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There are 12489 results for: content related to: Blockade of HERG K + channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656

  1. You have free access to this content
    SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

    The Journal of Physiology

    Volume 588, Issue 17, September 2010, Pages: 3157–3167, Matthew Perry, Michael Sanguinetti and John Mitcheson

    Article first published online : 31 AUG 2010, DOI: 10.1113/jphysiol.2010.194670

  2. Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

    Journal of Applied Toxicology

    Volume 29, Issue 3, April 2009, Pages: 183–206, Sebastian Polak, Barbara Wiśniowska and Jerzy Brandys

    Article first published online : 5 NOV 2008, DOI: 10.1002/jat.1395

  3. The EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells

    Cell Biology International

    Volume 35, Issue 3, March 2011, Pages: 193–199, Na Huang, Jiang-Fang Lian, Jian-Hua Huo, Li-Ying Liu, Lei Ni, Xi Yang, Jian-Qing Zhou, Zong-Fang Li, Tu-Sheng Song and Chen Huang

    Article first published online : 2 JAN 2013, DOI: 10.1042/CBI20100022

  4. hERG Channel Physiology and Drug-Binding Structure–Activity Relationships

    Antitargets: Prediction and Prevention of Drug Side Effects

    Sarah Dalibalta, John S. Mitcheson, Pages: 89–108, 2008

    Published Online : 26 MAY 2008, DOI: 10.1002/9783527621460.ch4

  5. A Novel Missense Mutation Causing a G487R Substitution in the S2–S3 Loop of Human ether-à-go-go-Related Gene Channel

    Journal of Cardiovascular Electrophysiology

    Volume 23, Issue 11, November 2012, Pages: 1246–1253, KOSHI KINOSHITA, YOSHIAKI YAMAGUCHI, KOHKI NISHIDE, KATSUYA KIMOTO, YUKI NONOBE, AKIRA FUJITA, KENTA ASANO, TOSHIHIDE TABATA, HISASHI MORI, HIROSHI INOUE, YUKIKO HATA, KENKICHI FUKUROTANI and NAOKI NISHIDA

    Article first published online : 5 JUL 2012, DOI: 10.1111/j.1540-8167.2012.02383.x

  6. Partially Dominant Mutant Channel Defect Corresponding with Intermediate LQT2 Phenotype

    Pacing and Clinical Electrophysiology

    Volume 35, Issue 1, January 2012, Pages: 3–16, YAMINI KRISHNAN, RENJIAN ZHENG, CHRISTINE WALSH, YINGYING TANG and THOMAS V. McDONALD

    Article first published online : 25 SEP 2011, DOI: 10.1111/j.1540-8159.2011.03222.x

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    Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents

    British Journal of Pharmacology

    Volume 156, Issue 2, January 2009, Pages: 226–236, Daniel Scherer, David Hassel, Ramona Bloehs, Edgar Zitron, Katharina Von Löwenstern, Claudia Seyler, Dierk Thomas, Franziska Konrad, Heiner F. Bürgers, Gunnar Seemann, Wolfgang Rottbauer, Hugo A. Katus, Christoph A. Karle and Eberhard P. Scholz

    Article first published online : 19 JAN 2009, DOI: 10.1111/j.1476-5381.2008.00018.x

  8. Allosteric effects of erythromycin pretreatment on thioridazine block of hERG potassium channels

    British Journal of Pharmacology

    Volume 171, Issue 7, April 2014, Pages: 1668–1675, W J Crumb Jr

    Article first published online : 18 MAR 2014, DOI: 10.1111/bph.12575

  9. Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity

    Journal of Applied Toxicology

    Volume 27, Issue 1, January/February 2007, Pages: 78–85, Kiyokazu Yunomae, Satoko Ichisaki, Junko Matsuo, Shinichi Nagayama, Koichiro Fukuzaki, Ryoichi Nagata and Go Kito

    Article first published online : 5 DEC 2006, DOI: 10.1002/jat.1201

  10. Homology Models Applied to Toxicology

    Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals

    Stewart B. Kirton, Phillip J. Stansfeld, John S. Mitcheson, Michael J. Sutcliffe, Pages: 433–468, 2006

