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There are 5994 results for: content related to: Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN -λ and elevated secretion of Cxcl10

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    Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1165–1179, Yi-Cheng Chang, Yu-Hsiang Yu, Jin-Yuh Shew, Wei-Jei Lee, Juey-Jen Hwang, Yen-Hui Chen, Yet-Ran Chen, Pei-Chi Wei, Lee-Ming Chuang and Wen-Hwa Lee

    Version of Record online : 4 JUL 2013, DOI: 10.1002/emmm.201302679

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    Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1502–1522, Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El-Ashry and Joyce M. Slingerland

    Version of Record online : 27 AUG 2013, DOI: 10.1002/emmm.201302558

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    Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1278–1295, Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker-Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand and Mads Gyrd-Hansen

    Version of Record online : 1 JUL 2013, DOI: 10.1002/emmm.201303090

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    Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1871–1886, Katrin Kollmann, Jan Malte Pestka, Sonja Christin Kühn, Elisabeth Schöne, Michaela Schweizer, Kathrin Karkmann, Takanobu Otomo, Philip Catala-Lehnen, Antonio Virgilio Failla, Robert Percy Marshall, Matthias Krause, Rene Santer, Michael Amling, Thomas Braulke and Thorsten Schinke

    Version of Record online : 15 OCT 2013, DOI: 10.1002/emmm.201302979

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    The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1523–1536, Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone and Claudia Bagni

    Version of Record online : 16 SEP 2013, DOI: 10.1002/emmm.201302847

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    CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1775–1793, Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean-Louis Bourges, Francine Behar-Cohen, José-Alain Sahel, Xavier Guillonneau, William Raoul and Christophe Combadiere

    Version of Record online : 21 OCT 2013, DOI: 10.1002/emmm.201302692

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    Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1720–1739, Jeong-Hwan Yoon, Su Myung Jung, Seok Hee Park, Mitsuyasu Kato, Tadashi Yamashita, In-Kyu Lee, Katsuko Sudo, Susumu Nakae, Jin Soo Han, Ok-Hee Kim, Byung-Chul Oh, Takayuki Sumida, Masahiko Kuroda, Ji-Hyeon Ju, Kyeong Cheon Jung, Seong Hoe Park, Dae-Kee Kim and Mizuko Mamura

    Version of Record online : 11 OCT 2013, DOI: 10.1002/emmm.201302524

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    The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations

    EMBO Molecular Medicine

    Volume 8, Issue 5, May 2016, Pages: 442–457, Sven Diederichs, Lorenz Bartsch, Julia C Berkmann, Karin Fröse, Jana Heitmann, Caroline Hoppe, Deetje Iggena, Danny Jazmati, Philipp Karschnia, Miriam Linsenmeier, Thomas Maulhardt, Lino Möhrmann, Johannes Morstein, Stella V Paffenholz, Paula Röpenack, Timo Rückert, Ludger Sandig, Maximilian Schell, Anna Steinmann, Gjendine Voss, Jacqueline Wasmuth, Maria E Weinberger and Ramona Wullenkord

    Version of Record online : 18 MAR 2016, DOI: 10.15252/emmm.201506055

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    Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence

    EMBO Molecular Medicine

    Volume 5, Issue 9, September 2013, Pages: 1367–1382, Veronika Hampl, Claudia Martin, Achim Aigner, Sabrina Hoebel, Stephan Singer, Natalie Frank, Antonio Sarikas, Oliver Ebert, Ron Prywes, Thomas Gudermann and Susanne Muehlich

    Version of Record online : 29 JUL 2013, DOI: 10.1002/emmm.201202406

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    ERBB4 confers metastatic capacity in Ewing sarcoma

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1087–1102, Ariadna Mendoza-Naranjo, Amal El-Naggar, Daniel H. Wai, Priti Mistry, Nikola Lazic, Fernanda Rocha Rojas Ayala, Isabela Werneck da Cunha, Pablo Rodriguez-Viciana, Hongwei Cheng, Jose H. Tavares Guerreiro Fregnani, Patrick Reynolds, Robert J. Arceci, Andrew Nicholson, Timothy J. Triche, Fernando A. Soares, Adrienne M. Flanagan, Yuzhuo Z. Wang, Sandra J. Strauss and Poul H. Sorensen

