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There are 8608 results for: content related to: Activation of IL -27 signalling promotes development of postinfluenza pneumococcal pneumonia

  1. You have full text access to this OnlineOpen article
    The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene

    EMBO Molecular Medicine

    Marta Luna-Sánchez, Elena Díaz-Casado, Emanuele Barca, Miguel Ángel Tejada, Ángeles Montilla-García, Enrique Javier Cobos, Germaine Escames, Dario Acuña-Castroviejo, Catarina M Quinzii and Luis Carlos López

    Article first published online : 23 MAR 2015, DOI: 10.15252/emmm.201404632

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    Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

    EMBO Molecular Medicine

    Volume 7, Issue 4, April 2015, Pages: 394–410, Harsha D Devalla, Verena Schwach, John W Ford, James T Milnes, Said El-Haou, Claire Jackson, Konstantinos Gkatzis, David A Elliott, Susana M Chuva de Sousa Lopes, Christine L Mummery, Arie O Verkerk and Robert Passier

    Article first published online : 19 FEB 2015, DOI: 10.15252/emmm.201404757

  3. You have full text access to this OnlineOpen article
    Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1502–1522, Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El-Ashry and Joyce M. Slingerland

    Article first published online : 27 AUG 2013, DOI: 10.1002/emmm.201302558

  4. You have full text access to this OnlineOpen article
    Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis

    EMBO Molecular Medicine

    Volume 7, Issue 2, February 2015, Pages: 140–157, Cao Dan, Bian Jinjun, Hua Zi-Chun, Ma Lin, Chen Wei, Zhang Xu, Zhou Ri, Cheng Shun, Sun Wen-Zhu, Jiao Qing-Cai and Yin Wu

    Article first published online : 22 DEC 2014, DOI: 10.15252/emmm.201404797

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    A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency

    EMBO Molecular Medicine

    Volume 7, Issue 4, April 2015, Pages: 438–449, Chuan Liu, Hongyu Ding, Xiaoxi Li, Christian P Pallasch, Liya Hong, Dianwu Guo, Yi Chen, Difei Wang, Wei Wang, Yajie Wang, Michael T Hemann and Hai Jiang

    Article first published online : 10 MAR 2015, DOI: 10.15252/emmm.201404580

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    Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension

    EMBO Molecular Medicine

    Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin and Stephen Y Chan

    Article first published online : 30 MAR 2015, DOI: 10.15252/emmm.201404511

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    Towards a new combination therapy for tuberculosis with next generation benzothiazinones

    EMBO Molecular Medicine

    Volume 6, Issue 3, March 2014, Pages: 372–383, Vadim Makarov, Benoit Lechartier, Ming Zhang, João Neres, Astrid M van der Sar, Susanne A Raadsen, Ruben C Hartkoorn, Olga B Ryabova, Anthony Vocat, Laurent A Decosterd, Nicolas Widmer, Thierry Buclin, Wilbert Bitter, Koen Andries, Florence Pojer, Paul J Dyson and Stewart T Cole

    Article first published online : 5 FEB 2014, DOI: 10.1002/emmm.201303575

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    Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine

    EMBO Molecular Medicine

    Joan Castellsagué, Bernat Gel, Juana Fernández-Rodríguez, Roger Llatjós, Ignacio Blanco, Yolanda Benavente, Diana Pérez-Sidelnikova, Javier García-del Muro, Joan Maria Viñals, August Vidal, Rafael Valdés-Mas, Ernest Terribas, Adriana López-Doriga, Miguel Angel Pujana, Gabriel Capellá, Xose S Puente, Eduard Serra, Alberto Villanueva and Conxi Lázaro

    Article first published online : 25 MAR 2015, DOI: 10.15252/emmm.201404430

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    ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

    EMBO Molecular Medicine

    Volume 6, Issue 2, February 2014, Pages: 278–294, Mathilde Romagnoli, Nora D Mineva, Michael Polmear, Catharina Conrad, Srimathi Srinivasan, Delphine Loussouarn, Sophie Barillé-Nion, Irene Georgakoudi, Áine Dagg, Enda W McDermott, Michael J Duffy, Patricia M. McGowan, Uwe Schlomann, Maddy Parsons, Jörg W Bartsch and Gail E Sonenshein

    Article first published online : 27 DEC 2013, DOI: 10.1002/emmm.201303373

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    Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

    EMBO Molecular Medicine

    Volume 7, Issue 3, March 2015, Pages: 339–356, Agnes Lau, Alex McDonald, Nathalie Daude, Charles E Mays, Eric D Walter, Robin Aglietti, Robert CC Mercer, Serene Wohlgemuth, Jacques van der Merwe, Jing Yang, Hristina Gapeshina, Chae Kim, Jennifer Grams, Beipei Shi, Holger Wille, Aru Balachandran, Gerold Schmitt-Ulms, Jiri G Safar, Glenn L Millhauser and David Westaway

