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There are 1633 results for: content related to: Large genomic rearrangements and germline epimutations in Lynch syndrome

  1. Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility

    Human Mutation

    Volume 33, Issue 1, January 2012, Pages: 180–188, Michel Crépin, Marie-Claire Dieu, Sophie Lejeune, Fabienne Escande, Denis Boidin, Nicole Porchet, Gilles Morin, Sylvie Manouvrier, Michèle Mathieu and Marie-Pierre Buisine

    Article first published online : 31 OCT 2011, DOI: 10.1002/humu.21617

  2. Epimutations and Cancer Susceptibility

    Standard Article


    Mathew Aidan Sloane, Luke Benjamin Hesson and Robyn Lynne Ward

    Published Online : 17 MAR 2014, DOI: 10.1002/9780470015902.a0024615

  3. Germline Epimutation: A Basis for Epigenetic Disease in Humans

    Annals of the New York Academy of Sciences

    Volume 1054, Issue 1, November 2005, Pages: 68–77, DAVID I.K. MARTIN, ROBYN WARD and CATHERINE M. SUTER

    Article first published online : 6 JAN 2006, DOI: 10.1196/annals.1345.009

  4. Epigenetic mechanisms in the pathogenesis of Lynch syndrome

    Clinical Genetics

    Volume 85, Issue 5, May 2014, Pages: 403–412, P. Peltomäki

    Article first published online : 17 FEB 2014, DOI: 10.1111/cge.12349

  5. Identification of new cases of early-onset colorectal cancer with an MLH1 epimutation in an ethnically diverse South African cohort

    Clinical Genetics

    Volume 80, Issue 5, November 2011, Pages: 428–434, MP Hitchins, SE Owens, C-T Kwok, G Godsmark, UF Algar and RS Ramesar

    Article first published online : 4 MAY 2011, DOI: 10.1111/j.1399-0004.2011.01660.x

  6. You have free access to this content
    De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one

    International Journal of Cancer

    Volume 128, Issue 4, 15 February 2011, Pages: 869–878, Ajay Goel, Thuy-Phuong Nguyen, Hon-Chiu E. Leung, Takeshi Nagasaka, Jennifer Rhees, Erin Hotchkiss, Mildred Arnold, Pia Banerji, Minoru Koi, Chau-To Kwok, Deborah Packham, Lara Lipton, C. Richard Boland, Robyn L. Ward and Megan P. Hitchins

    Article first published online : 27 APR 2010, DOI: 10.1002/ijc.25422

  7. MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer

    Clinical Genetics

    Volume 71, Issue 3, March 2007, Pages: 232–237, L Valle, P Carbonell, V Fernandez, AM Dotor, M Sanz, J Benitez and M Urioste

    Article first published online : 12 JAN 2007, DOI: 10.1111/j.1399-0004.2007.00751.x



    Volume 68, Issue 3, March 2014, Pages: 673–683, Robert E. Furrow and Marcus W. Feldman

    Article first published online : 29 AUG 2013, DOI: 10.1111/evo.12225

  9. Dawning of the epigenetic era in hereditary cancer

    Clinical Genetics

    Volume 85, Issue 5, May 2014, Pages: 413–416, M.P. Hitchins and H.T. Lynch

    Article first published online : 1 APR 2014, DOI: 10.1111/cge.12369

  10. Screening of DNA methylation at the H19 promoter or the distal region of its ICR1 ensures efficient detection of chromosome 11p15 epimutations in Russell–Silver syndrome

    American Journal of Medical Genetics Part A

    Volume 149A, Issue 11, November 2009, Pages: 2415–2423, Shin-Ichi Horike, Jose Carlos P. Ferreira, Makiko Meguro-Horike, Sanaa Choufani, Adam C. Smith, Cheryl Shuman, Wendy Meschino, David Chitayat, Elaine Zackai, Stephen W. Scherer and Rosanna Weksberg

    Article first published online : 28 OCT 2009, DOI: 10.1002/ajmg.a.33065

  11. Prenatal findings and epimutations for paternal uniparental disomy for chromosome 14 syndrome

    Journal of Obstetrics and Gynaecology Research

    Volume 41, Issue 7, July 2015, Pages: 1133–1136, Takafumi Watanabe, Hayato Go, Masayo Kagami, Shun Yasuda, Yasuhisa Nomura and Keiya Fujimori

