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There are 21108 results for: content related to: Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity

  1. You have free access to this content
    Management of lipid disorders in patients living with HIV

    The Journal of Clinical Pharmacology

    Volume 55, Issue 9, September 2015, Pages: 957–974, Merle Myerson, Carlos Malvestutto and Judith A. Aberg

    Version of Record online : 23 JUN 2015, DOI: 10.1002/jcph.473

  2. Lack of Potential Pharmacokinetic and Pharmacodynamic Interactions Between Piragliatin, a Glucokinase Activator, and Simvastatin in Patients With Type 2 Diabetes Mellitus

    The Journal of Clinical Pharmacology

    Volume 56, Issue 6, June 2016, Pages: 675–682, Angela Georgy, Suoping Zhai, Zhenming Liang, Mark Boldrin and Jianguo Zhi

    Version of Record online : 21 DEC 2015, DOI: 10.1002/jcph.640

  3. Enzyme- and transporter-mediated beverage–drug interactions: An update on fruit juices and green tea

    The Journal of Clinical Pharmacology

    Volume 55, Issue 12, December 2015, Pages: 1313–1331, Guohua An, Jatinder Kaur Mukker, Hartmut Derendorf and Reginald F. Frye

    Version of Record online : 30 JUL 2015, DOI: 10.1002/jcph.563

  4. Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine

    The Journal of Clinical Pharmacology

    Volume 54, Issue 2, February 2014, Pages: 141–149, Ayyappa Chaturvedula, Mark E. Sale and Howard Lee

    Version of Record online : 21 SEP 2013, DOI: 10.1002/jcph.176

  5. You have full text access to this OnlineOpen article
    Assessment of Disease-Related Therapeutic Protein Drug-Drug Interaction for Etrolizumab in Patients With Moderately to Severely Active Ulcerative Colitis

    The Journal of Clinical Pharmacology

    Volume 56, Issue 6, June 2016, Pages: 693–704, Xiaohui Wei, Jane R. Kenny, Leslie Dickmann, Romeo Maciuca, Caroline Looney and Meina T. Tang

    Version of Record online : 11 JAN 2016, DOI: 10.1002/jcph.649

  6. Pharmacokinetic interaction between simvastatin and fenofibrate with staggered and simultaneous dosing: Does it matter?

    The Journal of Clinical Pharmacology

    Volume 54, Issue 9, September 2014, Pages: 1038–1047, Anneke Winsemius, Jean-Claude Ansquer, Matthias Olbrich, Peter van Amsterdam, Patrick Aubonnet, Katrin Beckmann, Stefan Driessen, Hanneke van Assche, Gabi Piskol, Dirk Lehnick and Katsuhiro Mihara

    Version of Record online : 1 APR 2014, DOI: 10.1002/jcph.291

  7. Simvastatin therapy decreases MMP-9 levels in obese women

    The Journal of Clinical Pharmacology

    Volume 53, Issue 10, October 2013, Pages: 1072–1077, Vanessa Leite Andrade, Izabella Batistelli do Valle and Valeria Cristina Sandrim

    Version of Record online : 1 AUG 2013, DOI: 10.1002/jcph.146

  8. The interaction of diltiazem with simvastatin

    Clinical Pharmacology & Therapeutics

    Volume 67, Issue 3, March 2000, Pages: 267–274, Omaima Mousa, D. Craig Brater, Kimberly J. Sundblad and Stephen D. Hall

    Version of Record online : 26 MAR 2000, DOI: 10.1067/mcp.2000.104609

  9. Simvastatin Does Not Affect CYP3A Activity, Quantified by the Erythromycin Breath Test and Oral Midazolam Pharmacokinetics, in Healthy Male Subjects

    The Journal of Clinical Pharmacology

    Volume 40, Issue 11, November 2000, Pages: 1274–1279, Dr. Thomayant Prueksaritanont, Dr. José M. Vega, Dr. J. Douglas Rogers, Ms. Kathleen Gagliano, Dr. Howard E. Greenberg, Ms. Lisa Gillen, Ms. Mary Jo Brucker, Ms. Debra McLoughlin, Ms. Peggy H. Wong and Dr. Scott A. Waldman

    Version of Record online : 19 MAR 2013, DOI: 10.1177/009127000004001112

  10. Predicting the “First dose in children” of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages

    The Journal of Clinical Pharmacology

    Volume 54, Issue 9, September 2014, Pages: 1006–1015, Ashley Strougo, Ashraf Yassen, Claire Monnereau, Meindert Danhof and Jan Freijer

