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There are 19328 results for: content related to: Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

  1. PTEN: One Gene, Many Syndromes

    Human Mutation

    Volume 22, Issue 3, September 2003, Pages: 183–198, Charis Eng

    Version of Record online : 24 JUL 2003, DOI: 10.1002/humu.10257

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    Loss of phosphatase and tensin homolog enhances cell invasion and migration through aKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance


    Volume 53, Issue 5, May 2011, Pages: 1558–1569, Karen Man-Fong Sze, Kris Lai-Ting Wong, Glanice Kin-Yan Chu, Joyce Man-Fong Lee, Tai-On Yau and Irene Oi-Lin Ng

    Version of Record online : 22 APR 2011, DOI: 10.1002/hep.24232

  3. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

    Journal of Cellular Physiology

    Volume 226, Issue 11, November 2011, Pages: 2762–2781, James A. McCubrey, Linda S. Steelman, C. Ruth Kempf, William H. Chappell, Stephen L. Abrams, Franca Stivala, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Jörg Bäsecke, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Lucio Cocco and Alberto M. Martelli

    Version of Record online : 24 AUG 2011, DOI: 10.1002/jcp.22647

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    Direct identification of PTEN phosphorylation sites

    FEBS Letters

    Volume 528, Issue 1-3, September 25, 2002, Pages: 145–153, Susan J. Miller, David Y. Lou, David C. Seldin, William S. Lane and Benjamin G. Neel

    Version of Record online : 29 AUG 2002, DOI: 10.1016/S0014-5793(02)03274-X

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    Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration

    The Journal of Physiology

    Volume 590, Issue 4, February 2012, Pages: 777–792, Margaret Sperow, Raymond B. Berry, Ildar T. Bayazitov, Guo Zhu, Suzanne J. Baker and Stanislav S. Zakharenko

    Version of Record online : 10 JAN 2012, DOI: 10.1113/jphysiol.2011.220236

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    Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: An international, multicenter, prospective study


    Volume 121, Issue 5, March 1, 2015, Pages: 688–696, Haider Mahdi, Jessica L. Mester, Emily A. Nizialek, Joanne Ngeow, Chad Michener and Charis Eng

    Version of Record online : 5 NOV 2014, DOI: 10.1002/cncr.29106

  7. Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses

    The Journal of Pathology

    Volume 236, Issue 4, August 2015, Pages: 421–432, Rohan Samarakoon, Sevann Helo, Amy D Dobberfuhl, Nidah S Khakoo, Lucas Falke, Jessica M Overstreet, Roel Goldschmeding and Paul J Higgins

    Version of Record online : 27 APR 2015, DOI: 10.1002/path.4538

  8. Constipation, polyps, or cancer? let PTEN predict your future

    American Journal of Medical Genetics Part A

    Volume 122A, Issue 4, 1 November 2003, Pages: 315–322, Charis Eng

    Version of Record online : 18 AUG 2003, DOI: 10.1002/ajmg.a.20477

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    Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines

    EMBO Molecular Medicine

    Volume 4, Issue 8, August 2012, Pages: 791–807, Kuo-Pao Lai, Shinichi Yamashita, Chiung-Kuei Huang, Shuyuan Yeh and Chawnshang Chang

    Version of Record online : 29 JUN 2012, DOI: 10.1002/emmm.201101140

  10. Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells

    Molecular Carcinogenesis

    Volume 52, Issue 8, August 2013, Pages: 611–618, Ananda Mukherjee and Parimal Karmakar

    Version of Record online : 4 APR 2012, DOI: 10.1002/mc.21903

  11. PTEN Hamartoma Tumor Syndrome

    Management of Genetic Syndromes

    Emily Edelman, Charis Eng, Pages: 661–675, 2010

    Published Online : 17 MAY 2010, DOI: 10.1002/9780470893159.ch44

  12. Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies

    Journal of Cellular Biochemistry

    Volume 116, Issue 9, September 2015, Pages: 1837–1847, Yongming Xi and Yan Chen

    Version of Record online : 23 JUL 2015, DOI: 10.1002/jcb.25159

  13. Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle

    Liver International

    Volume 35, Issue 4, April 2015, Pages: 1354–1366, Simon M. Schultze, Maren Dietrich, Debby Hynx, Andreas Geier, Markus Niessen, Giatgen A. Spinas, Brian A. Hemmings and Oliver Tschopp

    Version of Record online : 24 JUN 2014, DOI: 10.1111/liv.12600

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    Converting cancer mutations into therapeutic opportunities

    EMBO Molecular Medicine

    Volume 1, Issue 6-7, September/October 2009, Pages: 297–299, Tom O'Brien and David Stokoe

    Version of Record online : 28 SEP 2009, DOI: 10.1002/emmm.200900044

  15. SLUG is a direct transcriptional repressor of PTEN tumor suppressor

    The Prostate

    Volume 75, Issue 9, June 15, 2015, Pages: 907–916, Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw and Wen-Shu Wu

    Version of Record online : 1 MAR 2015, DOI: 10.1002/pros.22974

  16. Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growth

    Journal of Surgical Oncology

    Volume 84, Issue 3, November 2003, Pages: 166–172, Ji Shin Lee, Hyung Seok Kim, Young Bok Kim, Min Cheol Lee and Chang Soo Park

    Version of Record online : 29 OCT 2003, DOI: 10.1002/jso.10302

  17. Loss of PTEN is associated with progression to androgen independence

    The Prostate

    Volume 66, Issue 9, 15 June 2006, Pages: 895–902, Jerod Bertram, James W. Peacock, Ladan Fazli, Alice L.-F. Mui, Stephen W. Chung, Michael E. Cox, Brett Monia, Martin E. Gleave and Christopher J. Ong

    Version of Record online : 22 FEB 2006, DOI: 10.1002/pros.20411

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    Altering PI3K—Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation

    Biology of the Cell

    Volume 101, Issue 11, November 2009, Pages: 661–682, Ariel Finkielsztein and Gregory M. Kelly

    Version of Record online : 3 JAN 2012, DOI: 10.1042/BC20090034

  19. Suppression of PTEN Transcription by UVA

    Journal of Biochemical and Molecular Toxicology

    Volume 27, Issue 2, February 2013, Pages: 184–191, Baozhong Zhao, Mei Ming and Yu-Ying He

    Version of Record online : 5 NOV 2012, DOI: 10.1002/jbt.21451

  20. Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors

    Journal of Cutaneous Pathology

    Volume 39, Issue 5, May 2012, Pages: 493–499, Tariq Al-Zaid, Jeremy S. Ditelberg, Victor G. Prieto, Dina Lev, Raja Luthra, Michael A. Davies, A. Hafeez Diwan, Wei-Lien Wang and Alexander J. Lazar

    Version of Record online : 5 APR 2012, DOI: 10.1111/j.1600-0560.2012.01888.x