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There are 10080 results for: content related to: Discovery of novel potent ΔF 508- CFTR correctors that target the nucleotide binding domain

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    Antimicrobial peptides and gut microbiota in homeostasis and pathology

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1465–1483, Maureen J. Ostaff, Eduard Friedrich Stange and Jan Wehkamp

    Version of Record online : 23 AUG 2013, DOI: 10.1002/emmm.201201773

  2. You have full text access to this OnlineOpen article
    Gene therapy on the move

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1642–1661, Kerstin B. Kaufmann, Hildegard Büning, Anne Galy, Axel Schambach and Manuel Grez

    Version of Record online : 17 SEP 2013, DOI: 10.1002/emmm.201202287

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    Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1502–1522, Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El-Ashry and Joyce M. Slingerland

    Version of Record online : 27 AUG 2013, DOI: 10.1002/emmm.201302558

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    CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1775–1793, Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean-Louis Bourges, Francine Behar-Cohen, José-Alain Sahel, Xavier Guillonneau, William Raoul and Christophe Combadiere

    Version of Record online : 21 OCT 2013, DOI: 10.1002/emmm.201302692

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    Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1720–1739, Jeong-Hwan Yoon, Su Myung Jung, Seok Hee Park, Mitsuyasu Kato, Tadashi Yamashita, In-Kyu Lee, Katsuko Sudo, Susumu Nakae, Jin Soo Han, Ok-Hee Kim, Byung-Chul Oh, Takayuki Sumida, Masahiko Kuroda, Ji-Hyeon Ju, Kyeong Cheon Jung, Seong Hoe Park, Dae-Kee Kim and Mizuko Mamura

    Version of Record online : 11 OCT 2013, DOI: 10.1002/emmm.201302524

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    Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1000–1016, Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin and Claude Libert

    Version of Record online : 30 MAY 2013, DOI: 10.1002/emmm.201202100

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    Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1103–1118, Jonathan J. Cherry, Erkan Y. Osman, Matthew C. Evans, Sungwoon Choi, Xuechao Xing, Gregory D. Cuny, Marcie A. Glicksman, Christian L. Lorson and Elliot J. Androphy

    Version of Record online : 5 JUN 2013, DOI: 10.1002/emmm.201202305

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    p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118 acetylation

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1662–1683, Rajan Gogna, Esha Madan, Mahmood Khan, Uttam Pati and Periannan Kuppusamy

    Version of Record online : 1 OCT 2013, DOI: 10.1002/emmm.201202055

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    Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1165–1179, Yi-Cheng Chang, Yu-Hsiang Yu, Jin-Yuh Shew, Wei-Jei Lee, Juey-Jen Hwang, Yen-Hui Chen, Yet-Ran Chen, Pei-Chi Wei, Lee-Ming Chuang and Wen-Hwa Lee

    Version of Record online : 4 JUL 2013, DOI: 10.1002/emmm.201302679

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    Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1278–1295, Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker-Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand and Mads Gyrd-Hansen

    Version of Record online : 1 JUL 2013, DOI: 10.1002/emmm.201303090

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    Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1128–1145, Christina Gedicke-Hornung, Verena Behrens-Gawlik, Silke Reischmann, Birgit Geertz, Doreen Stimpel, Florian Weinberger, Saskia Schlossarek, Guillaume Précigout, Ingke Braren, Thomas Eschenhagen, Giulia Mearini, Stéphanie Lorain, Thomas Voit, Patrick A. Dreyfus, Luis Garcia and Lucie Carrier

    Version of Record online : 29 MAY 2013, DOI: 10.1002/emmm.201202168

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    Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1871–1886, Katrin Kollmann, Jan Malte Pestka, Sonja Christin Kühn, Elisabeth Schöne, Michaela Schweizer, Kathrin Karkmann, Takanobu Otomo, Philip Catala-Lehnen, Antonio Virgilio Failla, Robert Percy Marshall, Matthias Krause, Rene Santer, Michael Amling, Thomas Braulke and Thorsten Schinke

    Version of Record online : 15 OCT 2013, DOI: 10.1002/emmm.201302979

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    The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1523–1536, Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone and Claudia Bagni

    Version of Record online : 16 SEP 2013, DOI: 10.1002/emmm.201302847

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    Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation

    EMBO Molecular Medicine

    Volume 5, Issue 9, September 2013, Pages: 1431–1442, Yongbo Wang, Andreas Gogol-Döring, Hao Hu, Sebastian Fröhler, Yunxia Ma, Marvin Jens, Jonas Maaskola, Yasuhiro Murakawa, Claudia Quedenau, Markus Landthaler, Vera Kalscheuer, Dagmar Wieczorek, Yang Wang, Yuhui Hu and Wei Chen

    Version of Record online : 22 AUG 2013, DOI: 10.1002/emmm.201302663

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    Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1852–1870, Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Manuela Gellert, Christopher H. Lillig, Haike Antelmann, Juan A. Hermoso and Sven Hammerschmidt

    Version of Record online : 18 OCT 2013, DOI: 10.1002/emmm.201202435

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    Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence

    EMBO Molecular Medicine

    Volume 5, Issue 9, September 2013, Pages: 1367–1382, Veronika Hampl, Claudia Martin, Achim Aigner, Sabrina Hoebel, Stephan Singer, Natalie Frank, Antonio Sarikas, Oliver Ebert, Ron Prywes, Thomas Gudermann and Susanne Muehlich

    Version of Record online : 29 JUL 2013, DOI: 10.1002/emmm.201202406

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    ERBB4 confers metastatic capacity in Ewing sarcoma

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1087–1102, Ariadna Mendoza-Naranjo, Amal El-Naggar, Daniel H. Wai, Priti Mistry, Nikola Lazic, Fernanda Rocha Rojas Ayala, Isabela Werneck da Cunha, Pablo Rodriguez-Viciana, Hongwei Cheng, Jose H. Tavares Guerreiro Fregnani, Patrick Reynolds, Robert J. Arceci, Andrew Nicholson, Timothy J. Triche, Fernando A. Soares, Adrienne M. Flanagan, Yuzhuo Z. Wang, Sandra J. Strauss and Poul H. Sorensen

    Version of Record online : 16 MAY 2013, DOI: 10.1002/emmm.201202343

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    Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 984–999, Shanshan W. Howland, Chek Meng Poh, Sin Yee Gun, Carla Claser, Benoit Malleret, Nilabh Shastri, Florent Ginhoux, Gijsbert M. Grotenbreg and Laurent Rénia

    Version of Record online : 16 MAY 2013, DOI: 10.1002/emmm.201202273

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    MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1017–1034, Henry S. Cheng, Nirojini Sivachandran, Andrew Lau, Emilie Boudreau, Jimmy L. Zhao, David Baltimore, Paul Delgado-Olguin, Myron I. Cybulsky and Jason E. Fish

    Version of Record online : 3 JUN 2013, DOI: 10.1002/emmm.201202318

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    Alteration of the microRNA network during the progression of Alzheimer's disease

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1613–1634, Pierre Lau, Koen Bossers, Rekin's Janky, Evgenia Salta, Carlo Sala Frigerio, Shahar Barbash, Roy Rothman, Annerieke S. R. Sierksma, Amantha Thathiah, David Greenberg, Aikaterini S. Papadopoulou, Tilmann Achsel, Torik Ayoubi, Hermona Soreq, Joost Verhaagen, Dick F. Swaab, Stein Aerts and Bart De Strooper

    Version of Record online : 9 SEP 2013, DOI: 10.1002/emmm.201201974