    Version of Record online : 28 MAR 2014, DOI: 10.1002/jcph.294

  11. A mechanistic physiologically based pharmacokinetic-enzyme turnover model involving both intestine and liver to predict CYP3A induction-mediated drug–drug interactions

    Journal of Pharmaceutical Sciences

    Volume 102, Issue 8, August 2013, Pages: 2819–2836, Haifang Guo, Can Liu, Jia Li, Mian Zhang, Mengyue Hu, Ping Xu, Li Liu and Xiaodong Liu

    Version of Record online : 11 JUN 2013, DOI: 10.1002/jps.23613

  12. Comparison of midazolam and simvastatin as cytochrome P450 3A probes

    Clinical Pharmacology & Therapeutics

    Volume 79, Issue 4, April 2006, Pages: 350–361, Ellen Chung, Anne N. Nafziger, David J. Kazierad and Joseph S. Bertino Jr

    Version of Record online : 16 APR 2006, DOI: 10.1016/j.clpt.2005.11.016

  13. Pharmacokinetic interaction of intravenous fentanyl with ketoconazole

    The Journal of Clinical Pharmacology

    Volume 55, Issue 6, June 2015, Pages: 708–717, Victoria C. Ziesenitz, Sonja K. König, Nina S. Mahlke, Gisela Skopp, Walter E. Haefeli and Gerd Mikus

    Version of Record online : 16 FEB 2015, DOI: 10.1002/jcph.469

  14. Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: An overview

    The Journal of Clinical Pharmacology

    Volume 53, Issue 12, December 2013, Pages: 1228–1239, Noboru Toda and Tomio Okamura

    Version of Record online : 30 SEP 2013, DOI: 10.1002/jcph.179

  15. Impact of Tesamorelin, a Growth Hormone-Releasing Factor (GRF) Analogue, on the Pharmacokinetics of Simvastatin and Ritonavir in Healthy Volunteers

    Clinical Pharmacology in Drug Development

    Volume 2, Issue 3, July 2013, Pages: 237–245, Shirley Teng, Diane Potvin, Jean-Claude Mamputu, Geneviève Vincent, Monika Zoltowska, Josée Morin, Saida Hatimi, Sophie-Elise Michaud, Kim High and Murray P. Ducharme

    Version of Record online : 15 MAY 2013, DOI: 10.1002/cpdd.27

  16. The impact of interacting drugs on dispensed doses of warfarin in the Swedish population: A novel use of population based drug registers

    The Journal of Clinical Pharmacology

    Volume 53, Issue 12, December 2013, Pages: 1322–1327, M.L. Andersson, J.D. Lindh and B. Mannheimer

    Version of Record online : 17 SEP 2013, DOI: 10.1002/jcph.174

  17. Studies to Investigate the Pharmacokinetic Interactions Between Ranolazine and Ketoconazole, Diltiazem, or Simvastatin During Combined Administration in Healthy Subjects

    The Journal of Clinical Pharmacology

    Volume 45, Issue 4, April 2005, Pages: 422–433, Dr Markus Jerling, Bee-Lian Huan, Dr Kwan Leung, Nancy Chu, Dr Hisham Abdallah and Dr Ziad Hussein

    Version of Record online : 7 MAR 2013, DOI: 10.1177/0091270004273992

  18. The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects

    The Journal of Clinical Pharmacology

    Volume 54, Issue 4, April 2014, Pages: 422–431, Thomas N. Kakuda, Rodica M. Van Solingen-Ristea, Joelle Onkelinx, Tanja Stevens, Fatima Aharchi, Goedele De Smedt, Monika Peeters, Lorant Leopold and Richard M.W. Hoetelmans

    Version of Record online : 19 NOV 2013, DOI: 10.1002/jcph.214

  19. Time-Dependent Inhibition and Induction of Human Cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, In Vitro and In Vivo in Healthy Subjects

    The Journal of Clinical Pharmacology

    Volume 53, Issue 6, June 2013, Pages: 642–653, Shyeilla Dhuria, Heidi Einolf, James Mangold, Suman Sen, Helen Gu, Lai Wang and Scott Cameron

    Version of Record online : 15 APR 2013, DOI: 10.1002/jcph.79

  20. Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK

    The Journal of Clinical Pharmacology

    Volume 55, Issue 9, September 2015, Pages: 1012–1023, Linh Nguyen, Jaymes Holland, Dale Miles, Caroline Engel, Natacha Benrimoh, Terry O'Reilly and Steven Lacy

    Version of Record online : 2 JUN 2015, DOI: 10.1002/jcph.510