukundan Attur, Edwin S. Chan, Hayf E. Al-Mussawir, Mandar Dave, Mark C. Fisher, Steven A. Stuchin, Steven B. Abramson and Michael H. Pillinger

    Article first published online : 30 AUG 2007, DOI: 10.1002/art.22824

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    Adrenaline increases glucose transport via a Rap1-p38MAPK pathway in rat vascular smooth muscle cells

    British Journal of Pharmacology

    Volume 151, Issue 4, June 2007, Pages: 476–482, Y Kanda and Y Watanabe

    Article first published online : 29 JAN 2009, DOI: 10.1038/sj.bjp.0707247

  15. Prenylation is not necessary for endogenous Ras activation in non-malignant cells

    Journal of Cellular Biochemistry

    Volume 97, Issue 2, 1 February 2006, Pages: 412–422, Arif Khwaja, Mark E.C. Dockrell, Bruce M. Hendry and Claire C. Sharpe

    Article first published online : 26 SEP 2005, DOI: 10.1002/jcb.20641

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    Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis

    Journal of Neurochemistry

    Volume 125, Issue 5, June 2013, Pages: 698–712, Zhengwei Li, Chengdong Sun, Tao Zhang, Jianbing Mo, Qiong Shi, Xianfeng Zhang, Maochun Yuan, Long Chen, Xueqiang Mao, Rutong Yu and Xiuping Zhou

    Article first published online : 19 APR 2013, DOI: 10.1111/jnc.12249

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    Simvastatin Suppresses Self-Renewal of Mouse Embryonic Stem Cells by Inhibiting RhoA Geranylgeranylation

    STEM CELLS

    Volume 25, Issue 7, July 2007, Pages: 1654–1663, Mi-Hee Lee, Yee Sook Cho and Yong-Mahn Han

    Article first published online : 26 APR 2007, DOI: 10.1634/stemcells.2006-0753

  18. Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease

    European Journal of Neuroscience

    Volume 17, Issue 1, January 2003, Pages: 93–102, V. Meske, F. Albert, D. Richter, J. Schwarze and T. G. Ohm

    Article first published online : 8 JAN 2003, DOI: 10.1046/j.1460-9568.2003.02433.x

  19. Bombyx mori Ras proteins BmRas1, BmRas2 and BmRas3 are neither farnesylated nor palmitoylated but are geranylgeranylated

    Insect Molecular Biology

    Volume 19, Issue 3, June 2010, Pages: 291–301, K. Moriya, T. Tsubota, N. Ishibashi, A. Yafune, T. Suzuki, J. Kobayashi, T. Shiotsuki and T. Utsumi

    Article first published online : 23 DEC 2009, DOI: 10.1111/j.1365-2583.2009.00982.x

  20. The small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival

    Journal of Cellular Biochemistry

    Volume 106, Issue 5, 1 April 2009, Pages: 896–902, Tomohiko Yoshida, Mary F. Clark and Paula H. Stern

    Article first published online : 30 JAN 2009, DOI: 10.1002/jcb.22059