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There are 1038380 results for: content related to: New targets for old diseases: lessons from mucolipidosis type II

  1. You have full text access to this OnlineOpen article
    Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1871–1886, Katrin Kollmann, Jan Malte Pestka, Sonja Christin Kühn, Elisabeth Schöne, Michaela Schweizer, Kathrin Karkmann, Takanobu Otomo, Philip Catala-Lehnen, Antonio Virgilio Failla, Robert Percy Marshall, Matthias Krause, Rene Santer, Michael Amling, Thomas Braulke and Thorsten Schinke

    Article first published online : 15 OCT 2013, DOI: 10.1002/emmm.201302979

  2. Molecular analysis of cell lines from patients with mucolipidosis II and mucolipidosis III

    American Journal of Medical Genetics Part A

    Volume 149A, Issue 12, December 2009, Pages: 2753–2761, Maryam Zarghooni and Sarma S.R. Dittakavi

    Article first published online : 24 NOV 2009, DOI: 10.1002/ajmg.a.33134

  3. Mucolipidosis II-Related Mutations Inhibit the Exit from the Endoplasmic Reticulum and Proteolytic Cleavage of GlcNAc-1-Phosphotransferase Precursor Protein (GNPTAB)

    Human Mutation

    Volume 35, Issue 3, March 2014, Pages: 368–376, Raffaella De Pace, Maria Francisca Coutinho, Friedrich Koch-Nolte, Friedrich Haag, Maria João Prata, Sandra Alves, Thomas Braulke and Sandra Pohl

    Article first published online : 15 JAN 2014, DOI: 10.1002/humu.22502

  4. You have full text access to this OnlineOpen article
    Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1502–1522, Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El-Ashry and Joyce M. Slingerland

    Article first published online : 27 AUG 2013, DOI: 10.1002/emmm.201302558

  5. You have full text access to this OnlineOpen article
    Antimicrobial peptides and gut microbiota in homeostasis and pathology

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1465–1483, Maureen J. Ostaff, Eduard Friedrich Stange and Jan Wehkamp

    Article first published online : 23 AUG 2013, DOI: 10.1002/emmm.201201773

  6. You have full text access to this OnlineOpen article
    CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1775–1793, Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean-Louis Bourges, Francine Behar-Cohen, José-Alain Sahel, Xavier Guillonneau, William Raoul and Christophe Combadiere

    Article first published online : 21 OCT 2013, DOI: 10.1002/emmm.201302692

  7. You have full text access to this OnlineOpen article
    Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1720–1739, Jeong-Hwan Yoon, Su Myung Jung, Seok Hee Park, Mitsuyasu Kato, Tadashi Yamashita, In-Kyu Lee, Katsuko Sudo, Susumu Nakae, Jin Soo Han, Ok-Hee Kim, Byung-Chul Oh, Takayuki Sumida, Masahiko Kuroda, Ji-Hyeon Ju, Kyeong Cheon Jung, Seong Hoe Park, Dae-Kee Kim and Mizuko Mamura

    Article first published online : 11 OCT 2013, DOI: 10.1002/emmm.201302524

  8. You have full text access to this OnlineOpen article
    Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1852–1870, Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Manuela Gellert, Christopher H. Lillig, Haike Antelmann, Juan A. Hermoso and Sven Hammerschmidt

    Article first published online : 18 OCT 2013, DOI: 10.1002/emmm.201202435

  9. You have free access to this content
    Mucolipin-1 Is a Lysosomal Membrane Protein Required for Intracellular Lactosylceramide Traffic

    Traffic

    Volume 7, Issue 10, October 2006, Pages: 1388–1398, Paul R. Pryor, Frank Reimann, Fiona M. Gribble and J. Paul Luzio

    Article first published online : 13 SEP 2006, DOI: 10.1111/j.1600-0854.2006.00475.x

  10. You have full text access to this OnlineOpen article
    Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1918–1934, Yasir A. Syed, Alexandra Baer, Matthias P. Hofer, Ginez A. González, Jon Rundle, Szymon Myrta, Jeffrey K. Huang, Chao Zhao, Moritz J. Rossner, Matthew W. B. Trotter, Gert Lubec, Robin J. M. Franklin and Mark R. Kotter

    Article first published online : 21 OCT 2013, DOI: 10.1002/emmm.201303123

  11. You have full text access to this OnlineOpen article
    A major role for RCAN1 in atherosclerosis progression

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1901–1917, Nerea Méndez-Barbero, Vanesa Esteban, Silvia Villahoz, Amelia Escolano, Katia Urso, Arantzazu Alfranca, Cristina Rodríguez, Susana A. Sánchez, Tsuyoshi Osawa, Vicente Andrés, José Martínez-González, Takashi Minami, Juan Miguel Redondo and Miguel R. Campanero

