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There are 31876 results for: content related to: Back to the future: a new ‘old’ lead for tuberculosis

  1. You have free access to this content
    Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

    Molecular Microbiology

    Volume 78, Issue 6, December 2010, Pages: 1591–1605, Virginie Molle, Gulcin Gulten, Catherine Vilchèze, Romain Veyron-Churlet, Isabelle Zanella-Cléon, James C. Sacchettini, William R. Jacobs Jr and Laurent Kremer

    Article first published online : 9 NOV 2010, DOI: 10.1111/j.1365-2958.2010.07446.x

  2. You have full text access to this OnlineOpen article
    Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

    EMBO Molecular Medicine

    Volume 4, Issue 10, October 2012, Pages: 1032–1042, Ruben C. Hartkoorn, Claudia Sala, João Neres, Florence Pojer, Sophie Magnet, Raju Mukherjee, Swapna Uplekar, Stefanie Boy-Röttger, Karl-Heinz Altmann and Stewart T. Cole

    Article first published online : 17 SEP 2012, DOI: 10.1002/emmm.201201689

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    A silent mutation in mabA confers isoniazid resistance on Mycobacterium tuberculosis

    Molecular Microbiology

    Volume 91, Issue 3, February 2014, Pages: 538–547, Hiroki Ando, Tohru Miyoshi-Akiyama, Shinya Watanabe and Teruo Kirikae

    Article first published online : 9 JAN 2014, DOI: 10.1111/mmi.12476

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    Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

    Molecular Microbiology

    Volume 46, Issue 2, October 2002, Pages: 453 –466, Michelle H. Larsen, Catherine Vilchèze, Laurent Kremer, Gurdyal S. Besra, Linda Parsons, Max Salfinger, Leonid Heifets, Manzour H. Hazbon, David Alland, James C. Sacchettini and William R. Jacobs Jr

    Article first published online : 24 OCT 2002, DOI: 10.1046/j.1365-2958.2002.03162.x

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    Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells

    Cellular Microbiology

    Volume 14, Issue 8, August 2012, Pages: 1219–1230, Jessica H. Tonry, Beth A. McNichol, Nalini Ramarao, Daniel S. Chertow, Kwang Sik Kim, Scott Stibitz, Olaf Schneewind, Fatah Kashanchi, Charles L. Bailey, Serguei Popov and Myung-Chul Chung

    Article first published online : 17 APR 2012, DOI: 10.1111/j.1462-5822.2012.01791.x

  6. Biological Evaluation of Potent Triclosan-Derived Inhibitors of the Enoyl–Acyl Carrier Protein Reductase InhA in Drug-Sensitive and Drug-Resistant Strains of Mycobacterium tuberculosis


    Volume 9, Issue 11, November 2014, Pages: 2528–2537, Dr. Jozef Stec, Dr. Catherine Vilchèze, Dr. Shichun Lun, Dr. Alexander L. Perryman, Xin Wang, Prof. Joel S. Freundlich, Prof. William Bishai, Prof. William R. Jacobs Jr. and Prof. Alan P. Kozikowski

    Article first published online : 27 AUG 2014, DOI: 10.1002/cmdc.201402255

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    Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis

    Protein Science

    Volume 16, Issue 8, August 2007, Pages: 1617–1627, Nicole A. Kruh, Richa Rawat, Béla P. Ruzsicska and Peter J. Tonge

    Article first published online : 2 JAN 2009, DOI: 10.1110/ps.062749007

  8. Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis


    Volume 4, Issue 2, February 13, 2009, Pages: 241–248, Joel S. Freundlich, Feng Wang, Catherine Vilchèze, Gulcin Gulten, Robert Langley, Guy A. Schiehser, David P. Jacobus, William R. Jacobs Jr. and James C. Sacchettini

    Article first published online : 7 JAN 2009, DOI: 10.1002/cmdc.200800261

  9. Virtually Designed Triclosan-Based Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis and of Plasmodium falciparum

    Molecular Informatics

    Volume 34, Issue 5, May 2015, Pages: 292–307, Luc C. Owono Owono, Fidele Ntie-Kang, Melalie Keita, Eugene Megnassan, Vladimir Frecer and Stanislav Miertus

    Article first published online : 7 MAY 2015, DOI: 10.1002/minf.201400141

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    Protein–protein interactions within the Fatty Acid Synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability

    Molecular Microbiology

    Volume 54, Issue 5, December 2004, Pages: 1161–1172, Romain Veyron-Churlet, Olivier Guerrini, Lionel Mourey, Mamadou Daffé and Didier Zerbib

