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There are 5470 results for: content related to: The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer

  1. You have free access to this content
    Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma

    International Journal of Cancer

    Volume 133, Issue 8, 15 October 2013, Pages: 1813–1824, Anja Müller, Chuanbing Zang, Cindrilla Chumduri, Bernd Dörken, Peter T. Daniel and Christian W. Scholz

    Version of Record online : 15 JUN 2013, DOI: 10.1002/ijc.28206

  2. The effect of the dual PI3K and mTOR inhibitor BEZ235 on tumour growth and osteolytic bone disease in multiple myeloma

    European Journal of Haematology

    Volume 94, Issue 4, April 2015, Pages: 343–354, Zhen Ying Gan, Stephen Fitter, Kate Vandyke, Luen B. To, Andrew C.W. Zannettino and Sally K. Martin

    Version of Record online : 17 SEP 2014, DOI: 10.1111/ejh.12436

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    The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk

    International Journal of Cancer

    Volume 132, Issue 11, 1 June 2013, Pages: 2682–2693, Christian Seitz, Manuela Hugle, Silvia Cristofanon, Aurélie Tchoghandjian and Simone Fulda

    Version of Record online : 4 DEC 2012, DOI: 10.1002/ijc.27935

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    Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer

    International Journal of Cancer

    Volume 133, Issue 4, 15 August 2013, Pages: 984–996, Areumnuri Kim, Jung-Eun Lee, Seung-Sook Lee, Cherin Kim, Sun-Joo Lee, Won-Suk Jang and Sunhoo Park

    Version of Record online : 8 MAR 2013, DOI: 10.1002/ijc.28073

  5. Combination of Phosphatidylinositol 3-Kinases Pathway Inhibitor and Photodynamic Therapy in Endothelial and Tumor Cells

    Photochemistry and Photobiology

    Volume 88, Issue 5, September/October 2012, Pages: 1265–1272, Babasola Fateye, Weihua Li, Chenguang Wang and Bin Chen

    Version of Record online : 21 MAY 2012, DOI: 10.1111/j.1751-1097.2012.01160.x

  6. You have free access to this content
    NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells

    Journal of Bone and Mineral Research

    Volume 25, Issue 10, October 2010, Pages: 2126–2137, Sally K Martin, Stephen Fitter, Li Fei Bong, Jennifer J Drew, Stan Gronthos, Peter R Shepherd and Andrew CW Zannettino

    Version of Record online : 30 APR 2010, DOI: 10.1002/jbmr.114

  7. Activated mTOR/P70S6K signaling pathway is involved in insulinoma tumorigenesis

    Journal of Surgical Oncology

    Volume 106, Issue 8, 15 December 2012, Pages: 972–980, Han-Xiang Zhan, Lin Cong, Yu-Pei Zhao, Tai-Ping Zhang, Ge Chen, Li Zhou and Jun-Chao Guo

    Version of Record online : 18 JUN 2012, DOI: 10.1002/jso.23176

  8. You have full text access to this OnlineOpen article
    Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma

    Pigment Cell & Melanoma Research

    Volume 29, Issue 6, November 2016, Pages: 643–655, Bih-Rong Wei, Helen T. Michael, Charles H.C. Halsey, Cody J. Peer, Amit Adhikari, Jennifer E. Dwyer, Shelley B. Hoover, Rajaa El Meskini, Serguei Kozlov, Zoe Weaver Ohler, William. D. Figg, Glenn Merlino and R. Mark Simpson

    Version of Record online : 22 SEP 2016, DOI: 10.1111/pcmr.12512

  9. Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma

    Liver International

    Volume 33, Issue 5, May 2013, Pages: 780–793, Martha M. Kirstein, Aristeidis E. Boukouris, Deepika Pothiraju, Laura E. Buitrago-Molina, Silke Marhenke, Jutta Schütt, Johanna Orlik, Florian Kühnel, Jan Hegermann, Michael P. Manns and Arndt Vogel

    Version of Record online : 15 MAR 2013, DOI: 10.1111/liv.12126

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    V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis


    Volume 55, Issue 5, May 2012, Pages: 1473–1484, Matthias Evert, Diego F. Calvisi, Katja Evert, Valentina De Murtas, Gioia Gasparetti, Sandra Mattu, Giulia Destefanis, Sara Ladu, Antje Zimmermann, Salvatore Delogu, Sara Thiel, Andrea Thiele, Silvia Ribback and Frank Dombrowski

    Version of Record online : 4 APR 2012, DOI: 10.1002/hep.25600

  11. Untangling knots between autophagic targets and candidate drugs, in cancer therapy

    Cell Proliferation

    Volume 48, Issue 2, April 2015, Pages: 119–139, Tao Xie, Si-Jia Li, Ming-Rui Guo, Yue Wu, Hang-Yu Wang, Ke Zhang, Xue Zhang, Liang Ouyang and Jie Liu

