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There are 29475 results for: content related to: Engineering a mammalian super producer

  1. Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture

    Biotechnology and Bioengineering

    Volume 98, Issue 4, 1 November 2007, Pages: 825–841, Toey Nivitchanyong, Amanda Martinez, Adiba Ishaque, John E. Murphy, Konstantin Konstantinov, Michael J. Betenbaugh and John Thrift

    Version of Record online : 18 MAY 2007, DOI: 10.1002/bit.21479

  2. Engineering mammalian cells in bioprocessing – current achievements and future perspectives

    Biotechnology and Applied Biochemistry

    Volume 55, Issue 4, April 2010, Pages: 175–189, Yiping Lim, Niki S. C. Wong, Yih Yean Lee, Sebastian C. Y. Ku, Danny C. F. Wong and Miranda G. S. Yap

    Version of Record online : 23 DEC 2010, DOI: 10.1042/BA20090363

  3. You have free access to this content
    Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

    Biotechnology and Bioengineering

    Volume 103, Issue 3, 15 June 2009, Pages: 592–608, Haimanti Dorai, Yun Seung Kyung, Dawn Ellis, CherylAnn Kinney, Chengbin Lin, David Jan, Gordon Moore and Michael J. Betenbaugh

    Version of Record online : 22 JAN 2009, DOI: 10.1002/bit.22269

  4. Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines

    Biotechnology Progress

    Volume 26, Issue 5, September/October 2010, Pages: 1367–1381, Haimanti Dorai, Dawn Ellis, Yun Seung Keung, Marguerite Campbell, Minhong Zhuang, Chengbin Lin and Michael J. Betenbaugh

    Version of Record online : 24 MAR 2010, DOI: 10.1002/btpr.426

  5. Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells

    Biotechnology and Bioengineering

    Volume 97, Issue 4, 1 July 2007, Pages: 877–892, Bruno Figueroa Jr., Eric Ailor, Douglas Osborne, J. Marie Hardwick, Mitchell Reff and Michael J. Betenbaugh

    Version of Record online : 10 NOV 2006, DOI: 10.1002/bit.21222

  6. Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions

    Biotechnology and Bioengineering

    Volume 85, Issue 6, 20 March 2004, Pages: 589–600, Bruno Figueroa Jr., Sulin Chen, George A. Oyler, J. Marie Hardwick and Michael J. Betenbaugh

    Version of Record online : 2 FEB 2004, DOI: 10.1002/bit.10913

  7. Dose-dependent reduction of apoptosis in nutrient-limited cultures of NS/0 myeloma cells transfected with the E1B-19K adenoviral gene

    Biotechnology and Bioengineering

    Volume 63, Issue 5, 5 June 1999, Pages: 516–528, Sylvain Mercille, Pierre Jolicoeur, Christian Gervais, Denis Paquette, Dick D. Mosser and Bernard Massie

    Version of Record online : 26 MAR 2000, DOI: 10.1002/(SICI)1097-0290(19990605)63:5<516::AID-BIT2>3.0.CO;2-9

  8. Membrane Protein Expression in Mammalian Cells

    Production of Membrane Proteins: Strategies for Expression and Isolation

    Deniz B. Hizal, Erika Ohsfeldt, Sunny Mai, Michael J. Betenbaugh, Pages: 139–165, 2011

    Published Online : 18 JUN 2011, DOI: 10.1002/9783527634521.ch5

  9. Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures

    Biotechnology and Bioengineering

    Volume 97, Issue 3, 15 June 2007, Pages: 601–614, Nilou Arden, Brian S. Majors, Shin-hyung Ahn, George Oyler and Michael J. Betenbaugh

    Version of Record online : 5 DEC 2006, DOI: 10.1002/bit.21254

  10. Apoptosis-resistant E1B-19K-expressing NS/0 myeloma cells exhibit increased viability and chimeric antibody productivity under perfusion culture conditions

    Biotechnology and Bioengineering

    Volume 63, Issue 5, 5 June 1999, Pages: 529–543, Sylvain Mercille and Bernard Massie

    Version of Record online : 26 MAR 2000, DOI: 10.1002/(SICI)1097-0290(19990605)63:5<529::AID-BIT3>3.0.CO;2-X

  11. Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL

    Biotechnology and Bioengineering

    Volume 101, Issue 3, 15 October 2008, Pages: 567–578, Brian S. Majors, Michael J. Betenbaugh, Nels E. Pederson and Gisela G. Chiang

    Version of Record online : 15 APR 2008, DOI: 10.1002/bit.21917

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    Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

    Biotechnology and Bioengineering

    Volume 91, Issue 2, 20 July 2005, Pages: 180–189, Diane M. Dinnis and David C. James

    Version of Record online : 5 MAY 2005, DOI: 10.1002/bit.20499

  13. Metabolic engineering II. Eukaryotic systems

    Biotechnology and Bioengineering

    Volume 79, Issue 5, 5 September 2002, Pages: 509–531, Martin Fussenegger and Michael J. Betenbaugh

    Version of Record online : 18 JUL 2002, DOI: 10.1002/bit.10405

  14. Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-xL on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media

    Biotechnology and Bioengineering

    Volume 80, Issue 6, 20 December 2002, Pages: 706–716, Heiko Meents, Barbara Enenkel, Hans M. Eppenberger, Rolf G. Werner and Martin Fussenegger

    Version of Record online : 10 OCT 2002, DOI: 10.1002/bit.10449

  15. A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells

    Biotechnology and Bioengineering

    Volume 108, Issue 7, July 2011, Pages: 1651–1661, Aliaksandr Druz, Chia Chu, Brian Majors, Rodell Santuary, Michael Betenbaugh and Joseph Shiloach

    Version of Record online : 11 MAR 2011, DOI: 10.1002/bit.23092

  16. Study of caspase inhibitors for limiting death in mammalian cell culture

    Biotechnology and Bioengineering

    Volume 81, Issue 3, 5 February 2003, Pages: 329–340, Tina M. Sauerwald, George A. Oyler and Michael J. Betenbaugh

    Version of Record online : 3 DEC 2002, DOI: 10.1002/bit.10473

  17. Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition

    Biotechnology and Bioengineering

    Volume 103, Issue 4, 1 July 2009, Pages: 757–766, Yeon-Gu Kim, Jee Yon Kim, Chaya Mohan and Gyun Min Lee

    Version of Record online : 12 FEB 2009, DOI: 10.1002/bit.22298

  18. Effect of Bcl-xL overexpression on lactate metabolism in chinese hamster ovary cells producing antibody

    Biotechnology Progress

    Volume 29, Issue 6, November/December 2013, Pages: 1594–1598, Tae Kwang Ha, Min Kyoung Jeon, Da young Yu and Gyun Min Lee

    Version of Record online : 30 SEP 2013, DOI: 10.1002/btpr.1805

  19. Bcl-xL mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells

    Biotechnology and Bioengineering

    Volume 91, Issue 7, 30 September 2005, Pages: 779–792, Gisela G. Chiang and William P. Sisk

    Version of Record online : 28 JUN 2005, DOI: 10.1002/bit.20551

  20. Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines

    Biotechnology and Bioengineering

    Volume 106, Issue 1, 1 May 2010, Pages: 42–56, Padraig Doolan, Paula Meleady, Niall Barron, Michael Henry, Ross Gallagher, Patrick Gammell, Mark Melville, Martin Sinacore, Kevin McCarthy, Mark Leonard, Timothy Charlebois and Martin Clynes

    Version of Record online : 20 JAN 2010, DOI: 10.1002/bit.22670