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There are 26608 results for: content related to: Engineering a mammalian super producer

  1. Engineering mammalian cells in bioprocessing – current achievements and future perspectives

    Biotechnology and Applied Biochemistry

    Volume 55, Issue 4, April 2010, Pages: 175–189, Yiping Lim, Niki S. C. Wong, Yih Yean Lee, Sebastian C. Y. Ku, Danny C. F. Wong and Miranda G. S. Yap

    Article first published online : 23 DEC 2010, DOI: 10.1042/BA20090363

  2. Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells

    Biotechnology and Bioengineering

    Volume 99, Issue 1, 1 January 2008, Pages: 155–164, Sebastian C.Y. Ku, Daphne T.W. Ng, Miranda G.S. Yap and Sheng-Hao Chao

    Article first published online : 5 JUL 2007, DOI: 10.1002/bit.21562

  3. You have free access to this content
    Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

    Biotechnology and Bioengineering

    Volume 91, Issue 2, 20 July 2005, Pages: 180–189, Diane M. Dinnis and David C. James

    Article first published online : 5 MAY 2005, DOI: 10.1002/bit.20499

  4. Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL

    Biotechnology and Bioengineering

    Volume 101, Issue 3, 15 October 2008, Pages: 567–578, Brian S. Majors, Michael J. Betenbaugh, Nels E. Pederson and Gisela G. Chiang

    Article first published online : 15 APR 2008, DOI: 10.1002/bit.21917

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    Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

    Biotechnology and Bioengineering

    Volume 103, Issue 3, 15 June 2009, Pages: 592–608, Haimanti Dorai, Yun Seung Kyung, Dawn Ellis, CherylAnn Kinney, Chengbin Lin, David Jan, Gordon Moore and Michael J. Betenbaugh

    Article first published online : 22 JAN 2009, DOI: 10.1002/bit.22269

  6. Metabolic engineering II. Eukaryotic systems

    Biotechnology and Bioengineering

    Volume 79, Issue 5, 5 September 2002, Pages: 509–531, Martin Fussenegger and Michael J. Betenbaugh

    Article first published online : 18 JUL 2002, DOI: 10.1002/bit.10405

  7. Non-invasive UPR monitoring system and its applications in CHO production cultures

    Biotechnology and Bioengineering

    Volume 110, Issue 8, August 2013, Pages: 2184–2194, Zhimei Du, David Treiber, Rebecca E. McCoy, Amanda K. Miller, Mei Han, Feng He, Sarah Domnitz, Carole Heath and Pranhitha Reddy

    Article first published online : 26 MAR 2013, DOI: 10.1002/bit.24877

  8. Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures

    Biotechnology and Bioengineering

    Volume 97, Issue 3, 15 June 2007, Pages: 601–614, Nilou Arden, Brian S. Majors, Shin-hyung Ahn, George Oyler and Michael J. Betenbaugh

    Article first published online : 5 DEC 2006, DOI: 10.1002/bit.21254

  9. Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines

    Biotechnology Progress

    Volume 26, Issue 5, September/October 2010, Pages: 1367–1381, Haimanti Dorai, Dawn Ellis, Yun Seung Keung, Marguerite Campbell, Minhong Zhuang, Chengbin Lin and Michael J. Betenbaugh

    Article first published online : 24 MAR 2010, DOI: 10.1002/btpr.426

  10. Enhanced transient recombinant protein production in CHO cells through the co-transfection of the product gene with Bcl-xL

    Biotechnology Journal

    Volume 9, Issue 9, September 2014, Pages: 1164–1174, Matthew P. Zustiak, Lisa Jose, Yueqing Xie, Jianwei Zhu and Michael J. Betenbaugh

    Article first published online : 8 MAY 2014, DOI: 10.1002/biot.201300468

  11. A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells

    Biotechnology and Bioengineering

    Volume 108, Issue 7, July 2011, Pages: 1651–1661, Aliaksandr Druz, Chia Chu, Brian Majors, Rodell Santuary, Michael Betenbaugh and Joseph Shiloach

    Article first published online : 11 MAR 2011, DOI: 10.1002/bit.23092

  12. Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1

    Journal of Chemical Technology and Biotechnology

    Volume 86, Issue 7, July 2011, Pages: 923–934, Joe Codamo, Jeff Jia Cheng Hou, Benjamin S. Hughes, Peter P. Gray and Trent P. Munro

    Article first published online : 15 FEB 2011, DOI: 10.1002/jctb.2572

  13. Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture

    Biotechnology and Bioengineering

    Volume 98, Issue 4, 1 November 2007, Pages: 825–841, Toey Nivitchanyong, Amanda Martinez, Adiba Ishaque, John E. Murphy, Konstantin Konstantinov, Michael J. Betenbaugh and John Thrift

    Article first published online : 18 MAY 2007, DOI: 10.1002/bit.21479

  14. Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells

    Biotechnology Progress

    Volume 26, Issue 2, March/April 2010, Pages: 517–526, Sebastian C. Y. Ku, Poh Choo Toh, Yih Yean Lee, Janet Chusainow, Miranda G. S. Yap and Sheng-Hao Chao

    Article first published online : 24 NOV 2009, DOI: 10.1002/btpr.322

  15. Protein Glycosylation: Analysis, Characterization, and Engineering

    Standard Article

    Encyclopedia of Industrial Biotechnology

    Mikael R. Andersen, Jong Hyun Nam and Susan T. Sharfstein

    Published Online : 16 MAY 2011, DOI: 10.1002/9780470054581.eib649

  16. Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions

    Biotechnology and Bioengineering

    Volume 85, Issue 6, 20 March 2004, Pages: 589–600, Bruno Figueroa Jr., Sulin Chen, George A. Oyler, J. Marie Hardwick and Michael J. Betenbaugh

    Article first published online : 2 FEB 2004, DOI: 10.1002/bit.10913

  17. Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells

    Biotechnology and Bioengineering

    Volume 92, Issue 4, 20 November 2005, Pages: 452–461, Yeon Kyu Kim, Hwa Sung Shin, Noboru Tomiya, Yuan C. Lee, Michael J. Betenbaugh and Hyung Joon Cha

    Article first published online : 15 JUL 2005, DOI: 10.1002/bit.20605

  18. Membrane Protein Expression in Mammalian Cells

    Production of Membrane Proteins: Strategies for Expression and Isolation

    Deniz B. Hizal, Erika Ohsfeldt, Sunny Mai, Michael J. Betenbaugh, Pages: 139–165, 2011

    Published Online : 18 JUN 2011, DOI: 10.1002/9783527634521.ch5

  19. Bcl-xL mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells

    Biotechnology and Bioengineering

    Volume 91, Issue 7, 30 September 2005, Pages: 779–792, Gisela G. Chiang and William P. Sisk

    Article first published online : 28 JUN 2005, DOI: 10.1002/bit.20551

  20. Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-xL on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media

    Biotechnology and Bioengineering

    Volume 80, Issue 6, 20 December 2002, Pages: 706–716, Heiko Meents, Barbara Enenkel, Hans M. Eppenberger, Rolf G. Werner and Martin Fussenegger

    Article first published online : 10 OCT 2002, DOI: 10.1002/bit.10449