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There are 9580 results for: content related to: Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

  1. You have full text access to this OnlineOpen article
    Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria

    EMBO Molecular Medicine

    Volume 5, Issue 2, February 2013, Pages: 250–263, Michel Obeid, Jean-François Franetich, Audrey Lorthiois, Audrey Gego, Anne Charlotte Grüner, Maurel Tefit, Claude Boucheix, Georges Snounou and Dominique Mazier

    Article first published online : 19 DEC 2012, DOI: 10.1002/emmm.201201677

  2. FTY720: Placebo-Controlled Study of the Effect on Cardiac Rate and Rhythm in Healthy Subjects

    The Journal of Clinical Pharmacology

    Volume 46, Issue 8, August 2006, Pages: 895–904, Dr Robert Schmouder, Ms Denise Serra, Dr Yibin Wang, Dr John M. Kovarik, Dr John DiMarco, Dr Thomas L. Hunt and Ms Marie-Claude Bastien

    Article first published online : 8 MAR 2013, DOI: 10.1177/0091270006289853

  3. FTY720, a Novel Immunomodulator in de Novo Kidney Transplant Patients: Pharmacokinetics and Exposure-Response Relationship

    The Journal of Clinical Pharmacology

    Volume 45, Issue 11, November 2005, Pages: 1268–1278, Dr Andrej Skerjanec, Dr Helio Tedesco, Dr Hans-H. Neumayer, Dr Edward Cole, Dr Klemens Budde, Dr Chyi-Hung Hsu and Dr Robert Schmouder

    Article first published online : 8 MAR 2013, DOI: 10.1177/0091270005279799

  4. Modulation of IL-33/ST2-TIR and TLR Signalling Pathway by Fingolimod and Analogues in Immune Cells

    Scandinavian Journal of Immunology

    Volume 80, Issue 6, December 2014, Pages: 398–407, K. Rüger, F. Ottenlinger, M. Schröder, A. Živković, H. Stark, J. M. Pfeilschifter and H. H. Radeke

    Article first published online : 26 NOV 2014, DOI: 10.1111/sji.12238

  5. Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization

    British Journal of Pharmacology

    Volume 171, Issue 21, November 2014, Pages: 4797–4807, David A Sykes, Darren M Riddy, Craig Stamp, Michelle E Bradley, Neil McGuiness, Afrah Sattikar, Danilo Guerini, Ines Rodrigues, Albrecht Glaenzel, Mark R Dowling, Florian Mullershausen and Steven J Charlton

    Article first published online : 24 OCT 2014, DOI: 10.1111/bph.12620

  6. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720

    Birth Defects Research Part A: Clinical and Molecular Teratology

    Volume 94, Issue 10, October 2012, Pages: 790–803, Janee Gelineau-van Waes, Mark A. Rainey, Joyce R. Maddox, Kenneth A. Voss, Andrew J. Sachs, Nicole M. Gardner, Justin D. Wilberding and Ronald T. Riley

    Article first published online : 18 SEP 2012, DOI: 10.1002/bdra.23074

  7. You have free access to this content
    Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis

    Inflammatory Bowel Diseases

    Volume 10, Issue 3, May 2004, Pages: 182–192, Tsunekazu Mizushima, Toshinori Ito, Daisuke Kishi, Yasuyuki Kai, Hiroshi Tamagawa, Riichiro Nezu, Hiroshi Kiyono and Hikaru Matsuda

    Article first published online : 14 DEC 2006, DOI: 10.1097/00054725-200405000-00002

  8. FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1

    Journal of Digestive Diseases

    Volume 15, Issue 5, May 2014, Pages: 246–259, Ying Xing, Zhi Hong Wang, Dong Hong Ma and Ying Han

    Article first published online : 20 APR 2014, DOI: 10.1111/1751-2980.12131

  9. Egress: a receptor-regulated step in lymphocyte trafficking

    Immunological Reviews

    Volume 195, Issue 1, October 2003, Pages: 160–177, Hugh Rosen, Germana Sanna and Christopher Alfonso

    Article first published online : 10 SEP 2003, DOI: 10.1034/j.1600-065X.2003.00068.x

  10. Involvement of vacuolar H+-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720

    Pigment Cell & Melanoma Research

    Kwang Hong Tay, Xiaoying Liu, Mengna Chi, Lei Jin, Chen Chen Jiang, Su Tang Guo, Nicole M. Verrills, Hsin-Yi Tseng and Xu Dong Zhang

