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There are 28927 results for: content related to: Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis

  1. Multiple signal pathways in obesity-associated cancer

    Obesity Reviews

    Volume 12, Issue 12, December 2011, Pages: 1063–1070, J. Chen

    Article first published online : 21 AUG 2011, DOI: 10.1111/j.1467-789X.2011.00917.x

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    A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma

    BJU International

    Volume 110, Issue 11c, December 2012, Pages: E1237–E1248, Penelope Korkolopoulou, Georgia Levidou, Eleni-Andriana Trigka, Niki Prekete, Maria Karlou, Irene Thymara, Stratigoula Sakellariou, Paraskevi Fragkou, Dimitrios Isaiadis, Petros Pavlopoulos, Efstratios Patsouris and Angelica A. Saetta

    Article first published online : 29 OCT 2012, DOI: 10.1111/j.1464-410X.2012.11569.x

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    Print Only

    Journal of Gastroenterology and Hepatology

    Volume 28, Issue S3, October 2013, Pages: 694–919,

    Article first published online : 17 SEP 2013, DOI: 10.1111/jgh.12363_3

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    The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk

    International Journal of Cancer

    Volume 132, Issue 11, 1 June 2013, Pages: 2682–2693, Christian Seitz, Manuela Hugle, Silvia Cristofanon, Aurélie Tchoghandjian and Simone Fulda

    Article first published online : 4 DEC 2012, DOI: 10.1002/ijc.27935

  5. You have full text access to this OnlineOpen article
    PI3K/AKT/mTOR pathway activation in primary and corresponding metastatic breast tumors after adjuvant endocrine therapy

    International Journal of Cancer

    Volume 135, Issue 5, 01 September 2014, Pages: 1257–1263, Karin Beelen, Laurien D.C. Hoefnagel, Mark Opdam, Jelle Wesseling, J. Sanders, Andrew D. Vincent, Paul J. van Diest and Sabine C. Linn

    Article first published online : 27 FEB 2014, DOI: 10.1002/ijc.28769

  6. Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/AKT/mTOR Signaling Cascade in Human Leukemia HL-60 Cells

    Journal of Cellular Biochemistry

    Volume 116, Issue 6, June 2015, Pages: 985–997, Suresh Kumar, Santosh Kumar Guru, Anup Singh Pathania, Sudhakar Manda, Ajay Kumar, Sandip B. Bharate, Ram A. Vishwakarma, Fayaz Malik and Shashi Bhushan

    Article first published online : 10 APR 2015, DOI: 10.1002/jcb.25053

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    Molecular mechanisms regulating the hormone sensitivity of breast cancer

    Cancer Science

    Volume 105, Issue 11, November 2014, Pages: 1377–1383, Eriko Tokunaga, Yuichi Hisamatsu, Kimihiro Tanaka, Nami Yamashita, Hiroshi Saeki, Eiji Oki, Hiroyuki Kitao and Yoshihiko Maehara

    Article first published online : 29 OCT 2014, DOI: 10.1111/cas.12521

  8. Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease

    Journal of Digestive Diseases

    Volume 14, Issue 12, December 2013, Pages: 662–669, Shun Hua Long, Yao He, Min Hu Chen, Kang Cao, Yu Jun Chen, Bai Li Chen, Ren Mao, Sheng Hong Zhang, Zhen Hua Zhu, Zhi Rong Zeng and Pin Jin Hu

    Article first published online : 5 NOV 2013, DOI: 10.1111/1751-2980.12095

  9. Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations

    British Journal of Pharmacology

    Volume 171, Issue 16, August 2014, Pages: 3801–3813, M Moschetta, A Reale, C Marasco, A Vacca and M R Carratù

    Article first published online : 25 JUL 2014, DOI: 10.1111/bph.12749

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    Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways

    British Journal of Pharmacology

    Volume 163, Issue 7, August 2011, Pages: 1520–1532, O Gomez, A Sanchez-Rodriguez, MQU Le, C Sanchez-Caro, F Molina-Holgado and E Molina-Holgado

    Article first published online : 12 JUL 2011, DOI: 10.1111/j.1476-5381.2011.01414.x

  11. Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway

    Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

    Courtney A. Granville, Regan M. Memmott, Joell J. Gills, Phillip A. Dennis, Pages: 966–996, 2008

    Published Online : 26 MAY 2008, DOI: 10.1002/9783527619665.ch38

  12. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

    Journal of Neurochemistry

    Volume 133, Issue 5, June 2015, Pages: 739–749, Antonella Tramutola, Judy C. Triplett, Fabio Di Domenico, Dana M. Niedowicz, Michael P. Murphy, Raffaella Coccia, Marzia Perluigi and D. Allan Butterfield

    Article first published online : 26 FEB 2015, DOI: 10.1111/jnc.13037

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    The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies

    Oral Diseases

    R Vander Broek, S Mohan, DF Eytan, Z Chen and C Van Waes

    Article first published online : 23 DEC 2013, DOI: 10.1111/odi.12206

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    Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation

    Aging Cell

    Volume 11, Issue 2, April 2012, Pages: 305–314, Hitoshi Takahashi, Daiki Okamura, Marlene E. Starr, Hiroshi Saito and B. Mark Evers

    Article first published online : 1 FEB 2012, DOI: 10.1111/j.1474-9726.2011.00787.x

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    MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma


    Volume 55, Issue 6, June 2012, Pages: 1852–1862, YuXiang Fang, Jing-Lun Xue, Qi Shen, Jinzhong Chen and Ling Tian

    Article first published online : 29 MAY 2012, DOI: 10.1002/hep.25576

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    Targeting mTOR in renal cell carcinoma


    Volume 115, Issue S10, 15 May 2009, Pages: 2313–2320, Gary R. Hudes

    Article first published online : 28 APR 2009, DOI: 10.1002/cncr.24239

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    Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

    International Journal of Cancer

    Volume 130, Issue 7, 1 April 2012, Pages: 1695–1705, Naghma Khan, Farrukh Afaq, Fatima H. Khusro, Vaqar Mustafa Adhami, Yewseok Suh and Hasan Mukhtar

    Article first published online : 26 AUG 2011, DOI: 10.1002/ijc.26178

  18. Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells

    Cell Biology International

    Volume 33, Issue 2, February 2009, Pages: 230–238, Grace P.W. Chan, Eddy H.T. Wu and Yung H. Wong

    Article first published online : 2 JAN 2013, DOI: 10.1016/j.cellbi.2008.11.010

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    Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer

    International Journal of Cancer

    Volume 133, Issue 4, 15 August 2013, Pages: 984–996, Areumnuri Kim, Jung-Eun Lee, Seung-Sook Lee, Cherin Kim, Sun-Joo Lee, Won-Suk Jang and Sunhoo Park

    Article first published online : 8 MAR 2013, DOI: 10.1002/ijc.28073

  20. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways

    Journal of Cellular Physiology

    Volume 226, Issue 11, November 2011, Pages: 2762–2781, James A. McCubrey, Linda S. Steelman, C. Ruth Kempf, William H. Chappell, Stephen L. Abrams, Franca Stivala, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Jörg Bäsecke, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Lucio Cocco and Alberto M. Martelli

    Article first published online : 24 AUG 2011, DOI: 10.1002/jcp.22647