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There are 21074 results for: content related to: Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

  1. You have full text access to this OnlineOpen article
    miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

    EMBO Molecular Medicine

    Volume 4, Issue 9, September 2012, Pages: 882–895, Ryan M. Allen, Tyler J. Marquart, Carolyn J. Albert, Frederick J. Suchy, David Q.-H. Wang, Meenakshisundaram Ananthanarayanan, David A. Ford and Ángel Baldán

    Article first published online : 5 JUL 2012, DOI: 10.1002/emmm.201201228

  2. You have full text access to this OnlineOpen article
    TSC22D4 is a molecular output of hepatic wasting metabolism

    EMBO Molecular Medicine

    Volume 5, Issue 2, February 2013, Pages: 294–308, Allan Jones, Kilian Friedrich, Maria Rohm, Michaela Schäfer, Carolyn Algire, Philipp Kulozik, Oksana Seibert, Karin Müller-Decker, Tjeerd Sijmonsma, Daniela Strzoda, Carsten Sticht, Norbert Gretz, Geesje M. Dallinga-Thie, Barbara Leuchs, Manfred Kögl, Wolfgang Stremmel, Mauricio Berriel Diaz and Stephan Herzig

    Article first published online : 11 JAN 2013, DOI: 10.1002/emmm.201201869

    Corrected by:

    Corrigendum: Corrigendum

    Vol. 5, Issue 6, 965, Article first published online: 4 JUN 2013

  3. You have full text access to this OnlineOpen article
    Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

    EMBO Molecular Medicine

    Volume 6, Issue 9, September 2014, Pages: 1133–1141, Leigh Goedeke, Alessandro Salerno, Cristina M Ramírez, Liang Guo, Ryan M Allen, Xiaoke Yin, Sarah R Langley, Christine Esau, Amarylis Wanschel, Edward A Fisher, Yajaira Suárez, Angel Baldán, Manuel Mayr and Carlos Fernández-Hernando

    Article first published online : 18 JUL 2014, DOI: 10.15252/emmm.201404046

  4. You have full text access to this OnlineOpen article
    An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

    EMBO Molecular Medicine

    Volume 7, Issue 2, February 2015, Pages: 175–189, Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo and Naoyuki Taniguchi

    Article first published online : 15 JAN 2015, DOI: 10.15252/emmm.201404438

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    A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

    EMBO Molecular Medicine

    Volume 6, Issue 4, April 2014, Pages: 519–538, Giorgia Zadra, Cornelia Photopoulos, Svitlana Tyekucheva, Pedram Heidari, Qing Ping Weng, Giuseppe Fedele, Hong Liu, Natalia Scaglia, Carmen Priolo, Ewa Sicinska, Umar Mahmood, Sabina Signoretti, Neal Birnberg and Massimo Loda

    Article first published online : 4 FEB 2014, DOI: 10.1002/emmm.201302734

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    Corrigendum: A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

    Vol. 6, Issue 10, 1357, Article first published online: 1 SEP 2014

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    Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

    EMBO Molecular Medicine

    Volume 6, Issue 9, September 2014, Pages: 1105–1120, Jermaine Goveia, Peter Stapor and Peter Carmeliet

    Article first published online : 25 JUL 2014, DOI: 10.15252/emmm.201404156

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    The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene

    EMBO Molecular Medicine

    Marta Luna-Sánchez, Elena Díaz-Casado, Emanuele Barca, Miguel Ángel Tejada, Ángeles Montilla-García, Enrique Javier Cobos, Germaine Escames, Dario Acuña-Castroviejo, Catarina M Quinzii and Luis Carlos López

    Article first published online : 23 MAR 2015, DOI: 10.15252/emmm.201404632

  8. You have full text access to this OnlineOpen article
    Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

    EMBO Molecular Medicine

    Volume 7, Issue 3, March 2015, Pages: 339–356, Agnes Lau, Alex McDonald, Nathalie Daude, Charles E Mays, Eric D Walter, Robin Aglietti, Robert CC Mercer, Serene Wohlgemuth, Jacques van der Merwe, Jing Yang, Hristina Gapeshina, Chae Kim, Jennifer Grams, Beipei Shi, Holger Wille, Aru Balachandran, Gerold Schmitt-Ulms, Jiri G Safar, Glenn L Millhauser and David Westaway

    Article first published online : 6 FEB 2015, DOI: 10.15252/emmm.201404588

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    A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

    EMBO Molecular Medicine

    Volume 6, Issue 8, August 2014, Pages: 1062–1074, Jérémie Gautheron, Mihael Vucur, Florian Reisinger, David Vargas Cardenas, Christoph Roderburg, Christiane Koppe, Karina Kreggenwinkel, Anne Theres Schneider, Matthias Bartneck, Ulf Peter Neumann, Ali Canbay, Helen Louise Reeves, Mark Luedde, Frank Tacke, Christian Trautwein, Mathias Heikenwalder and Tom Luedde

    Article first published online : 24 JUN 2014, DOI: 10.15252/emmm.201403856

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    SIL1, a causative cochaperone gene of Marinesco-Sjögren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex

