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There are 8110488 results for: content related to: Caudo-rostral brain spreading of α-synuclein through vagal connections

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    Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases

    EMBO Molecular Medicine

    Volume 9, Issue 1, January 2017, Pages: 112–132, Irene Sambri, Rosa D'Alessio, Yulia Ezhova, Teresa Giuliano, Nicolina Cristina Sorrentino, Vincenzo Cacace, Maria De Risi, Mauro Cataldi, Lucio Annunziato, Elvira De Leonibus and Alessandro Fraldi

    Version of Record online : 23 NOV 2016, DOI: 10.15252/emmm.201606965

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    Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis

    EMBO Molecular Medicine

    Volume 7, Issue 1, January 2015, Pages: 102–123, Raffaele Strippoli, Jesús Loureiro, Vanessa Moreno, Ignacio Benedicto, María Luisa Pérez Lozano, Olga Barreiro, Teijo Pellinen, Susana Minguet, Miguel Foronda, Maria Teresa Osteso, Enrique Calvo, Jesús Vázquez, Manuel López Cabrera and Miguel Angel del Pozo

    Version of Record online : 30 DEC 2014, DOI: 10.15252/emmm.201404127

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    SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome

    EMBO Molecular Medicine

    Volume 8, Issue 9, September 2016, Pages: 1019–1038, Alexandre Janer, Julien Prudent, Vincent Paupe, Somayyeh Fahiminiya, Jacek Majewski, Nicolas Sgarioto, Christine Des Rosiers, Anik Forest, Zhen-Yuan Lin, Anne-Claude Gingras, Grant Mitchell, Heidi M McBride and Eric A Shoubridge

    Version of Record online : 7 JUL 2016, DOI: 10.15252/emmm.201506159

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    Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension

    EMBO Molecular Medicine

    Volume 7, Issue 6, June 2015, Pages: 695–713, Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin and Stephen Y Chan

    Version of Record online : 30 MAR 2015, DOI: 10.15252/emmm.201404511

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    A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases

    EMBO Molecular Medicine

    Volume 8, Issue 6, June 2016, Pages: 609–625, Jakob Körbelin, Godwin Dogbevia, Stefan Michelfelder, Dirk A Ridder, Agnes Hunger, Jan Wenzel, Henning Seismann, Melanie Lampe, Jacqueline Bannach, Manolis Pasparakis, Jürgen A Kleinschmidt, Markus Schwaninger and Martin Trepel

    Version of Record online : 22 APR 2016, DOI: 10.15252/emmm.201506078

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    ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

    EMBO Molecular Medicine

    Volume 6, Issue 2, February 2014, Pages: 278–294, Mathilde Romagnoli, Nora D Mineva, Michael Polmear, Catharina Conrad, Srimathi Srinivasan, Delphine Loussouarn, Sophie Barillé-Nion, Irene Georgakoudi, Áine Dagg, Enda W McDermott, Michael J Duffy, Patricia M. McGowan, Uwe Schlomann, Maddy Parsons, Jörg W Bartsch and Gail E Sonenshein

    Version of Record online : 27 DEC 2013, DOI: 10.1002/emmm.201303373

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    Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

    EMBO Molecular Medicine

    Volume 7, Issue 3, March 2015, Pages: 339–356, Agnes Lau, Alex McDonald, Nathalie Daude, Charles E Mays, Eric D Walter, Robin Aglietti, Robert CC Mercer, Serene Wohlgemuth, Jacques van der Merwe, Jing Yang, Hristina Gapeshina, Chae Kim, Jennifer Grams, Beipei Shi, Holger Wille, Aru Balachandran, Gerold Schmitt-Ulms, Jiri G Safar, Glenn L Millhauser and David Westaway

    Version of Record online : 6 FEB 2015, DOI: 10.15252/emmm.201404588

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    Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

    EMBO Molecular Medicine

    Volume 6, Issue 4, April 2014, Pages: 442–457, Matthias Schäfer, Ann-Helen Willrodt, Svitlana Kurinna, Andrea S Link, Hany Farwanah, Alexandra Geusau, Florian Gruber, Olivier Sorg, Aaron J Huebner, Dennis R Roop, Konrad Sandhoff, Jean-Hilaire Saurat, Erwin Tschachler, Marlon R Schneider, Lutz Langbein, Wilhelm Bloch, Hans-Dietmar Beer and Sabine Werner

    Version of Record online : 6 FEB 2014, DOI: 10.1002/emmm.201303281

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    Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality

    EMBO Molecular Medicine

    Volume 8, Issue 11, November 2016, Pages: 1340–1359, Lin Li, Xiaotian Qi, Weili Sun, Hisham Abdel-Azim, Siyue Lou, Hong Zhu, Nemani V Prasadarao, Alice Zhou, Hiroyuki Shimada, Koichi Shudo, Yong-Mi Kim, Sajad Khazal, Qiaojun He, David Warburton and Lingtao Wu

    Version of Record online : 13 OCT 2016, DOI: 10.15252/emmm.201606434

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    Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