    Article first published online : 6 FEB 2015, DOI: 10.15252/emmm.201404588

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    Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

    EMBO Molecular Medicine

    Volume 6, Issue 4, April 2014, Pages: 442–457, Matthias Schäfer, Ann-Helen Willrodt, Svitlana Kurinna, Andrea S Link, Hany Farwanah, Alexandra Geusau, Florian Gruber, Olivier Sorg, Aaron J Huebner, Dennis R Roop, Konrad Sandhoff, Jean-Hilaire Saurat, Erwin Tschachler, Marlon R Schneider, Lutz Langbein, Wilhelm Bloch, Hans-Dietmar Beer and Sabine Werner

    Article first published online : 6 FEB 2014, DOI: 10.1002/emmm.201303281

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    A single epidermal stem cell strategy for safe ex vivo gene therapy

    EMBO Molecular Medicine

    Volume 7, Issue 4, April 2015, Pages: 380–393, Stéphanie Droz-Georget Lathion, Ariane Rochat, Graham Knott, Alessandra Recchia, Danielle Martinet, Sara Benmohammed, Nicolas Grasset, Andrea Zaffalon, Nathalie Besuchet Schmutz, Emmanuelle Savioz-Dayer, Jacques Samuel Beckmann, Jacques Rougemont, Fulvio Mavilio and Yann Barrandon

    Article first published online : 27 FEB 2015, DOI: 10.15252/emmm.201404353

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    Murine Langerin+ dermal dendritic cells prime CD8+T cells while Langerhans cells induce cross-tolerance

    EMBO Molecular Medicine

    Volume 6, Issue 9, September 2014, Pages: 1191–1204, Vincent Flacher, Christoph H Tripp, David G Mairhofer, Ralph M Steinman, Patrizia Stoitzner, Juliana Idoyaga and Nikolaus Romani

    Article first published online : 1 AUG 2014, DOI: 10.15252/emmm.201303283

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    Corrigendum: Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance

    Vol. 6, Issue 12, 1638, Article first published online: 3 DEC 2014

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    An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

    EMBO Molecular Medicine

    Volume 7, Issue 2, February 2015, Pages: 175–189, Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo and Naoyuki Taniguchi

    Article first published online : 15 JAN 2015, DOI: 10.15252/emmm.201404438

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    Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

    EMBO Molecular Medicine

    Camille Duluc, Siham Moatassim-Billah, Mounira Chalabi-Dchar, Aurélie Perraud, Rémi Samain, Florence Breibach, Marion Gayral, Pierre Cordelier, Marie-Bernadette Delisle, Marie-Pierre Bousquet-Dubouch, Richard Tomasini, Herbert Schmid, Muriel Mathonnet, Stéphane Pyronnet, Yvan Martineau and Corinne Bousquet

    Article first published online : 1 APR 2015, DOI: 10.15252/emmm.201404346

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    Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

    EMBO Molecular Medicine

    Volume 6, Issue 3, March 2014, Pages: 335–346, Toru Hosoi, Rie Yamaguchi, Kikuko Noji, Suguru Matsuo, Sachiko Baba, Keisuke Toyoda, Takahiro Suezawa, Takaaki Kayano, Shinpei Tanaka and Koichiro Ozawa

    Article first published online : 14 JAN 2014, DOI: 10.1002/emmm.201303227

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    Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

    EMBO Molecular Medicine

    Guus M Bol, Farhad Vesuna, Min Xie, Jing Zeng, Khaled Aziz, Nishant Gandhi, Anne Levine, Ashley Irving, Dorian Korz, Saritha Tantravedi, Marise R Heerma van Voss, Kathleen Gabrielson, Evan A Bordt, Brian M Polster, Leslie Cope, Petra van der Groep, Atul Kondaskar, Michelle A Rudek, Ramachandra S Hosmane, Elsken van der Wall, Paul J van Diest, Phuoc T Tran and Venu Raman

    Article first published online : 27 MAR 2015, DOI: 10.15252/emmm.201404368

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    Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1278–1295, Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker-Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand and Mads Gyrd-Hansen

    Article first published online : 1 JUL 2013, DOI: 10.1002/emmm.201303090

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    Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1128–1145, Christina Gedicke-Hornung, Verena Behrens-Gawlik, Silke Reischmann, Birgit Geertz, Doreen Stimpel, Florian Weinberger, Saskia Schlossarek, Guillaume Précigout, Ingke Braren, Thomas Eschenhagen, Giulia Mearini, Stéphanie Lorain, Thomas Voit, Patrick A. Dreyfus, Luis Garcia and Lucie Carrier

    Article first published online : 29 MAY 2013, DOI: 10.1002/emmm.201202168

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    The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

    EMBO Molecular Medicine

    Volume 6, Issue 9, September 2014, Pages: 1161–1174, Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi-Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England and Andrew M Blanks

    Article first published online : 23 JUL 2014, DOI: 10.15252/emmm.201403944