    Version of Record online : 16 MAY 2013, DOI: 10.1002/emmm.201202343

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    MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1017–1034, Henry S. Cheng, Nirojini Sivachandran, Andrew Lau, Emilie Boudreau, Jimmy L. Zhao, David Baltimore, Paul Delgado-Olguin, Myron I. Cybulsky and Jason E. Fish

    Version of Record online : 3 JUN 2013, DOI: 10.1002/emmm.201202318

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    Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1918–1934, Yasir A. Syed, Alexandra Baer, Matthias P. Hofer, Ginez A. González, Jon Rundle, Szymon Myrta, Jeffrey K. Huang, Chao Zhao, Moritz J. Rossner, Matthew W. B. Trotter, Gert Lubec, Robin J. M. Franklin and Mark R. Kotter

    Version of Record online : 21 OCT 2013, DOI: 10.1002/emmm.201303123

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    A major role for RCAN1 in atherosclerosis progression

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1901–1917, Nerea Méndez-Barbero, Vanesa Esteban, Silvia Villahoz, Amelia Escolano, Katia Urso, Arantzazu Alfranca, Cristina Rodríguez, Susana A. Sánchez, Tsuyoshi Osawa, Vicente Andrés, José Martínez-González, Takashi Minami, Juan Miguel Redondo and Miguel R. Campanero

    Version of Record online : 15 OCT 2013, DOI: 10.1002/emmm.201302842

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    Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1759–1774, Lorena Pereira, Ana Igea, Begoña Canovas, Ignacio Dolado and Angel R. Nebreda

    Version of Record online : 24 SEP 2013, DOI: 10.1002/emmm.201302732

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    An essential role for decorin in bladder cancer invasiveness

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1835–1851, Mohamed El Behi, Sophie Krumeich, Catalina Lodillinsky, Aurélie Kamoun, Lorenzo Tibaldi, Gaël Sugano, Aurélien De Reynies, Elodie Chapeaublanc, Agnès Laplanche, Thierry Lebret, Yves Allory, François Radvanyi, Olivier Lantz, Ana María Eiján, Isabelle Bernard-Pierrot and Clotilde Théry

    Version of Record online : 20 OCT 2013, DOI: 10.1002/emmm.201302655

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    Pathological impact of SMN2 mis-splicing in adult SMA mice

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1586–1601, Kentaro Sahashi, Karen K. Y. Ling, Yimin Hua, John Erby Wilkinson, Tomoki Nomakuchi, Frank Rigo, Gene Hung, David Xu, Ya-Ping Jiang, Richard Z. Lin, Chien-Ping Ko, C. Frank Bennett and Adrian R. Krainer

    Version of Record online : 9 SEP 2013, DOI: 10.1002/emmm.201302567

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    Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1000–1016, Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin and Claude Libert

    Version of Record online : 30 MAY 2013, DOI: 10.1002/emmm.201202100

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    Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1227–1246, Shin-Da Lee, Ted Weita Lai, Shinn-Zong Lin, Chen-Huan Lin, Yung-Hsiang Hsu, Chi-Yuan Li, Hsiao-Jung Wang, Wei Lee, Ching-Yuan Su, Yung-Luen Yu and Woei-Cherng Shyu

    Version of Record online : 8 JUL 2013, DOI: 10.1002/emmm.201202258

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    Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1051–1066, Tuan Zea Tan, Qing Hao Miow, Ruby Yun-Ju Huang, Meng Kang Wong, Jieru Ye, Jieying Amelia Lau, Meng Chu Wu, Luqman Hakim Bin Abdul Hadi, Richie Soong, Mahesh Choolani, Ben Davidson, Jahn M. Nesland, Ling-Zhi Wang, Noriomi Matsumura, Masaki Mandai, Ikuo Konishi, Boon-Cher Goh, Jeffrey T. Chang, Jean Paul Thiery and Seiichi Mori

    Version of Record online : 13 MAY 2013, DOI: 10.1002/emmm.201201823

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    The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1196–1212, Florian A. Siebzehnrubl, Daniel J. Silver, Bugra Tugertimur, Loic P. Deleyrolle, Dorit Siebzehnrubl, Matthew R. Sarkisian, Kelly G. Devers, Antony T. Yachnis, Marius D. Kupper, Daniel Neal, Nancy H. Nabilsi, Michael P. Kladde, Oleg Suslov, Simone Brabletz, Thomas Brabletz, Brent A. Reynolds and Dennis A. Steindler

    Version of Record online : 1 JUL 2013, DOI: 10.1002/emmm.201302827