    Article first published online : 13 NOV 2014, DOI: 10.1111/pcmr.12326

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    A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

    British Journal of Pharmacology

    Volume 138, Issue 7, April 2003, Pages: 1303–1312, Yumiko Matsuoka, Yukitoshi Nagahara, Masahiko Ikekita and Takahisa Shinomiya

    Article first published online : 30 JAN 2009, DOI: 10.1038/sj.bjp.0705182

  12. The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

    British Journal of Pharmacology

    Volume 172, Issue 1, January 2015, Pages: 80–92, A Slowik, T Schmidt, C Beyer, S Amor, T Clarner and M Kipp

    Article first published online : 15 DEC 2014, DOI: 10.1111/bph.12938

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    The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells

    European Journal of Immunology

    Volume 35, Issue 2, February 2005, Pages: 533–545, Hansgeorg Müller, Susanne Hofer, Nicole Kaneider, Hannes Neuwirt, Birgit Mosheimer, Gert Mayer, Günther Konwalinka, Christine Heufler and Martin Tiefenthaler

    Article first published online : 18 JAN 2005, DOI: 10.1002/eji.200425556

  14. You have full text access to this Open Access content
    Therapeutic approach for type 1 diabetes mellitus using the novel immunomodulator FTY720 (fingolimod) in combination with once-daily injection of insulin glargine in non-obese diabetic mice

    Journal of Diabetes Investigation

    Volume 3, Issue 2, April 2012, Pages: 132–137, Takumi Tsuji, Mariko Inoue, Yuya Yoshida, Tetsuro Fujita, Yukikazu Kaino and Takeyuki Kohno

    Article first published online : 20 SEP 2011, DOI: 10.1111/j.2040-1124.2011.00160.x

  15. FTY720 Pharmacokinetics in Mild to Moderate Hepatic Impairment

    The Journal of Clinical Pharmacology

    Volume 45, Issue 4, April 2005, Pages: 446–452, Dr J. M. Kovarik, Dr R. L. Schmouder, Dr D. Serra, Dr Y. Wang, Dr H. Wiegand, Dr S. C. Dilzer and Dr K. C. Lasseter

    Article first published online : 7 MAR 2013, DOI: 10.1177/0091270004274288

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    FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow

    European Journal of Immunology

    Volume 38, Issue 12, December 2008, Pages: 3290–3303, Toshimitsu Fujii, Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Naoya Sakamoto, Tetsuya Nakamura, Kiichiro Tsuchiya, Ryuichi Okamoto and Mamoru Watanabe

    Article first published online : 13 NOV 2008, DOI: 10.1002/eji.200838359

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    FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase

    British Journal of Pharmacology

    Volume 166, Issue 4, June 2012, Pages: 1411–1418, Léon JA Spijkers, Astrid E Alewijnse and Stephan LM Peters

    Article first published online : 17 MAY 2012, DOI: 10.1111/j.1476-5381.2012.01865.x

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    FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer

    International Journal of Cancer

    Volume 117, Issue 6, 20 December 2005, Pages: 1039–1048, Chee-Wai Chua, Davy Tak-Wing Lee, Ming-Tat Ling, Chun Zhou, Kwan Man, Joanna Ho, Franky L. Chan, Xianghong Wang and Yong-Chuan Wong

    Article first published online : 28 JUN 2005, DOI: 10.1002/ijc.21243

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    Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma


    Volume 53, Issue 6, June 2011, Pages: 1943–1958, Hany A. Omar, Chih-Chien Chou, Lisa D. Berman-Booty, Yihui Ma, Jui-Hsiang Hung, Dasheng Wang, Takayuki Kogure, Tushar Patel, Luigi Terracciano, Natarajan Muthusamy, John C. Byrd, Samuel K. Kulp and Ching-Shih Chen

    Article first published online : 2 MAY 2011, DOI: 10.1002/hep.24293

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    The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers

    Transplant International

    Volume 20, Issue 10, October 2007, Pages: 895–903, María L. Del Rio, Oliver Pabst, Pablo Ramirez, Giovanna Penuelas-Rivas, Reinhold Förster and Jose-Ignacio Rodriguez-Barbosa

    Article first published online : 10 SEP 2007, DOI: 10.1111/j.1432-2277.2007.00539.x