    Version of Record online : 4 FEB 2015, DOI: 10.1111/cpr.12167

  12. You have free access to this content
    The novel phosphoinositide 3-kinase–mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factor

    International Journal of Cancer

    Volume 133, Issue 2, 15 July 2013, Pages: 505–513, Takako Sano, Shinji Takeuchi, Takayuki Nakagawa, Daisuke Ishikawa, Shigeki Nanjo, Tadaaki Yamada, Takahiro Nakamura, Kunio Matsumoto and Seiji Yano

    Version of Record online : 12 FEB 2013, DOI: 10.1002/ijc.28034

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    Crosstalk Between the PI3K/mTOR and MEK/ERK Pathways Involved in the Maintenance of Self-Renewal and Tumorigenicity of Glioblastoma Stem-Like Cells


    Volume 28, Issue 11, November 2010, Pages: 1930–1939, Jun Sunayama, Ken-Ichiro Matsuda, Atsushi Sato, Ken Tachibana, Kaori Suzuki, Yoshitaka Narita, Soichiro Shibui, Kaori Sakurada, Takamasa Kayama, Arata Tomiyama and Chifumi Kitanaka

    Version of Record online : 18 NOV 2010, DOI: 10.1002/stem.521

  14. You have full text access to this Open Access content
    Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy

    Cancer Science

    Volume 99, Issue 9, September 2008, Pages: 1734–1740, Dexin Kong and Takao Yamori

    Version of Record online : 4 JUL 2008, DOI: 10.1111/j.1349-7006.2008.00891.x

  15. You have free access to this content
    PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells

    Clinical and Experimental Pharmacology and Physiology

    Volume 42, Issue 12, December 2015, Pages: 1317–1326, Jiezhong Chen, Renfu Shao, Feng Li, Michael Monteiro, Jun-Ping Liu, Zhi Ping Xu and Wenyi Gu

    Version of Record online : 19 NOV 2015, DOI: 10.1111/1440-1681.12493

  16. Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor-Naïve Advanced Pancreatic Neuroendocrine Tumors

    The Oncologist

    Ramon Salazar, Rocio Garcia-Carbonero, Steven K. Libutti, Andrew E. Hendifar, Ana Custodio, Rosine Guimbaud, Catherine Lombard-Bohas, Sergio Ricci, Heinz-Josef Klümpen, Jaume Capdevila, Nicholas Reed, Annemiek Walenkamp, Enrique Grande, Sufiya Safina, Tim Meyer, Oliver Kong, Herve Salomon, Ranjana Tavorath and James C. Yao

    Version of Record online : 14 DEC 2017, DOI: 10.1634/theoncologist.2017-0144

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    Clinical implications and diagnostic usefulness of correlation between soluble major histocompatibility complex class I chain-related molecule a and protumorigenic cytokines in pancreatic ductal adenocarcinoma


    Volume 119, Issue 1, 1 January 2013, Pages: 233–244, Hye Won Chung, Sunphil Jang and Jong-Baeck Lim

    Version of Record online : 26 JUN 2012, DOI: 10.1002/cncr.27669

  18. Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma

    The Journal of Pathology

    Volume 236, Issue 2, June 2015, Pages: 142–154, Hexige Saiyin, Christine M Ardito-Abraham, Yanhua Wu, Youheng Wei, Yuan Fang, Xu Han, Jianang Li, Ping Zhou, Qing Yi, Anirban Maitra, Jun O Liu, David A Tuveson, Wenhui Lou and Long Yu

    Version of Record online : 17 FEB 2015, DOI: 10.1002/path.4506

  19. Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells

    Molecular Carcinogenesis

    Volume 52, Issue 9, September 2013, Pages: 667–675, Yong Weon Yi, Hyo Jin Kang, Hee Jeong Kim, Jae Seok Hwang, Antai Wang and Insoo Bae

    Version of Record online : 4 APR 2012, DOI: 10.1002/mc.21905

  20. You have full text access to this OnlineOpen article
    Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

    Journal of Cellular and Molecular Medicine

    Volume 17, Issue 11, November 2013, Pages: 1397–1409, Meng Ling Choong, Christian Pecquet, Vishal Pendharkar, Carmen C. Diaconu, Jacklyn Wei Yan Yong, Shi Jing Tai, Si Fang Wang, Jean-Philippe Defour, Kanda Sangthongpitag, Jean-Luc Villeval, William Vainchenker, Stefan N. Constantinescu and May Ann Lee

    Version of Record online : 19 NOV 2013, DOI: 10.1111/jcmm.12156