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There are 5930 results for: content related to: TNF α cleavage beyond TACE / ADAM 17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis

  1. You have full text access to this OnlineOpen article
    p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118 acetylation

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1662–1683, Rajan Gogna, Esha Madan, Mahmood Khan, Uttam Pati and Periannan Kuppusamy

    Article first published online : 1 OCT 2013, DOI: 10.1002/emmm.201202055

  2. You have full text access to this OnlineOpen article
    Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1918–1934, Yasir A. Syed, Alexandra Baer, Matthias P. Hofer, Ginez A. González, Jon Rundle, Szymon Myrta, Jeffrey K. Huang, Chao Zhao, Moritz J. Rossner, Matthew W. B. Trotter, Gert Lubec, Robin J. M. Franklin and Mark R. Kotter

    Article first published online : 21 OCT 2013, DOI: 10.1002/emmm.201303123

  3. You have full text access to this OnlineOpen article
    Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1502–1522, Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El-Ashry and Joyce M. Slingerland

    Article first published online : 27 AUG 2013, DOI: 10.1002/emmm.201302558

  4. You have full text access to this OnlineOpen article
    Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1000–1016, Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin and Claude Libert

    Article first published online : 30 MAY 2013, DOI: 10.1002/emmm.201202100

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    Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1871–1886, Katrin Kollmann, Jan Malte Pestka, Sonja Christin Kühn, Elisabeth Schöne, Michaela Schweizer, Kathrin Karkmann, Takanobu Otomo, Philip Catala-Lehnen, Antonio Virgilio Failla, Robert Percy Marshall, Matthias Krause, Rene Santer, Michael Amling, Thomas Braulke and Thorsten Schinke

    Article first published online : 15 OCT 2013, DOI: 10.1002/emmm.201302979

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    Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1720–1739, Jeong-Hwan Yoon, Su Myung Jung, Seok Hee Park, Mitsuyasu Kato, Tadashi Yamashita, In-Kyu Lee, Katsuko Sudo, Susumu Nakae, Jin Soo Han, Ok-Hee Kim, Byung-Chul Oh, Takayuki Sumida, Masahiko Kuroda, Ji-Hyeon Ju, Kyeong Cheon Jung, Seong Hoe Park, Dae-Kee Kim and Mizuko Mamura

    Article first published online : 11 OCT 2013, DOI: 10.1002/emmm.201302524

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    Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1484–1501, Norbert Odolczyk, Janine Fritsch, Caroline Norez, Nathalie Servel, Melanie Faria da Cunha, Sara Bitam, Anna Kupniewska, Ludovic Wiszniewski, Julien Colas, Krzysztof Tarnowski, Danielle Tondelier, Ariel Roldan, Emilie L. Saussereau, Patricia Melin-Heschel, Grzegorz Wieczorek, Gergely L. Lukacs, Michal Dadlez, Grazyna Faure, Harald Herrmann, Mario Ollero, Frédéric Becq, Piotr Zielenkiewicz and Aleksander Edelman

    Article first published online : 27 AUG 2013, DOI: 10.1002/emmm.201302699

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    Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1227–1246, Shin-Da Lee, Ted Weita Lai, Shinn-Zong Lin, Chen-Huan Lin, Yung-Hsiang Hsu, Chi-Yuan Li, Hsiao-Jung Wang, Wei Lee, Ching-Yuan Su, Yung-Luen Yu and Woei-Cherng Shyu

    Article first published online : 8 JUL 2013, DOI: 10.1002/emmm.201202258

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    VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy

    EMBO Molecular Medicine

    Volume 5, Issue 9, September 2013, Pages: 1415–1430, Minah Kim, Hyeung Ju Park, Jae Won Seol, Jeon Yeob Jang, Young-Suk Cho, Kyu Rae Kim, Youngsok Choi, John P. Lydon, Francesco J. DeMayo, Masabumi Shibuya, Napoleone Ferrara, Hoon-Ki Sung, Andras Nagy, Kari Alitalo and Gou Young Koh