    EMBO Molecular Medicine

    Volume 6, Issue 3, March 2014, Pages: 414–429, Yutaka Inaguma, Nanako Hamada, Hidenori Tabata, Ikuko Iwamoto, Makoto Mizuno, Yoshiaki V Nishimura, Hidenori Ito, Rika Morishita, Motomasa Suzuki, Kinji Ohno, Toshiyuki Kumagai and Koh-ichi Nagata

    Article first published online : 29 JAN 2014, DOI: 10.1002/emmm.201303069

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    Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles

    EMBO Molecular Medicine

    Volume 6, Issue 2, February 2014, Pages: 239–258, Monica Giannotta, Sara Benedetti, Francesco Saverio Tedesco, Monica Corada, Marianna Trani, Rocco D'Antuono, Queensta Millet, Fabrizio Orsenigo, Beatriz G Gálvez, Giulio Cossu and Elisabetta Dejana

    Article first published online : 30 DEC 2013, DOI: 10.1002/emmm.201302520

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    Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

    EMBO Molecular Medicine

    Volume 6, Issue 9, September 2014, Pages: 1142–1160, Vinicia A Polito, Hongmei Li, Heidi Martini-Stoica, Baiping Wang, Li Yang, Yin Xu, Daniel B Swartzlander, Michela Palmieri, Alberto di Ronza, Virginia M-Y Lee, Marco Sardiello, Andrea Ballabio and Hui Zheng

    Article first published online : 28 JUL 2014, DOI: 10.15252/emmm.201303671

  13. Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRα-SREBP1c-dependent mechanism (肝X受体活化可通过LXRα-SREBP1c依赖的机制诱导SCD1表达来增加肝脏脂肪酸不饱和度)

    Journal of Diabetes

    Volume 6, Issue 3, May 2014, Pages: 212–220, Xiaoyan Zhang, Jia Liu, Wen Su, Jing Wu, Chunjiong Wang, Xiaomu Kong, Jan-Åke Gustafsson, Jie Ding, Xiaosong Ma and Youfei Guan

    Article first published online : 30 SEP 2013, DOI: 10.1111/1753-0407.12081

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    Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide

    EMBO Molecular Medicine

    Youn Sook Lee, Jin Seok Park, Su Myung Jung, Sang-Doo Kim, Jun Hwan Kim, Jae Young Lee, Kyeong Cheon Jung, Mizuko Mamura, Sangho Lee, Seong-Jin Kim, Yoe-Sik Bae and Seok Hee Park

    Article first published online : 12 MAR 2015, DOI: 10.15252/emmm.201404653

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    Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1852–1870, Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Manuela Gellert, Christopher H. Lillig, Haike Antelmann, Juan A. Hermoso and Sven Hammerschmidt

    Article first published online : 18 OCT 2013, DOI: 10.1002/emmm.201202435

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    HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice

    EMBO Molecular Medicine

    Volume 7, Issue 1, January 2015, Pages: 78–101, Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Xigui Chen, Hidenori Homma, Toshikazu Sasabe, Jun Shimizu, Shigeomi Shimizu, Takuya Tamura, Shin-ichi Muramatsu and Hitoshi Okazawa

    Article first published online : 15 DEC 2014, DOI: 10.15252/emmm.201404392

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    Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

    EMBO Molecular Medicine

    Volume 7, Issue 2, February 2015, Pages: 190–210, Julia R Clarke, Natalia M Lyra e Silva, Claudia P Figueiredo, Rudimar L Frozza, Jose H Ledo, Danielle Beckman, Carlos K Katashima, Daniela Razolli, Bruno M Carvalho, Renata Frazão, Marina A Silveira, Felipe C Ribeiro, Theresa R Bomfim, Fernanda S Neves, William L Klein, Rodrigo Medeiros, Frank M LaFerla, Jose B Carvalheira, Mario J Saad, Douglas P Munoz, Licio A Velloso, Sergio T Ferreira and Fernanda G De Felice

    Article first published online : 23 JAN 2015, DOI: 10.15252/emmm.201404183

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    Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1759–1774, Lorena Pereira, Ana Igea, Begoña Canovas, Ignacio Dolado and Angel R. Nebreda

    Article first published online : 24 SEP 2013, DOI: 10.1002/emmm.201302732

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    Specific roles for dendritic cell subsets during initiation and progression of psoriasis

    EMBO Molecular Medicine

    Volume 6, Issue 10, October 2014, Pages: 1312–1327, Elisabeth Glitzner, Ana Korosec, Patrick M Brunner, Barbara Drobits, Nicole Amberg, Helia B Schonthaler, Tamara Kopp, Erwin F Wagner, Georg Stingl, Martin Holcmann and Maria Sibilia

    Article first published online : 12 SEP 2014, DOI: 10.15252/emmm.201404114

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    Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome

    EMBO Molecular Medicine

    Volume 6, Issue 8, August 2014, Pages: 1043–1061, Rachid El Fatimy, Federico Miozzo, Anne Le Mouël, Ryma Abane, Leslie Schwendimann, Délara Sabéran-Djoneidi, Aurélie de Thonel, Illiasse Massaoudi, Liliana Paslaru, Kazue Hashimoto-Torii, Elisabeth Christians, Pasko Rakic, Pierre Gressens and Valérie Mezger

    Article first published online : 15 JUL 2014, DOI: 10.15252/emmm.201303311