    Article first published online : 6 FEB 2015, DOI: 10.1111/jog.12665

  12. Epimutation at human chromosome 14q32.2 in a boy with a upd(14)mat-like clinical phenotype

    Clinical Genetics

    Volume 75, Issue 3, March 2009, Pages: 251–258, U Zechner, N Kohlschmidt, G Rittner, N Damatova, V Beyer, T Haaf and O Bartsch

    Article first published online : 31 DEC 2008, DOI: 10.1111/j.1399-0004.2008.01116.x

  13. You have free access to this content
    Carcinogenic mechanisms of endometrial cancer: Involvement of genetics and epigenetics

    Journal of Obstetrics and Gynaecology Research

    Volume 40, Issue 8, August 2014, Pages: 1957–1967, Kouji Banno, Megumi Yanokura, Miho Iida, Kenta Masuda and Daisuke Aoki

    Article first published online : 11 AUG 2014, DOI: 10.1111/jog.12442



    Volume 68, Issue 3, March 2014, Pages: 644–655, Koen J.F. Verhoeven and Veronica Preite

    Article first published online : 13 DEC 2013, DOI: 10.1111/evo.12320

  15. Increased incidence of aberrant DNA methylation within diverse imprinted gene loci outside of IGF2/H19 in Silver–Russell syndrome

    Clinical Genetics

    Volume 81, Issue 4, April 2012, Pages: 366–377, K Kannenberg, C Urban and G Binder

    Article first published online : 8 FEB 2012, DOI: 10.1111/j.1399-0004.2012.01844.x

  16. You have full text access to this Open Access content
    A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory

    Journal of Cellular and Molecular Medicine

    Volume 14, Issue 1-2, January-February 2010, Pages: 181–197, Margot G.F. Van Lier, Anja Wagner, Monique E. Van Leerdam, Katharina Biermann, Ernst J. Kuipers, Ewout W. Steyerberg, Hendrikus Jan Dubbink and Winand N.M. Dinjens

    Article first published online : 19 NOV 2009, DOI: 10.1111/j.1582-4934.2009.00977.x

  17. Genome-Wide Allelic Methylation Analysis Reveals Disease-Specific Susceptibility to Multiple Methylation Defects in Imprinting Syndromes

    Human Mutation

    Volume 34, Issue 4, April 2013, Pages: 595–602, Franck Court, Alex Martin-Trujillo, Valeria Romanelli, Intza Garin, Isabel Iglesias-Platas, Ira Salafsky, Miriam Guitart, Guiomar Perez de Nanclares, Pablo Lapunzina and David Monk

    Article first published online : 19 FEB 2013, DOI: 10.1002/humu.22276

  18. You have free access to this content
    Do age-associated DNA methylation changes increase the risk of malignant transformation?


    Volume 37, Issue 1, January 2015, Pages: 20–24, Wolfgang Wagner, Carola I. Weidner and Qiong Lin

    Article first published online : 9 OCT 2014, DOI: 10.1002/bies.201400063

  19. Silver-Russell patients showing a broad range of ICR1 and ICR2 hypomethylation in different tissues

    Clinical Genetics

    Volume 80, Issue 1, July 2011, Pages: 83–88, M Begemann, S Spengler, D Kanber, A Haake, M Baudis, I Leisten, G Binder, S Markus, T Rupprecht, H Segerer, S Fricke-Otto, R Mühlenberg, R Siebert, K Buiting and T Eggermann

    Article first published online : 22 JUL 2010, DOI: 10.1111/j.1399-0004.2010.01514.x

  20. Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles

    Genes, Chromosomes and Cancer

    Volume 50, Issue 3, March 2011, Pages: 178–185, Jessie Auclair, Thomas Vaissière, Françoise Desseigne, Christine Lasset, Valérie Bonadona, Sophie Giraud, Jean-Christophe Saurin, Marie-Odile Joly, Dominique Leroux, Laurence Faivre, Carole Audoynaud, Gilles Montmain, Eric Ruano, Zdenko Herceg, Alain Puisieux and Qing Wang

    Article first published online : 9 DEC 2010, DOI: 10.1002/gcc.20842