    EMBO Molecular Medicine

    Volume 7, Issue 5, May 2015, Pages: 648–669, Guus M Bol, Farhad Vesuna, Min Xie, Jing Zeng, Khaled Aziz, Nishant Gandhi, Anne Levine, Ashley Irving, Dorian Korz, Saritha Tantravedi, Marise R Heerma van Voss, Kathleen Gabrielson, Evan A Bordt, Brian M Polster, Leslie Cope, Petra van der Groep, Atul Kondaskar, Michelle A Rudek, Ramachandra S Hosmane, Elsken van der Wall, Paul J van Diest, Phuoc T Tran and Venu Raman

    Version of Record online : 27 MAR 2015, DOI: 10.15252/emmm.201404368

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    IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms

    EMBO Molecular Medicine

    Volume 6, Issue 7, July 2014, Pages: 952–969, Jing Wang, Jes S Lindholt, Galina K Sukhova, Michael A Shi, Mingcan Xia, Han Chen, Meixiang Xiang, Aina He, Yi Wang, Na Xiong, Peter Libby, Jian-An Wang and Guo-Ping Shi

    Version of Record online : 24 JUN 2014, DOI: 10.15252/emmm.201303811

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    The amyloid hypothesis of Alzheimer's disease at 25 years

    EMBO Molecular Medicine

    Volume 8, Issue 6, June 2016, Pages: 595–608, Dennis J Selkoe and John Hardy

    Version of Record online : 29 MAR 2016, DOI: 10.15252/emmm.201606210

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    Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

    EMBO Molecular Medicine

    Volume 7, Issue 2, February 2015, Pages: 127–139, Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andres Obregón-Henao, Marcela Henao Tamayo, Randall Basaraba, Beate Kampmann, Katherine M Henry, Joseph Burgon, Stephen A Renshaw, Angeleen Fleming, Robert R Kay, Karen E Anderson, Phillip T Hawkins, Diane J Ordway, David C Rubinsztein and Rodrigo Andres Floto

    Version of Record online : 22 DEC 2014, DOI: 10.15252/emmm.201404137

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    CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1775–1793, Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean-Louis Bourges, Francine Behar-Cohen, José-Alain Sahel, Xavier Guillonneau, William Raoul and Christophe Combadiere

    Version of Record online : 21 OCT 2013, DOI: 10.1002/emmm.201302692

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    Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

    EMBO Molecular Medicine

    Volume 7, Issue 9, September 2015, Pages: 1179–1197, Lian Zhao, Matthew K Zabel, Xu Wang, Wenxin Ma, Parth Shah, Robert N Fariss, Haohua Qian, Christopher N Parkhurst, Wen-Biao Gan and Wai T Wong

    Version of Record online : 2 JUL 2015, DOI: 10.15252/emmm.201505298

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    The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

    EMBO Molecular Medicine

    Volume 7, Issue 11, November 2015, Pages: 1426–1449, Chunbo He, Dagan Mao, Guohua Hua, Xiangmin Lv, Xingcheng Chen, Peter C Angeletti, Jixin Dong, Steven W Remmenga, Kerry J Rodabaugh, Jin Zhou, Paul F Lambert, Peixin Yang, John S Davis and Cheng Wang

    Version of Record online : 28 SEP 2015, DOI: 10.15252/emmm.201404976

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    SIL1, a causative cochaperone gene of Marinesco-Sjögren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex

    EMBO Molecular Medicine

    Volume 6, Issue 3, March 2014, Pages: 414–429, Yutaka Inaguma, Nanako Hamada, Hidenori Tabata, Ikuko Iwamoto, Makoto Mizuno, Yoshiaki V Nishimura, Hidenori Ito, Rika Morishita, Motomasa Suzuki, Kinji Ohno, Toshiyuki Kumagai and Koh-ichi Nagata

    Version of Record online : 29 JAN 2014, DOI: 10.1002/emmm.201303069

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    Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles

    EMBO Molecular Medicine

    Volume 6, Issue 2, February 2014, Pages: 239–258, Monica Giannotta, Sara Benedetti, Francesco Saverio Tedesco, Monica Corada, Marianna Trani, Rocco D'Antuono, Queensta Millet, Fabrizio Orsenigo, Beatriz G Gálvez, Giulio Cossu and Elisabetta Dejana

    Version of Record online : 30 DEC 2013, DOI: 10.1002/emmm.201302520

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    Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA

    EMBO Molecular Medicine

    Volume 8, Issue 9, September 2016, Pages: 1082–1098, Thomas Michler, Stefanie Große, Stefan Mockenhaupt, Natalie Röder, Ferdinand Stückler, Bettina Knapp, Chunkyu Ko, Mathias Heikenwalder, Ulrike Protzer and Dirk Grimm

    Version of Record online : 29 JUL 2016, DOI: 10.15252/emmm.201506172

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    Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

    EMBO Molecular Medicine

    Volume 8, Issue 7, July 2016, Pages: 729–744, Femke Heindryckx, François Binet, Markella Ponticos, Krista Rombouts, Joey Lau, Johan Kreuger and Pär Gerwins

    Version of Record online : 25 MAY 2016, DOI: 10.15252/emmm.201505925