    Article first published online : 2 AUG 2013, DOI: 10.1002/emmm.201302618

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    Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1128–1145, Christina Gedicke-Hornung, Verena Behrens-Gawlik, Silke Reischmann, Birgit Geertz, Doreen Stimpel, Florian Weinberger, Saskia Schlossarek, Guillaume Précigout, Ingke Braren, Thomas Eschenhagen, Giulia Mearini, Stéphanie Lorain, Thomas Voit, Patrick A. Dreyfus, Luis Garcia and Lucie Carrier

    Article first published online : 29 MAY 2013, DOI: 10.1002/emmm.201202168

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    A major role for RCAN1 in atherosclerosis progression

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1901–1917, Nerea Méndez-Barbero, Vanesa Esteban, Silvia Villahoz, Amelia Escolano, Katia Urso, Arantzazu Alfranca, Cristina Rodríguez, Susana A. Sánchez, Tsuyoshi Osawa, Vicente Andrés, José Martínez-González, Takashi Minami, Juan Miguel Redondo and Miguel R. Campanero

    Article first published online : 15 OCT 2013, DOI: 10.1002/emmm.201302842

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    Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation

    EMBO Molecular Medicine

    Volume 5, Issue 9, September 2013, Pages: 1383–1401, Kouji Izumi, Lei-Ya Fang, Atsushi Mizokami, Mikio Namiki, Lei Li, Wen-Jye Lin and Chawnshang Chang

    Article first published online : 27 AUG 2013, DOI: 10.1002/emmm.201202367

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    CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1775–1793, Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean-Louis Bourges, Francine Behar-Cohen, José-Alain Sahel, Xavier Guillonneau, William Raoul and Christophe Combadiere

    Article first published online : 21 OCT 2013, DOI: 10.1002/emmm.201302692

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    Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1852–1870, Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Manuela Gellert, Christopher H. Lillig, Haike Antelmann, Juan A. Hermoso and Sven Hammerschmidt

    Article first published online : 18 OCT 2013, DOI: 10.1002/emmm.201202435

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    VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1569–1585, Christopher R. Heier, Jesse M. Damsker, Qing Yu, Blythe C. Dillingham, Tony Huynh, Jack H. Van der Meulen, Arpana Sali, Brittany K. Miller, Aditi Phadke, Luana Scheffer, James Quinn, Kathleen Tatem, Sarah Jordan, Sherry Dadgar, Olga C. Rodriguez, Chris Albanese, Michael Calhoun, Heather Gordish-Dressman, Jyoti K. Jaiswal, Edward M. Connor, John M. McCall, Eric P. Hoffman, Erica K. M. Reeves and Kanneboyina Nagaraju

    Article first published online : 9 SEP 2013, DOI: 10.1002/emmm.201302621

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    Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1537–1555, Junwei Li, Serena Bonifati, Georgi Hristov, Tiina Marttila, Séverine Valmary-Degano, Sven Stanzel, Martina Schnölzer, Christiane Mougin, Marc Aprahamian, Svitlana P. Grekova, Zahari Raykov, Jean Rommelaere and Antonio Marchini

    Article first published online : 17 SEP 2013, DOI: 10.1002/emmm.201302796

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    Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1103–1118, Jonathan J. Cherry, Erkan Y. Osman, Matthew C. Evans, Sungwoon Choi, Xuechao Xing, Gregory D. Cuny, Marcie A. Glicksman, Christian L. Lorson and Elliot J. Androphy

    Article first published online : 5 JUN 2013, DOI: 10.1002/emmm.201202305

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    Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1278–1295, Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker-Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand and Mads Gyrd-Hansen

    Article first published online : 1 JUL 2013, DOI: 10.1002/emmm.201303090

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    Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 984–999, Shanshan W. Howland, Chek Meng Poh, Sin Yee Gun, Carla Claser, Benoit Malleret, Nilabh Shastri, Florent Ginhoux, Gijsbert M. Grotenbreg and Laurent Rénia

    Article first published online : 16 MAY 2013, DOI: 10.1002/emmm.201202273

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    Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1759–1774, Lorena Pereira, Ana Igea, Begoña Canovas, Ignacio Dolado and Angel R. Nebreda

    Article first published online : 24 SEP 2013, DOI: 10.1002/emmm.201302732