    Article first published online : 30 SEP 2004, DOI: 10.1111/j.1365-2958.2004.04334.x

  11. Crucial components of mycobacterium type II fatty acid biosynthesis (Fas-II) and their inhibitors

    FEMS Microbiology Letters

    Volume 360, Issue 2, November 2014, Pages: 87–99, Xiangke Duan, Xiaohong Xiang and Jianping Xie

    Article first published online : 21 OCT 2014, DOI: 10.1111/1574-6968.12597

  12. Time-Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy


    Volume 9, Issue 4, April 2014, Pages: 776–791, Dr. Pan Pan, Dr. Susan E. Knudson, Dr. Gopal R. Bommineni, Dr. Huei-Jiun Li, Cheng-Tsung Lai, Dr. Nina Liu, Prof. Miguel Garcia-Diaz, Prof. Carlos Simmerling, Dr. Sachindra S. Patil, Prof. Richard A. Slayden and Prof. Peter J. Tonge

    Article first published online : 11 MAR 2014, DOI: 10.1002/cmdc.201300429

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    Inhibin A enhances bone formation during distraction osteogenesis

    Journal of Orthopaedic Research

    Volume 30, Issue 2, February 2012, Pages: 288–295, Daniel S. Perrien, Kristy M. Nicks, Lichu Liu, Nisreen S. Akel, Anthony W. Bacon, Robert A. Skinner, Frances L. Swain, James Aronson, Larry J. Suva and Dana Gaddy

    Article first published online : 1 AUG 2011, DOI: 10.1002/jor.21501

  14. Structure-Based Design of a Novel Class of Potent Inhibitors of InhA, the Enoyl Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis: A Computer Modelling Approach

    Chemical Biology & Drug Design

    Volume 72, Issue 5, November 2008, Pages: 444–449, Gita Subba Rao, Rajakrishnan Vijayakrishnan and Manoj Kumar

    Article first published online : 16 OCT 2008, DOI: 10.1111/j.1747-0285.2008.00722.x

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    Preliminary Investigations of the Effect of Lipophilic Analogues of the Active Metabolite of Isoniazid Toward Bacterial and Plasmodial Strains

    Chemical Biology & Drug Design

    Volume 79, Issue 6, June 2012, Pages: 1001–1006, Tamara Delaine, Vania Bernardes-Génisson, Annaïk Quémard, Patricia Constant, Frédéric Cosledan, Bernard Meunier and Jean Bernadou

    Article first published online : 10 APR 2012, DOI: 10.1111/j.1747-0285.2012.01374.x

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    Triclosan inhibition of mycobacterial InhA in Saccharomyces cerevisiae: yeast mitochondria as a novel platform for in vivo antimycolate assays

    Letters in Applied Microbiology

    Volume 50, Issue 4, April 2010, Pages: 399–405, A. Gurvitz

    Article first published online : 27 JAN 2010, DOI: 10.1111/j.1472-765X.2010.02812.x

  17. Inhibin alpha gene expression in human trophoblasts is regulated by interactions between TFAP2 and cAMP signaling pathways

    Molecular Reproduction and Development

    Volume 81, Issue 11, November 2014, Pages: 1009–1018, Christophe L. Depoix, Frédéric Debiève and Corinne Hubinont

    Article first published online : 30 OCT 2014, DOI: 10.1002/mrd.22421

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    A pyrosequencing method for molecular monitoring of regions in the inhA, ahpC and rpoB genes of Mycobacterium tuberculosis

    Clinical Microbiology and Infection

    Volume 16, Issue 6, June 2010, Pages: 607–612, E. Garza-González, G. M. González, A. Rentería, W. Cruz-Pulido, G. Rivera and V. Bocanegra-García

    Article first published online : 7 AUG 2009, DOI: 10.1111/j.1469-0691.2009.02932.x

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    Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis

    Molecular Microbiology

    Volume 38, Issue 3, November 2000, Pages: 514–525, Richard A. Slayden, Richard E. Lee and Clifton E. Barry 3rd

    Article first published online : 7 JAN 2002, DOI: 10.1046/j.1365-2958.2000.02145.x

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    Secreted Bacillus anthracis proteases target the host fibrinolytic system

    FEMS Immunology & Medical Microbiology

    Volume 62, Issue 2, July 2011, Pages: 173–181, Myung-Chul Chung, Shelley C. Jorgensen, Jessica H. Tonry, Fatah Kashanchi, Charles Bailey and Serguei Popov

    Article first published online : 4 APR 2011, DOI: 10.1111/j.1574-695X.2011.00798.x