    Article first published online : 15 OCT 2013, DOI: 10.1002/emmm.201302842

  12. Combined Tarsal and Carpal Tunnel Syndrome in Mucolipidosis Type III

    Annals of the New York Academy of Sciences

    Volume 1151, Issue 1, January 2009, Pages: 77–84, Izelle Smuts, Denise Potgieter and Francois Hendrikus Van Der Westhuizen

    Article first published online : 23 DEC 2008, DOI: 10.1111/j.1749-6632.2008.03451.x

  13. You have full text access to this OnlineOpen article
    Pathological impact of SMN2 mis-splicing in adult SMA mice

    EMBO Molecular Medicine

    Volume 5, Issue 10, October 2013, Pages: 1586–1601, Kentaro Sahashi, Karen K. Y. Ling, Yimin Hua, John Erby Wilkinson, Tomoki Nomakuchi, Frank Rigo, Gene Hung, David Xu, Ya-Ping Jiang, Richard Z. Lin, Chien-Ping Ko, C. Frank Bennett and Adrian R. Krainer

    Article first published online : 9 SEP 2013, DOI: 10.1002/emmm.201302567

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    Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1000–1016, Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin and Claude Libert

    Article first published online : 30 MAY 2013, DOI: 10.1002/emmm.201202100

  15. You have full text access to this OnlineOpen article
    Gene therapy on the move

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1642–1661, Kerstin B. Kaufmann, Hildegard Büning, Anne Galy, Axel Schambach and Manuel Grez

    Article first published online : 17 SEP 2013, DOI: 10.1002/emmm.201202287

  16. You have full text access to this OnlineOpen article
    Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

    EMBO Molecular Medicine

    Volume 5, Issue 7, July 2013, Pages: 1103–1118, Jonathan J. Cherry, Erkan Y. Osman, Matthew C. Evans, Sungwoon Choi, Xuechao Xing, Gregory D. Cuny, Marcie A. Glicksman, Christian L. Lorson and Elliot J. Androphy

    Article first published online : 5 JUN 2013, DOI: 10.1002/emmm.201202305

  17. You have full text access to this OnlineOpen article
    Compound loss of muscleblind-like function in myotonic dystrophy

    EMBO Molecular Medicine

    Volume 5, Issue 12, December 2013, Pages: 1887–1900, Kuang-Yung Lee, Moyi Li, Mini Manchanda, Ranjan Batra, Konstantinos Charizanis, Apoorva Mohan, Sonisha A. Warren, Christopher M. Chamberlain, Dustin Finn, Hannah Hong, Hassan Ashraf, Hideko Kasahara, Laura P. W. Ranum and Maurice S. Swanson

    Article first published online : 8 OCT 2013, DOI: 10.1002/emmm.201303275

  18. You have full text access to this OnlineOpen article
    p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118 acetylation

    EMBO Molecular Medicine

    Volume 5, Issue 11, November 2013, Pages: 1662–1683, Rajan Gogna, Esha Madan, Mahmood Khan, Uttam Pati and Periannan Kuppusamy

    Article first published online : 1 OCT 2013, DOI: 10.1002/emmm.201202055

  19. You have full text access to this OnlineOpen article
    Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human

    EMBO Molecular Medicine

    Volume 5, Issue 8, August 2013, Pages: 1165–1179, Yi-Cheng Chang, Yu-Hsiang Yu, Jin-Yuh Shew, Wei-Jei Lee, Juey-Jen Hwang, Yen-Hui Chen, Yet-Ran Chen, Pei-Chi Wei, Lee-Ming Chuang and Wen-Hwa Lee

    Article first published online : 4 JUL 2013, DOI: 10.1002/emmm.201302679

  20. You have full text access to this OnlineOpen article
    A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth

    EMBO Molecular Medicine

    Volume 5, Issue 9, September 2013, Pages: 1322–1334, Yuqing Zhang, Jingxuan Yang, Xiaobo Cui, Yong Chen, Vivian F. Zhu, John P. Hagan, Huamin Wang, Xianjun Yu, Sally E. Hodges, Jing Fang, Paul J. Chiao, Craig D. Logsdon, William E. Fisher, F. Charles Brunicardi, Changyi Chen, Qizhi Yao, Martin E. Fernandez-Zapico and Min Li

    Article first published online : 16 JUL 2013, DOI: 10.1002/emmm.201302507