    Published Online : 7 DEC 2006, DOI: 10.1002/9780470145890.ch16

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    Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue

    British Journal of Pharmacology

    Volume 169, Issue 6, July 2013, Pages: 1322–1334, R Varkevisser, M J C Houtman, T Linder, K C G de Git, H D M Beekman, R R Tidwell, A P IJzerman, A Stary-Weinzinger, M A Vos and M A G van der Heyden

    Article first published online : 21 JUN 2013, DOI: 10.1111/bph.12208

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    High potency inhibition of hERG potassium channels by the sodium–calcium exchange inhibitor KB-R7943

    British Journal of Pharmacology

    Volume 165, Issue 7, April 2012, Pages: 2260–2273, Hongwei Cheng, Yihong Zhang, Chunyun Du, Christopher E Dempsey and Jules C Hancox

    Article first published online : 9 MAR 2012, DOI: 10.1111/j.1476-5381.2011.01688.x

  13. Getting to the heart of hERG K+ channel gating

    The Journal of Physiology

    Accepted manuscript online: 27 MAR 2015, Matthew D Perry, Chai-An Ng, Stefan A Mann, Arash Sadrieh, Mohammad Imtiaz, Adam P Hill and Jamie I Vandenberg

    DOI: 10.1113/JP270095

  14. QSAR and Pharmacophores for Drugs Involved in hERG Blockage

    Antitargets: Prediction and Prevention of Drug Side Effects

    Maurizio Recanatini, Andrea Cavalli, Pages: 109–126, 2008

    Published Online : 26 MAY 2008, DOI: 10.1002/9783527621460.ch5

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    hERG subunit composition determines differential drug sensitivity

    British Journal of Pharmacology

    Volume 164, Issue 2b, September 2011, Pages: 419–432, N Abi-Gerges, H Holkham, EMC Jones, CE Pollard, J-P Valentin and GA Robertson

    Article first published online : 28 AUG 2011, DOI: 10.1111/j.1476-5381.2011.01378.x

  16. QT prolongation through hERG K+ channel blockade: Current knowledge and strategies for the early prediction during drug development

    Medicinal Research Reviews

    Volume 25, Issue 2, March 2005, Pages: 133–166, Maurizio Recanatini, Elisabetta Poluzzi, Matteo Masetti, Andrea Cavalli and Fabrizio De Ponti

    Article first published online : 16 AUG 2004, DOI: 10.1002/med.20019

  17. Up-regulation of miR-21 and miR-23a Contributes to As2O3-induced hERG Channel Deficiency

    Basic & Clinical Pharmacology & Toxicology

    Xin Zhao, Yuan-Qi Shi, Cai-Chuan Yan, Pan-feng Feng, Xue Wang, Rui Zhang, Xiao Zhang and Bao-Xin Li

    Article first published online : 17 DEC 2014, DOI: 10.1111/bcpt.12348

  18. Prediction of hERG Potassium Channel Blocking Actions Using Combination of Classification and Regression Based Models: A Mixed Descriptors Approach

    Molecular Informatics

    Volume 31, Issue 11-12, December 2012, Pages: 879–894, Supratik Kar and Kunal Roy

    Article first published online : 30 NOV 2012, DOI: 10.1002/minf.201200039

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    Drug-induced hERG Block and Long QT Syndrome

    Cardiovascular Therapeutics

    Volume 29, Issue 4, August 2011, Pages: 251–259, Harry J. Witchel

    Article first published online : 9 APR 2010, DOI: 10.1111/j.1755-5922.2010.00154.x

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    Modulation of HERG current and herg gene expression during retinoic acid treatment of human neuroblastoma cells: Potentiating effects of BDNF

    Journal of Neurobiology

    Volume 40, Issue 2, August 1999, Pages: 214–225, Annarosa Arcangeli, Barbara Rosati, Olivia Crociani, Alessia Cherubini, Lucrezia Fontana, Beatrice Passani, Enzo Wanke and Massimo Olivotto

    Article first published online : 20 JUL 1999, DOI: 10.1002/(SICI)1097-4695(199908)40:2<214::AID-NEU7>3.0.CO;2-0